Abstract:
:A community outbreak of legionellosis occurred in Barrow-in-Furness, Cumbria, during July and August 2002. A descriptive study and active case-finding were instigated and all known wet cooling systems and other potential sources were investigated. Genotypic and phenotypic analysis, and amplified fragment length polymorphism of clinical human and environmental isolates confirmed the air-conditioning unit of a council-owned arts and leisure centre to be the source of infection. Subsequent sequence-based typing confirmed this link. One hundred and seventy-nine cases, including seven deaths [case fatality rate (CFR) 3·9%] were attributed to the outbreak. Timely recognition and management of the incident very likely led to the low CFR compared to other outbreaks. The outbreak highlights the responsibility associated with managing an aerosol-producing system, with the potential to expose and infect a large proportion of the local population and the consequent legal ramifications and human cost.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Bennett E,Ashton M,Calvert N,Chaloner J,Cheesbrough J,Egan J,Farrell I,Hall I,Harrison TG,Naik FC,Partridge S,Syed Q,Gent RNdoi
10.1017/S0950268813002483subject
Has Abstractpub_date
2014-08-01 00:00:00pages
1763-77issue
8eissn
0950-2688issn
1469-4409pii
S0950268813002483journal_volume
142pub_type
杂志文章abstract::A survey of the seroprevalence of pertussis antibodies in a representative sample of the population from Catalonia was carried out. Ninety-seven municipalities and 30 schools were randomly selected to recruit the 2126 subjects who participated in the study. A serum sample was obtained from all individuals participatin...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268801005325
更新日期:2001-04-01 00:00:00
abstract::The objective of this study was to determine the distribution of Shiga toxin-producing Escherichia coli (STEC) virulence markers (stx1, stx2, eae, ehxA) in E. coli strains isolated from young calves aged fewer than 7 days (bobby calves). In total, 299 recto-anal mucosal swabs were collected from animals at two slaught...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268814000089
更新日期:2014-12-01 00:00:00
abstract::Literature surrounding the burden of and factors associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in persons with tuberculosis (TB) disease remains limited and focused on populations outside the USA. Cross-matched New York City (NYC) TB and viral hepatitis surveillance data were used to es...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268814002970
更新日期:2015-07-01 00:00:00
abstract::In this work, we applied the random amplified polymorphic DNA (RAPD) technique to evaluate the genetic diversity in Photobacterium damselae subsp. piscicida (formerly Pasteurella piscicida), an important pathogen for different marine fish. Regardless of the oligonucleotide primer employed, the 29 isolates of Ph. damse...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268899004252
更新日期:2000-08-01 00:00:00
abstract::In the European Union, Meat Inspection (MI) aims to protect public health by ensuring that minimal hazardous material enters in the food chain. It also contributes to the detection and monitoring of animal diseases and welfare problems but its utility for animal surveillance has been assessed partially for some diseas...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268814003379
更新日期:2015-08-01 00:00:00
abstract::Piglets between 1 and 40 days of age were inoculated with varying numbers and with different isolates of Streptococcus suis type 2 by the intranasal, intravenous and subarachnoid routes. Less than 100 organisms of an isolate cultured from apparently normal pigs caused subclinical infection in 1-day-old piglets after i...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800048081
更新日期:1990-12-01 00:00:00
abstract::The importance of carrier animals (those in whom virus persists after recovery from disease or acute infection) and their potential role in the spread of disease remain open questions within foot-and-mouth disease epidemiology. Using simple probabilistic models we attempt to quantify the effect of emergency vaccinatio...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268809002349
更新日期:2009-10-01 00:00:00
abstract::We describe an outbreak of simultaneous Clostridium difficile and norovirus infections in a long-term-care facility. Thirty patients experienced acute gastroenteritis, and four had co-infection with identical C. difficile 027 and genotype II.4 New Orleans norovirus strains. Co-occurring infection requires improved und...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268813000241
更新日期:2013-08-01 00:00:00
abstract::We examined the prevalence, correlates and trends of H. pylori infection in Israel using residual sera obtained in 2007-2008 from 1466 Jewish subjects aged 0-77 years and 897 Arabs aged 0-19 years, and in 2000-2001 from 627 Jewish and 575 Arab subjects aged 0-19 years. H. pylori IgG antibodies were measured by ELISA. ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268811002081
更新日期:2012-07-01 00:00:00
abstract::An outbreak of trichinosis occurred during January 1995 in a south Lebanese village with a population of 800-1000 persons. The estimated number of persons treated for a Trichinella-like illness was 200. Sixty-three persons sought medical attention at a local infirmary: 44 of them were diagnosed as having trichinosis o...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268897007875
更新日期:1997-12-01 00:00:00
abstract::Louse-borne relapsing fever (LBRF) is an epidemic disease with a fascinating history from Hippocrates' times, through the 6th century 'Yellow Plague', to epidemics in Ireland, Scotland and England in the 19th century and two large Afro-Middle Eastern pandemics in the 20th century. An endemic focus persists in Ethiopia...
journal_title:Epidemiology and infection
pub_type: 杂志文章,评审
doi:10.1017/S0950268819000116
更新日期:2019-01-01 00:00:00
abstract::The epidemiological target of lockdowns is to drive down the effective reproduction number (Rt) to less than 1. A key unknown is the duration that lockdowns need to be in place to achieve this and which lockdown measures are effective. Daily number of laboratory confirmed community coronavirus 2019 cases were extracte...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268820002964
更新日期:2020-12-09 00:00:00
abstract::We examined the relationship between meteorological parameters and hand, foot and mouth disease (HFMD) activity. Meteorological data collected from 2000 to 2004 were tested for correlation with HFMD consultation rates calculated through the sentinel surveillance system in Hong Kong. The regression model constructed wa...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268810002256
更新日期:2010-12-01 00:00:00
abstract::Despite national guidance recommending testing and vaccination of household contacts of hepatitis B-infected pregnant women, provision and uptake of this is sub-optimal. The aim of this study was to evaluate the use of in-home dried blood spot (DBS) testing to increase testing and vaccination of household contacts of ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268815003325
更新日期:2016-07-01 00:00:00
abstract::We recruited 1591 patients who presented to our fever clinics from 23 January 2020 to 16 February 2020. The different imaging findings between COVID-19 pneumonia and influenza A viruses, influenza B virus pneumonia were also investigated. Most patients were infected by influenza A and B viruses in the flu-season. A la...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268820001971
更新日期:2020-09-02 00:00:00
abstract::Pathogenic Vibrio species are naturally-occurring bacteria in freshwater and saline aquatic environments. Counts of free-living bacteria in water are generally less than required to induce disease. Increases in number of organisms towards an infective dose can occur as water temperatures rise seasonally followed by gr...
journal_title:Epidemiology and infection
pub_type: 杂志文章,评审
doi:10.1017/s0950268800030326
更新日期:1989-08-01 00:00:00
abstract::To gain insight into pertussis disease dynamics, we studied age-specific long-term periodicity and seasonality of pertussis in The Netherlands. Hierarchical time-series models were used to analyse the monthly reported pertussis incidence in January 1996-June 2006 by age group. The incidence of pertussis showed a sligh...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268809002489
更新日期:2009-10-01 00:00:00
abstract::A 10-month longitudinal household study of pre-school children and their families was undertaken with monthly visits collecting epidemiological data and nasopharyngeal swabs in Hertfordshire, England from 2001 to 2002. Pneumococcal culture was with standard methods. In total, 121 families (489 individuals) took part. ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268805004012
更新日期:2005-10-01 00:00:00
abstract::The introduction and the widespread use of the varicella vaccine in Taiwan has led to a 75-80% decrease in the incidence of varicella in children. However the vaccine's long-term impact on the incidence of herpes zoster (HZ) has attracted attention. By controlling gender, underlying diseases, and age effects, a Poisso...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268811001786
更新日期:2012-06-01 00:00:00
abstract::To assess areas at risk for poliovirus circulation in Ecuador, we first selected provinces at highest risk based on low immunization coverage with three doses of oral poliovirus vaccine, and a low number of reported cases of acute flaccid paralysis (AFP). Subsequently, we reviewed discharge data for the period 1996--2...
journal_title:Epidemiology and infection
pub_type: 杂志文章,多中心研究
doi:10.1017/s0950268804002626
更新日期:2004-10-01 00:00:00
abstract::We investigated the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) carriage in a convenience sample of purposely selected populations of dogs, cats and horses in the Greater London area. Swabs from carriage sites were pooled, enriched and processed by standard bacteriological methods. The presence of...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S095026881000227X
更新日期:2011-07-01 00:00:00
abstract::We examined stool specimens for viral pathogens from 50 children referred to hospital due to acute gastroenteritis (AGE) resulting from consuming drinking water contaminated with sewage in a Finnish community using PCR methods. Rotavirus was detected in 33 (66%), human calicivirus in 31 (62%), and both in 40% of cases...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268809991671
更新日期:2010-09-01 00:00:00
abstract::The possible association between Toxoplasma gondii infection and paediatric haematological malignancies in a group of patients and control subjects was evaluated in the present study. We performed an age-, gender- and residence frequency-matched case-control study of 101 blood cancer patients under 18 years of age, al...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268818002194
更新日期:2018-11-01 00:00:00
abstract::Escherichia coli O157 infections cause an estimated 60 deaths and 73 000 illnesses annually in the United States. A marked summer peak in incidence is largely unexplained. We investigated an outbreak of E. coli O157 infections at an agricultural fair in Ohio and implicated consumption of beverages made with fairground...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268803001237
更新日期:2003-12-01 00:00:00
abstract::Fourteen people living in or near the city of Gloucester fell ill with Legionnaires' disease caused by Legionella pneumophila serogroup (SG) 1 between 27 August and 27 October 1986. Another patient had fallen ill on 30 May. Nine of the 15 were diagnosed retrospectively during a case finding exercise. There were three ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800048767
更新日期:1991-08-01 00:00:00
abstract::Filariasis is one of the major public health concerns in India. Approximately 600 million people spread across 250 districts of India are at risk of filariasis. To predict this disease, a pilot scale study was carried out in 30 villages of Karimnagar district of Telangana from 2004 to 2007 to collect epidemiological a...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268819001481
更新日期:2019-09-02 00:00:00
abstract::Most influenza virus infections are associated with mild disease. One approach to estimate the occurrence of influenza virus infections in individuals is via repeated measurement of humoral antibody titres. We used baseline and convalescent antibody titres measured by haemagglutination inhibition (HI) and viral neutra...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268816000583
更新日期:2016-08-01 00:00:00
abstract::The Infectious Disease Society of America (IDSA) publishes guidelines regularly for the management of skin and soft tissue infections; however, the extent to which practice patterns follow these guidelines and if this can affect treatment failure rates is unknown. We observed the treatment failure rates from a multice...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268818003291
更新日期:2018-12-05 00:00:00
abstract::An outbreak of Campylobacter jejuni infection occurred in a South Wales Valleys housing estate. Illness in estate residents was associated with tap water consumption [population attributable risk (PAR) 50%, relative risk (RR) 2.53, 95% confidence interval (CI) 1.9-3.37] and residence in the upper estate (PAR 49%, RR 2...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268807007960
更新日期:2007-10-01 00:00:00
abstract::Samples from 2427 cattle, 661 goats, 104 sheep, 98 camels and 82 horses were screened for brucella infections by the Rose Bengal Test and positive reactors confirmed by the complement fixation test. In cattle, the highest individual seroprevalence was in dairy herds kept under the intensive husbandry system, with an i...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268899004501
更新日期:2000-10-01 00:00:00