Abstract:
:Ewing family tumors (EFTs) and prostate carcinomas are characterized by rearrangement of ETS genes, most commonly FLI1 (EFTs) and ERG (prostate carcinomas). Previously, we characterized an antibody against ERG (EPR3864) for detecting ERG-rearranged prostate carcinoma. Because EPR3864 also cross-reacts with FLI1, we evaluated the usefulness of EPR3864 for discriminating EFTs from other small round blue cell tumors (SRBCTs) with immunohistochemistry. Of 57 evaluable EFTs, 47 (82%) demonstrated at least moderate, diffuse, nuclear ERG/FLI1 staining (including 89% and 100% of cases with confirmed EWSR1:FLI1 and EWSR1:ERG fusions, respectively), of which 1, 3, and 43 showed negative, cytoplasmic, or membranous CD99 staining, respectively. Among other SRBCTs (61 cases, 7 types), at least moderate, diffuse, nuclear EPR3864 staining was seen in all precursor B-lymphoblastic lymphomas/leukemias and subsets of Burkitt lymphomas (10%) and synovial sarcomas (45%). In summary, EPR3864 may be useful in detecting EWSR1:FLI1 and EWSR1:ERG rearranged EFTs in addition to prostate carcinomas.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Tomlins SA,Palanisamy N,Brenner JC,Stall JN,Siddiqui J,Thomas DG,Lucas DR,Chinnaiyan AM,Kunju LPdoi
10.1309/AJCPN4L1BMRQPEITsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
771-9issue
6eissn
0002-9173issn
1943-7722pii
139/6/771journal_volume
139pub_type
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journal_title:American journal of clinical pathology
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更新日期:2019-09-09 00:00:00
abstract::Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group with an intermediate prognosis. Previous studies have suggested that the Fms-like tyrosine kinase-3 internal tandem duplication (FLT...
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abstract::The expression of human E-cadherin in normal tissues and in benign and malignant tumors of female genital organs was examined immunohistochemically with a monoclonal antibody, HECD-1, specific for human E-cadherin. The normal tissues included the ovary, fallopian tube, uterine endometrium, uterine cervix, and vagina. ...
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journal_title:American journal of clinical pathology
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更新日期:2000-07-01 00:00:00
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journal_title:American journal of clinical pathology
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doi:
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abstract::Urine cultures represent 40-50% of specimens processed by hospital clinical microbiology laboratories. An accurate rapid screening method to detect positive urine cultures could greatly improve laboratory efficiency. Three hundred eighty-two unselected urines were screened by nephelometry at 2, 4, and 5 hours of shaki...
journal_title:American journal of clinical pathology
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更新日期:1993-10-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1999-06-01 00:00:00
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更新日期:2007-09-01 00:00:00
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更新日期:2008-10-01 00:00:00
abstract::Three stillborn fetuses are reported in which an abdominal wall defect was associated with defects in the urogenital and anal region. Autopsy of these fetuses provided clues indicative of how and where the embryonic development went wrong. The malformation involved a disturbance of the cell deposition process, occurri...
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更新日期:1991-11-01 00:00:00
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更新日期:1997-11-01 00:00:00
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更新日期:1997-11-01 00:00:00
abstract::FNAB is the most important advance in the management of thyroid nodules in the past two decades. Dr Mazzaferri has said that finding a thyroid cancer in a thyroid nodule is like finding a needle in a haystack. Fine-needle aspiration biopsy is like applying a strong electromagnet to find that needle. It should be avail...
journal_title:American journal of clinical pathology
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更新日期:1997-10-01 00:00:00
abstract::This study examines the relationship between age and mitogen-induced lymphocyte blastogenesis. Lymphocytes were stimulated with PHA; Concanavalin A (Con A), and PWM in 156 normal, healthy subjects ranging in age from birth to 75 years. The findings indicate a gradual but significant decrease in PHA- and Con A-induced ...
journal_title:American journal of clinical pathology
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abstract::The clinical, light microscopic, and immunohistochemical features of 14 sinonasal malignant melanomas were studied to show their diverse morphologic appearance and distinction from therapeutically more amenable neoplasms that occur in this region. The tumors arose in 6 men and 8 women (median age, 70 years). Eleven pa...
journal_title:American journal of clinical pathology
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更新日期:1991-12-01 00:00:00
abstract:OBJECTIVES:Endocervical curettage (ECC) specimens may be limited by scant tissue. We evaluated whether a cellular concentration processing method could improve their diagnostic quality. METHODS:Between October 2018 and June 2019, ECC specimens were assigned chronologically to one of two groups: nonconcentrated ECC (NE...
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:1976-02-01 00:00:00