Volatile anesthetics enhance flash-induced gamma oscillations in rat visual cortex.

abstract：BACKGROUND:Nitric oxide released by inducible nitric oxide synthase (iNOS) plays an important role in immune responses and systemic vasodilation in septic shock. Volatile anesthetics have been reported to interfere with signal transduction and gene expression. We studied the effect of volatile anesthetics on activity a...

journal_title：Anesthesiology

authors： Tschaikowsky K,Ritter J,Schröppel K,Kühn M

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Our objective was to elucidate the direct effects of fentanyl and morphine on cardiac excitation-contraction coupling using individual, field-stimulated rat ventricular myocytes. METHODS:Freshly isolated myocytes were loaded with fura-2 and field stimulated (0.3 Hz) at 28 degrees C. Amplitude and timing of ...

journal_title：Anesthesiology

authors： Kanaya N,Zakhary DR,Murray PA,Damron DS

更新日期：1998-12-01 00:00:00

abstract：:The effects of halothane (0.75% and 1.5%) and isoflurane (2.6%) on macroscopic Ca2+ and K+ channel currents (ICa and IK, respectively) were investigated in voltage-clamped vascular muscle cells from the canine coronary artery. Single coronary arterial cells were dialyzed with K+ glutamate solution and superfused with ...

journal_title：Anesthesiology

authors： Buljubasic N,Rusch NJ,Marijic J,Kampine JP,Bosnjak ZJ

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger inflammation are unclear. The authors hypothesize that extracellular histones, a newly identified inflammatory mediator, play important roles in the pathogenesis of ARDS....

journal_title：Anesthesiology

authors： Zhang Y,Wen Z,Guan L,Jiang P,Gu T,Zhao J,Lv X,Wen T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Up to 84% of women who undergo operative vaginal delivery receive neuraxial analgesia. However, little is known about the association between neuraxial analgesia and neonatal morbidity in women who undergo operative vaginal delivery. The authors hypothesized that neuraxial analgesia is associated with a redu...

journal_title：Anesthesiology

authors： Butwick AJ,Wong CA,Lee HC,Blumenfeld YJ,Guo N

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Sevoflurane is a volatile general anesthetic that differs in chemical nature from the gaseous anesthetic nitrous oxide. In a controlled laboratory setting, the authors characterized the subjective, psychomotor, and analgesic effects of sevoflurane and nitrous oxide at two equal minimum alveolar subanesthetic...

journal_title：Anesthesiology

authors： Galinkin JL,Janiszewski D,Young CJ,Klafta JM,Klock PA,Coalson DW,Apfelbaum JL,Zacny JP

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Due to potential neurologic sequelae, the risk:benefit ratio of thoracic epidural analgesia is controversial. Surprisingly, however, few available data address neurologic complications. The incidence of neurologic complications occurring after thoracic epidural catheterization was studied in patients schedul...

journal_title：Anesthesiology

authors： Giebler RM,Scherer RU,Peters J

更新日期：1997-01-01 00:00:00

abstract：:Premedication with diazepam, hydroxyzine or secobarbital significantly increased ketamine-induced sleep time (137 +/- 3.5 min, 135 +/- 9.2 min, 128 +/- 4.7 min) over that of unpremedicated controls (98.5 +/- 4.4 min) in man. The corresponding mean plasma half-lives (t1/2) of ketamine were longer in patients premedicat...

journal_title：Anesthesiology

authors： Lo JN,Cumming JF

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND:Succinylcholine causes immediate and severe arterial hypotension in swine with the malignant hyperthermia phenotype. The underlying mechanisms are unknown. METHODS:Malignant hyperthermia-susceptible (MHS; n = 10) and normal swine (n = 5) were anesthetized with thiopental. The following were monitored: elect...

journal_title：Anesthesiology

authors： Sigg DC,Iaizzo PA

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of glutamate receptor mediates fast excitatory neurotransmission in the central nervous system. Many general anesthetics inhibit AMPA receptors in vitro; however, it is not certain if this inhibition contributes to the behavioral pro...

journal_title：Anesthesiology

authors： Joo DT,Gong D,Sonner JM,Jia Z,MacDonald JF,Eger EI 2nd,Orser BA

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Awake tracheal intubation may evoke reflex bronchoconstriction in asthmatics. Whether this effect is altered by the choice of the local anesthetic used or by pretreatment with a beta2-adrenoceptor agonist is unknown. Therefore, we assessed the effect of awake fiberoptic intubation after lidocaine or dyclonin...

journal_title：Anesthesiology

authors： Groeben H,Schlicht M,Stieglitz S,Pavlakovic G,Peters J

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Crystalloid solutions are used to restore intravascular volume in septic patients, but each solution has limitations. The authors compared the effects of three crystalloid solutions on hemodynamics, organ function, microcirculation, and survival in a sepsis model. METHODS:Peritonitis was induced by injectio...

journal_title：Anesthesiology

authors： Orbegozo D,Su F,Santacruz C,He X,Hosokawa K,Creteur J,De Backer D,Vincent JL

更新日期：2016-10-01 00:00:00

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Craniotomy for brain tumor displays significant morbidity and mortality, and no score is available to discriminate high-risk patients. Our objective was to validate a prediction score for postoperative neurosurgical complications...

journal_title：Anesthesiology

authors： Cinotti R,Bruder N,Srairi M,Paugam-Burtz C,Beloeil H,Pottecher J,Geeraerts T,Atthar V,Guéguen A,Triglia T,Josserand J,Vigouroux D,Viquesnel S,Lakhal K,Galliez M,Blanloeil Y,Le Thuaut A,Feuillet F,Rozec B,Asehnoune K

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Pentobarbital decreases the gain of the baroreceptor reflex on the order of 50%, and this blunting is caused nearly entirely by decreasing cardioinhibitory parasympathetic activity. The most likely site of action of pentobarbital is the gamma-aminobutyric acid type A (GABA(A)) receptor. The authors tested wh...

journal_title：Anesthesiology

authors： Irnaten M,Walwyn WM,Wang J,Venkatesan P,Evans C,Chang KS,Andresen MC,Hales TG,Mendelowitz D

更新日期：2002-09-01 00:00:00

abstract：:In late 1846, following his successful public demonstrations of surgical anesthesia, Boston dentist William T. G. Morton selected Letheon as the commercial name for the ether-based "preparation" he had used to produce insensibility to pain. We have not identified a first-hand account of the coinage of Letheon. Althoug...

journal_title：Anesthesiology

authors： Haridas RP,Gionfriddo M,Bause GS

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The dorsal horn of the spinal cord is a pivotal point for transmission of neuronal pain. During spinal and epidural anesthesia, the neurons of the dorsal horn are exposed to local anesthetics. Unfortunately, little is known about the action of local anesthetics on the major ionic conductances in dorsal horn ...

journal_title：Anesthesiology

authors： Olschewski A,Hempelmann G,Vogel W,Safronov BV

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Recent evidence suggests that anesthetic action within the spinal cord is important in suppressing somatic responses to painful stimuli. Whether the brain influences this response is not clear. This study was designed to test the hypothesis that the brain affects anesthetic requirements. METHODS:Six goats w...

journal_title：Anesthesiology

authors： Borges M,Antognini JF

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:There is substantial and growing literature on the actions of general anesthetics on a variety of neurotransmitter-gated ion channels, with the greatest attention being focused on inhibitory gamma-amino butyric acid type A receptors. In contrast, glutamate receptors, the most important class of fast excitato...

journal_title：Anesthesiology

authors： Plested AJ,Wildman SS,Lieb WR,Franks NP

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Mutations in the ryanodine type 1 receptor (RyR1) are causative for malignant hyperthermia. Studies in human B lymphocytes have shown that measurement of RyR1-mediated intracellular Ca(2+) (Ca(2+)(i)) release can differentiate between normal and malignant hyperthermia-susceptible individuals. The authors hav...

journal_title：Anesthesiology

authors： McKinney LC,Butler T,Mullen SP,Klein MG

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Results from previous studies have shown favorable effects from the addition of buprenorphine to local anesthetics used for interscalene or axillary perivascular brachial plexus blocks. The main objective of the current study was to determine whether addition of buprenorphine could enhance bupivacaine analge...

journal_title：Anesthesiology

authors： Candido KD,Hennes J,Gonzalez S,Mikat-Stevens M,Pinzur M,Vasic V,Knezevic NN

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Directional connectivity from anterior to posterior brain regions (or "feedback" connectivity) has been shown to be inhibited by propofol and sevoflurane. In this study the authors tested the hypothesis that ketamine would also inhibit cortical feedback connectivity in frontoparietal networks. METHODS:Sur...

journal_title：Anesthesiology

authors： Lee U,Ku S,Noh G,Baek S,Choi B,Mashour GA

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Cardiac surgery requiring the use of cardiopulmonary bypass is frequently complicated by coagulopathic bleeding that, largely due to the shortcomings of conventional coagulation tests, is difficult to manage. This study evaluated a novel transfusion algorithm that uses point-of-care coagulation testing. MET...

journal_title：Anesthesiology

authors： Karkouti K,McCluskey SA,Callum J,Freedman J,Selby R,Timoumi T,Roy D,Rao V

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Sympathetic nerve activity was recorded in the leg during high thoracic epidural anesthesia with a segmental sensory blockade of the upper thoracic dermatomes to test the hypothesis that the sympathetic blockade accompanying thoracic epidural anesthesia includes caudal parts of the sympathetic nervous system...

journal_title：Anesthesiology

authors： Magnúsdóttir H,Kirnö K,Ricksten SE,Elam M

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Prostacyclin (PGI2) is known to be an important mediator of peripheral pain sensation (nociception) whereas little is known about its role in central sensitization. METHODS:The levels of the stable PGI2-metabolite 6-keto-prostaglandin F1α (6-keto-PGF1α) and of prostaglandin E2 (PGE2) were measured in the do...

journal_title：Anesthesiology

authors： Schuh CD,Brenneis C,Zhang DD,Angioni C,Schreiber Y,Ferreiros-Bouzas N,Pierre S,Henke M,Linke B,Nüsing R,Scholich K,Geisslinger G

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:During laparoscopic surgery utilizing carbon dioxide as the insufflating agent, nitrous oxide will diffuse into the peritoneal cavity if it is used as part of the anesthetic. Bowel perforation and the subsequent release of volatile bowel gas could create a explosion hazard. METHODS:Two related studies were ...

journal_title：Anesthesiology

authors： Neuman GG,Sidebotham G,Negoianu E,Bernstein J,Kopman AF,Hicks RG,West ST,Haring L

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Enflurane and isoflurane are structural isomers with different anesthetic potencies and side effects. It is not clear whether these differences are produced by differing occupancy of common protein binding sites or by occupancy of different sites, but the very similar molecular properties make the latter pos...

journal_title：Anesthesiology

authors： Liu R,Eckenhoff RG

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The role of endothelial nitric oxide synthase (eNOS) in isoflurane postconditioning (IsoPC)-elicited cardioprotection is poorly understood. The authors addressed this issue using eNOS mice. METHODS:In vivo or Langendorff-perfused mouse hearts underwent 30 min of ischemia followed by 2 h of reperfusion in th...

journal_title：Anesthesiology

authors： Ge ZD,Pravdic D,Bienengraeber M,Pratt PF Jr,Auchampach JA,Gross GJ,Kersten JR,Warltier DC

更新日期：2010-01-01 00:00:00

abstract：:This study examined the efficacy of patient-controlled epidural analgesia (PCEA) during labor and compared the suitability of three different PCEA solutions. After establishing effective epidural analgesia with 12 ml of 0.25% bupivacaine, 72 parturients in active labor were randomly assigned to one of four groups: phy...

journal_title：Anesthesiology

authors： Lysak SZ,Eisenach JC,Dobson CE 2nd

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics depress left ventricular contractile function by altering voltage-dependent slow calcium (Ca2+) channel activity in the sarcolemmal membrane. This investigation examined the left ventricular systolic and diastolic mechanical effects of the dihydropyridine Ca2+ channel antagonist nifedipi...

journal_title：Anesthesiology

authors： Pagel PS,Hettrick DA,Warltier DC

更新日期：1994-07-01 00:00:00

abstract：:The effect of chronic renal failure (RF) on the pharmacokinetics of morphine was studied in nine patients with end-stage RF, aged 58 +/- 8 yr (SD), and in seven control patients, aged 58 +/- 15 yr, undergoing peripheral surgery under general anesthesia. All patients received 0.2 mg X kg-1 as an intravenous bolus injec...

journal_title：Anesthesiology

authors： Chauvin M,Sandouk P,Scherrmann JM,Farinotti R,Strumza P,Duvaldestin P

更新日期：1987-03-01 00:00:00