Abstract:
:Mutants of the influenza virus A/seal/Mass/1/80 (H7N7) are described which contain an insertion of 60 nucleotides in the hemagglutinin (HA) gene, derived most probably by recombination between the HA gene and the nucleoprotein gene of the same virus. The nonhomologous RNA recombination resulted in an enhanced hemagglutinin cleavability associated with broadening of the host cell spectrum, increased hemolytic activity, and increased pathogenicity for chickens.
journal_name
Virologyjournal_title
Virologyauthors
Orlich M,Gottwald H,Rott Rdoi
10.1006/viro.1994.1555subject
Has Abstractpub_date
1994-10-01 00:00:00pages
462-5issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(84)71555-8journal_volume
204pub_type
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