Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia.

abstract：:As the natural resistance-associated macrophage protein 1 Nramp1 (also known as Slc11a1) modulates Kupffer cell (KC) activation, and KC are responsible for the early phase of warm ischemia/reperfusion (I/R) to the liver, we hypothesized that livers of Nramp1(-/-) mice will be protected from early-phase I/R injury comp...

journal_title：Journal of leukocyte biology

authors： Wyllie S,Seu P,Gao FQ,Gros P,Goss JA

更新日期：2002-11-01 00:00:00

abstract：:In this study, we examined the expression of nerve growth factor (NGF) and its receptors in mouse macrophages and the mechanisms involved in the effect of NGF on tumor necrosis factor (TNF)-alpha production. Macrophages expressed NGF and the NGF receptors TrkA and p75. Treatment of J744 cells or peritoneal macrophages...

journal_title：Journal of leukocyte biology

authors： Barouch R,Kazimirsky G,Appel E,Brodie C

更新日期：2001-06-01 00:00:00

abstract：:CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by macrophages in lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last de...

journal_title：Journal of leukocyte biology

authors： Sanjurjo L,Aran G,Roher N,Valledor AF,Sarrias MR

更新日期：2015-08-01 00:00:00

abstract：:Lipopolysaccharide-induced CXC chemokine (LIX) is a novel murine neutrophil-chemoattractant CXC chemokine cloned as a glucocorticoid-attenuated response gene. We investigated LIX message expression in an acute endotoxemia model. LIX message peaks later than KC or macrophage inflammatory protein-2 (MIP-2) and remains e...

journal_title：Journal of leukocyte biology

authors： Rovai LE,Herschman HR,Smith JB

更新日期：1998-10-01 00:00:00

abstract：:There is growing evidence that, in addition to their role as initiators of immune responses, dendritic cells (DC) can exhibit tolerogenic properties. Immature DC deficient in cell surface costimulatory/accessory molecules can prolong organ and pancreatic islet allograft survival, whereas in vitro manipulation of DC by...

journal_title：Journal of leukocyte biology

authors： Lu L,Lee WC,Takayama T,Qian S,Gambotto A,Robbins PD,Thomson AW

更新日期：1999-08-01 00:00:00

abstract：:The tissue-fixed macrophage is a key cellular element in the initiation and regulation of inflammation. Understanding the regulation of macrophage activation may provide valuable clues to the mechanisms involved in both beneficial and deleterious effects of inflammation. The lymphokine interferon-gamma (IFN-gamma) is ...

journal_title：Journal of leukocyte biology

authors： Williams JG,Jurkovich GJ,Hahnel GB,Maier RV

更新日期：1992-12-01 00:00:00

abstract：:Inbred mouse strains have been known for many years to vary in their degree of susceptibility to different types of infectious diseases. The genetic basis of these interstrain differences is sometimes simple but often complex. In a few cases, positional cloning has been used successfully to identify single gene effect...

journal_title：Journal of leukocyte biology

authors： Fortier A,Min-Oo G,Forbes J,Lam-Yuk-Tseung S,Gros P

更新日期：2005-06-01 00:00:00

abstract：:The promoters of the IL-8, MCP-1, and RANTES genes contain binding sites for the redox-responsive transcription factors AP-1 and NF-kappaB, which have been shown to be important for their expression. In this overview, we present evidence from our laboratories that the stimulus-specific regulation of these chemokines b...

journal_title：Journal of leukocyte biology

authors： Roebuck KA,Carpenter LR,Lakshminarayanan V,Page SM,Moy JN,Thomas LL

更新日期：1999-03-01 00:00:00

abstract：:TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We ha...

journal_title：Journal of leukocyte biology

authors： Verstak B,Stack J,Ve T,Mangan M,Hjerrild K,Jeon J,Stahl R,Latz E,Gay N,Kobe B,Bowie AG,Mansell A

更新日期：2014-09-01 00:00:00

abstract：:Anti-proteinase-3 (anti-PR3) or anti-myeloperoxidase (anti-MPO) antibodies are capable of activating human neutrophils primed by TNF-alpha in vitro. We described previously the involvement of FcgammaRIIa and beta(2) integrins in this neutrophil activation. In the literature, the requirement of TNF priming has been att...

journal_title：Journal of leukocyte biology

authors： Reumaux D,Hordijk PL,Duthilleul P,Roos D

更新日期：2006-12-01 00:00:00

abstract：:Patients with head and neck squamous cell carcinoma (HNSCC) have increased levels of immune-suppressive peripheral blood CD34+ cells. This study showed that the peripheral blood CD34+ cells of HNSCC patients are capable of differentiating into dendritic cells. Because CD34+ cells can differentiate through several path...

journal_title：Journal of leukocyte biology

authors： Lathers DM,Lubbers E,Wright MA,Young MR

更新日期：1999-05-01 00:00:00

abstract：:Neutrophils can attach to E-selectin under flow. Proposed ligands for E-selectin carry SLe(x)-type glycans. The leukocyte beta2 integrins are glycosylated with SLe(x). Thus, we speculated that beta2 integrins could support attachment to E-selectin. To test this hypothesis, we coated 10-microm-diameter microspheres wit...

journal_title：Journal of leukocyte biology

authors： Crutchfield KL,Shinde Patil VR,Campbell CJ,Parkos CA,Allport JR,Goetz DJ

更新日期：2000-02-01 00:00:00

abstract：:Quartz was injected into a hind food of BALB/c and DBA/2 mice and on days 40, 90, and 180 the progressive response ensuing in the draining popliteal lymph node (PLN) was investigated by histopathology and immunohistopathology. The area of silicotic nodules (ASN) was measured by morphometry, and, by this parameter, str...

journal_title：Journal of leukocyte biology

authors： Weirich U,Friemann J,Rehn B,Henkelüdecke U,Lammers T,Sorg C,Bruch J,Gleichmann E

更新日期：1996-02-01 00:00:00

abstract：:Viral recognition programs DCs to express Signal 3 molecules that promote the differentiation of effector CD8(+) T cells. Besides IL-12, another DC-derived IL-12 family member, IL-27, has been reported to contribute herein, but its specific role is not well understood. Here, we show that whereas IL-12 potently induces...

journal_title：Journal of leukocyte biology

authors： de Groot R,van Beelen AJ,Bakdash G,Taanman-Kueter EW,de Jong EC,Kapsenberg ML

更新日期：2012-09-01 00:00:00

abstract：:The recognition of pathogen-associated molecular patterns by TLRs triggers the activation of innate and adaptive immune responses. Flagellin, the agonist of TLR5, is expressed by prokaryotes and eukaryotes, and DNA sequences containing unmethylated CpG dinucleotides, agonists of TLR9, are present essentially in prokar...

journal_title：Journal of leukocyte biology

authors： Merlo A,Calcaterra C,Mènard S,Balsari A

更新日期：2007-09-01 00:00:00

abstract：:The effect of selected monosaccharides on the random migration of normal adult rabbit alveolar macrophages (AM) was investigated. It was observed that 10 mM of L-fucose, L-galactose, or D-mannose stimulated AM migration 1.5-2.0 times. In addition, derivatives of L-fucose and D-mannose occupying the carbon-6 position s...

journal_title：Journal of leukocyte biology

authors： Takata I,Chida K,Gordon MR,Myrvik QN,Ricardo MJ Jr,Kucera LS

更新日期：1987-03-01 00:00:00

abstract：:The synthesis and secretion of prostaglandins and leukotrienes by mouse peritoneal macrophages is under several regulatory controls. Arachidonic acid must first be released from phospholipid stores by the action of phospholipases. Macrophages have the capacity to deacylate arachidonic acid directly from the SN2 positi...

journal_title：Journal of leukocyte biology

authors： Bonney RJ,Humes JL

更新日期：1984-01-01 00:00:00

abstract：:Recently, several studies, including those with respiratory syncytial virus, mouse pneumovirus, and simian virus 5, have reported that virus-specific CD8+ effector cells entering the lung as a result of respiratory infection undergo significant loss of function. The impaired function in these cells has been proposed t...

journal_title：Journal of leukocyte biology

authors： Arimilli S,Palmer EM,Alexander-Miller MA

更新日期：2008-03-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA), a member of the immunoglobulin supergene family, is recognized by a specific 80-kd receptor on Kupffer cells and alveolar macrophages. Peritoneal macrophages were harvested from male Sprague-Dawley rats 72 h after intraperitoneal injection with thioglycolate broth and from unstimulated ...

journal_title：Journal of leukocyte biology

authors： Toth CA

更新日期：1992-05-01 00:00:00

abstract：:IRG are a family of IFN-regulated proteins that are critical for resistance to infection. Mouse IRG proteins are divided into GMS and GKS subfamilies, based on a sequence within the G1 GTP-binding motif. The GMS proteins have a particularly profound impact on immunity, as typified by Irgm1, of which absence leads to a...

journal_title：Journal of leukocyte biology

authors： Henry SC,Traver M,Daniell X,Indaram M,Oliver T,Taylor GA

更新日期：2010-02-01 00:00:00

abstract：:Tyrosine phosphorylation is an important component of the signaling pathways responsible for the activation of the macrophage respiratory burst. Because the virulence plasmid of Yersinia enterocolitica encodes a phosphotyrosine phosphatase, YopH, it is possible that the pathogenic strategy of Y. enterocolitica involve...

journal_title：Journal of leukocyte biology

authors： Green SP,Hartland EL,Robins-Browne RM,Phillips WA

更新日期：1995-06-01 00:00:00

abstract：:GCs are widely prescribed to treat inflammatory disorders and autoimmune and allergic diseases. Their anti-inflammatory and immunosuppressive effects may be related, in part, to their ability to control the maturation and functions of DCs. Here, we report that GCs inhibit the maturation of human CD34-DCs induced by th...

journal_title：Journal of leukocyte biology

authors： Larangé A,Antonios D,Pallardy M,Kerdine-Römer S

更新日期：2012-01-01 00:00:00

abstract：:Mice with a naturally occurring Csfm(op)/Csfm(op) (op/op) gene mutation lack functional macrophage-colony stimulating factor (M-CSF) and are deficient of M-CSF-derived macrophages. They are severely monocytopenic, and their remaining M-CSF-independent macrophages were shown to differ in differentiation and distinct fu...

journal_title：Journal of leukocyte biology

authors： Schönlau F,Schlesiger C,Ehrchen J,Grabbe S,Sorg C,Sunderkötter C,Ehrehen J

更新日期：2003-05-01 00:00:00

abstract：:Adherence of monocytes to extracellular matrix components is critical for their accumulation at sites of infection. To gain insight into the factors that regulate monocyte recruitment, we have studied monocyte adherence with regard to the regulatory effects of bacterial lipopolysaccharide (LPS) and the mechanisms invo...

journal_title：Journal of leukocyte biology

authors： Owen CA,Campbell EJ,Stockley RA

更新日期：1992-04-01 00:00:00

abstract：:The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is a powerful suppressor of inflammation mediated by macrophages, which express at least two receptors, melanocortin 1 and 3 receptors (MC1r and MC3r) that bind alpha-MSH. Albeit, the anti-inflammatory activity of alpha-MSH has been well documented in m...

journal_title：Journal of leukocyte biology

authors： Li D,Taylor AW

更新日期：2008-07-01 00:00:00

abstract：:Type I IFNs play an important role in innate and adaptive immunity against viral infections. A novel type I IFN, namely IFN-ε, which can protect against vaginal transmission of HSV2 and Chlamydia muridarum bacterial infection, has been described in mice and humans. Nevertheless, the principle cell type and the express...

journal_title：Journal of leukocyte biology

authors： Demers A,Kang G,Ma F,Lu W,Yuan Z,Li Y,Lewis M,Kraiselburd EN,Montaner L,Li Q

更新日期：2014-12-01 00:00:00

abstract：:Several members of the cytokine network play an important role in controlling the replication of the human immunodeficiency virus (HIV) in several experimental systems. Their effects can be categorized in the following three functional groups: (1) HIV-inductive cytokines; (2) HIV-suppressive cytokines; (3) cytokines w...

journal_title：Journal of leukocyte biology

authors： Vicenzi E,Biswas P,Mengozzi M,Poli G

更新日期：1997-07-01 00:00:00

abstract：:CD137 ligand (CD137L) is expressed on APCs and crosslinks CD137, a powerful costimulatory molecule on T cells during cognate interactions, and thereby greatly enhances immune responses. We report that CD137 can be transferred from activated T cells and from tumor cells that express CD137 to other cells via trogocytosi...

journal_title：Journal of leukocyte biology

authors： Shao Z,Harfuddin Z,Pang WL,Nickles E,Koh LK,Schwarz H

更新日期：2015-05-01 00:00:00

abstract：:This study investigated the expression of MUC5B by AMs in the lungs of cigarette smokers and nonsmokers. We analyzed MUC5B expression by measuring the levels of apomucin and mRNA in human BALF cells from 50 subjects (20 nonsmokers, 17 patients with CB, and 13 patients with COPD). apoMUC5B was observed in BALF mononucl...

journal_title：Journal of leukocyte biology

authors： Sepper R,Prikk K,Metsis M,Sergejeva S,Pugatsjova N,Bragina O,Marran S,Fehniger TE

更新日期：2012-08-01 00:00:00

abstract：:HIV-infected monocytes form highly invasive network on basement membrane matrix and secrete high levels of 92-kd metalloproteinase (MMP-9), an enzyme that degrades basement membrane proteins. In the present study, using matrigel as a model basement membrane system, we demonstrate that treatment of human immunodeficien...

journal_title：Journal of leukocyte biology

authors： Dhawan S,Wahl LM,Heredia A,Zhang Y,Epstein JS,Meltzer MS,Hewlett IK

更新日期：1995-12-01 00:00:00