Investigation on reference intervals and regional differences of platelet indices in healthy Chinese Han adults.

Abstract:

BACKGROUND:Reference intervals are important for interpretation of clinical laboratory tests. The platelet (PLT) indices such as the mean platelet volume (MPV) and platelet distribution width (PDW) are newer hematological parameters, which have been recently reported as clinically valuable biomarkers. However, there are not many studies that have estimated the reference intervals for these parameters in healthy Chinese Han adults. OBJECTIVE:The objectives of this study were to establish reference values of PLT indices [including PLT count, MPV, PDW, platelet-large cell ratio (P-LCR), and plateletcrit (Pct)] for healthy Chinese Han adults. We also aimed to determine the region-based differences of PLT indices in China. METHODS:A total of 4,642 volunteers with a mean age of 43 were recruited from six regions of China. PLT indices were performed on Sysmex XE-2100 hematology analyzers, whose traceability was well verified. RESULTS:There were significant region-based differences for all PLT indices. Reference people in Chengdu had the lowest mean PLT count and Pct, but the highest MPV, PDW, and P-LCR among the six regions. Therefore, we derived the reference intervals in Chinese Han population excluding Chengdu reference people for PLT indices as PLT count: (127-341) × 10(9)/l; MPV: (9.20-13.30) fl; PDW: 9.90-19.00%; P-LCR: 18.10-52.00%; Pct: 16.00-41.00%. CONCLUSIONS:Region-specific reference intervals are essential as there were statistically significant region-related differences in the PLT parameters. The reference intervals established in this study differed from the existing reference values. Chengdu region may need proper specific reference ranges, which apply to their people, for all PLT parameters.

journal_name

J Clin Lab Anal

authors

Hong J,Min Z,Bai-shen P,Jie Z,Ming-ting P,Xian-zhang H,Xiao-ke H,Lan-lan W,Xin Z,Wei G,Rui Q,Wen-xiang C,Xin-zhong W,Yue-yun M,Hong S

doi

10.1002/jcla.21721

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

21-7

issue

1

eissn

0887-8013

issn

1098-2825

journal_volume

29

pub_type

杂志文章
  • Performance characteristics of a transcription-mediated nucleic acid amplification assay for qualitative detection of hepatitis C virus RNA.

    abstract::The detection of hepatitis C virus (HCV) RNA by nucleic acid amplification techniques is the method of choice to differentiate between ongoing and past infection, and can be used to monitor the course of HCV infection. In this study, we evaluated the performance characteristics of a newly developed transcription-media...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1042

    authors: Ross RS,Viazov SO,Hoffmann S,Roggendorf M

    更新日期:2001-01-01 00:00:00

  • Isolation and characterizations of clarithromycin-resistant Mycobacterium avium clinical isolates.

    abstract::Mycobacterium avium is an important intracellular pathogen, particularly in AIDS patients. It also shows the second frequency among nontuberculous mycobacteria infections in Korea. Point mutations of domain V region of the 23S rRNA gene has been known to confer clarithromycin resistance to M. avium. In order to isolat...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20403

    authors: Lee SH,Park YK,Kim CK,Kim HJ

    更新日期:2011-01-01 00:00:00

  • Does polycythemia affect interleukin-6 response pattern in early postnatal period?

    abstract:INTRODUCTION:Neonatal polycythemia may result in increased cytokine production. We aimed to investigate whether polycythemia and partial exchange transfusion (PET) affect interleukin-6 (IL-6) response pattern in early neonatal period. METHODS:Ninety-four newborns, 57 with polycythemia (Group 1) and 37 as control group...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20413

    authors: Akdag A,Dilli D,Erdeve O,Oğuz SS,Dilmen U

    更新日期:2010-01-01 00:00:00

  • Gender-related differences in hepatic activity of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in humans.

    abstract::Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which are most abundant in the liver, are the main enzymes involved in ethanol metabolism in humans. Gender-related differences in total liver ADH and ALDH activity among different animal species have been observed in many studies. We measured total ADH an...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.10076

    authors: Chrostek L,Jelski W,Szmitkowski M,Puchalski Z

    更新日期:2003-01-01 00:00:00

  • More sensitive and simpler immune complex transfer enzyme immunoassay for antithyroglobulin IgG in serum.

    abstract::A more sensitive and simpler immune complex transfer enzyme immunoassay for antithyroglobulin IgG in serum and its use for the measurement of antithyroglobulin IgG in healthy subjects and patients with thyroid diseases are described. Antithyroglobulin IgG in test serum was reacted simultaneously with dinitrophenylthyr...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860030306

    authors: Kohno T,Mitsukawa T,Matsukura S,Tsunetoshi Y,Ishikawa E

    更新日期:1989-01-01 00:00:00

  • Comparison of point-of-care and central laboratory analyzers for blood gas and lactate measurements.

    abstract:BACKGROUND:Blood gas analysis and blood lactate measurement have important roles in patient management. Point-of-care (POC) testing simplifies and provides rapid blood gas and lactate measurements. This study aimed to compare pH, pCO2 , pO2 , and lactate measurements between a POC device and a benchtop blood gas analyz...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22885

    authors: Indrasari ND,Wonohutomo JP,Sukartini N

    更新日期:2019-06-01 00:00:00

  • Effect of temperature on lysosomal enzyme activity during preparation and storage of dried blood spots.

    abstract:BACKGROUND:The use of dried blood spots (DBS) for the assay of lysosomal enzymes has facilitated the implementation of pilot studies for newborn screening for lysosomal storage disorders in various developed countries. The aim of the study was to determine the influence of ambient temperature during DBS preparation and...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22220

    authors: Supriya M,De T,Christopher R

    更新日期:2018-01-01 00:00:00

  • Data mining: The association of 2-h postprandial plasma glucose with the fasting plasma glucose in a large Chinese population.

    abstract:BACKGROUND:It is generally believed that the lower limit of postprandial plasma glucose is the same or higher than that of fasting plasma glucose (FPG). This study aimed to investigate the relationship between 2-h postprandial plasma glucose (2-hPG) and FPG. Insulin sensitivity and β-cell function were also evaluated. ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23404

    authors: Sun D,Li D,Yu S,Zhang K,Cheng X

    更新日期:2020-09-01 00:00:00

  • Performance evaluation of Mindray CAL 8000(BC-6800 and SC-120) hematology analyzer and slidemaker/stainer.

    abstract:INTRODUCTION:The Mindray CAL 8000 is a cellular analysis line that consists of the BC-6800, an automated hematology analyzer, and the SC-120, an automated slidemaker/stainer. We evaluated the performances of the BC-6800 and the SC-120. METHODS:Four hundred and eight normal and abnormal samples were analyzed. The perfo...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22065

    authors: Lee HT,Park PW,Seo YH,Kim KH,Seo JY,Jeong JH,Kim MJ,Ahn JY

    更新日期:2017-07-01 00:00:00

  • Microparticle-enhanced nephelometric immunoassay of human plasminogen.

    abstract::A microparticle-enhanced nephelometric immunoassay was developed for plasminogen quantitation in human plasma. It is based on the nephelometric measurement of the light scattered by microparticle clusters formed during a sandwich reaction between plasminogen, microparticle--anti-plasminogen conjugate, and the free ant...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-2825(1996)10:2<85::AID-JCLA5>3.

    authors: Marchal E,Montagne P,Cuillière ML,Béné MC,Faure G

    更新日期:1996-01-01 00:00:00

  • Combination of preoperative NLR, PLR and CEA could increase the diagnostic efficacy for I-III stage CRC.

    abstract:BACKGROUND:Inflammation plays an important role in the development and progression of CRC. The members of inflammatory biomarkers, preoperative NLR and PLR, have been proved by numerous studies to be promising prognostic biomarkers for CRC. However, the diagnostic value of the two biomarkers in CRC remains unknown, and...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22075

    authors: Peng HX,Yang L,He BS,Pan YQ,Ying HQ,Sun HL,Lin K,Hu XX,Xu T,Wang SK

    更新日期:2017-09-01 00:00:00

  • Diurnal variation of biopyrrin excretion in random urine specimens is not corrected by creatinine.

    abstract::Circulating bilirubin is thought to function as a physiological antioxidant. One of the decomposition products of this process is the biopyrrins, which include two regioisomers: biotripyrrin-a (1,14,15,17-tetrahydro-2,7,13-trimethyl-1,14-deoxy-3-vinyl-16H-tripyrrin-8,12-dipropionic acid) and biotripyrrin-b (1,14,15,17...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20157

    authors: Ihara H,Matsumoto T,Morita Y,Hirano A,Okada M,Hashizume N,Shioji I,Yoshimura H

    更新日期:2007-01-01 00:00:00

  • Molecular detection of trisomy 21 by bicolor competitive fluorescent PCR.

    abstract:OBJECTIVE:To develop a reliable and specific method for rapid prenatal diagnosis of Trisomy 21 (Down syndrome). METHODS:We established a dual color competitive fluorescent Polymerase Chain Reaction (PCR) to measure the gene dosage of Down syndrome critical region (DSCR), a single copy sequence in chromosome 21. Anothe...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.21593

    authors: Wang Y,Zhang X,Ling B,He C,Xia Q,Chen F,Miyamori I,Yang Z,Fan C

    更新日期:2013-05-01 00:00:00

  • M30 does not predict the severity of hepatosteatosis, whereas adiponectin level declined with increase of ALT and the severity of hepatic steatosis.

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is an emerging problem all over the world. Because NAFLD and polycystic ovary syndrome (PCOS) are both closely related with insulin resistance, it would be necessary to determine the rate of presence of NAFLD in PCOS patients. So, this study aimed to investigate the u...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.21697

    authors: Caner S,Altınbaş A,Saykı M,Büyükcam F,Yılmaz B,Çakal E,Çoban Ş,Delibaşı T

    更新日期:2014-09-01 00:00:00

  • Angiotoxicity and atherogenicity of cholesterol oxides.

    abstract::Cholesterol in the diet can readily autoxidize and be absorbed and transported in plasma lipoproteins. Cholesterol oxides can also be endogenously produced in tissues via free-radical-induced reactions. Some cholesterol oxides, notably cholestane-3 beta, 5 alpha, 6 beta-triol and 25-hydroxycholesterol, have been shown...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章,评审

    doi:10.1002/jcla.1860050212

    authors: Peng SK,Hu B,Morin RJ

    更新日期:1991-01-01 00:00:00

  • Identification of plasma hsa_circ_0008673 expression as a potential biomarker and tumor regulator of breast cancer.

    abstract:OBJECTIVE:Cell-free circular RNAs (circRNAs) are stable and abundantly exist in body fluids. In this study, we aimed to investigate plasma cell-free circRNAs as a novel class of biomarkers for the diagnosis of breast cancer (BC). METHODS:Differentially expressed circRNAs from 6 normal and 6 BC plasma samples were dete...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23393

    authors: Hu Y,Song Q,Zhao J,Ruan J,He F,Yang X,Yu X

    更新日期:2020-09-01 00:00:00

  • Sensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) for (anti-human T-cell leukemia virus type I) IgG in serum using recombinant gag p24(14-214) as antigen.

    abstract::A sensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) for (anti-human T-cell leukemia virus type I) IgG (anti-HTLV-I IgG) in serum using recombinant gag p24(14-214) of HTLV-I is described. The recombinant gag p24(14-214) is soluble in the absence of detergents and allows the use of enzymes other ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860060509

    authors: Kohno T,Hirota K,Sakoda I,Yamasaki M,Yokoo Y,Ishikawa E

    更新日期:1992-01-01 00:00:00

  • Long non-coding RNAE330013P06 promotes progression of breast cancer with type 2 diabetes.

    abstract:BACKGROUND:In previous research, we found diabetes rather than obesity was an independent risk factor of breast cancer. However, why diabetes could lead to increased risk of breast cancer patients remains elusive. Long non-coding RNAE330013P06 has been shown to be upregulated in diabetes, and long non-coding RNAs gener...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23172

    authors: Chen R,Shi P,Zhang Y,Wu H,Li X,Yang W,Luo F,JinmingXue,Yao L,Yang J,Wang W,Zhang B,Li P,Miao Y,Wang Q,Tian F

    更新日期:2020-05-01 00:00:00

  • Circular RNA SMARCA5 correlates with favorable clinical tumor features and prognosis, and increases chemotherapy sensitivity in intrahepatic cholangiocarcinoma.

    abstract:OBJECTIVE:This present study aimed to investigate the correlation of circular RNA SMARCA5 (circ-SMARCA5) with clinicopathological features and overall survival (OS), and the effect of circ-SMARCA5 on cell proliferation and chemotherapy sensitivity to cisplatin/gemcitabine in intrahepatic cholangiocarcinoma (ICC). METH...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23138

    authors: Lu Q,Fang T

    更新日期:2020-04-01 00:00:00

  • Evaluation of direct agglutination test (DAT) and ELISA for serodiagnosis of visceral leishmaniasis in India.

    abstract::The direct agglutination test (DAT) and the enzyme-linked immunosorbent assay (ELISA) were used for serodiagnosis of parasitologically confirmed Indian visceral leishmaniasis (VL) cases. All the sera of VL cases were positive by both the methods. DAT titres of VL cases were greater than or equal to 1:3,200, and ELISA ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860050502

    authors: Pal A,Mukerji K,Basu D,Naskar K,Mallick KK,Ghosh DK

    更新日期:1991-01-01 00:00:00

  • The changes of antifungal susceptibilities caused by the phenotypic switching of Candida species in 229 patients with vulvovaginal candidiasis.

    abstract:OBJECTIVE:This study was to investigate the changes of antifungal susceptibilities caused by the phenotypic switching in patients with vulvovaginal candidiasis (VVC). METHODS:229 women were enrolled in this study. The vaginal smears of these patients were collected and gram stained for fungal microscopic observation. ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22644

    authors: Tang Y,Yu F,Huang L,Hu Z

    更新日期:2019-01-01 00:00:00

  • Setup of a Protocol of Molecular Diagnosis of β-Thalassemia Mutations in Tunisia using Denaturing High-Performance Liquid Chromatography (DHPLC).

    abstract:BACKGROUNDS:β-Thalassemia is one of the most prevalent worldwide autosomal recessive disorders. It presents a great molecular heterogeneity resulting from more than 200 causative mutations in the β-globin gene. In Tunisia, β-thalassemia represents the most prevalent monogenic hemoglobin disorder with 2.21% of carriers....

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.21867

    authors: Sahli CA,Ben Salem I,Jouini L,Laouini N,Dabboubi R,Hadj Fredj S,Siala H,Othmeni R,Dakhlaoui B,Fattoum S,Bibi A,Messaoud T

    更新日期:2016-09-01 00:00:00

  • Detection of viral infections by in situ PCR: theoretical considerations and possible value in diagnostic pathology.

    abstract::The technique that allows for in situ detection of PCR-amplified DNA and cDNA has improved remarkably quickly over the past 5 years. As of this writing, one can expect good results after a relatively quick "learning curve." The technique demands some skill in working with glass slides and cells/tissues. Thus, I recomm...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1098-2825(1996)10:6<335::AID-JCLA5>3

    authors: Nuovo GJ

    更新日期:1996-01-01 00:00:00

  • Serum miR-146a, miR-155, and miR-210 as potential markers of Graves' disease.

    abstract:BACKGROUND:Previous studies have demonstrated that dysfunctional regulatory T cells (Tregs) may be associated with Graves' disease (GD). In this study, we evaluated four serum Treg-associated miRNAs (miR-210, miR-182, miR-155, and miR-146a) expressions and assessed the potential of serum miRNAs as biomarkers of GD. ME...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22266

    authors: Zheng L,Zhuang C,Wang X,Ming L

    更新日期:2018-02-01 00:00:00

  • The impact of vascular endothelial growth factor +405 C/G polymorphism on long-term outcome and severity of coronary artery disease.

    abstract:BACKGROUND:The association between genetic variations of vascular endothelial growth factor (VEGF) gene and the risk for atherosclerosis has been hypothesized. We aimed to assess the relationship between rs2010963 (+405 C/G) polymorphism and presence, severity, and outcome of coronary artery disease (CAD) in an Iranian...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22066

    authors: Kalayi Nia S,Ziaee S,Boroumand MA,Sotudeh Anvari M,Pourgholi L,Jalali A

    更新日期:2017-07-01 00:00:00

  • Significance of cerebrospinal fluid adenosine deaminase isoenzymes in tuberculous (TB) meningitis.

    abstract::Adenosine deaminase (ADA) exists as two isoenzymes, ADA(1) and ADA(2). It appears that the ADA(2) isoenzyme originates mainly from monocytes and macrophages. In tuberculous pleural effusions most of the ADA activity consists of ADA(2). The aim of this prospective study was to analyse ADA isoenzymes in the CSF of patie...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1033

    authors: Schutte CM,Ungerer JP,du Plessis H,van der Meyden CH

    更新日期:2001-01-01 00:00:00

  • fbl gene as a species-specific target for Staphylococcus lugdunensis identification.

    abstract::Staphylococcus lugdunensis is an unusually virulent coagulase-negative species, associated with severe infections. The present report describes the development of a single-step, species-specific PCR protocol for S. lugdunensis identification. fbl gene, encoding a fibrinogen-binding adhesin, was exploited and assessed ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20352

    authors: Chatzigeorgiou KS,Siafakas N,Petinaki E,Zerva L

    更新日期:2010-01-01 00:00:00

  • Detection of submicroscopic chromosomal aberrations by chromosomal microarray analysis for the prenatal diagnosis of central nervous system abnormalities.

    abstract:BACKGROUND:Central nervous system (CNS) abnormalities are a group of serious birth defects associated with high rates of stillbirths, infant death, or abnormal development, and various disease-causing copy number variations play a much more important role in the etiology of CNS abnormalities. This study intends to pres...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23434

    authors: Song T,Xu Y,Li Y,Jia L,Zheng J,Dang Y,Wan S,Zheng Y,Zhang J,Yang H

    更新日期:2020-10-01 00:00:00

  • Modified salting-out method for DNA isolation from newborn cord blood nucleated cells.

    abstract::The present work describes modification of a widely used salting-out procedure to rapidly extract DNA suitable for PCR, using the ARMS method to amplify a target sequence in the beta-globin gene. The salting-out DNA extraction procedure did not completely remove or decrease the presence of inhibitors to PCR in a consi...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:

    authors: Noguera NI,Tallano CE,Bragós IM,Milani AC

    更新日期:2000-01-01 00:00:00

  • The association of NLRP3 and TNFRSF1A polymorphisms with risk of ankylosing spondylitis and treatment efficacy of etanercept.

    abstract:BACKGROUND:To discover how NLRP3 and TNFRSF1A polymorphisms affect the efficacy of traditional medicine and etanercept for ankylosing spondylitis (AS) patients. METHODS:Single nucleotide polymorphism (SNP) and haplotype analyses were conducted based on determined NLRP3 and TNFRSF1A among AS patients. We subsequently a...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22138

    authors: Zhao S,Chen H,Wu G,Zhao C

    更新日期:2017-11-01 00:00:00