Leflunomide: friend or foe for systemic lupus erythematosus?

abstract：:Aseptic loosening is the predominant cause of total hip implant failure. It has been assumed that a layer or membrane, containing macrophages, fibroblasts and vascular endothelial cells, of synovial-like tissue develops at the implant-to-bone interface almost invariably and, with time, somehow leads to loosening of th...

journal_title：Rheumatology international

authors： Xu JW,Konttinen YT,Li TF,Waris V,Lassus J,Matucci-Cerinic M,Sorsa T,Santavirta TS

更新日期：1998-01-01 00:00:00

abstract：:Osteopoikilosis, a form of osteosclerotic disorders, is a rare bone dysplasia with typical radiologic findings. The pathology, which sometimes requires attention in differential diagnosis due to its radiologic appearance, has been reported previously with other diseases. In this report, a case diagnosed with both reac...

journal_title：Rheumatology international

authors： Mesci E

更新日期：2006-05-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is an autoimmune spondyloarthropathy involving principally the sacroiliac joint and axial skeleton. Spinal cord involvement is an infrequent and late complication. It mostly results from compressive myelopathy due to skeletal osteopathy and usually presents with radiculomyelopathic sensory ...

journal_title：Rheumatology international

authors： Chen WH,Yin HL,Lin HS,Chen CJ

更新日期：2011-07-01 00:00:00

abstract：:The objectives of this study are to describe appropriateness and drug treatment of comorbidities in fibromyalgia (FM). Cross-sectional study of a group of patients. Number of drugs, indication, duration and appropriateness of prescriptions were evaluated. Patients were classified as: group 1, (FM/FM) previous FM diagn...

journal_title：Rheumatology international

authors： Rivera J,Vallejo MA

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Neprilysin (neutral endopeptidase, 3:4:24:11, CD10) (NEP) is a Zn metallopeptidase linked to controlling inflammation through the degradation of neuropeptides involved in neurogenic inflammation of chronic rheumatic diseases. The aim of our study was to evaluate circulating activity and cellular expression of...

journal_title：Rheumatology international

authors： Simonini G,Azzari C,Gelli AM,Giani T,Calabri GB,Leoncini G,Del Rosso A,Generini S,Cimaz R,Cerinic MM,Falcini F

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To describe the prevalence of and evaluate the factors associated with fatigue patients with psoriatic arthritis (PsA) in an Asian population. METHODS:We used baseline data from a registry of patients with PsA attending an outpatient clinic of a tertiary hospital in Singapore. Demographic data and disease ch...

journal_title：Rheumatology international

authors： Tan JSQ,Fong W,Kwan YH,Leung YY

更新日期：2020-11-01 00:00:00

abstract：:To study the mechanisms of chondrocyte damage, chondrocyte cytotoxicity as shown by chromium-51 release induced by polymorphonuclear leukocytes (PMNLs) was examined. PMNLs significantly enhanced chondrocyte cytotoxicity in the presence of phorbol dibutyrate. This chondrocyte damage was abolished by the addition of cat...

journal_title：Rheumatology international

authors： Saura R,Matsubara T,Hirohata K,Itoh H

更新日期：1992-01-01 00:00:00

abstract：:The presence of specific anti-Proteus antibodies in active, rheumatoid arthritis (RA) patients, has been demonstrated by four different techniques: indirect bacterial agglutination, ELISA, Western blotting and immunofluorescence. Furthermore, anti-HLA-DR4 tissue typing sera have been shown to bind to Proteus microorga...

journal_title：Rheumatology international

authors： Ebringer A,Khalafpour S,Wilson C

更新日期：1989-01-01 00:00:00

abstract：:The aim of this study was to compare health related quality of life (HRQoL) and assess functional and psychological status in rheumatoid arthritis (RA), fibromyalgia syndrome (FS) patients and controls (each 30 subjects). Demographic characteristics, pain and sleep disturbance by Visual Analog Scale, depression by Bec...

journal_title：Rheumatology international

authors： Tander B,Cengiz K,Alayli G,Ilhanli I,Canbaz S,Canturk F

更新日期：2008-07-01 00:00:00

abstract：:Using commercially available antigens, enzyme-linked immunosorbent assays (ELISAs) were set up to demonstrate antibodies of IgG class against Sm and SS-A. Anti-Sm antibodies were demonstrated in 40% of patients with systemic lupus erythematosus (SLE), in 12% of patients with SJögren's syndrome, in 6% of patients with ...

journal_title：Rheumatology international

authors： Gripenberg M,Teppo AM,Friman C

更新日期：1991-01-01 00:00:00

abstract：:We investigated the effect of chrysotherapy on the Fc and complement receptor binding activity of peripheral blood (PB) monocytes and peritoneal (PE) macrophages isolated from normal rats and rats with adjuvant induced arthritis. The adjuvant induced severe disease in Dark Agouti (DA) rats and less marked disease in J...

journal_title：Rheumatology international

authors： Haynes DR,Garrett IR,Vernon-Roberts B

更新日期：1988-01-01 00:00:00

abstract：:Caffeine, a commonly consumed food constituent, is known to exert beneficial physiological effects in humans. There is a lack of comprehensive population data for the effects of caffeine intake on urate metabolism. Therefore, the aim of this study was to determine whether coffee, tea, and caffeine intake influences se...

journal_title：Rheumatology international

authors： Bae J,Park PS,Chun BY,Choi BY,Kim MK,Shin MH,Lee YH,Shin DH,Kim SK

更新日期：2015-02-01 00:00:00

abstract：:The purpose of this study was to detect the frequency of inflammatory cervical spine changes and characteristic features such as resorption in rheumatoid arthritis (RA) with arthritis mutilans (AM) hand deformity. The series included 23 patients with AM hand deformity who fulfilled the 1987 American Rheumatism Associa...

journal_title：Rheumatology international

authors： Laiho K,Belt E,Kauppi M

更新日期：2001-08-01 00:00:00

abstract：:The minor allele of the non-synonymous single nucleotide polymorphism (SNP) +1858C>T within the PTPN22 gene has now been unequivocally confirmed as conferring susceptibility to RA in population from Europe and America, but not in population from Asia. The aim of this study was to jointly address and integrate these se...

journal_title：Rheumatology international

authors： Huang JJ,Qiu YR,Li HX,Sun DH,Yang J,Yang CL

更新日期：2012-03-01 00:00:00

abstract：:Bisphosphonates such as alendronate, risedronate and zoledronate have revolutionised the treatment for osteoporosis and Paget's disease. These drugs reduce fracture risk and probably mortality in patients with osteoporosis. However, they have a long in vivo half-life following cessation and may be associated with dela...

journal_title：Rheumatology international

authors： Wong PK,Borromeo GL,Wark JD

更新日期：2013-09-01 00:00:00

abstract：:Knee osteoarthritis is a common disease in the elderly population worldwide. The alleviation of the symptoms associated with this disease can be achieved with physical exercise that induces a cascade of molecular and cellular processes. Of the neurotrophins, brain-derived neurotrophic factor (BDNF) appears to be the m...

journal_title：Rheumatology international

authors： Gomes WF,Lacerda AC,Mendonça VA,Arrieiro AN,Fonseca SF,Amorim MR,Teixeira AL,Teixeira MM,Miranda AS,Coimbra CC,Brito-Melo GE

更新日期：2014-06-01 00:00:00

abstract：:The aim of the study was to analyze the concentrations of sTNFR1 and sTNFR2 in both plasma and synovial fluid of patients with primary knee osteoarthritis (OA) and to determine their relationship to self-reported pain, stiffness and physical function. Twenty-seven patients with knee OA and 19 healthy subjects were enr...

journal_title：Rheumatology international

authors： Simão AP,Almeida TM,Mendonça VA,Santos SA,Gomes WF,Coimbra CC,Lacerda AC

更新日期：2014-12-01 00:00:00

abstract：:The aim of this study was to investigate the frequency of patients with rheumatoid arthritis (RA) who have inflammatory back pain (IBP) and meet the existing classification criteria for ankylosing spondylitis (AS) and spondyloarthritis (SpA). We included 167 patients fulfilling the ACR 1987 revised criteria for RA. Af...

journal_title：Rheumatology international

authors： Can G,Solmaz D,Binicier O,Akar S,Birlik M,Soysal O,Akkoc N,Manisali M,Onen F

更新日期：2013-05-01 00:00:00

abstract：:Psoriatic arthritis (PsA) patients are at a higher risk of systemic inflammatory sequelae, leading to microalbuminuria, cardiovascular (CVD) and neuropsychiatric (NPD) disease. Our aim is to present the existing literature about the relationship between CVD, kidney and NPD in PsA. The literature evaluation of PsA reve...

journal_title：Rheumatology international

authors： Markousis-Mavrogenis G,Nurmohamed MT,Koutsogeorgopoulou L,Dimitroulas T,Katsifis G,Vartela V,Mitsikostas D,Kolovou G,Tektonidou M,Voulgari P,Sfikakis PP,Kitas GD,Mavrogeni SI

更新日期：2020-09-01 00:00:00

abstract：:To evaluate the correlation between measurements of antinuclear antibodies serum levels by enzyme immunoassay (ANA-EIA), and the degree of systemic lupus erythematosus disease activity. To retest the performance of the test compared to measurement of antinuclear antibodies by immunofluorescence (ANA-IIF). Eighty-five ...

journal_title：Rheumatology international

authors： Paz E,Adawi M,Lavi I,Mussel Y,Mader R

更新日期：2007-08-01 00:00:00

abstract：:The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...

journal_title：Rheumatology international

authors： Tuominen R,Möttönen T,Suominen C,Vahlberg T,Tuominen S

更新日期：2010-09-01 00:00:00

abstract：:The objective of the study was to investigate the possibility whether the in vitro treatment with vitamin D3 can restore the impaired expression of protein kinase C (PKC) isoenzymes and IL-2 production in the lymphocytes of patients with systemic lupus erythematosus (SLE). Purified T lymphocytes from 14 patients with ...

journal_title：Rheumatology international

authors： Czifra G,Tóth B,Kovács I,Bíró T,Griger Z,Baráth S,Tarr T,Zeher M,Sipka S

更新日期：2014-05-01 00:00:00

abstract：:The purpose of this study was to determine the effects of an oral preparation containing hyaluronic acid on osteoarthritic knee joint pain and function as well as changes in inflammatory cytokines, bradykinin, and leptin. We also used heavy water to determine the turnover rates of glycosaminoglycans in synovial fluid....

journal_title：Rheumatology international

authors： Nelson FR,Zvirbulis RA,Zonca B,Li KW,Turner SM,Pasierb M,Wilton P,Martinez-Puig D,Wu W

更新日期：2015-01-01 00:00:00

abstract：:This review explores the prevalence and factors associated with disturbed sleep for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis in order to clarify consistent findings in this otherwise disparate research field. The association of physical, demographic and psychological factors co...

journal_title：Rheumatology international

authors： Leverment S,Clarke E,Wadeley A,Sengupta R

更新日期：2017-02-01 00:00:00

abstract：:Interleukin-6 (IL-6) was detected at low levels in plasma [0.014 +/- 0.006 ng/ml (mean +/- SEM] and in high amounts in synovial fluid [SF; 2.6 +/- 2.2 ng/ml (mean +/- SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR (n = 15) or with histological parameters of acut...

journal_title：Rheumatology international

authors： Sack U,Kinne RW,Marx T,Heppt P,Bender S,Emmrich F

更新日期：1993-01-01 00:00:00

abstract：:This study aims to elucidate plasma oxidant/antioxidant status in patients with rheumatoid arthritis (RA). Fasting blood samples were obtained from 24 patients with RA and 20 control subjects. Antioxidant potential (AOP) value, nonenzymatic superoxide radical scavenger activity (NSSA), and malondialdehyde (MDA) levels...

journal_title：Rheumatology international

authors： Oztürk HS,Cimen MY,Cimen OB,Kaçmaz M,Durak I

更新日期：1999-01-01 00:00:00

abstract：:Takayasu arteritis (TA) is a rare autoimmune disease of unknown etiology. Genome-wide association studies (GWAS) have demonstrated association between genetic variants of IL12B and IL6 and TA. Since TA has been reported with ethnic heterogeneity, we sought to investigate whether the single-nucleotide-polymorphisms (SN...

journal_title：Rheumatology international

authors： Wen X,Chen S,Li P,Li J,Wu Z,Li Y,Li L,Yuan H,Tian X,Zhang F,Li Y

更新日期：2017-04-01 00:00:00

abstract：:Isoform 4 of the human peptidylarginine deiminase (hPAD4) enzyme may be responsible for the citrullination of antigens in rheumatoid arthritis (RA) and has been shown to be itself the target of disease-specific autoantibodies. Here, we have tested whether the level of serum anti-hPAD4 antibodies in RA patients is stab...

journal_title：Rheumatology international

authors： Pollmann S,Stensland M,Halvorsen EH,Sollid LM,Kvien TK,Fleckenstein B,Molberg O

更新日期：2012-05-01 00:00:00

abstract：:This retrospective medical chart review aimed to provide a current, real-world overview of biologic usage in patients with rheumatoid arthritis (RA) in Germany, Spain, and the UK, and estimate clinical and healthcare utilization outcomes associated with early versus late treatment. Adults (≥18 years) with a confirmed ...

journal_title：Rheumatology international

authors： Emery P,Solem C,Majer I,Cappelleri JC,Tarallo M

更新日期：2015-11-01 00:00:00

abstract：:Pancreatitis is a relatively rare but severe manifestation in systemic lupus erythematosus (SLE) patients. We report a case of a 39-year-old woman with previous SLE diagnose treated with prednisone and mycophenolate mofetil who developed an acute pancreatitis complicated by pancreatic pseudocysts within the context of...

journal_title：Rheumatology international

authors： Cairoli E,Pérez G,Briva A,Cancela M,Alonso J

更新日期：2010-03-01 00:00:00