Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses.


:The early detection by the host of invading microorganisms, including viruses, depends on a limited number of specific receptors that recognize pathogen-associated molecular patterns (PAMPs). A few of these PAMPs, including ssRNA and dsRNA, are recognized by Toll-like receptors (TLR)-7/8 and TLR3, respectively. Activation of an antiviral TLR-dependent signaling cascade leads to the activation of the key transcription factors IRF and NF-kappaB, which promote antiviral responses through induction of specific genes. Recently, a second system has been described, which relies on the cytoplasmic recognition of dsRNA by RNA helicases such as RIG-I. In this review, we discuss the mechanistic aspects of these important arms of the host innate response to dsRNA and a few viral strategies utilized to counteract them.


Mol Cell


Molecular cell


Meylan E,Tschopp J




Has Abstract


2006-06-09 00:00:00














  • Histone Acetyltransferase 1 Links Metabolism and Transcription to Cell-Cycle Progression.

    abstract::HAT1 is an essential gene in mammals that acetylates newly synthesized histone H4 and is involved in chromatin assembly and genome maintenance. In this issue of Molecular Cell, Gruber et al. (2019) show that HAT1 binds to and stimulates H4 gene expression in a growth-factor- and glucose-dependent manner. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Denu JM

    更新日期:2019-08-22 00:00:00

  • A Eukaryotic Sensor for Membrane Lipid Saturation.

    abstract::Maintaining a fluid bilayer is essential for cell signaling and survival. Lipid saturation is a key factor determining lipid packing and membrane fluidity, and it must be tightly controlled to guarantee organelle function and identity. A dedicated eukaryotic mechanism of lipid saturation sensing, however, remains elus...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Covino R,Ballweg S,Stordeur C,Michaelis JB,Puth K,Wernig F,Bahrami A,Ernst AM,Hummer G,Ernst R

    更新日期:2016-07-07 00:00:00

  • Scd6 targets eIF4G to repress translation: RGG motif proteins as a class of eIF4G-binding proteins.

    abstract::The formation of mRNPs controls the interaction of the translation and degradation machinery with individual mRNAs. The yeast Scd6 protein and its orthologs regulate translation and mRNA degradation in yeast, C. elegans, D. melanogaster, and humans by an unknown mechanism. We demonstrate that Scd6 represses translatio...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Rajyaguru P,She M,Parker R

    更新日期:2012-01-27 00:00:00

  • The Mitochondrial Basis of Aging.

    abstract::A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in mitochondria function contributes to aging. In particular, we discuss how mitochondria contribute to specific...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审


    authors: Sun N,Youle RJ,Finkel T

    更新日期:2016-03-03 00:00:00

  • Single-Molecule Imaging Uncovers Rules Governing Nonsense-Mediated mRNA Decay.

    abstract::Nonsense-mediated decay (NMD) is a surveillance system that degrades mRNAs containing a premature termination codon (PTC) and plays important roles in protein homeostasis and disease. The efficiency of NMD is variable, impacting the clinical outcome of genetic mutations. However, limited resolution of bulk analyses ha...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Hoek TA,Khuperkar D,Lindeboom RGH,Sonneveld S,Verhagen BMP,Boersma S,Vermeulen M,Tanenbaum ME

    更新日期:2019-07-25 00:00:00

  • Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.

    abstract::Upon glucose restriction, eukaryotic cells upregulate oxidative metabolism to maintain homeostasis. Using genetic screens, we find that the mitochondrial serine hydroxymethyltransferase (SHMT2) is required for robust mitochondrial oxygen consumption and low glucose proliferation. SHMT2 catalyzes the first step in mito...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Minton DR,Nam M,McLaughlin DJ,Shin J,Bayraktar EC,Alvarez SW,Sviderskiy VO,Papagiannakopoulos T,Sabatini DM,Birsoy K,Possemato R

    更新日期:2018-02-15 00:00:00

  • A network model of the molecular organization of chromatin in Drosophila.

    abstract::Chromatin governs gene regulation and genome maintenance, yet a substantial fraction of the chromatin proteome is still unexplored. Moreover, a global model of the chromatin protein network is lacking. By screening >100 candidates we identify 42 Drosophila proteins that were not previously associated with chromatin, w...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: van Bemmel JG,Filion GJ,Rosado A,Talhout W,de Haas M,van Welsem T,van Leeuwen F,van Steensel B

    更新日期:2013-02-21 00:00:00

  • Signaling from across the way: transactivation of VEGF receptors by HSPGs.

    abstract::Heparan sulfate proteoglycans (HSPGs) influence the signaling of many growth factors, and recent work shows that they can promote VEGF signaling in trans from the surface of an adjacent cell. This mode of signaling also alters the activation state and internalization of VEGF receptors. ...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审


    authors: Selleck SB

    更新日期:2006-05-19 00:00:00

  • Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.

    abstract::The Ca2+ -activated K+ channel KCa3.1 is required for Ca2+ influx and the subsequent activation of B and T cells. Inhibitors of KCa3.1 are in development to treat autoimmune diseases and transplant rejection, underscoring the importance in understanding how these channels are regulated. We show that nucleoside diphosp...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Srivastava S,Li Z,Ko K,Choudhury P,Albaqumi M,Johnson AK,Yan Y,Backer JM,Unutmaz D,Coetzee WA,Skolnik EY

    更新日期:2006-12-08 00:00:00

  • Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen.

    abstract::ER-associated degradation (ERAD) of glycoproteins depends on dual recognition of protein misfolding and remodeling of the substrate's N-linked glycans. After recognition, substrates are retrotranslocated to the cytosol for proteasomal degradation. To explore the directionality of this process, we fused a highly stable...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Bhamidipati A,Denic V,Quan EM,Weissman JS

    更新日期:2005-09-16 00:00:00

  • Structural basis of Rho GTPase-mediated activation of the formin mDia1.

    abstract::Diaphanous-related formins (DRFs) regulate dynamics of unbranched actin filaments during cell contraction and cytokinesis. DRFs are autoinhibited through intramolecular binding of a Diaphanous autoinhibitory domain (DAD) to a conserved N-terminal regulatory element. Autoinhibition is relieved through binding of the GT...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Otomo T,Otomo C,Tomchick DR,Machius M,Rosen MK

    更新日期:2005-04-29 00:00:00

  • Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.

    abstract::Ubiquitin-mediated proteolysis regulates the activity of diverse receptor systems. Here, we identify Smurf2, a C2-WW-HECT domain ubiquitin ligase and show that Smurf2 associates constitutively with Smad7. Smurf2 is nuclear, but binding to Smad7 induces export and recruitment to the activated TGF beta receptor, where i...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Kavsak P,Rasmussen RK,Causing CG,Bonni S,Zhu H,Thomsen GH,Wrana JL

    更新日期:2000-12-01 00:00:00

  • ERp29 triggers a conformational change in polyomavirus to stimulate membrane binding.

    abstract::Membrane penetration of nonenveloped viruses is a poorly understood process. We have investigated early stages of this process by studying the conformational change experienced by polyomavirus (Py) in the lumen of the endoplasmic reticulum (ER), a step that precedes its transport into the cytosol. We show that a PDI-l...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Magnuson B,Rainey EK,Benjamin T,Baryshev M,Mkrtchian S,Tsai B

    更新日期:2005-10-28 00:00:00

  • Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.

    abstract::Histone H3K4 demethylase LSD1 plays an important role in stem cell biology, especially in the maintenance of the silencing of differentiation genes. However, how the function of LSD1 is regulated and the differentiation genes are derepressed are not understood. Here, we report that elimination of LSD1 promotes embryon...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Han X,Gui B,Xiong C,Zhao L,Liang J,Sun L,Yang X,Yu W,Si W,Yan R,Yi X,Zhang D,Li W,Li L,Yang J,Wang Y,Sun YE,Zhang D,Meng A,Shang Y

    更新日期:2014-08-07 00:00:00

  • A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.

    abstract::X-linked mental retardation (XLMR) is an inherited disorder that mostly affects males and is caused by mutations in genes located on the X chromosome. Here, we show that the XLMR protein PHF8 and a C. elegans homolog F29B9.2 catalyze demethylation of di- and monomethylated lysine 9 of histone H3 (H3K9me2/me1). The PHD...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Kleine-Kohlbrecher D,Christensen J,Vandamme J,Abarrategui I,Bak M,Tommerup N,Shi X,Gozani O,Rappsilber J,Salcini AE,Helin K

    更新日期:2010-04-23 00:00:00

  • Different aa-tRNAs are selected uniformly on the ribosome.

    abstract::Ten E. coli aminoacyl-tRNAs (aa-tRNAs) were assessed for their ability to decode cognate codons on E. coli ribosomes by using three assays that evaluate the key steps in the decoding pathway. Despite a wide variety of structural features, each aa-tRNA exhibited similar kinetic and thermodynamic properties in each assa...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Ledoux S,Uhlenbeck OC

    更新日期:2008-07-11 00:00:00

  • Adaptation in CRISPR-Cas Systems.

    abstract::Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system in prokaryotes. The system preserves memories of prior infections by integrating short segments of foreign DNA, termed spacers, into the CRISPR array in a process termed adaptati...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审


    authors: Sternberg SH,Richter H,Charpentier E,Qimron U

    更新日期:2016-03-17 00:00:00

  • Glucose-induced β-catenin acetylation enhances Wnt signaling in cancer.

    abstract::Nuclear accumulation of β-catenin, a widely recognized marker of poor cancer prognosis, drives cancer cell proliferation and senescence bypass and regulates incretins, critical regulators of fat and glucose metabolism. Diabetes, characterized by elevated blood glucose levels, is associated with increased cancer risk, ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Chocarro-Calvo A,García-Martínez JM,Ardila-González S,De la Vieja A,García-Jiménez C

    更新日期:2013-02-07 00:00:00

  • RNA binding of PRC2: promiscuous or well ordered?

    abstract::The polycomb repressive complex 2 (PRC2) methylates histones for epigenetic silencing and associates with thousands of protein-coding and noncoding RNAs. How the recruitment of PRC2 to specific sites is facilitated is currently unclear. Two recent studies have deciphered the impact of RNA binding on PRC2 recruitment a...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Kretz M,Meister G

    更新日期:2014-07-17 00:00:00

  • PML, SUMO, and RNF4: guardians of nuclear protein quality.

    abstract::In this issue of Molecular Cell, Guo et al. (2014) report that misfolded or aggregated nuclear proteins, such as pathogenic polyQ proteins, are cleared by a SUMO-dependent quality control pathway, which involves the E3 SUMO ligase PML and the SUMO-targeted ubiquitin ligase RNF4. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Gärtner A,Muller S

    更新日期:2014-07-03 00:00:00

  • An Arginine Nexus in the RNA Polymerase II CTD.

    abstract::In this issue of Molecular Cell,Sharma et al. (2019) show that normal cell growth requires conversion of an arginine residue in the RNA polymerase II C-terminal domain (CTD) to citrulline, uncovering a potential regulatory pathway involving opposing arginine modifications. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Corden JL

    更新日期:2019-01-03 00:00:00

  • Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates.

    abstract::Tethering of synaptic vesicles (SVs) to the active zone determines synaptic strength, although the molecular basis governing SV tethering is elusive. Here, we discover that small unilamellar vesicles (SUVs) and SVs from rat brains coat on the surface of condensed liquid droplets formed by active zone proteins RIM, RIM...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Wu X,Ganzella M,Zhou J,Zhu S,Jahn R,Zhang M

    更新日期:2021-01-07 00:00:00

  • L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure.

    abstract::We have identified human MBT domain-containing protein L3MBTL2 as an integral component of a protein complex that we termed Polycomb repressive complex 1 (PRC1)-like 4 (PRC1L4), given the copresence of PcG proteins RING1, RING2, and PCGF6/MBLR. PRC1L4 also contained E2F6 and CBX3/HP1γ, known to function in transcripti...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Trojer P,Cao AR,Gao Z,Li Y,Zhang J,Xu X,Li G,Losson R,Erdjument-Bromage H,Tempst P,Farnham PJ,Reinberg D

    更新日期:2011-05-20 00:00:00

  • JunD protects cells from p53-dependent senescence and apoptosis.

    abstract::JunD is the most broadly expressed member of the Jun family and the AP-1 transcription factor complex. Primary fibroblasts lacking JunD displayed p53-dependent growth arrest, upregulated p19(Arf) expression, and premature senescence. In contrast, immortalized cell lines lacking JunD showed increased proliferation and ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Weitzman JB,Fiette L,Matsuo K,Yaniv M

    更新日期:2000-11-01 00:00:00

  • Manipulation by Methylation: Garnishing mRNAs with m6Am.

    abstract::In two recent publications in Molecular Cell,Boulias et al. (2019) and Sendinc et al. (2019) use complementary approaches to map m6Am modification sites transcriptome-wide and demonstrate that m6Am can repress translation while increasing the stability of a subset of low-abundance transcripts. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Doxtader KA,Nam Y

    更新日期:2019-08-08 00:00:00

  • Chromatin remodeling in vivo: evidence for a nucleosome sliding mechanism.

    abstract::Members of the ISWI family of chromatin remodeling factors exhibit ATP-dependent nucleosome sliding, loading, and spacing activities in vitro. However, it is unclear which of these activities are utilized by ISWI complexes to remodel chromatin in vivo. We therefore sought to identify the mechanisms of chromatin remode...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Fazzio TG,Tsukiyama T

    更新日期:2003-11-01 00:00:00

  • AMPK phosphorylation of raptor mediates a metabolic checkpoint.

    abstract::AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and biosynthetic processes, in part through its inhibition of the rapamycin-sensitive mTOR (mTORC1) pathway. AMPK phosphorylation of the TSC...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Gwinn DM,Shackelford DB,Egan DF,Mihaylova MM,Mery A,Vasquez DS,Turk BE,Shaw RJ

    更新日期:2008-04-25 00:00:00

  • Myotonic dystrophy: the role of the CUG triplet repeats in splicing of a novel DMPK exon and altered cytoplasmic DMPK mRNA isoform ratios.

    abstract::The mechanism by which (CTG)n expansion in the 3' UTR of the DMPK gene causes myotonic dystrophy (DM) is unknown. We identified four RNA splicing factors--hnRNP C, U2AF (U2 auxiliary factor), PTB (polypyrimidine tract binding protein), and PSF (PTB associated splicing factor)--that bind to two short regions 3' of the ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Tiscornia G,Mahadevan MS

    更新日期:2000-06-01 00:00:00

  • Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

    abstract::Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP sequencing in mouse embryonic stem cells (ESCs). Refined bioinformat...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Bulut-Karslioglu A,De La Rosa-Velázquez IA,Ramirez F,Barenboim M,Onishi-Seebacher M,Arand J,Galán C,Winter GE,Engist B,Gerle B,O'Sullivan RJ,Martens JH,Walter J,Manke T,Lachner M,Jenuwein T

    更新日期:2014-07-17 00:00:00

  • Partners in Crime: Clandestine Operations among RAS-RAF Accomplices in Promoting Tumorigenesis.

    abstract::In this issue of Molecular Cell, Terrell et al. (2019) characterize the interactions of RAS-RAF complexes in live cells. Using bioluminescence resonance energy transfer (BRET) technology, they show that individual RAF family members exhibit distinct binding affinities to each RAS family protein, with CRAF exhibiting h...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Venkatanarayan A,Malek S

    更新日期:2019-12-19 00:00:00