当前位置： SCI文献检索 > MOLECULAR CELL期刊下所有文献 > Indecent exposure: when telomeres become uncapped.

Indecent exposure: when telomeres become uncapped.

Abstract：

:The protective "cap" that assembles at chromosome ends recruits and controls an intricate network of biochemical activities, each one critical for telomere structure and the maintenance of genomic stability. Recent studies have uncovered the components of telomere caps and have started to define the pathways that lead from telomere dysfunction to chromosomal catastrophe.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Ferreira MG,Miller KM,Cooper JP

doi

10.1016/s1097-2765(03)00531-8

subject

Has Abstract

pub_date

2004-01-16 00:00:00

pages

7-18

issue

1

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(03)00531-8

journal_volume

13

pub_type

杂志文章,评审

相关文献

MOLECULAR CELL文献大全
  • Myotonic dystrophy: the role of the CUG triplet repeats in splicing of a novel DMPK exon and altered cytoplasmic DMPK mRNA isoform ratios.

    abstract：:The mechanism by which (CTG)n expansion in the 3' UTR of the DMPK gene causes myotonic dystrophy (DM) is unknown. We identified four RNA splicing factors--hnRNP C, U2AF (U2 auxiliary factor), PTB (polypyrimidine tract binding protein), and PSF (PTB associated splicing factor)--that bind to two short regions 3' of the ...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/s1097-2765(00)80261-0

    authors： Tiscornia G,Mahadevan MS

    更新日期：2000-06-01 00:00:00

  • A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.

    abstract：:In solid tissues of vertebrates, initiation of mitochondrial DNA replication encompasses a broad zone downstream of the major noncoding region (NCR). In contrast, analysis with two-dimensional agarose gel electrophoresis of mitochondrial DNA replication intermediates in cultured human cells revealed initiation concent...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2005.05.002

    authors： Yasukawa T,Yang MY,Jacobs HT,Holt IJ

    更新日期：2005-06-10 00:00:00

  • Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.

    abstract：:Melanoma and other cancers harbor oncogenic mutations in the protein kinase B-Raf, which leads to constitutive activation and dysregulation of MAP kinase signaling. In order to elucidate molecular determinants responsible for B-Raf control of cancer phenotypes, we present a method for phosphoprotein profiling, using n...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2009.03.007

    authors： Old WM,Shabb JB,Houel S,Wang H,Couts KL,Yen CY,Litman ES,Croy CH,Meyer-Arendt K,Miranda JG,Brown RA,Witze ES,Schweppe RE,Resing KA,Ahn NG

    更新日期：2009-04-10 00:00:00

  • Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells.

    abstract：:Polycomb group (PcG) proteins exert essential functions in the most disparate biological processes. The contribution of PcG proteins to cell commitment and differentiation relates to their ability to repress transcription of developmental regulators in embryonic stem (ES) cells and in committed cell lineages, includin...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2009.08.008

    authors： Juan AH,Kumar RM,Marx JG,Young RA,Sartorelli V

    更新日期：2009-10-09 00:00:00

  • Controlling cytokinesis through promiscuous phosphorylation outside BARs.

    abstract：:In this issue of Molecular Cell, Roberts-Galbraith and colleagues report that a key cytokinetic regulator in fission yeast, Cdc15, is phosphorylated on numerous sites that collectively, but not individually, control its oligomerization state and its associations with the plasma membrane and interacting proteins. ...

    journal_title：Molecular cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.molcel.2010.06.028

    authors： Glotzer M

    更新日期：2010-07-09 00:00:00

  • Features of ribosome-peptidyl-tRNA interactions essential for tryptophan induction of tna operon expression.

    abstract：:Certain nascent peptide sequences, when within the ribosomal exit tunnel, can inhibit translation termination and/or peptide elongation. The 24 residue leader peptidyl-tRNA of the tna operon of E. coli, TnaC-tRNA(Pro), in the presence of excess tryptophan, resists cleavage at the tnaC stop codon. TnaC residue Trp12 is...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2005.06.013

    authors： Cruz-Vera LR,Rajagopal S,Squires C,Yanofsky C

    更新日期：2005-08-05 00:00:00

  • Linking activators and basals in transcription: it is all in one family.

    abstract：:Analysis of nuclear hormone receptor function in cells derived from xeroderma pigmentosum patients reveals novel links between DNA repair and transcription and points to novel mechanisms of regulating transcriptional regulators. ...

    journal_title：Molecular cell

    pub_type： 杂志文章,评审

    doi：10.1016/s1097-2765(02)00511-7

    authors： Timmers HT

    更新日期：2002-04-01 00:00:00

  • Activation of the bacterial sensor kinase PhoQ by acidic pH.

    abstract：:The Salmonellae PhoQ sensor kinase senses the mammalian phagosome environment to activate a transcriptional program essential for virulence. The PhoQ periplasmic domain binds divalent cations, forming bridges with inner membrane phospholipids to maintain PhoQ repression. PhoQ also binds and is activated by cationic an...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2007.03.008

    authors： Prost LR,Daley ME,Le Sage V,Bader MW,Le Moual H,Klevit RE,Miller SI

    更新日期：2007-04-27 00:00:00

  • SLC19A1 Is an Importer of the Immunotransmitter cGAMP.

    abstract：:2'3'-cyclic-GMP-AMP (cGAMP) is a second messenger that activates the antiviral stimulator of interferon genes (STING) pathway. We recently identified a novel role for cGAMP as a soluble, extracellular immunotransmitter that is produced and secreted by cancer cells. Secreted cGAMP is then sensed by host cells, elicitin...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2019.05.006

    authors： Ritchie C,Cordova AF,Hess GT,Bassik MC,Li L

    更新日期：2019-07-25 00:00:00

  • Psh1 is an E3 ubiquitin ligase that targets the centromeric histone variant Cse4.

    abstract：:Cse4 is a variant of histone H3 that is incorporated into a single nucleosome at each centromere in budding yeast. We have discovered an E3 ubiquitin ligase, called Psh1, which controls the cellular level of Cse4 via ubiquitylation and proteolysis. The activity of Psh1 is dependent on both its RING and zinc finger dom...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2010.10.014

    authors： Hewawasam G,Shivaraju M,Mattingly M,Venkatesh S,Martin-Brown S,Florens L,Workman JL,Gerton JL

    更新日期：2010-11-12 00:00:00

  • The Mcm2-7 complex has in vitro helicase activity.

    abstract：:Helicases unwind duplex DNA ahead of the polymerases at the replication fork. However, the identity of the eukaryotic replicative helicase has been controversial; in vivo studies implicate the ring-shaped heterohexameric Mcm2-7 complex, although only a specific subset of Mcm subunits (Mcm467) unwind DNA in vitro. To a...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2008.05.020

    authors： Bochman ML,Schwacha A

    更新日期：2008-07-25 00:00:00

  • The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules.

    abstract：:Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress granules are important in the stress response and may contribute to some degenerative diseases. Here, we describe the stress granule transcriptome of yeast and mammalian cells through RNA-sequencing (RNA-seq) analysis of purified stre...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2017.10.015

    authors： Khong A,Matheny T,Jain S,Mitchell SF,Wheeler JR,Parker R

    更新日期：2017-11-16 00:00:00

  • Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

    abstract：:The Rictor/mTOR complex (also known as mTORC2) plays a critical role in cellular homeostasis by phosphorylating AGC kinases such as Akt and SGK at their hydrophobic motifs to activate downstream signaling. However, the regulation of mTORC2 and whether it has additional function(s) remain largely unknown. Here, we repo...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2010.08.016

    authors： Gao D,Wan L,Inuzuka H,Berg AH,Tseng A,Zhai B,Shaik S,Bennett E,Tron AE,Gasser JA,Lau A,Gygi SP,Harper JW,DeCaprio JA,Toker A,Wei W

    更新日期：2010-09-10 00:00:00

  • Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.

    abstract：:The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase that polyubiquitinates specific substrates at precise times in the cell cycle, thereby triggering the events of late mitosis in a strict order. The robust substrate specificity of the APC/C prevents the potentially deleterious degradation of non...

    journal_title：Molecular cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.molcel.2016.09.006

    authors： Davey NE,Morgan DO

    更新日期：2016-10-06 00:00:00

  • Glucose-induced β-catenin acetylation enhances Wnt signaling in cancer.

    abstract：:Nuclear accumulation of β-catenin, a widely recognized marker of poor cancer prognosis, drives cancer cell proliferation and senescence bypass and regulates incretins, critical regulators of fat and glucose metabolism. Diabetes, characterized by elevated blood glucose levels, is associated with increased cancer risk, ...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2012.11.022

    authors： Chocarro-Calvo A,García-Martínez JM,Ardila-González S,De la Vieja A,García-Jiménez C

    更新日期：2013-02-07 00:00:00

  • ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks.

    abstract：:Double-strand breaks (DSBs) of DNA in eukaryotic cells are predominantly repaired by non-homologous end joining (NHEJ). The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which ...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2017.08.021

    authors： Lee KY,Im JS,Shibata E,Dutta A

    更新日期：2017-10-05 00:00:00

  • Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.

    abstract：:Cells undergo apoptosis upon exposure to severe DNA damage stress. Under this condition, p73 is phosphorylated and activated by c-Abl. The transcription coactivator Yap1 binds p73 to generate a complex that escapes p73 proteasomal degradation and recruits p300 to support transcription of proapoptotic genes. However, t...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2007.12.022

    authors： Levy D,Adamovich Y,Reuven N,Shaul Y

    更新日期：2008-02-15 00:00:00

  • Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis.

    abstract：:Programmed cell death is a gene-directed process involved in the development and homeostasis of multicellular organisms. The most common mode of programmed cell death is apoptosis, which is characterized by a stereotypical set of biochemical and morphological hallmarks. Here we report that Escherichia coli also exhibi...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2012.04.027

    authors： Dwyer DJ,Camacho DM,Kohanski MA,Callura JM,Collins JJ

    更新日期：2012-06-08 00:00:00

  • Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

    abstract：:Argonaute proteins associate with small RNAs that guide mRNA degradation, translational repression, or a combination of both. The human Argonaute family has eight members, four of which (Ago1 through Ago4) are closely related and coexpressed in many cell types. To understand the biological function of the different Ag...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2004.07.007

    authors： Meister G,Landthaler M,Patkaniowska A,Dorsett Y,Teng G,Tuschl T

    更新日期：2004-07-23 00:00:00

  • Transient DNA Occupancy of the SMC Interarm Space in Prokaryotic Condensin.

    abstract：:Multi-subunit SMC ATPases control chromosome superstructure and DNA topology, presumably by DNA translocation and loop extrusion. Chromosomal DNA is entrapped within the tripartite SMCkleisin ring. Juxtaposed SMC heads ("J heads") or engaged SMC heads ("E heads") split the SMCkleisin ring into "S" and "K" sub-compartm...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2019.05.001

    authors： Vazquez Nunez R,Ruiz Avila LB,Gruber S

    更新日期：2019-07-25 00:00:00

  • Molecular links between centrosome and midbody.

    abstract：:The terminal step in cytokinesis that severs a cell in two-abscission-is poorly understood. In Developmental Cell, Fabbro et al (2005) identify a centrosome protein whose multiple phosphorylations regulate its movement from centrosome to midbody and completion of abscission. ...

    journal_title：Molecular cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.molcel.2005.10.010

    authors： Doxsey SJ

    更新日期：2005-10-28 00:00:00

  • Mechanism of foreign DNA selection in a bacterial adaptive immune system.

    abstract：:In bacterial and archaeal CRISPR immune pathways, DNA sequences from invading bacteriophage or plasmids are integrated into CRISPR loci within the host genome, conferring immunity against subsequent infections. The ribonucleoprotein complex Cascade utilizes RNAs generated from these loci to target complementary "nonse...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2012.03.020

    authors： Sashital DG,Wiedenheft B,Doudna JA

    更新日期：2012-06-08 00:00:00

  • Applied force provides insight into transcriptional pausing and its modulation by transcription factor NusA.

    abstract：:Transcriptional pausing by RNA polymerase (RNAP) plays an essential role in gene regulation. Pausing is modified by various elongation factors, including prokaryotic NusA, but the mechanisms underlying pausing and NusA function remain unclear. Alternative models for pausing invoke blockade events that precede transloc...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2011.09.018

    authors： Zhou J,Ha KS,La Porta A,Landick R,Block SM

    更新日期：2011-11-18 00:00:00

  • Modular RNA heats up.

    abstract：:In this issue of Molecular Cell, Mariner et al. (2008) demonstrate that Alu RNA from a human SINE represses RNA polymerase II transcription during heat shock. This noncoding RNA is the first example of a "protein-like" transcription factor with a distinct modular architecture. ...

    journal_title：Molecular cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.molcel.2008.02.001

    authors： Shamovsky I,Nudler E

    更新日期：2008-02-29 00:00:00

  • Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1.

    abstract：:R loop, a transcription intermediate containing RNA:DNA hybrids and displaced single-stranded DNA (ssDNA), has emerged as a major source of genomic instability. RNaseH1, which cleaves the RNA in RNA:DNA hybrids, plays an important role in R loop suppression. Here we show that replication protein A (RPA), an ssDNA-bind...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2017.01.029

    authors： Nguyen HD,Yadav T,Giri S,Saez B,Graubert TA,Zou L

    更新日期：2017-03-02 00:00:00

  • Hit and run: transient deubiquitylase activity in a chromatin-remodeling complex.

    abstract：:In this issue of Molecular Cell, Conaway and colleagues (Yao et al., 2008) provide a glimpse into an interesting mechanism to control a deubiquitylating enzyme via interaction of two complexes-the 19S proteasome regulatory particle and an ATP-dependent nucleosome remodeling complex. ...

    journal_title：Molecular cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.molcel.2008.09.005

    authors： Zediak VP,Berger SL

    更新日期：2008-09-26 00:00:00

  • Too much of a good thing: the Prl-3 in p53's oyster.

    abstract：:In this issue of Molecular Cell, Basak et al. (2008) identify Prl-3 as a p53-inducible gene acting in DNA damage-induced cell-cycle arrest. Both deletion and overexpression of Prl-3 can be cytostatic, adding to a growing list of genes whose expression must be carefully titrated for proper cell proliferation. ...

    journal_title：Molecular cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.molcel.2008.04.006

    authors： Hinds PW

    更新日期：2008-05-09 00:00:00

  • FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.

    abstract：:The Fanconi anemia (FA) pathway is implicated in DNA repair and cancer predisposition. Central to this pathway is the FA core complex, which is targeted to chromatin by FANCM and FAAP24 following replication stress. Here we show that FANCM and FAAP24 interact with the checkpoint protein HCLK2 independently of the FA c...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2008.10.014

    authors： Collis SJ,Ciccia A,Deans AJ,Horejsí Z,Martin JS,Maslen SL,Skehel JM,Elledge SJ,West SC,Boulton SJ

    更新日期：2008-11-07 00:00:00

  • A model for how ribosomal release factors induce peptidyl-tRNA cleavage in termination of protein synthesis.

    abstract：:A major unresolved question in messenger RNA translation is how ribosomal release factors terminate protein synthesis. Class 1 release factors decode stop codons and trigger hydrolysis of the bond between the nascent polypeptide and tRNA some 75 A away from the decoding site. While the gross features of the release fa...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2007.06.032

    authors： Trobro S,Aqvist J

    更新日期：2007-09-07 00:00:00

  • Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.

    abstract：:tRNAs are subject to numerous modifications, including methylation. Mutations in the human N7-methylguanosine (m7G) methyltransferase complex METTL1/WDR4 cause primordial dwarfism and brain malformation, yet the molecular and cellular function in mammals is not well understood. We developed m7G methylated tRNA immunop...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2018.06.001

    authors： Lin S,Liu Q,Lelyveld VS,Choe J,Szostak JW,Gregory RI

    更新日期：2018-07-19 00:00:00