Abstract:
BACKGROUND:The authors sought to determine whether subjects with pathophysiological conditions that are characterized by increased concentrations of aldosterone have increased susceptibility to the side effects of neonatal anesthesia with sevoflurane. METHODS:Postnatal day 4-20 (P4-P20) rats were exposed to sevoflurane, 6% and 2.1%, for 3 min and 60-360 min, respectively. Exogenous aldosterone was administered to imitate pathophysiological conditions with increased concentrations of aldosterone. RESULTS:Six hours of anesthesia with sevoflurane on P4-P5 rats resulted in a more than 30-fold increase in serum concentrations of aldosterone (7.02 ± 1.61 ng/dl vs. 263.75 ± 22.31 ng/dl, mean ± SE, n = 5-6) and reduced prepulse inhibition of the acoustic startle response (F(2,37) = 5.66, P < 0.001). Administration of exogenous aldosterone during anesthesia with sevoflurane enhanced seizure-like electroencephalogram patterns in neonatal rats (48.25 ± 15.91 s vs. 222.00 ± 53.87 s, mean ± SE, n = 4) but did not affect electroencephalographic activity in older rats. Exogenous aldosterone increased activation of caspase-3 (F(3,28) = 11.02, P < 0.001) and disruption of prepulse inhibition of startle (F(3,46) = 6.36; P = 0.001) caused by sevoflurane. Intracerebral administration of oxytocin receptor agonists resulted in depressed seizure-like electroencephalogram patterns (F(2,17) = 6.37, P = 0.009), reduced activation of caspase-3 (t(11) = 2.83, P = 0.016), and disruption of prepulse inhibition of startle (t(7) = -2.9; P = 0.023) caused by sevoflurane. CONCLUSIONS:These results suggest that adverse developmental effects of neonatal anesthesia with sevoflurane may involve both central and peripheral actions of the anesthetic. Subjects with increased concentrations of aldosterone may be more vulnerable, whereas intracerebral oxytocin receptor agonists may be neuroprotective.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Cao W,Pavlinec C,Gravenstein N,Seubert CN,Martynyuk AEdoi
10.1097/ALN.0b013e318266c62dsubject
Has Abstractpub_date
2012-10-01 00:00:00pages
791-800issue
4eissn
0003-3022issn
1528-1175journal_volume
117pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Nitric oxide (NO) formed from L-arginine is exhaled by mammals and regulates pulmonary vascular tone. Little is known about how its formation is stimulated. METHODS:The concentration of NO in exhaled air was monitored by chemiluminescence in pentobarbital-anesthetized rabbits receiving mechanical ventilatio...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199504000-00021
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Due to potential neurologic sequelae, the risk:benefit ratio of thoracic epidural analgesia is controversial. Surprisingly, however, few available data address neurologic complications. The incidence of neurologic complications occurring after thoracic epidural catheterization was studied in patients schedul...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199701000-00009
更新日期:1997-01-01 00:00:00
abstract::Evidence of developmental toxicity of clinically used nondepolarizing muscle relaxants was sought in rat embryos grown in culture. Embryos were explanted at 8 AM on day 9 of gestation (presomite stage, plug day = day 0), and were cultured in rotating bottles with medium containing various concentrations of d-tubocurar...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199206000-00021
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects in patients emerging from anesthesia. This study quantified these effects of ketamine and related them to steady-state plasma concentrations. METHODS:Ketamine or saline was administered in a single-blinded crossover prot...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199801000-00015
更新日期:1998-01-01 00:00:00
abstract::The authors evaluated the systemic and cerebral hemodynamic and metabolic effects of 1 h of hypotension to a mean arterial pressure of either 50 mmHg or 40 mmHg induced by intravenous adenosine or ATP in dogs maintained on 70% nitrous oxide and 0.1% halothane. Following the hypotensive period, brain biopsy specimens w...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198504000-00010
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:The local anesthetic bupivacaine exists in two stereoisomeric forms, R(+)- and S(-)-bupivacaine. Because of its lower cardiac and central nervous system toxicity, attempts were made recently to introduce S(-)-bupivacaine into clinical anesthesia. We investigated stereoselective actions of R(+)-and S(-)-bupiv...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199909000-00031
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Lamotrigine inhibits glutamate release through the preferential blockade of voltage-dependent Na+ channels. In contrast, morphine reduces release of excitatory amino acids through the activation of opioid receptors and also inhibits tetrodotoxin-resistant Na+ channels on peripheral afferent neurons. The curr...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200204000-00020
更新日期:2002-04-01 00:00:00
abstract::Distribution and elimination of lidocaine and mepivacaine were studies in 114 subjects after obstetric epidural anesthesia, Epinephrine significantly lowered the concentrations of lidocaine in the mothers' circulations by about 33 per cent, and the concentrations of mepivacaine by about 22 per cent. It also significan...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197506000-00014
更新日期:1975-06-01 00:00:00
abstract::Halothane-induced lipid peroxidation was studied in microsomes from phenobarbital-pretreated male rats at defined steady state oxygen partial pressures (PO2). At PO2 less than 10 mmHg on addition of halothane to NADPH-reduced microsomes, significant increases in malondialdehyde (MDA) formation, oxygen uptake, and conj...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198501000-00009
更新日期:1985-01-01 00:00:00
abstract::The effect of neuromuscular blockade with vecuronium on the hemodynamic responses to a noxious stimulus was investigated in male Sprague-Dawley rats. The rats were anesthetized with either halothane (group 1, n = 10), or isoflurane (group 2, n = 10). The maximum values for heart rate and mean arterial pressure during ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198908000-00009
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:During emergence from anesthesia, breathing 100% oxygen is frequently used to provide a safety margin toward hypoxemia in case an airway problem occurs. Oxygen breathing has been shown to cause pulmonary gas exchange disorders in healthy individuals. This study investigates how oxygen breathing during emerge...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000161
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:In patients with acute respiratory distress syndrome (ARDS), the ventilatory approach is based on tidal volume (VT) of 10-15 ml/kg and positive end-expiratory pressure (PEEP). To avoid further pulmonary injury, decreasing VT and allowing PaCO2 to increase (permissive hypercapnia) has been suggested. Effects ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199510000-00010
更新日期:1995-10-01 00:00:00
abstract::The goal of this randomized study of high-risk surgical patients was to determine whether intraoperative thoracic epidural anesthesia in combination with light general anesthesia alters postoperative morbidity when compared to a standard technique of "balanced" general anesthesia. A total of 173 patients scheduled for...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199110000-00010
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:To interpret correctly the results from studies performed during surgery and anesthesia it is necessary to dissect the separate effect of the anesthetic technique itself. The purpose of this study was to investigate the metabolic effects of epidural blockade (T7-S1) with bupivacaine 0.25% after 12 h fasting ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200001000-00015
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Postoperative nausea and vomiting (PONV) is a commonly observed adverse effect of general anesthesia. Recently, ondansetron, a new serotonin3 (5-hydroxytryptamine3) receptor antagonist was shown to be effective in the prophylaxis and prevention of chemotherapy-induced nausea and vomiting in children and adul...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199410000-00006
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate a new, physiologically inspired method for the analysis of the electroencephalogram during propofol-remifentanil anesthesia. Based on fixed-order autoregressive moving-average modeling, this method was hypothesized to be capable of dissociating the effects that hypno...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0b013e3181e3d8a6
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Preterm and ex-preterm infants are at risk for life-threatening apnea after general anesthesia. The authors attempted to define the postconceptual age beyond which apnea is less likely to occur and to identify the factors that predispose to postanesthetic apnea. METHODS:Ninety-one infants younger than 60 we...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199306000-00009
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:The authors sought to understand neural correlates of anesthetic-induced unconsciousness. Cortical gamma oscillations have been associated with neural processes supporting conscious perception, but the effect of general anesthesia on these oscillations is controversial. In this study, the authors examined th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200505000-00012
更新日期:2005-05-01 00:00:00
abstract::Thiopental-14C (30 mg and 10 muCi/kg) was injected intravenously into rats 36-48 hours following bilateral nephrectomy and one minute after pretreatment with sulfadimethoxine (30 mg/kg, iv). Control groups of normal and sham-operated animals were used. The distributions of radioactivity in plasma, brain, and heart 1, ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197612000-00008
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Previous studies reported that thoracic epidural anesthesia (TEA) protected against a decrease in gastric intramucosal pH, suggesting that TEA increased gut mucosal perfusion. The current study examines the effects of TEA on ileal mucosa using intravital microscopy in anesthetized rats. METHODS:Nineteen rat...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200009000-00036
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the mos...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000002508
更新日期:2019-02-01 00:00:00
abstract::The aim of the study was to establish whether there exists a relationship between blood methadone concentration and analgesic response and the intrasubject and intersubject variability in this relationship. Sixteen general surgical (upper abdominal) and orthopedic (spinal fusion) patients were administered methadone (...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
abstract::Intrathecally administered alpha 2-adrenergic agonists produce analgesia in humans but may also produce hypotension and bradycardia. To further characterize hemodynamic depression produced by intrathecally administered alpha 2-adrenergic agonists, clonidine (100-1,500 micrograms) was injected into the cervical, thorac...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199104000-00021
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:General anesthetics reduce neuron loss following focal cerebral ischemia in rodents. The relative efficacy of this action among different anesthetics clinically used for neuroprotection is uncertain. In addition, it remains unclear how anesthetics compare to neuroprotection afforded by mild hypothermia. This...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200005000-00024
更新日期:2000-05-01 00:00:00
abstract::Ninety women undergoing gynecologic laparoscopy were randomly given clonidine 3 or 4.5 micrograms/kg or saline intramuscularly 45-60 min prior to induction of anesthesia. Anesthesia was induced with thiopental 3.5 mg/kg and maintained with 0.3% end-tidal isoflurane in nitrous oxide and oxygen. The laparoscopy did not ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199005000-00004
更新日期:1990-05-01 00:00:00
abstract::Robert D. Dripps, M.D. (1911 to 1973), helped found academic anesthesiology. Newly reviewed teaching slides from the University of Pennsylvania (Philadelphia, Pennsylvania) contain six anesthesia records from 1965 to 1967 that involved Dripps. They illustrate the clinical philosophy he taught-to consider administratio...
journal_title:Anesthesiology
pub_type: 传,历史文章,杂志文章
doi:10.1097/ALN.0000000000001109
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Sedative-hypnotic drugs not only increase sedation, but also impair memory as serum concentration increases. These drugs also produce profound changes in the auditory event-related potential (ERP). The ability of various ERP components to predict changes in sedation and memory produced by various drugs was t...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200110000-00018
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:No externally validated risk score for postoperative pulmonary complications (PPCs) is currently available. The authors tested the generalizability of the Assess Respiratory Risk in Surgical Patients in Catalonia risk score for PPCs in a large European cohort (Prospective Evaluation of a RIsk Score for posto...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000000334
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Women generally report greater sensitivity to pain than do men, and healthy young women require 20% more anesthetic than healthy age-matched men to prevent movement in response to noxious electrical stimulation. In contrast, minimum alveolar concentration (MAC) for xenon is 26% less in elderly Japanese women...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-200311000-00010
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Spontaneous breaths during airway pressure release ventilation (APRV) have to overcome the resistance of the artificial airway. Automatic tube compensation provides ventilatory assistance by increasing airway pressure during inspiration and lowering airway pressure during expiration, thereby compensating for...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200108000-00020
更新日期:2001-08-01 00:00:00