Abstract:
BACKGROUND:Aggression has been suggested to be related to abnormal brain 5-HT activity. This amine is synthesized in brain from tryptophan, which is transported through the blood-brain barrier in competition with other amino acids. The relationship between tryptophan and its endogenous amino acid competitors in plasma might thus influence the availability of tryptophan in the brain and consequently brain 5-HT activity. METHODS:Plasma amino acids were determined in 89 offenders who had committed various violent and non-violent crimes and in 14 healthy controls. RESULTS:Both tryptophan and its competitors were higher in offenders who had committed violent crimes compared both with non-violent offenders and with controls. No difference was, however, seen in the relationship between tryptophan and its competitors. CONCLUSIONS:The results support the contention that violent behaviour is related to biochemical deviations but could not explain a possible decreased brain 5-HT activity.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Eriksson T,Lidberg Ldoi
10.1017/s0033291796003935subject
Has Abstractpub_date
1997-03-01 00:00:00pages
477-81issue
2eissn
0033-2917issn
1469-8978journal_volume
27pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 传,历史文章,杂志文章,meta分析
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-12-01 00:00:00
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更新日期:1998-01-01 00:00:00
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更新日期:2000-01-01 00:00:00
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