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Hepatitis C virus and HIV antibodies in patients with hepatocellular carcinoma in Zimbabwe: a pilot study.

Abstract：

:To determine the role of hepatitis C virus (HCV) infection in the aetiology of hepatocellular carcinoma (HCC) in Zimbabwe, HCV antibodies (anti-HCV) were determined in sera from 63 HCC patients using a second generation enzyme immunoassay. Anti-HCV was found in 15 patients (23.8%), 12 of whom (80%) were males. The mean ages of anti-HCV positive and anti-HCV negative patients were 62.1 (SD = 10.6) and 44.3 (SD = 15.2) years, respectively (P < 0.001). HIV antibodies were found in 17/59 patients (28.8%), 12 of whom (70.6%) were males. The mean ages of HIV positive and HIV negative patients were 39.4 (SD = 15.2) and 51.0 (SD = 15.2) years (P = 0.011). Hepatitis B surface antigen (HBsAg) was detected in 26/61 patients (42.6%) with mean ages of HBsAg positive vs negative patients of 41.5 (SD = 15.4) years for HIV positive and 53.1 (SD = 15.1) years for HIV negative subjects (P = 0.005). Younger HCC patients had high prevalences of HBsAg and anti-HIV and a low prevalence of anti-HCV; while older patients had a high prevalence of anti-HCV and low prevalences of HBsAg and anti-HIV. This study suggested that HCV infection is probably an important aetiological agent of HCC in Zimbabwe; however, the role of HIV infection as a cause of HCC either singly or as a co-factor with hepatitis B virus infection remains speculative and warrants further study. :Several studies have reported a high prevalence of hepatitis C virus (HCV) antibodies (anti-HCV) in patients with hepatocellular carcinoma (HCC). In addition, HIV infection may be a causative factor for HCC. To determine the role of HCV infection in the etiology of HCC in Zimbabwe, the presence of anti-HCV was assessed in sera from 63 HCC patients using a second-generation enzyme immunoassay. Anti-HCV was isolated in 15 patients (23.8%), of whom 12 were male. The mean ages of anti-HCV-positive and anti-HCV-negative patients were 62.1 and 44.3 years, respectively. HIV antibodies were found in 17 (28.8%) of 59 patients, of whom 12 were male. The mean ages of HIV-positive and HIV-negative patients were 39.4 and 51.0 years, respectively. Hepatitis B surface antigen (HBsAg) was detected in 26 of 61 patients (42.6%), with the mean ages of HBsAg-positive versus HBsAg-negative patients of 41.5 years for HIV-positive and 53.1 years for HIV-negative subjects. Younger HCC patients had high prevalences of HBsAg and anti-HIV, and a low prevalence of anti-HCV, while older patients had a high prevalence of anti-HCV and low prevalences of HBsAg and anti-HIV. These findings suggest that HCV infection is probably an important etiological agent of HCC in Zimbabwe.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Weinig M,Hakim JG,Gudza I,Tobaiwa O

doi

10.1016/s0035-9203(97)90029-8

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

570-2

issue

eissn

0035-9203

issn

1878-3503

journal_volume

pub_type

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Hepatitis C virus and HIV antibodies in patients with hepatocellular carcinoma in Zimbabwe: a pilot study.