Abstract：
OBJECTIVE:To determine the neuromuscular and performance effects of acute and long-term exposure to selective serotonin reuptake inhibitors (SSRIs). DESIGN:Two randomized, double-blind, crossover studies. SETTING:Departments of Kinesiology and Medicine, McMaster University, Hamilton, Ont, Canada. PARTICIPANTS:Eleven healthy, college-aged men in the acute study; 12 healthy, college-aged men in the chronic study. INTERVENTIONS:In the acute study, subjects were given a placebo and fluoxetine (40 mg) 6 hours before testing, in the chronic study, they were given fluoxetine (40mg/d) and an identical placebo for 2 weeks before testing. MAIN OUTCOME MEASURES:Target measures were maximum voluntary contractions (MVCs), evoked peak torque, and percentage of motor unit activation for muscle strength and central drive. Repeated Wingate cycle ergometer tests were used to measure anaerobic power, capacity, and fatigue index. VO2max tests (80%, 90%) were used to measure time to exhaustion and cardiorespiratory responses. RESULTS:In the acute study phase, MVC was lower for fluoxetine versus placebo (p =.05) and a slight fatigue resistance was measured in the repeated Wingate tests for the fluoxetine group; however, there were no affects on any other measured variable. In the chronic study phase, minute ventilation was lower for the fluoxetine trial (p <.05); however, there were no treatment affects on any of the other measurements. CONCLUSION:Acute and chronic SSRI intake does not effect strength or high-intensity exercise performance in young adult men.
journal_name
Arch Phys Med Rehabiljournal_title
Archives of physical medicine and rehabilitationauthors
Parise G,Bosman MJ,Boecker DR,Barry MJ,Tarnopolsky MAdoi
10.1053/apmr.2001.23275subject
Has Abstractpub_date
2001-07-01 00:00:00pages
867-71issue
7eissn
0003-9993issn
1532-821Xpii
S0003-9993(01)83864-8journal_volume
82pub_type
临床试验,杂志文章,随机对照试验abstract：OBJECTIVE:To validate the administration of the Life-Space Assessment (LSA) and Physical Activity Scale for the Elderly (PASE) surveys to proxy informants, as would be necessary when measuring long-term outcomes in acutely ill, hospitalized older adults who are initially incapacitated but eventually return to the commu...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2014.03.027
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:To investigate whether body weight-supported treadmill training (BWSTT) is of long-term benefit for patients with Parkinson's disease (PD). DESIGN:Randomized controlled trial. SETTING:Inpatient rehabilitation unit for neurologic diseases in Japan. PARTICIPANTS:Twenty-four patients (Hoehn and Yahr stages 2....
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/apmr.2002.34603
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVE:To identify predictors and outcomes associated with receiving inadequate empirical antimicrobial treatment for bloodstream infections (BSIs) in persons with spinal cord injury (SCI). DESIGN:Retrospective cohort study from October 1, 1997, through September 30, 2004. SETTING:A Department of Veterans Affairs ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2009.02.012
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:To investigate how accurately a portable three-dimensional (3-D) scanner and a multipurpose two-dimensional (2-D) real-time scanner determined bladder volumes. STUDY DESIGN:Prospective, controlled clinical trial, single-blind, crossover design. SETTING AND PARTICIPANTS:Twenty-three inpatients with permanent...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章
doi：10.1016/s0003-9993(00)90215-6
更新日期：2000-01-01 00:00:00
abstract：:This paper outlines a suggested protocol for community exercise programs for the rehabilitation of patients with coronary heart disease. Information presented is based on more than seven years of experience gained by the Cardio-Pulmonary Research Institute through programs in Seattle, Mercer Island, and Yakima, WA, an...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of combination cathodal transcranial direct current stimulation (tDCS) and virtual reality (VR) therapy for upper extremity (UE) training in patients with subacute stroke. DESIGN:Pilot randomized controlled trial. Patients were randomly assigned to 1 of 3 groups: group A received c...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.apmr.2013.10.027
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:To quantify habitual walking speed and estimate the prevalence of low habitual walking speed (<0.8m/s and <0.5m/s) in nursing home residents; and secondarily to gain some insight into whether demographic, health, and functional outcomes could predict the nursing home residents' walking speed. DESIGN:Cross-se...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.apmr.2015.06.021
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To show cortical reorganization in hemiparetic patients with a primary motor cortex (M1) infarct including the precentral knob by using functional magnetic resonance imaging (fMRI). DESIGN:Case-control. SETTING:Outpatient clinics in the rehabilitation department of a university hospital. PARTICIPANTS:Two s...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2004.11.043
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVE:The ability to measure and visualize shape change (deformation) of a residual limb within and between prostheses is an important step toward improved prosthetic fit assessment. The objective was to develop measurement and visualization methods for below-knee residual limb soft tissue shape change after donnin...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/s0003-9993(98)90355-0
更新日期：1998-07-01 00:00:00
abstract：:Failed back surgery syndrome (FBSS) is a long-lasting, often disabling, and relatively frequent (5%-10%) complication of lumbosacral spine surgery. Epidural fibrosis is among the most common causes of FBSS, and it is often recalcitrant to treatment. Repeated surgery for fibrosis has only a 30% to 35% success rate, whe...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1053/apmr.2001.21867
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVE:To investigate the course of mechanical efficiency of handrim wheelchair propulsion during rehabilitation of subjects with (in)complete paraplegia and tetraplegia. DESIGN:Subjects were tested at the start of active rehabilitation (t1), 3 months later (t2), and when discharged from inpatient rehabilitation (t...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.apmr.2004.11.025
更新日期：2005-07-01 00:00:00
abstract：:Wrist driven flexor hinge orthosis (WDFHO) linkage movements were analyzed graphically for existing kit form orthoses and modified orthoses. The graphical analysis indicated improved function by increased torque and resultant pinch force in modified orthoses. A geometric solution to pivot point location which will all...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：OBJECTIVE:To analyze differences in carpal tunnel syndrome (CTS) prevalence using a combination of electrodiagnostic studies (EDSs) and symptoms using EDS criteria varied across a range of cutpoints and compared with symptoms in both ≥1 and ≥2 median nerve-served digits. DESIGN:Pooled data from 5 prospective cohorts. ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2014.08.004
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of functional electric stimulation (FES) of lower limb muscles during 30 minutes of upright standing on the central and peripheral hemodynamic response in persons with spinal cord injury (SCI). DESIGN:A repeated-measure design. Subjects were used as their own control and underwent 2 t...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1053/apmr.2001.25984
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of a patient's sex on various measures of injury severity and outcome after rehabilitation in a matched sample of patients with traumatic brain injury (TBI). DESIGN:Retrospective data were retrieved from a database that contains information routinely collected on all patients admitt...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2003.05.007
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:To compare results of the observational Wisconsin Gait Scale (WGS) and global gait indexes such as Gait Deviation Index (GDI) and Gait Variability Index (GVI), constituting an objective method of assessing gait, and taking into account parameters identified during 3-dimensional gait analysis (3DGA). DESIGN:A...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2018.12.031
更新日期：2019-09-01 00:00:00
abstract：:This self-directed learning module highlights recent research in assessment of stroke outcomes and management of the psychosocial consequences of stroke. It is a part of the chapter on stroke rehabilitation in the Self-Directed Physiatric Education Program for practitioners and trainees in physical medicine and rehabi...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,评审
doi：10.1016/s0003-9993(99)90098-9
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVE:To evaluate whether amitriptyline is more effective than placebo in improving phantom limb pain or residual limb pain. DESIGN:Randomized controlled trial of amitriptyline for 6 weeks. SETTING:University hospital. PARTICIPANTS:Thirty-nine persons with amputation-related pain lasting more than 6 months. INT...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0003-9993(03)00476-3
更新日期：2004-01-01 00:00:00
abstract：:Recordings of pressure within the bladder, urethra, rectum, and external anal sphincter with image intensification and videotaping were carried out in spinal cord injury patients with complete and incomplete lesions, during spinal shock and in the chronic stage. The behavior of the external urethral sphincter and the ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：
更新日期：1975-05-01 00:00:00
abstract：OBJECTIVES:The aims of the present systematic review and meta-analysis were to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in an apparently healthy population. DATA SOURCES:Two authors systematicall...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,meta分析
doi：10.1016/j.apmr.2018.01.008
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the use of exercise therapy for the treatment of craniomandibular disorders (CMDs). DESIGN:Before-after trial. All patients were assigned to a waiting list, serving as a no-treatment control period. SETTING:Outpatient clinic for physical medicine and rehabilitation of the University of Vienna. ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章
doi：10.1053/apmr.2000.6282
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:Examine neurorehabilitation therapists' clinical predictions and attributions for outcomes. DESIGN:Single sample, repeated measures. PARTICIPANTS:A sample of 51 neurorehabilitation therapists selected from representative disciplines including occupational therapy, physical therapy, speech therapy, and recre...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/s0003-9993(95)80505-2
更新日期：1995-06-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of low-intensity laser therapy in the treatment of musculoskeletal low back pain. DESIGN:A double-masked, placebo-controlled, randomized clinical trial. SETTING:A physical medicine and rehabilitation clinic. PARTICIPANTS:Sixty-three ambulatory men and women between the ages of 1...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0003-9993(99)90167-3
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:To predict the place of discharge or discharge Functional Independence Measure (FIM) score for stroke survivors with moderate disability using neural network modeling. Our previous work demonstrated that the FIM predicts the level of recovery for stroke survivors with either severe or mild disabilities. DESI...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/s0003-9993(97)90222-7
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness of 2 rehabilitative approaches for improving paretic limb reaching by chronic stroke subjects. DESIGN:Pre- and posttest reaching to targets ipsilateral, midline, and contralateral to the impaired side. SETTING:Training in subjects' homes; testing in a laboratory setting. PARTI...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.apmr.2004.01.028
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To determine if women's dress shoes with heels of just 1.5 in (3.8 cm) in height increases knee joint torques, which are thought to be relevant to the development and/or progression of knee osteoarthritis (OA) in both the medial and patellofemoral compartments. DESIGN:Randomized controlled trial. SETTING:A ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.apmr.2004.09.018
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of isokinetic exercise versus a program of patient education on pain and function in older persons with knee osteoarthritis. DESIGN:A randomized, comparative clinical trial, with interventions lasting 8 weeks and evaluations of 12 weeks. SETTING:An outpatient Veterans Affairs Medical...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0003-9993(99)90032-1
更新日期：1999-10-01 00:00:00
abstract：OBJECTIVE:To investigate in vitro the effect of different on-off electrostimulation times on the fatigue of 2 pelvic muscles, the iliococcygeus and pubococcygeus (mainly fast), and the soleus muscle of the limb (mainly slow). DESIGN:Nonrandomized controlled trial and before-after trial. SETTINGS:In vitro study in tis...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1053/apmr.2002.30925
更新日期：2002-04-01 00:00:00
abstract：:A vexing issue in disability research today is the specification and measurement of long-term outcome measures relevant to the evaluation of independent living (IL) programs and services. The purpose of this article is to present 2 long-term outcome measures that are sensitive to both the philosophy of the IL movement...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：
更新日期：1982-02-01 00:00:00
abstract：OBJECTIVE:To determine the association of various symptoms and psychiatric diagnoses with a remote history of mild traumatic brain injury (MTBI) and a current diagnosis of posttraumatic stress disorder (PTSD). DESIGN:Cross-sectional cohort study. SETTING:Nonclinical. PARTICIPANTS:Three groups of randomly selected co...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2009.01.023
更新日期：2009-07-01 00:00:00
