Impact of physical exercise on reaction time in patients with Parkinson's disease-data from the Berlin BIG Study.

Abstract:

OBJECTIVE:To determine whether physical activity may affect cognitive performance in patients with Parkinson's disease by measuring reaction times in patients participating in the Berlin BIG study. DESIGN:Randomized controlled trial, rater-blinded. SETTING:Ambulatory care. PARTICIPANTS:Patients with mild to moderate Parkinson's disease (N=60) were randomly allocated to 3 treatment arms. Outcome was measured at the termination of training and at follow-up 16 weeks after baseline in 58 patients (completers). INTERVENTIONS:Patients received 16 hours of individual Lee Silverman Voice Treatment-BIG training (BIG; duration of treatment, 4wk), 16 hours of group training with Nordic Walking (WALK; duration of treatment, 8wk), or nonsupervised domestic exercise (HOME; duration of instruction, 1hr). MAIN OUTCOME MEASURES:Cued reaction time (cRT) and noncued reaction time (nRT). RESULTS:Differences between treatment groups in improvement in reaction times from baseline to intermediate and baseline to follow-up assessments were observed for cRT but not for nRT. Pairwise t test comparisons revealed differences in change in cRT at both measurements between BIG and HOME groups (intermediate: -52ms; 95% confidence interval [CI], -84/-20; P=.002; follow-up: 55ms; CI, -105/-6; P=.030) and between WALK and HOME groups (intermediate: -61ms; CI, -120/-2; P=.042; follow-up: -78ms; CI, -136/-20; P=.010). There was no difference between BIG and WALK groups (intermediate: 9ms; CI, -49/67; P=.742; follow-up: 23ms; CI, -27/72; P=.361). CONCLUSION:Supervised physical exercise with Lee Silverman Voice Treatment-BIG or Nordic Walking is associated with improvement in cognitive aspects of movement preparation.

journal_name

Arch Phys Med Rehabil

authors

Ebersbach G,Ebersbach A,Gandor F,Wegner B,Wissel J,Kupsch A

doi

10.1016/j.apmr.2013.10.020

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

996-9

issue

5

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(13)01117-9

journal_volume

95

pub_type

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