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GTP: gatekeeper for autophagy.

Abstract：

:Chaperone-mediated autophagy (CMA) is involved in cellular quality control, and in the response to stress, deterioration in CMA contributes to the aging phenotype and to various disorders. The paper by Bandyopadhyay et al. in this issue of Molecular Cell demonstrates the role of GTP binding by elongation factor 1 alpha (EF1alpha) in regulating the lysosomal uptake of CMA substrates.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Beau I,Codogno P

doi

10.1016/j.molcel.2010.08.005

subject

Has Abstract

pub_date

2010-08-27 00:00:00

pages

485-6

issue

4

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(10)00615-5

journal_volume

39

pub_type

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