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Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains.

Abstract：

:The CCCH finger protein PIE-1 is a regulator of germ cell fate that segregates with the germ lineage in early embryos. At each asymmetric division, PIE-1 is inherited preferentially by the germline daughter and is excluded from the somatic daughter. We show that this asymmetry is regulated at the protein level by two complementary mechanisms. The first acts before cell division to enrich PIE-1 in the cytoplasm destined for the germline daughter. The second acts after cell division to eliminate any PIE-1 left in the somatic daughter. The latter mechanism depends on PIE-1's first CCCH finger (ZF1), which targets PIE-1 for degradation in somatic blastomeres. ZF1s in two other germline proteins, POS-1 and MEX-1, are also degraded in somatic blastomeres, suggesting that localized degradation also acts on these proteins to exclude them from somatic lineages.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Reese KJ,Dunn MA,Waddle JA,Seydoux G

doi

10.1016/s1097-2765(00)00043-5

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

445-55

issue

2

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(00)00043-5

journal_volume

6

pub_type

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