Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.

Abstract:

OBJECTIVE:To evaluate whether amitriptyline is more effective than placebo in improving phantom limb pain or residual limb pain. DESIGN:Randomized controlled trial of amitriptyline for 6 weeks. SETTING:University hospital. PARTICIPANTS:Thirty-nine persons with amputation-related pain lasting more than 6 months. INTERVENTION:Six-week trial of amitriptyline (titrated up to 125 mg/d) or an active placebo (benztropine mesylate). MAIN OUTCOME MEASURES:Analyses were conducted to examine whether there was a medication group effect on the primary outcomes (average pain intensity) and secondary outcome measures (disability, satisfaction with life, handicap). RESULTS:No significant differences were found between the treatment groups in outcome variables when controlling for initial pain scores. CONCLUSIONS:Our findings do not support the use of amitriptyline in the treatment of postamputation pain.

journal_name

Arch Phys Med Rehabil

authors

Robinson LR,Czerniecki JM,Ehde DM,Edwards WT,Judish DA,Goldberg ML,Campbell KM,Smith DG,Jensen MP

doi

10.1016/s0003-9993(03)00476-3

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

1-6

issue

1

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(03)00476-3

journal_volume

85

pub_type

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