A 44-month clinical-brain MRI follow-up in a patient with B12 deficiency.

abstract：OBJECTIVE:We aimed to perform an observational study of age at loss of independent ambulation (LoA) and side-effect profiles associated with different glucocorticoid corticosteroid (GC) regimens in Duchenne muscular dystrophy (DMD). METHODS:We studied 340 participants in the Cooperative International Neuromuscular Res...

journal_title：Neurology

authors： Bello L,Gordish-Dressman H,Morgenroth LP,Henricson EK,Duong T,Hoffman EP,Cnaan A,McDonald CM,CINRG Investigators.

更新日期：2015-09-22 00:00:00

abstract：OBJECTIVE:To assess the clinical, urodynamic, and neurophysiologic features of patients with persisting bladder, bowel, and sexual dysfunction after transverse myelitis in myelin oligodendrocyte glycoprotein antibody (MOG-Ab) disease. METHODS:Patients with a history of MOG-Ab disease-related transverse myelitis seen p...

journal_title：Neurology

authors： Li V,Malladi P,Simeoni S,Pakzad M,Everett R,Satukijchai C,Leite MI,Palace J,Panicker JN

更新日期：2020-11-24 00:00:00

abstract：:Fourteen patients with Alzheimer's disease were evaluated by psychometric testing, fluorodeoxyglucose positron emission tomography (PET), and EEG. They were divided into two groups according to the EEG findings. Group A (seven patients) had normal alpha backgrounds and group B (seven patients) had decreased alpha back...

journal_title：Neurology

authors： Sheridan PH,Sato S,Foster N,Bruno G,Cox C,Fedio P,Chase TN

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term outcome of patients with spinal cord infarct (SCI) and identify prognostic predictors. METHODS:We reviewed 115 patients with SCI treated between 1990 and 2007. Severity of impairment was defined using the American Spinal Injury Association (ASIA) scoring. Functional outcome endpo...

journal_title：Neurology

authors： Robertson CE,Brown RD Jr,Wijdicks EF,Rabinstein AA

更新日期：2012-01-10 00:00:00

abstract：:We report the cases of three siblings homozygous for a mutated transthyretin (TTR) gene that causes type I familial amyloidotic polyneuropathy (FAP), in whom we made the diagnosis by identifying both the mutated TTR gene and a variant TTR in their sera. Their serum levels for the variant TTR are twice those of patient...

journal_title：Neurology

authors： Yoshinaga T,Nakazato M,Ikeda S,Ohnishi A

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:To analyze the relationship between retinal thinning and nigral dopaminergic loss in de novo Parkinson disease (PD). METHODS:Forty-nine patients with PD and 54 age-matched controls were analyzed. Ophthalmologic examination and macula optical coherence tomography scans were performed with additional microperi...

journal_title：Neurology

authors： Ahn J,Lee JY,Kim TW,Yoon EJ,Oh S,Kim YK,Kim JM,Woo SJ,Kim KW,Jeon B

更新日期：2018-09-11 00:00:00

abstract：:Dementia occurs infrequently in patients with giant cell (temporal) arteritis (GCA). Three elderly women with biopsy-proven GCA showed abrupt cognitive decline during periods of clinically active GCA, 1 to 6 months after diagnostic temporal artery biopsy, during periods of corticosteroid taper. One patient had additio...

journal_title：Neurology

authors： Caselli RJ

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether neuronal activity-regulated pentraxin (Narp) colocalizes with hypocretin (Hcrt or orexin) in the normal human brain and to determine if Narp staining is lost in the narcoleptic human brain. BACKGROUND:Human narcolepsy is characterized by a loss of the peptide hypocretin in the hypothal...

journal_title：Neurology

authors： Blouin AM,Thannickal TC,Worley PF,Baraban JM,Reti IM,Siegel JM

更新日期：2005-10-25 00:00:00

abstract：:The objective of our study was to assess the 5-year risk of and prognostic factors for the development of clinically definite multiple sclerosis (CDMS) following optic neuritis. In a prospective cohort study design, 388 patients, who did not have probable or definite MS at study entry enrolled in the Optic Neuritis Tr...

journal_title：Neurology

authors： Optic Neuritis Study Group.

更新日期：1997-11-01 00:00:00

abstract：:Co-morbid conditions frequently occur in childhood epilepsy and may significantly affect epilepsy and its treatment. Similarly, epilepsy and antiepileptic drugs (AEDs) may affect these associated conditions. Co-morbidities that have a significant association with childhood epilepsy include attention-deficit/hyperactiv...

journal_title：Neurology

authors： Pellock JM

更新日期：2004-03-09 00:00:00

abstract：OBJECTIVE:To determine (1) if mortality among patients with idiopathic intracranial hypertension (IIH) enrolled in the Intracranial Hypertension Registry (IHR) is different from that of the general population of the United States and (2) what the leading underlying causes of death are among this cohort. METHODS:Mortal...

journal_title：Neurology

authors： Hermes SM,Miller NR,Waslo CS,Benes SC,Tanne E

更新日期：2020-08-18 00:00:00

abstract：OBJECTIVE:To determine the associations between amyloid-PET, tau-PET, and atrophy with the behavioral/dysexecutive presentation of Alzheimer disease (AD), how these differ from amnestic AD, and how they correlate to clinical symptoms. METHODS:We assessed 15 patients with behavioral/dysexecutive AD recruited from a ter...

journal_title：Neurology

authors： Therriault J,Pascoal TA,Savard M,Benedet AL,Chamoun M,Tissot C,Lussier F,Kang MS,Thomas E,Terada T,Rej S,Massarweh G,Nasreddine Z,Vitali P,Soucy JP,Saha-Chaudhuri P,Gauthier S,Rosa-Neto P

更新日期：2021-01-05 00:00:00

abstract：OBJECTIVE:To report our experience delivering intrathecal nusinersen through cervical puncture in patients with spinal muscular atrophy (SMA) with no lumbar access. BACKGROUND:SMA is a neuromuscular disorder characterized by profound muscle weakness, atrophy, and paralysis due to degeneration of the anterior horn cell...

journal_title：Neurology

authors： Veerapandiyan A,Pal R,D'Ambrosio S,Young I,Eichinger K,Collins E,Westesson PL,Kwon J,Ciafaloni E

更新日期：2018-08-14 00:00:00

abstract：OBJECTIVE:To evaluate the risk of relapses during pregnancy and in the first 3 months after delivery in 2 successive pregnancies in a cohort of French and Italian women with multiple sclerosis (MS). METHODS:A total of 93 women were included if they had had 2 pregnancies followed prospectively after MS onset between Ja...

journal_title：Neurology

authors： Benoit A,Durand-Dubief F,Amato MP,Portaccio E,Casey R,Roggerone S,Androdias G,Gignoux L,Ionescu I,Marrosu MG,Cocco E,Ghezzi A,Annovazzi P,Trojano M,Simone M,Marignier R,Confavreux C,Vukusic S

更新日期：2016-09-27 00:00:00

abstract：OBJECTIVES:We used functional MRI (fMRI), transcranial Doppler ultrasound, and visual evoked potentials (VEPs) to determine the nature of blood flow responses to functional brain activity and carbon dioxide (CO2) inhalation in patients with cerebral amyloid angiopathy (CAA), and their association with markers of CAA se...

journal_title：Neurology

authors： Peca S,McCreary CR,Donaldson E,Kumarpillai G,Shobha N,Sanchez K,Charlton A,Steinback CD,Beaudin AE,Flück D,Pillay N,Fick GH,Poulin MJ,Frayne R,Goodyear BG,Smith EE

更新日期：2013-11-05 00:00:00

abstract：:Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Abeta) crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD disease is currently being intensely discussed. In this case-control study on elderly nondemented subjects, the authors provide the first ...

journal_title：Neurology

authors： Fassbender K,Stroick M,Bertsch T,Ragoschke A,Kuehl S,Walter S,Walter J,Brechtel K,Muehlhauser F,Von Bergmann K,Lütjohann D

更新日期：2002-10-22 00:00:00

abstract：OBJECTIVE:To determine quantitative size thresholds for enlargement of the optic nerve, chiasm, and tract in children with neurofibromatosis type 1 (NF1). METHODS:Children 0.5-18.6 years of age who underwent high-resolution T1-weighted MRI were eligible for inclusion. This consisted of children with NF1 with or withou...

journal_title：Neurology

authors： Avery RA,Mansoor A,Idrees R,Biggs E,Alsharid MA,Packer RJ,Linguraru MG

更新日期：2016-06-14 00:00:00

abstract：OBJECTIVE:The authors investigated chronic cerebellar reorganization following unilateral cortical lesions in children and adults using PET to measure benzodiazepine receptor (BZR) binding with [11C]flumazenil (FMZ) and glucose metabolism with 2-deoxy-2[18F]fluoro-D-glucose (FDG). BACKGROUND:Crossed cerebellar diaschi...

journal_title：Neurology

authors： Niimura K,Chugani DC,Muzik O,Chugani HT

更新日期：1999-03-10 00:00:00

abstract：:We performed 15 dynamic gadolinium-DTPA (Gd-DTPA)-enhanced MRI studies in 8 patients with relapsing and remitting multiple sclerosis; 7 were follow-up studies. We measured the time course of enhancement in 102 enhancing lesions for up to 384 minutes, with rest breaks. Immediate postcontrast MRIs demonstrated many diff...

journal_title：Neurology

authors： Kermode AG,Tofts PS,Thompson AJ,MacManus DG,Rudge P,Kendall BE,Kingsley DP,Moseley IF,du Boulay EP,McDonald WI

更新日期：1990-02-01 00:00:00

abstract：:We used [18F]-2-fluoro-2-deoxy-D-glucose (FDG) and PET to study regional cerebral glucose utilization in seven patients with fatal familial insomnia (FFI), an inherited prion disease with a mutation at codon 178 of the prion protein gene. Four patients were methionine/methionine homozygotes at codon 129 (symptom durat...

journal_title：Neurology

authors： Cortelli P,Perani D,Parchi P,Grassi F,Montagna P,De Martin M,Castellani R,Tinuper P,Gambetti P,Lugaresi E,Fazio F

更新日期：1997-07-01 00:00:00

abstract：:The progressive myoclonus epilepsies (PMEs) are a devastating group of rare disorders(1) that manifest with increasing action myoclonus, which is also present at rest but activates with stimuli such as noise, light, or touch. Ultimately, patients become wheelchair-bound and experience early death. Neurologic signs tha...

journal_title：Neurology

authors： Knupp K,Wirrell E

更新日期：2014-02-04 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the relation of retinal microvascular signs and incident stroke and stroke mortality in an older population. METHODS:The authors took retinal photographs on baseline participants (3,654 patients aged 49+ years) of the Blue Mountains Eye Study (1992 to 1994). They asses...

journal_title：Neurology

authors： Mitchell P,Wang JJ,Wong TY,Smith W,Klein R,Leeder SR

更新日期：2005-10-11 00:00:00

abstract：OBJECTIVE:To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS:Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa ...

journal_title：Neurology

authors： Kaufmann H,Freeman R,Biaggioni I,Low P,Pedder S,Hewitt LA,Mauney J,Feirtag M,Mathias CJ,NOH301 Investigators.

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:Bapineuzumab, a humanized anti-amyloid-beta (Abeta) monoclonal antibody for the potential treatment of Alzheimer disease (AD), was evaluated in a multiple ascending dose, safety, and efficacy study in mild to moderate AD. METHODS:The study enrolled 234 patients, randomly assigned to IV bapineuzumab or place...

journal_title：Neurology

authors： Salloway S,Sperling R,Gilman S,Fox NC,Blennow K,Raskind M,Sabbagh M,Honig LS,Doody R,van Dyck CH,Mulnard R,Barakos J,Gregg KM,Liu E,Lieberburg I,Schenk D,Black R,Grundman M,Bapineuzumab 201 Clinical Trial Investigator

更新日期：2009-12-15 00:00:00

abstract：:We administered the Mini-Mental State Exam (MMSE) to 194 healthy men and women, ages 40 to 89 years. Total score was significantly associated with age (p less than 0.0001), but not vocabulary, education, Beck's Depression Inventory Score, or sex. The lowest quartile cutoff scores for the MMSE by decade were 40s - 29; ...

journal_title：Neurology

authors： Bleecker ML,Bolla-Wilson K,Kawas C,Agnew J

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVE:Physician prediction of outcome in critically ill neurologic patients impacts treatment decisions and goals of care. In this observational study, we prospectively compared predictions by neurointensivists to patient outcomes at 6 months. METHODS:Consecutive neurologic patients requiring mechanical ventilatio...

journal_title：Neurology

authors： Finley Caulfield A,Gabler L,Lansberg MG,Eyngorn I,Mlynash M,Buckwalter MS,Venkatasubramanian C,Wijman CA

更新日期：2010-04-06 00:00:00

abstract：:We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor o...

journal_title：Neurology

authors： Foster NL,Chase TN,Denaro A,Hare TA,Tamminga CA

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:The American Academy of Neurology (AAN) ALS Practice Parameter was published in April 1999. The ALS CARE Database has been collecting data on the management of patients with ALS in North America since 1996. OBJECTIVE:To compare the management of patients with ALS in North America as recorded in the ALS CARE...

journal_title：Neurology

authors： Bradley WG,Anderson F,Bromberg M,Gutmann L,Harati Y,Ross M,Miller RG,ALS CARE Study Group.

更新日期：2001-08-14 00:00:00

abstract：:Despite strong evidence of the importance of hereditary factors in the etiology of Tourette's syndrome (TS), research findings have consistently pointed to a role of environmental influences. A recent line of research has suggested that tic disorders and associated behavioral disturbances, such as obsessive-compulsive...

journal_title：Neurology

authors： Kurlan R

更新日期：1998-06-01 00:00:00

abstract：:Using a radioreceptor technique, we assayed serum trihexyphenidyl levels in patients with dystonia being treated chronically with high dosage. We found a significant correlation between total daily dose and the daily lowest (trough) serum levels. There was no relationship between serum levels and therapeutic response ...

journal_title：Neurology

authors： Burke RE,Fahn S

更新日期：1985-07-01 00:00:00