The association of NLRP3 and TNFRSF1A polymorphisms with risk of ankylosing spondylitis and treatment efficacy of etanercept.

Abstract:

BACKGROUND:To discover how NLRP3 and TNFRSF1A polymorphisms affect the efficacy of traditional medicine and etanercept for ankylosing spondylitis (AS) patients. METHODS:Single nucleotide polymorphism (SNP) and haplotype analyses were conducted based on determined NLRP3 and TNFRSF1A among AS patients. We subsequently analyzed the relationship between relevant clinical indexes and polymorphisms of NLRP3 and TNFRSF1A. RESULTS:The 4 SNP loci on NLRP3 and 3 SNP loci on TNFRSF1A showed significant linkage disequilibrium, respectively. The T allele of NLRP3 rs4612666 and the T allele of TFRSF1A rs4149570 are both associated with AS (P<.05). The T-A-C-T haplotype of NLRP3 as well as the G-C-C, T-C-C, T-C-T, and T-T-T haplotypes of TFRSF1A are associated with AS (P<.05). The morning stiffness time, BASDAI scoring, and ESR of patients receiving etanercept were significantly higher than those receiving traditional medicine. T allele of NLRP3 rs4612666 had a significantly greater negative impact on the ASAS20 improvement than C allele. Whereas the A allele of NLRP3 rs3806268 had a significantly greater positive impact on the ASAS20 improvement than G allele. There is no significant association between SNP and efficacy of traditional medicine in the treatment of AS. CONCLUSION:NLRP3 and TFRSF1A (rs4149570) are associated with AS susceptibility. There is a significant association between NLRP3 polymorphisms and treatment of etanercept.

journal_name

J Clin Lab Anal

authors

Zhao S,Chen H,Wu G,Zhao C

doi

10.1002/jcla.22138

subject

Has Abstract

pub_date

2017-11-01 00:00:00

issue

6

eissn

0887-8013

issn

1098-2825

journal_volume

31

pub_type

杂志文章
  • Multiple cutaneous infections caused by Prototheca wickerhamii.

    abstract:BACKGROUND:Prototheca species are a group of organisms ubiquitously existing in nature but have become a pathogenic threat to public health, which has aroused wide attention. Species identification and antifungal susceptibility have essential and valuable meanings to clinical diagnosis and treatment. METHODS:A case of...

    journal_title:Journal of clinical laboratory analysis

    pub_type:

    doi:10.1002/jcla.23492

    authors: Zhao F,Chen M,Fu Y

    更新日期:2020-11-01 00:00:00

  • Clinical significance of the serum IgM and IgG to SARS-CoV-2 in coronavirus disease-2019.

    abstract:OBJECTIVE:To explore the clinical value of serum IgM and IgG to SARS-CoV-2 in COVID-19. METHODS:105 COVID-19 patients were enrolled as the disease group. 197 non-COVID-19 patients served as the control group. Magnetic chemiluminescent immunoassay (MCLIA) was used to detect the IgM and IgG. RESULTS:The peak of positiv...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23649

    authors: Wu LX,Wang H,Gou D,Fu G,Wang J,Guo BQ

    更新日期:2020-11-13 00:00:00

  • A modification of the kinetic determination of pancuronium bromide based on its inhibitory effect on cholinesterase.

    abstract::A modification of the existing spectrophotometric kinetic method for the determination of pancuronium bromide (PCBr), based on pooled human serum cholinesterase (ChE, EC 3.1.1.8 acylcholine acylhydrolase) inhibition, was developed. Butyrylthiocholine iodide (concentration 1.667 mmol/L) was used as substrate and determ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20162

    authors: Stankov-Jovanovic VP,Nikolic-Mandic SD,Mandic LjM,Mitic VD

    更新日期:2007-01-01 00:00:00

  • Alterations of the hematologic cells in synthetic cannabinoid users.

    abstract:BACKGROUND:Functions, morphology, distributions, and index of the circulating cells are the most useful parameters that indicate various inflammatory and toxic conditions. The aim of this study was to investigate the clinical significance of these parameters in patients diagnosed with (synthetic) cannabis use disorder....

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22131

    authors: Guzel D,Yazici AB,Yazici E,Erol A

    更新日期:2017-11-01 00:00:00

  • Reduced expression of circRNA hsa_circ_0067582 in human gastric cancer and its potential diagnostic values.

    abstract:BACKGROUND:Gastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Circular RNAs (circRNAs) are an abundant kind of endogenous RNAs that recently are found play a crucial role in the cancer occurrence and development. Nevertheless, little is known ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23080

    authors: Yu X,Ding H,Yang L,Yu Y,Zhou J,Yan Z,Guo J

    更新日期:2020-03-01 00:00:00

  • Twelve years of the Brazilian External Quality Assessment Program in Immunohematology: benefits of the program.

    abstract::The Brazilian External Quality Assessment Program in Immunohematology (BEQAPI) was introduced with the objective of evaluating the quality of diagnosis in immunohematology. From 1992 to 2003, proficiency tests for ABO grouping, Rh (D, C, c, E, e), K phenotyping, direct antiglobulin testing (DAT), antibody screening (A...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20080

    authors: Melo L,Pellegrino J Jr,Bianco C,Castilho L

    更新日期:2005-01-01 00:00:00

  • Practical application of Westgard Sigma rules with run size in analytical biochemistry processes in clinical settings.

    abstract:BACKGROUND:The performance of 18 routine chemical detection methods was evaluated by the sigma (σ) metric, and Westgard Sigma rules with run size were used to establish internal quality control (IQC) standards to reduce patient risks. MATERIALS AND METHODS:External quality assessment (EQA) and internal quality control...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23665

    authors: Peng S,Zhang J,Zhou W,Mao W,Han Z

    更新日期:2020-12-03 00:00:00

  • Quality specification and status of internal quality control of cardiac biomarkers in China from 2011 to 2016.

    abstract:BACKGROUND:This study aimed to investigate the status of internal quality control (IQC) for cardiac biomarkers from 2011 to 2016 so that we can have overall knowledge of the precision level of measurements in China and set appropriate precision specifications. METHODS:Internal quality control data of cardiac biomarker...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22324

    authors: Li T,Wang W,Zhao H,He F,Zhong K,Yuan S,Wang Z

    更新日期:2018-05-01 00:00:00

  • An enzyme immunoassay for determining plasma concentrations of didemnin B.

    abstract::Didemnin A was conjugated at the amino terminus of the N-methylleucine residue, via the linkers N-succinimidyl-3-(2-pyridyldithio)-propionate and trans-1,4-maleimidomethyl-cyclohexane carboxylic acid, to keyhole limpet hemocyanin (KLH) and bovine serum albumin (BSA). The didemnin-KLH conjugates were used to hyperimmun...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860060307

    authors: Raybould TJ,Grothaus PG,Simpson SB,Bignami GS,Lazo CB,Newman RA

    更新日期:1992-01-01 00:00:00

  • Decreased frequency of circulating Th9 cells in patients with chronic hepatitis B infection.

    abstract:BACKGROUND:Chronic hepatitis B (CHB) is one of the major infectious diseases in which CD4+ T helper (Th) cells play a crucial role. Th9 cells are a distinct subset of CD4+ Th cells with important physiological functions. OBJECTIVE:The study aimed to assess the potential involvement of Th9 cells in the inadequate immun...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22246

    authors: Cui M,Lv Y,Lu J,Zhang W,Duan Y,Huang Y,Yang L,Li M,Liu W,Liu D,Yan H

    更新日期:2018-02-01 00:00:00

  • Novel rapid immunochromatographic test based on an enzyme immunoassay for detecting nucleocapsid antigen in SARS-associated coronavirus.

    abstract::A novel severe acute respiratory syndrome-associated coronavirus (SARS-CoV) has been discovered. The detection of both antigens and antibodies in SARS-CoV from human specimens with suspected SARS plays an important role in preventing infection. We developed a novel rapid immunochromatographic test (RICT) based on the ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20070

    authors: Kogaki H,Uchida Y,Fujii N,Kurano Y,Miyake K,Kido Y,Kariwa H,Takashima I,Tamashiro H,Ling AE,Okada M

    更新日期:2005-01-01 00:00:00

  • Evaluation of the QMS® Teicoplanin Immunoassay (ThermoFisher Scientific) on Cobas® 8000 System (Roche Diagnostics) and comparison to fluorescence polarization immunoassay for the determination of teicoplanin concentrations in human plasma.

    abstract:BACKGROUND:The performances of the QMS(®) Teicoplanin immunoassay recently developed on Cobas(®) 6000/8000 systems were evaluated and compared to a fluorescence polarization immunoassay (FPIA) [Teicoplanin Innofluor(®) Assay (Thermo Fisher Scientific, Indianapolis, IN)] on FLX analyzer (Abbott Laboratories, Abbott Park...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.21567

    authors: Dailly E,Fraissinet F,Deslandes G,Bouquié R,Jolliet P

    更新日期:2013-03-01 00:00:00

  • Significance of aneuploidy in non-Hodgkin lymphomas.

    abstract::The incidence of aneuploidy was determined by flow cytometric analysis in paraffin-embedded tumor samples of 125 patients with non-Hodgkin lymphoma (NHL). There were 48 low-grade (LG) and 77 high-grade (HG) tumors. Aneuploidy was found in 34 (27%) NHL, 15 (31%) LG, and 19 (25%) HG tumors. The analysis of patient survi...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860090602

    authors: Vucković J,Forenpoher G,Marusić M,Uzarević B,Sabioncello A,Stula N,Dubravcić M

    更新日期:1995-01-01 00:00:00

  • Differentiation of Candida dubliniensis from Candida albicans on rosemary extract agar and oregano extract agar.

    abstract::Candida dubliniensis is a recently described pathogenic species which shares many phenotypic features with Candida albicans and therefore, may be misidentified in microbiological laboratories. Because molecular methods can be onerous and unfeasible in routine mycological laboratories with restricted budgets such as th...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20237

    authors: de Loreto ES,Pozzatti P,Alves Scheid L,Santurio D,Morais Santurio J,Alves SH

    更新日期:2008-01-01 00:00:00

  • Role of TLR4 and miR-155 in peripheral blood mononuclear cell-mediated inflammatory reaction in coronary slow flow and coronary arteriosclerosis patients.

    abstract:BACKGROUND:To study the role of toll-like receptor 4 (TLR4) and MicroRNA-155 (miR-155) in the peripheral blood mononuclear cell (PBMC)-mediated inflammation in coronary slow flow (CSF) and coronary arteriosclerosis. METHODS:Patients were divided into acute coronary syndrome (ACS), stable angina pectoris (SAP), CSF, an...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22232

    authors: Huang J,Yang Q,He L,Huang J

    更新日期:2018-02-01 00:00:00

  • Rapid and sensitive headspace gas chromatography-mass spectrometry method for the analysis of ethanol in the whole blood.

    abstract:BACKGROUND:For the forensic aim, a sensitive and specific method using headspace gas chromatography coupled with mass spectrometry (GC/MS) has been developed for the quantitative determination of ethanol in blood using n-propanol as internal standard. GC was performed in isothermal mode with a GC run-time of 5.0 min. ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.21698

    authors: Xiao HT,He L,Tong RS,Yu JY,Chen L,Zou J,Li JQ,Bian Y,Zhang Y

    更新日期:2014-09-01 00:00:00

  • Serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy.

    abstract::The relationship between the levels of serum cystatin C and the prognostic stages of IgA nephropathy was determined in a multicenter trial in Japan. The levels of serum cystatin C in patients with IgA nephropathy were measured using the Dade Behring N Latex Cystain C assay. In 1995, the Joint Committee of the Special ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/1098-2825(2001)15:1<25::aid-jcla5>3.0.co;2

    authors: Tomino Y,Suzuki S,Gohda T,Kobayashi M,Horikoshi S,Imai H,Saito T,Kawamura T,Yorioka N,Harada T,Yasumoto Y,Kida H,Kobayashi Y,Endoh M,Sato H,Saito K

    更新日期:2001-01-01 00:00:00

  • Novel and sensitive noncompetitive enzyme immunoassay (hetero-two-site enzyme immunoassay) for alpha-human atrial natriuretic peptide in plasma.

    abstract::A novel and sensitive noncompetitive enzyme immunoassay (hetero-two-site enzyme immunoassay) for alpha-human atrial natriuretic peptide (alpha-hANP) in plasma, which uses only one monoclonal IgG for the ring structure of alpha-hANP, is described. Plasma was filtered through polysaccharide membrane to separate peptides...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860050506

    authors: Hashida S,Yamamoto N,Ishikawa E

    更新日期:1991-01-01 00:00:00

  • Anticytokeratins are a potential source of false-positive indirect immunofluorescence assays for C-ANCA.

    abstract::Antibodies to neutrophil cytoplasmic antigens (ANCA) targeted toward granule enzymes have been recognized as a valuable diagnostic tool in the detection of Wegener's granulomatosis and systemic vasculitides. However, the most commonly used method of detection, the indirect immunofluorescence assay, is prone to false-p...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-2825(1998)12:1<54::aid-jcla9>3.

    authors: Streicher J,Fabian B,Herkner K,Pointner H,Bayer PM

    更新日期:1998-01-01 00:00:00

  • Effect factors related to a high probability of hemodialysis independence in newly diagnosed multiple myeloma patients requiring hemodialysis.

    abstract:BACKGROUND:Renal failure is a severe complication of symptomatic myeloma, related to higher mortality. Recovery from dialysis dependence can lead to enormous survival benefits. We investigated the effect factors for probability of dialysis independence. METHODS:Retrospective data on 45 newly diagnosed MM (NDMM) patien...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23057

    authors: Song J,Jiang F,Liu H,Ding K,Ren Y,Li L,Wang G,Shao Z,Fu R

    更新日期:2020-02-01 00:00:00

  • Multivariable index for assessing the activity and predicting all-cause mortality in antineutrophil cytoplasmic antibody-associated vasculitis.

    abstract:BACKGROUND:So far, there has been no tool to estimate activity at diagnosis and predict all-cause mortality in patients with ANCA-associated vasculitis (AAV). Hence, we determined the initial predictors of them in patients with AAV. METHODS:We retrospectively reviewed the medical records of 182 patients with AAV. Seve...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23022

    authors: Kim MK,Choi H,Kim JY,Song JJ,Park YB,Lee SW

    更新日期:2020-01-01 00:00:00

  • A retrospective study on Escherichia coli bacteremia in immunocompromised patients: Microbiological features, clinical characteristics, and risk factors for shock and death.

    abstract:BACKGROUND:To evaluate clinical features, bacterial characteristics, and risk factors for shock and mortality of immunocompromised patients with Escherichia coli bacteremia. METHODS:A nearly 6-year retrospective study of E coli bacteremia in 188 immunocompromised patients at Xiangya Hospital was conducted. Demographic...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23319

    authors: Tao X,Wang H,Min C,Yu T,Luo Y,Li J,Hu Y,Yan Q,Liu WE,Zou M

    更新日期:2020-08-01 00:00:00

  • Contribution of adiponectin polymorphisms to the risk of coronary artery disease in a North-African Tunisian population.

    abstract:BACKGROUND:Adiponectin, an adipocyte-derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti-atherogenic, anti-inflammatory, antioxidative, and anti-apoptotic properties. In the current study, we have studied the association of two sing...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22446

    authors: Ghazouani L,Elmufti A,Baaziz I,Chaabane I,Ben Mansour H

    更新日期:2018-09-01 00:00:00

  • Lectin affinity electrophoresis of serum alkaline phosphatase in metastasized breast cancer.

    abstract::The use of serum alkaline phosphatase (ALP) isoenzymes as markers of breast cancer metastases and treatment efficacy has received little attention. Twenty-six breast cancer women (56+/-13 years, all post-menopausal) were prospectively evaluated during their first and third course of chemotherapy (4-week interval). Ser...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.20357

    authors: Le Bricon T,Gay-Bellile C,Cottu P,Benlakehal M,Guillon H,Houzé P

    更新日期:2010-01-01 00:00:00

  • Simultaneous measurement of neutrophil, lymphocyte, and monocyte glutathione by flow cytometry.

    abstract::A flow cytometric method for quantitation of glutathione (GSH) was applied to simultaneous analysis of the major leukocyte types in peripheral blood. Cellular thiols (predominantly GSH) were stained with monochlorobimane (MCIB), and thiol fluorescence was measured with a flow cytometer. The fluorescence of the thiols ...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.1860040503

    authors: Scott RB,Collins JM,Matin S,White F,Swerdlow PS

    更新日期:1990-01-01 00:00:00

  • A Mutagenic Primer Assay for Genotyping of the CRHR1 Gene Rare Variant rs1876828 (A/G) in Asians: A Cost-Effective SNP Typing.

    abstract:BACKGROUND:Today, the genetic and genomic research entered in a new era of high-throughput genotyping technology. However, mutagenic polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is still a choice of genotyping method in molecular epidemiological research. It has been extensively used fo...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.21832

    authors: Sharma N,Awasthi S,Phadke SR

    更新日期:2016-03-01 00:00:00

  • Association of Crohn's disease with Foxp3 gene polymorphisms and its colonic expression in Chinese patients.

    abstract:BACKGROUND:Fork head/winged helix transcription factor (Foxp3) plays a pivotal role in regulatory T (Treg) cells. The present study aimed to assess the association of Crohn's disease (CD) with Foxp3 polymorphisms and its colonic expression in Chinese patients. METHODS:The Foxp3 polymorphisms, rs3761547, rs2232365, rs2...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.22835

    authors: Xia S,Zhang D,Zheng S,Wu C,Lin Q,Ying S,Shao X,Jiang Y

    更新日期:2019-05-01 00:00:00

  • High level of D-dimer predicts ischemic stroke in patients with infective endocarditis.

    abstract:BACKGROUND:Ischemic stroke is one of the most prominent and serious neurological complications of infective endocarditis (IE). Our study was designed to evaluate the predictive value of higher level of plasma D-dimer on admission for the development of ischemic stroke in patients with IE. METHODS:In this prospective s...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.23206

    authors: Xu N,Fu Y,Wang S,Li S,Cai D

    更新日期:2020-05-01 00:00:00

  • Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma.

    abstract::Hypoxia and ischemia play important roles in the onset and progression of glaucoma. Insulin-like growth factors (IGF) are important neurotrophic agents that respond to hypoxia-ischemia. In this study, we enrolled 60 primary open angle glaucoma (POAG) patients and 104 healthy volunteers from the China Medical College H...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:10.1002/jcla.10106

    authors: Tsai FJ,Lin HJ,Chen WC,Chen HY,Fan SS

    更新日期:2003-01-01 00:00:00

  • Reliability of low-avidity IgG and of IgA in the diagnosis of primary infection by rubella virus with adaptation of a commercial test.

    abstract::The detection of IgA and low-avidity IgG and antibodies in serum is a potentially useful marker of recent infection by a microorganism. We studied the reliability of IgG avidity and presence of IgA for the diagnosis of recent acute infection by rubella virus. Low-avidity IgG (Avy-EIA test) was determined with a modifi...

    journal_title:Journal of clinical laboratory analysis

    pub_type: 杂志文章

    doi:

    authors: Gutiérrez J,Rodríguez MJ,De Ory F,Piédrola G,Maroto MC

    更新日期:1999-01-01 00:00:00