Antenatal phenobarbital therapy and neonatal outcome. I: Effect on intracranial hemorrhage.

Abstract:

OBJECTIVE:To evaluate the effect of antenatal phenobarbital (PB) therapy on neonatal intracranial hemorrhage (ICH) in preterm infants. DESIGN:Prospective, randomized, controlled trial. SETTING:Single institution study. SUBJECTS AND INTERVENTIONS:Women in preterm labor ( < 35 weeks' gestation) were assigned to control and treatment groups. The treatment group received 10 mg/kg (maximum, 1000 mg) PB intravenously, followed by 100 mg orally daily, until delivery. Neonates did not receive PB after birth. Head sonograms were performed on days 3, 7, and 14 and at discharge. Hemorrhage was classified as mild, moderate, or severe by a single reader. OUTCOME MEASURES:Incidence of neonatal ICH in all infants, infants weighing less than 1250 g, and infants of multiple gestations. RESULTS:The study population comprised 110 women, 60 in the control group and 50 in the PB group. Neonates in the control group (n = 74, including 10 pairs of twins and 2 sets of triplets) were comparable to those in the treatment group (n = 62, including 7 pairs of twins, 1 set of triplets, and 1 set of quadruplets) regarding birth weight, gestational age, and other clinical risk factors for ICH. There was a trend for the incidence of any grade of hemorrhage to be lower in the PB group (22% [14 of 62]) compared with the control group (35% [26 of 74]). Moderate and severe hemorrhages were significantly lower in the PB group (1.6% [1 of 62]) compared with the control group (9.4% [7 of 74]). Among infants weighing less than 1250 g, overall ICH was lower in the PB group (23% [6 of 26]) compared with the control group (51% [18 of 35]). Among multiple-gestation infants, overall ICH was 4.7% (1 of 21) in the PB group, compared with 31% (8 of 26) in the control group. CONCLUSIONS:Antenatal PB therapy results in a significant decrease in moderate and severe ICH in infants born at less than 35 weeks' gestation. Antenatal PB therapy also resulted in a decrease in the incidence of all grades of ICH in infants weighing less than 1250 g and infants born of multiple gestations.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Shankaran S,Cepeda E,Muran G,Mariona F,Johnson S,Kazzi SN,Poland R,Bedard MP

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

644-8

issue

5

eissn

0031-4005

issn

1098-4275

journal_volume

97

pub_type

临床试验,杂志文章,随机对照试验
  • Smoking patterns among adolescents with asthma attending upper secondary schools: a community-based study.

    abstract:OBJECTIVE:Smoking among people who have asthma may be a serious health problem. We studied the prevalence of smoking and the relations between smoking and asthma, symptoms, medicine, and gender differences among adolescents with asthma. METHODS:A national cross-sectional study on health and lifestyles was performed in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.5.e562

    authors: Precht DH,Keiding L,Madsen M

    更新日期:2003-05-01 00:00:00

  • Effectiveness and cost-effectiveness of letters, automated telephone messages, or both for underimmunized children in a health maintenance organization.

    abstract:BACKGROUND:Immunization rates have improved in the United States, but are still far from the national 90% goal for the year 2000. There is scant evidence about the effectiveness and costs of automated telephone messages to improve immunization rates among privately insured children. OBJECTIVE:To evaluate the effective...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.101.4.e3

    authors: Lieu TA,Capra AM,Makol J,Black SB,Shinefield HR

    更新日期:1998-04-01 00:00:00

  • Apparent Cause Analysis: A Safety Tool.

    abstract::Causal analysis is a core function of safety programs. Although established protocols exist for conducting root cause analysis for serious safety events, there is limited guidance for apparent cause analysis (ACA) in health care. At our institution, through a novel facilitated ACA approach, we aim to improve safety cu...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2019-1819

    authors: Parikh K,Hochberg E,Cheng JJ,Lavette LB,Merkeley K,Fahey L,Shah RK

    更新日期:2020-05-01 00:00:00

  • Serum transaminase levels in boys with Duchenne and Becker muscular dystrophy.

    abstract:OBJECTIVE:Serum alanine transaminase (ALT) and aspartate transaminase (AST) levels are commonly used as biochemical indicators of hepatocellular injury but can also detect occult muscle disease. High concomitant serum creatine phosphokinase (CPK) levels can point to muscle as the source of high transaminase levels. Nev...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0929

    authors: McMillan HJ,Gregas M,Darras BT,Kang PB

    更新日期:2011-01-01 00:00:00

  • Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants.

    abstract:BACKGROUND:Although caffeine use for apnea of prematurity is well studied, the long-term safety and benefit of routine early caffeine administration has not been explored. Our objective was to determine the association between early (within 2 days of birth) versus late caffeine exposure and neurodevelopmental outcomes ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-1348

    authors: Lodha A,Entz R,Synnes A,Creighton D,Yusuf K,Lapointe A,Yang J,Shah PS,investigators of the Canadian Neonatal Network (CNN) and the Canadian Neonatal Follow-up Network (CNFUN).

    更新日期:2019-01-01 00:00:00

  • Causal thinking in practice: strengths and weaknesses of the clinical vantage point.

    abstract::The place of causal inference in clinical practice is considered. One function relates to the validation of existing knowledge, as in the evaluation of the medical literature, and is exemplified by the process of editorial selection. A second function relates to the validation of potential knowledge, as in the testing...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Susser M

    更新日期:1984-11-01 00:00:00

  • Defining asthma in the preschool-aged child.

    abstract::A physician faces many challenges in making a definitive diagnosis of asthma in young children. Although there are clinical and historical features consistent with asthma, identical features are present in many other diseases. Furthermore, there is no specific test for asthma. Other diseases must always be ruled out b...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Strunk RC

    更新日期:2002-02-01 00:00:00

  • Health outcomes of a community-based therapy program for children with cancer--a shared-management approach.

    abstract::Critical to providing cancer therapy to children in rural areas is finding dependable sources of therapy near the patients' homes. In this study, comparison was made of 668 visits by 24 patients to nearby private practitioners, who carried out 70% of the therapy, with 712 visits by 22 other patients for whom all care ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kisker CT,Strayer F,Wong K,Clarke W,Strauss R,Tannous R,Janco R,Spevak J

    更新日期:1980-12-01 00:00:00

  • Improving Health and Safety at Camp.

    abstract::The American Academy of Pediatrics has created recommendations for health appraisal and preparation of young people before participation in day, resident, or family camps and to guide health and safety practices at camp. These recommendations are intended for parents and families, primary health care providers, and ca...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2019-1355

    authors: Ambrose MJ,Walton EA,COUNCIL ON SCHOOL HEALTH.

    更新日期:2019-07-01 00:00:00

  • Chronic Pain Assessment Tools for Cerebral Palsy: A Systematic Review.

    abstract:BACKGROUND AND OBJECTIVE:Chronic pain in children with cerebral palsy (CP) is underrecognized, leading to detriments in their physical, social, and mental well-being. Our objective was to identify, describe, and critique pediatric chronic pain assessment tools and make recommendations for clinical use for children with...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2015-0273

    authors: Kingsnorth S,Orava T,Provvidenza C,Adler E,Ami N,Gresley-Jones T,Mankad D,Slonim N,Fay L,Joachimides N,Hoffman A,Hung R,Fehlings D

    更新日期:2015-10-01 00:00:00

  • Effects of polycythemia and hyperviscosity on cutaneous blood flow and transcutaneous PO2 and PCO2 in the neonate.

    abstract::Neonatal hyperviscosity syndrome is known to affect multiple organ systems. The effects of polycythemic hyperviscosity on cutaneous blood flow and transcutaneous PO2 and PCO2 were compared in ten term infants prior to and following correction of the hyperviscous state. Cutaneous blood flow was measured by the heat cle...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Waffarn F,Tolle CD,Huxtable RF

    更新日期:1984-09-01 00:00:00

  • The delivery of immunizations and other preventive services in private practices.

    abstract:OBJECTIVES:To measure the proportion of children cared for in private practices who are fully immunized and have been screened for anemia, tuberculosis (TB), and lead poisoning by 2 years of age. DESIGN:Cross-sectional chart review. SETTING:Fifteen private pediatric practices in central North Carolina (11 chosen rand...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bordley WC,Margolis PA,Lannon CM

    更新日期:1996-04-01 00:00:00

  • Congenital left paraduodenal hernia causing chronic abdominal pain and abdominal catastrophe.

    abstract::Paraduodenal hernias are the most common type of congenital internal hernia. Because of its overall rare incidence, this entity is often overlooked during initial assessment of the patient. Lack of specific diagnostic criteria also makes diagnosis exceedingly difficult, and the resulting diagnostic delays can lead to ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-3701

    authors: Shi Y,Felsted AE,Masand PM,Mothner BA,Nuchtern JG,Rodriguez JR,Vasudevan SA

    更新日期:2015-04-01 00:00:00

  • The emergency physician and the office-based pediatrician: an EMSC team. American Academy of Pediatrics. Committee on Pediatric Emergency Medicine.

    abstract::In a quality and cost-conscious health care environment, the pediatrician and emergency physician must work as a team. This statement clarifies important issues of this relationship, including coordination of patient care, communication between clinicians, provision of continuity care, and responsibility for quality e...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.5.936

    authors:

    更新日期:1998-05-01 00:00:00

  • Corneal abrasions in young infants.

    abstract:OBJECTIVES:We sought to determine the prevalence of corneal abrasions and possible associations with fingernail length, demographic information, sleeping, and crying among young infants. METHODS:Parents of 1- to 12-week-old infants without symptoms who were presenting for well-child visits completed a brief questionna...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2023

    authors: Shope TR,Rieg TS,Kathiria NN

    更新日期:2010-03-01 00:00:00

  • Effect of hospital characteristics on outcomes from pediatric cardiopulmonary resuscitation: a report from the national registry of cardiopulmonary resuscitation.

    abstract:OBJECTIVE:Cardiac arrest is uncommon among pediatric patients. Prehospital data demonstrate differences in care processes between children and adults receiving cardiopulmonary resuscitation and advanced life support. We sought to evaluate whether children receiving in-hospital cardiopulmonary resuscitation would attain...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0453

    authors: Donoghue AJ,Nadkarni VM,Elliott M,Durbin D,American Heart Assocation National Registry of Cardiopulmonary Resuscitation Investigators.

    更新日期:2006-09-01 00:00:00

  • Clinical disease caused by Klebsiella in 2 unrelated patients with interleukin 12 receptor beta1 deficiency.

    abstract::Patients with interleukin 12 (IL-12)p40 or IL-12 receptor β1 (IL12Rβ1) deficiencies are prone to develop infections caused by mycobacteria and salmonella; other infections have only been rarely observed. In this report we describe 2 unrelated patients with complete autosomal recessive IL12Rβ1 deficiency who suffered f...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2504

    authors: Pedraza S,Lezana JL,Samarina A,Aldana R,Herrera MT,Boisson-Dupuis S,Bustamante J,Pages P,Casanova JL,Picard C

    更新日期:2010-10-01 00:00:00

  • Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study.

    abstract:OBJECTIVES:To compare the effects of a single nocturnal dose of 3 honey products (eucalyptus honey, citrus honey, or labiatae honey) to placebo (silan date extract) on nocturnal cough and difficulty sleeping associated with childhood upper respiratory tract infections (URIs). METHODS:A survey was administered to paren...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2011-3075

    authors: Cohen HA,Rozen J,Kristal H,Laks Y,Berkovitch M,Uziel Y,Kozer E,Pomeranz A,Efrat H

    更新日期:2012-09-01 00:00:00

  • Diagnosis of ill-defined pulmonary infiltrates by lateral decubitus chest radiography.

    abstract::The lateral decubitus chest radiograph is a useful procedure in the evaluation of ill-defined pulmonary densities that may stimulate infiltrates. This procedure, although described previously in the radiologic literature, has not been in frequent use. The procedure assists diagnosis in patients who are not able to tak...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Faerber EN,Darling DB,Leonidas JC

    更新日期:1983-02-01 00:00:00

  • Familial nonobstructive cardiomyopathy with endocardial fibroelastosis beyond infancy.

    abstract::A 10-year-old boy with congestive heart failure died in five months in spite of comprehensive medical treatment. Autopsy showed patchy areas of endocardial fibroelastosis of the left ventricle. The sister of this patient had followed a similar course at 13 years of age with death within six months of the onset of cong...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.410

    authors: Singh A,Doyle EF,Danilowicz DA,Finegold MJ

    更新日期:1978-03-01 00:00:00

  • The role of parental preferences in the management of fever without source among 3- to 36-month-old children: a decision analysis.

    abstract:OBJECTIVES:Recent analyses assessing the impact of the conjugate pneumococcal vaccine on the care of febrile children do not reflect the role parental preferences play in physicians' decisions. The objective of this study was to identify the management strategy that would best suit parents, on the basis of their values...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1865

    authors: Madsen KA,Bennett JE,Downs SM

    更新日期:2006-04-01 00:00:00

  • The increasing number of children using psychiatric services: analysis of a cumulative psychiatric case register.

    abstract::Psychosocial problems of children have received increasing attention in the pediatric literature, but it remains unclear to what extent psychiatric services are available and used for the treatment of these problems. This paper examines the utilization of psychiatric services by children over an 18-year period in Monr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Roghmann KJ,Babigian HM,Goldberg ID,Zastowny TR

    更新日期:1982-11-01 00:00:00

  • Status of newborn screening programs in the United States.

    abstract:BACKGROUND:Newborn screening programs have expanded over the years; currently, many programs screen for dozens of congenital conditions that, if not detected and treated early, could result in catastrophic health consequences, including death. Some programs, however, still require universal newborn screening for only a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2633C

    authors: Therrell BL,Johnson A,Williams D

    更新日期:2006-05-01 00:00:00

  • E-cigarettes and National Adolescent Cigarette Use: 2004-2014.

    abstract:BACKGROUND:E-cigarette use is rapidly increasing among adolescents in the United States, with some suggesting that e-cigarettes are the cause of declining youth cigarette smoking. We hypothesized that the decline in youth smoking changed after e-cigarettes arrived on the US market in 2007. METHODS:Data were collected ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-2450

    authors: Dutra LM,Glantz SA

    更新日期:2017-02-01 00:00:00

  • Enzymatic defect in a child with hereditary hepatic porphyria due to homozygous delta-aminolevulinic acid dehydratase deficiency: immunochemical studies.

    abstract::Immunochemical studies of the enzyme defect in the first reported child with acute hepatic porphyria due to homozygous delta-aminolevulinic acid dehydratase deficiency are described. This enzyme activity was markedly decreased (approximately 2% of the normal control level) in the proband, a 3-year-old boy, and interme...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fujita H,Sassa S,Lundgren J,Holmberg L,Thunell S,Kappas A

    更新日期:1987-12-01 00:00:00

  • Economic evaluation of the routine childhood immunization program in the United States, 2009.

    abstract:OBJECTIVES:To evaluate the economic impact of the 2009 routine US childhood immunization schedule, including diphtheria and tetanus toxoids and acellular pertussis, Haemophilus influenzae type b conjugate, inactivated poliovirus, measles/mumps/rubella, hepatitis B, varicella, 7-valent pneumococcal conjugate, hepatitis ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0698

    authors: Zhou F,Shefer A,Wenger J,Messonnier M,Wang LY,Lopez A,Moore M,Murphy TV,Cortese M,Rodewald L

    更新日期:2014-04-01 00:00:00

  • Sexuality, contraception, and the media. Committee on Public Education.

    abstract::Early sexual intercourse among American adolescents represents a major public health problem. Although early sexual activity may be caused by a variety of factors, the media are believed to play a significant role. In film, television, and music, sexual messages are becoming more explicit in dialogue, lyrics, and beha...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.107.1.191

    authors: American Academy of Pediatrics. Committee on Public Education, American Academy of Child and Adolescent psychiatry, American Psychological Association.

    更新日期:2001-01-01 00:00:00

  • Trends in mortality and morbidity for very low birth weight infants, 1991-1999.

    abstract:BACKGROUND:Medical care for very low birth weight (VLBW) infants and their mothers has changed dramatically during the 1990s, yet it is unclear how these changes have affected mortality and morbidity. OBJECTIVE:We used the Vermont Oxford Network Database to identify trends in clinical practice and patient outcomes for...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.110.1.143

    authors: Horbar JD,Badger GJ,Carpenter JH,Fanaroff AA,Kilpatrick S,LaCorte M,Phibbs R,Soll RF,Members of the Vermont Oxford Network.

    更新日期:2002-07-01 00:00:00

  • Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis.

    abstract:OBJECTIVE:Although universal immunization against Bordetella pertussis (whooping cough) infection has resulted in dramatic reductions in the incidence of pertussis, outbreaks continue to occur in countries with excellent vaccine coverage. Treatment of infection may ameliorate symptom severity during the catarrhal phase...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.114.1.e96

    authors: Langley JM,Halperin SA,Boucher FD,Smith B,Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC).

    更新日期:2004-07-01 00:00:00

  • Preventing neonatal group B streptococcal disease: cost-effectiveness in a health maintenance organization and the impact of delayed hospital discharge for newborns who received intrapartum antibiotics.

    abstract:OBJECTIVES:To estimate the cost and health benefits of implementing a risk factor-based prevention strategy for early-onset neonatal group B streptococcal (GBS) disease, using baseline assumptions and costs from a health maintenance organization. With the risk factor-based strategy, intrapartum antibiotics (IPAs) would...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.4.703

    authors: Mohle-Boetani JC,Lieu TA,Ray GT,Escobar G

    更新日期:1999-04-01 00:00:00