High expression of TNFSF13 in tumor cells and fibroblasts is associated with poor prognosis in non-small cell lung cancer.

Abstract:

OBJECTIVES:To examine high expression of tumor necrosis factor ligand superfamily member 13 (TNFSF13), which is correlated with several malignancies. METHODS:TNFSF13 messenger RNA expression in tumor cells and fibroblasts in a cohort of patients with non-small cell lung cancer (NSCLC) was analyzed by quantitative real-time polymerase chain reaction and immunohistochemistry using a tissue microarray. RESULTS:TNFSF13 expression was significantly higher in lung adenocarcinomas compared with squamous cell carcinomas (P = .022). High TNFSF13 expression in NSCLC stroma was related with low differentiation (P = .045) and sex (male > female, P = .005). Cox proportional hazards regression univariate and multivariable analysis revealed TNFSF13 expression in NSCLC tumor cells (P = .007) or fibroblasts (P = .027) as an independent prognostic factor in the 5-year overall survival rate. CONCLUSIONS:Our findings indicate TNFSF13 is a prognostic factor in NSCLC and suggest TNFSF13 may be a novel therapeutic target for NSCLC.

journal_name

Am J Clin Pathol

authors

Qian Z,Qingshan C,Chun J,Huijun Z,Feng L,Qiang W,Qiang X,Min Z

doi

10.1309/AJCP4JP8BZOMHEAW

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

226-33

issue

2

eissn

0002-9173

issn

1943-7722

pii

141/2/226

journal_volume

141

pub_type

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