Capsid protein gene variation among feline calicivirus isolates.

Abstract:

:We amplified the capsid protein gene fragments of 30 Japanese isolates of feline calicivirus (FCV), including the C, D, and E regions, by reverse transcription-polymerase chain reaction (RT-PCR), followed by direct sequencing. Alignment of the predicted amino acid sequences, together with other published sequences from the isolates obtained in other countries, demonstrated a marked heterogeneity among the isolates, confirming the current definition of hypervariable regions within the capsid protein: these regions give rise to the antigenic variations seen in FCV isolates. Phylogenetic analysis of the nucleotide sequences could not identify significant geographically or temporally separated clusters of FCV isolates, supporting the theory of a single genotype.

journal_name

Virus Genes

journal_title

Virus genes

authors

Horimoto T,Takeda Y,Iwatsuki-Horimoto K,Sugii S,Tajima T

doi

10.1023/a:1011892120875

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

171-4

issue

2

eissn

0920-8569

issn

1572-994X

journal_volume

23

pub_type

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