Acute and long-term treatment outcome in depressed inpatients with vs. without anxious features: results of a one-year follow-up study.

Abstract:

BACKGROUND:Anxious depression (AD) is common in patients with unipolar depression. It remains unclear if they have a higher level of depressive symptoms, a higher risk of non-response, a poorer prognosis and a higher relapse rate compared to non-anxious depressed (non-AD) patients. METHODS:168 patients took part in all three measurement points: (1) intake, (2) discharge and (3) follow-up. Patients fulfilled the criteria for anxious depression if they had a baseline score >7 on the anxiety/somatisation factor of the Hamilton Rating Scale for Depression (HRSD). Patients with AD and non-AD were compared regarding symptom reduction from intake to discharge as well as from discharge to one year after discharge. Primary outcome measure was the HRSD. RESULTS:The prevalence of AD was considerably high (81%). At intake, patients with AD had a significant higher score in the modified HRSD (M=20.67±4.12 vs. M=14.35±5.06). Both patient groups showed a significant and comparable intake-to-discharge symptom reduction in all inventories. Remission rates at discharge did not differ between AD and non-AD patients. At 1-year follow-up, AD patients showed a similar symptom severity compared to non-AD patients. CONCLUSION:Symptoms of anxiety are common in depressive disorders are associated with higher depressive symptoms at the beginning of treatment. Acute and longer-term treatment outcome of AD patients was comparable to that of non-AD patients. LIMITATIONS:Limitations of this study are the naturalistic design, treatment was not standardized and comorbid anxiety disorders were not assed using a structured interview.

journal_name

J Affect Disord

authors

Köhler S,Unger T,Hoffmann S,Steinacher B,Fydrich T

doi

10.1016/j.jad.2013.05.043

subject

Has Abstract

pub_date

2013-09-25 00:00:00

pages

1055-61

issue

3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(13)00422-9

journal_volume

150

pub_type

杂志文章
  • Clinical effects of electroconvulsive therapy in severe depression and concomitant changes in cerebral glucose metabolism--an exploratory study.

    abstract:OBJECTIVE:Electroconvulsive therapy (ECT) is an effective mode of treatment--especially for severe depression and for depression refractory to pharmacotherapy, nevertheless the mode of action of ECT is far from being fully understood. This study assessed the effects of a series of ECT in depressive subjects on cerebral...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.07.034

    authors: Reininghaus EZ,Reininghaus B,Ille R,Fitz W,Lassnig RM,Ebner C,Annamaria P,Hofmann P,Kapfhammer HP,Reingard A,Fazekas F,Ropele S,Enzinger C

    更新日期:2013-04-05 00:00:00

  • The biological basis of anxiety. An overview.

    abstract::The DSM-III divides anxiety disorders into two broad categories, Phobic Disorders and Anxiety States. Anxiety states characterised by panic attacks have been separated from generalised anxiety disorders. While this classification may not be generally accepted it is of heuristic value. Delineation of panic disorder as ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(85)90058-8

    authors: Judd FK,Burrows GD,Norman TR

    更新日期:1985-11-01 00:00:00

  • The role of prenatal social support in social inequalities with regard to maternal postpartum depression according to migrant status.

    abstract:BACKGROUND:An advantaged socioeconomic position (SEP) and satisfying social support during pregnancy (SSP) have been found to be protective factors of maternal postpartum depression (PDD). An advantaged SEP is also associated with satisfying SSP, making SSP a potential mediator of social inequalities in PPD. SEP, SSP a...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.04.024

    authors: Nakamura A,El-Khoury Lesueur F,Sutter-Dallay AL,Franck JÈ,Thierry X,Melchior M,van der Waerden J

    更新日期:2020-07-01 00:00:00

  • Feeling down? A systematic review of the gut microbiota in anxiety/depression and irritable bowel syndrome.

    abstract::Background Anxiety/depression and irritable bowel syndrome (IBS) are highly prevalent and burdensome conditions, whose co-occurrence is estimated between 44 and 84%. Shared gut microbiota alterations have been identified in these separate disorders relative to controls; however, studies have not adequately considered ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.jad.2020.01.124

    authors: Simpson CA,Mu A,Haslam N,Schwartz OS,Simmons JG

    更新日期:2020-04-01 00:00:00

  • Human fibroblasts as a relevant model to study signal transduction in affective disorders.

    abstract:BACKGROUND:Previous studies have demonstrated a blunted beta adrenoceptor-linked protein kinase A (PKA) response in the 900xg supernatant fraction of human fibroblasts cultured from patients with major depression. RESULTS:Results of the present studies demonstrate a significant reduction in the B(max) value of [3H]cyc...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/s0165-0327(99)00190-1

    authors: Manier DH,Shelton RC,Ellis TC,Peterson CS,Eiring A,Sulser F

    更新日期:2000-12-01 00:00:00

  • Depression in children and adolescents: new data on 'undertreatment' and a literature review on the efficacy of available treatments.

    abstract::This article reports on the treatment received by 38 adolescents during an episode of major depression which had a median duration of 4 months. The one subject who received any pharmacologic treatment was prescribed an antianxiety agent. Sixteen percent received psychotherapy. These results are consistent with evidenc...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/0165-0327(91)90037-s

    authors: Keller MB,Lavori PW,Beardslee WR,Wunder J,Ryan N

    更新日期:1991-03-01 00:00:00

  • Peritraumatic tonic immobility predicts a poor response to pharmacological treatment in victims of urban violence with PTSD.

    abstract:INTRODUCTION:Tonic immobility is the last defense against predation in animals and is characterized by paralysis and analgesia. In humans, it has only been reported in women victims of sexual abuse. OBJECTIVE:This study evaluated the prevalence of peritraumatic tonic immobility (PTI) in patients with PTSD and investig...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2007.07.015

    authors: Fiszman A,Mendlowicz MV,Marques-Portella C,Volchan E,Coutinho ES,Souza WF,Rocha V,Lima AA,Salomão FP,Mari JJ,Figueira I

    更新日期:2008-04-01 00:00:00

  • Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression.

    abstract:BACKGROUND:Depression is the single largest contributor to non-fatal health loss worldwide. A role of inflammation in major depressive disorder (MDD) was suggested, and we sought to determine if cytokine levels predict the severity of depressive symptomatology or distinguish MDD patients from healthy controls (HCs). M...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.02.042

    authors: Fanelli G,Benedetti F,Wang SM,Lee SJ,Jun TY,Masand PS,Patkar AA,Han C,Serretti A,Pae CU,Fabbri C

    更新日期:2019-04-15 00:00:00

  • Iowa Gambling Task performance in euthymic bipolar I disorder: a meta-analysis and empirical study.

    abstract:BACKGROUND:The Iowa Gambling Task (IGT) has been recommended as an index of reward sensitivity, which is elevated in bipolar disorder. We conducted a meta-analysis of IGT performance in euthymic bipolar I disorder compared with control participants. Findings indicated that people with bipolar disorder make more risky c...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jad.2012.11.027

    authors: Edge MD,Johnson SL,Ng T,Carver CS

    更新日期:2013-08-15 00:00:00

  • Prevalence of mixed mania using 3 definitions.

    abstract:OBJECTIVES:Mixed episodes are a combination of depressive and manic symptoms in bipolar disorder (BD). We want to identify the proportion of patients who have depressive symptoms during an acute episode and also the validity of current methods for its diagnosis. MATERIAL AND METHOD:Cross-sectional multicentre study of...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2009.12.019

    authors: Vieta E,Morralla C

    更新日期:2010-09-01 00:00:00

  • The effect of dexamethasone dosage upon plasma cortisol and dexamethasone during the DST.

    abstract::To investigate the effect of dexamethasone dosage upon the outcome of the dexamethasone suppression test (DST) and the role of concurrent plasma dexamethasone concentrations, four different dexamethasone dosages were administered to 119 hospitalized depressed patients (0.5 mg: n = 12; 1.0 mg: n = 30; 1.5 mg: n = 42; 2...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0165-0327(90)90018-4

    authors: Wiedemann K,Holsboer F

    更新日期:1990-06-01 00:00:00

  • Previous suicide attempt and subsequent risk of re-attempt and suicide: Are there differences in immigrant subgroups compared to Swedish-born individuals?

    abstract:BACKGROUND:Studies investigating how suicide attempting refugees and non-refugee migrants differ from Swedish-born individuals in terms of re-attempts and suicide are missing. It remains unknown how mental disorders and labour market marginalization (LMM) impact on these associations. METHODS:This longitudinal cohort ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.01.013

    authors: Niederkrotenthaler T,Mittendorfer-Rutz E,Mehlum L,Qin P,Björkenstam E

    更新日期:2020-03-15 00:00:00

  • Prevalence, clinical correlates and IQ of suicidal ideation in drug naïve Chinese Han patients with major depressive disorder.

    abstract:BACKGROUND:Suicidal ideation (SI) is a common and serious clinical concern in people with major depressive disorder (MDD). Inconsistent evidence suggests that individuals with SI may have a lower measured intelligence quotient (IQ) than those without SI. The aims of this study were to examine SI prevalence and its asso...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2018.12.017

    authors: Li X,Liu H,Hou R,Baldwin DS,Li R,Cui K,Liu C,Sun Q,Wang G,Tan Q,Xu X,Zhao J,Ning Y,Sun X

    更新日期:2019-04-01 00:00:00

  • Neural correlates of successful psychotherapy of depression in adolescents.

    abstract:BACKGROUND:While major effort has been put in investigating neural correlates of depression and its treatment in adults, less is known about the effects of psychotherapy in adolescents. Given the concordance of the ventral striatum, amygdala, hippocampus and the subgenual anterior cingulate cortex (sgACC) as correlates...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2015.05.020

    authors: Straub J,Plener PL,Sproeber N,Sprenger L,Koelch MG,Groen G,Abler B

    更新日期:2015-09-01 00:00:00

  • The cortisol suppressing effect of dexamethasone and oxazepam in depressed patients; significance of spontaneous levels and interindividual distribution.

    abstract::In 72 hospitalized depressed patients afternoon plasma cortisol (15.00-15.20) was measured in three ways: spontaneous (n = 72), 16 h after administration of 2 mg dexamethasone (n = 71) and 2 h after administration of 45 mg oxazepam (n = 28) or 60 mg oxazepam (n = 37). When cortisol values were log-transformed the hist...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(87)90047-4

    authors: Christensen P,Gram LF,Lolk A,Kragh-Sørensen P

    更新日期:1987-11-01 00:00:00

  • Complex trauma and intimate relationships: the impact of shame, guilt and dissociation.

    abstract:BACKGROUND:This study examined dissociation, shame, guilt and intimate relationship difficulties in those with chronic and complex PTSD. Little is known about how these symptom clusters interplay within the complex PTSD constellation. Dissociation was examined as a principle organizing construct within complex PTSD. In...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.10.010

    authors: Dorahy MJ,Corry M,Shannon M,Webb K,McDermott B,Ryan M,Dyer KF

    更新日期:2013-05-01 00:00:00

  • Parenting stress and family resilience affect the association of adverse childhood experiences with children's mental health and attention-deficit/hyperactivity disorder.

    abstract:INTRODUCTION:Exposure to adverse childhood experience (ACE) has harmful consequences for children's health and well-being. However, it is less clear how different social processes may amplify or mitigate the effects of ACE on children's mental health. We examined how parenting stress mediates and family resilience mode...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.03.132

    authors: Uddin J,Alharbi N,Uddin H,Hossain MB,Hatipoğlu SS,Long DL,Carson AP

    更新日期:2020-07-01 00:00:00

  • Mental disorders in motherhood according to prepregnancy BMI and pregnancy-related weight changes--A Danish cohort study.

    abstract:BACKGROUND:Previous studies have shown an association between prepregnancy BMI and postpartum depression, but little is known about this association beyond one year postpartum and the influence of postpartum weight retention (PPWR). METHODS:We used data from 70355 mothers from the Danish National Birth Cohort to estim...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2015.04.053

    authors: Bliddal M,Pottegård A,Kirkegaard H,Olsen J,Jørgensen JS,Sørensen TI,Wu C,Nohr EA

    更新日期:2015-09-01 00:00:00

  • Breastfeeding and the use of psychotropic medication: a review.

    abstract::The advisability of continuing breastfeeding is an important issue for women with postpartum depression or psychosis. A review of the literature on psychotropic drugs in breast milk is presented. All of the major classes of psychotropic drugs (antidepressants, antipsychotics, antianxiety agents, lithium, hypnotics) ha...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/0165-0327(90)90092-m

    authors: Buist A,Norman TR,Dennerstein L

    更新日期:1990-07-01 00:00:00

  • Affective and psychotic symptoms relate to different types of P300 alteration in depressive disorder.

    abstract:BACKGROUND:Previous findings of P300 alterations in depressive disorder have been controversial. We therefore used multivariate methods to study the relationship between P300 and affective and psychotic symptoms in depressive disorder. METHODS:The P300 of 22 psychotropic drug-free depressed out-patients was registered...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/s0165-0327(01)00410-4

    authors: Kaustio O,Partanen J,Valkonen-Korhonen M,Viinamäki H,Lehtonen J

    更新日期:2002-09-01 00:00:00

  • Bipolar disorder and self-stigma: A comparison with schizophrenia.

    abstract:AIM:Even though numerous studies have focused on the effects of self-stigma on patients with schizophrenia, little is known about self-stigma of patients with bipolar disorder (BD). In this study, a self-administered scale of self-stigmatising attitudes of patients with BD and schizophrenia was used to explore these at...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2015.05.038

    authors: Karidi MV,Vassilopoulou D,Savvidou E,Vitoratou S,Maillis A,Rabavilas A,Stefanis CN

    更新日期:2015-09-15 00:00:00

  • Pediatric bipolar disorder in a Spanish sample: results after 2.6years of follow-up.

    abstract:INTRODUCTION:Bipolar disorder (BD) often starts in childhood or adolescence. There is considerable scepticism outside the United States over the validity, stability and prevalence of BD in children and adolescents. Persistence of course lends support to the validity of a diagnosis. OBJECTIVES:To describe the longitudi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2011.01.013

    authors: Escamilla I,Wozniak J,Soutullo CA,Gamazo-Garrán P,Figueroa-Quintana A,Biederman J

    更新日期:2011-07-01 00:00:00

  • Manifestations of overarousal account for the association between cognitive anxiety sensitivity and suicidal ideation.

    abstract:BACKGROUND:Recent evidence suggests an association between cognitive anxiety sensitivity and suicidal ideation. Cognitive anxiety sensitivity has also been implicated as a precursor to various forms of overarousal. These manifestations of overarousal (i.e., agitation, insomnia, nightmares, and anger) may account for th...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2015.12.014

    authors: Rogers ML,Tucker RP,Law KC,Michaels MS,Anestis MD,Joiner TE

    更新日期:2016-03-01 00:00:00

  • Psychoeducation and online mood tracking for patients with bipolar disorder: A randomised controlled trial.

    abstract:BACKGROUND:Psychoeducation is an effective adjunct to medications in bipolar disorder (BD). Brief psychoeducational approaches have been shown to improve early identification of relapse. However, the optimal method of delivery of psychoeducation remains uncertain. Here, our objective was to compare a short therapist-fa...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jad.2016.06.064

    authors: Bilderbeck AC,Atkinson LZ,McMahon HC,Voysey M,Simon J,Price J,Rendell J,Hinds C,Geddes JR,Holmes E,Miklowitz DJ,Goodwin GM

    更新日期:2016-11-15 00:00:00

  • Gray matter abnormalities in patients with premenstrual dysphoric disorder: an optimized voxel-based morphometry.

    abstract:BACKGROUND:Although brain neurochemistry is thought to play a role in the development of premenstrual dysphoric disorder (PMDD), neuroimaging studies of PMDD are sparse. We examined the extent to which gray matter (GM) abnormalities were present in women with PMDD compared to healthy controls. METHODS:3.0T magnetic re...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.02.010

    authors: Jeong HG,Ham BJ,Yeo HB,Jung IK,Joe SH

    更新日期:2012-11-01 00:00:00

  • An adoption study comparing the prevalence of psychiatric illness in women who have adoptive and natural children compared with women who have adoptive children only.

    abstract::The current study compares the current and lifetime prevalence of affective disorder in women who have adopted and have natural children (n = 110) with women who only have adopted children (n = 176). There was no difference in lifetime prevalence of psychiatric disorder between the two groups and a nonsignificant tren...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(94)00105-i

    authors: Dean C,Dean NR,White A,Liu WZ

    更新日期:1995-04-16 00:00:00

  • Cognitive and family correlates of current suicidal ideation in children with bipolar disorder.

    abstract:BACKGROUND:Suicidality among youth with bipolar disorder is an extreme, but largely unaddressed, public health problem. The current study examined the psychosocial characteristics differentiating youth with varying severities of suicidal ideation that may dictate targets for suicide prevention interventions. METHODS:P...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2014.10.058

    authors: Weinstein SM,Van Meter A,Katz AC,Peters AT,West AE

    更新日期:2015-03-01 00:00:00

  • Determinants of access to health care for depression in 49 countries: A multilevel analysis.

    abstract:BACKGROUND:The relative importance of individual and country-level factors influencing access to diagnosis and treatment for depression across the world is fairly unknown. METHODS:We analysed cross-national data from the WHO World Health Surveys. Depression diagnosis and access to health care were ascertained using a ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2018.02.092

    authors: Araya R,Zitko P,Markkula N,Rai D,Jones K

    更新日期:2018-07-01 00:00:00

  • Early emotional disturbances during nicotine patch therapy in subjects with and without a history of depression.

    abstract:BACKGROUND:The goal of this study was to compare development of emotional symptomatology during smoking cessation with transdermal nicotine patches in subjects with and without a history of depression. METHODS:Twenty-five subjects, 14 with a history of depression and 11 without such a history, were evaluated before be...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/s0165-0327(01)00468-2

    authors: Carton S,Le Houezec J,Lagrue G,Jouvent R

    更新日期:2002-11-01 00:00:00

  • Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults.

    abstract:BACKGROUND:Adverse childhood experiences (ACEs) are associated with poor physical and mental health outcomes in adulthood. Adverse childhood experiences are also associated with shortened leukocyte telomere length (LTL) in adults, suggesting accelerated cell aging. No studies have yet assessed the relationship of ACEs ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2014.07.035

    authors: Chen SH,Epel ES,Mellon SH,Lin J,Reus VI,Rosser R,Kupferman E,Burke H,Mahan L,Blackburn EH,Wolkowitz OM

    更新日期:2014-12-01 00:00:00