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A network model of the molecular organization of chromatin in Drosophila.

Abstract：

:Chromatin governs gene regulation and genome maintenance, yet a substantial fraction of the chromatin proteome is still unexplored. Moreover, a global model of the chromatin protein network is lacking. By screening >100 candidates we identify 42 Drosophila proteins that were not previously associated with chromatin, which all display specific genomic binding patterns. Bayesian network modeling of the binding profiles of these and 70 known chromatin components yields a detailed blueprint of the in vivo chromatin protein network. We demonstrate functional compartmentalization of this network, and predict functions for most of the previously unknown chromatin proteins, including roles in DNA replication and repair, and gene activation and repression.

journal_name

Mol Cell

journal_title

Molecular cell

authors

van Bemmel JG,Filion GJ,Rosado A,Talhout W,de Haas M,van Welsem T,van Leeuwen F,van Steensel B

doi

10.1016/j.molcel.2013.01.040

subject

Has Abstract

pub_date

2013-02-21 00:00:00

pages

759-71

issue

4

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(13)00133-0

journal_volume

49

pub_type

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