Buprenorphine enhances and prolongs the postoperative analgesic effect of bupivacaine in patients receiving infragluteal sciatic nerve block.

abstract：:The effect of chronic renal failure (RF) on the pharmacokinetics of morphine was studied in nine patients with end-stage RF, aged 58 +/- 8 yr (SD), and in seven control patients, aged 58 +/- 15 yr, undergoing peripheral surgery under general anesthesia. All patients received 0.2 mg X kg-1 as an intravenous bolus injec...

journal_title：Anesthesiology

authors： Chauvin M,Sandouk P,Scherrmann JM,Farinotti R,Strumza P,Duvaldestin P

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is a sedative with modest analgesic efficacy, whereas remifentanil is an opioid analgesic with modest sedative potency. Synergy is often observed when sedative-hypnotics are combined with opioid analgesics in anesthetic practice. A three-phase crossover trial was conducted to study the pharma...

journal_title：Anesthesiology

authors： Weerink MAS,Barends CRM,Muskiet ERR,Reyntjens KMEM,Knotnerus FH,Oostra M,van Bocxlaer JFP,Struys MMRF,Colin PJ

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The authors' purpose in this study was to compare prospectively four different anesthetic induction and maintenance techniques using nitrous oxide with halothane and/or propofol for vomiting and recovery after outpatient tonsillectomy and adenoidectomy procedures in children. METHODS:Eighty unpremedicated c...

journal_title：Anesthesiology

authors： Ved SA,Walden TL,Montana J,Lea DE,Tefft MC,Kataria BK,Pudimat MA,Nicodemus HF,Milmoe GJ

更新日期：1996-07-01 00:00:00

abstract：:In order to elucidate the possible mechanism(s) by which opiates may affect cerebral and spinal circulation, and cerebral metabolism, cerebral blood flow (CBF) and spinal cord blood flow (SCBF) were measured simultaneously following intravenous or subarachnoid administration of morphine in dogs lightly anesthetized wi...

journal_title：Anesthesiology

authors： Matsumiya N,Dohi S

更新日期：1983-09-01 00:00:00

abstract：:Positive pressure ventilation can affect hemodynamic stability by neuroreflex-mediated activity. Inhalational anesthesia is known to attenuate the arterial baroreflex function; however, little information is known about the effect of volatile anesthetics on the lung inflation reflex. The influence of isoflurane on sta...

journal_title：Anesthesiology

authors： Cheng EY,Kay J,Hoka S,Bosnjak ZJ,Coon RL,Kampine JP

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:A class Ib antiarrhythmic drug, mexiletine, augments relaxations produced by adenosine triphosphate (ATP) sensitive K+ channel openers in isolated rat aortas, suggesting that it produces changes in the vasodilation mediated by ATP-sensitive K+ channels. Nitric oxide can induce its vasodilator effect via K+ c...

journal_title：Anesthesiology

authors： Kinoshita H,Ishikawa T,Hatano Y

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Conventional cardiopulmonary resuscitation (CPR) includes 80-100/min precordial compressions with intermittent positive pressure ventilation (IPPV) after every fifth compression. To prevent gastric insufflation, chest compressions are held during IPPV if the patient is not intubated. Elimination of IPPV woul...

journal_title：Anesthesiology

authors： Hevesi ZG,Thrush DN,Downs JB,Smith RA

更新日期：1999-04-01 00:00:00

abstract：:The solutions to the problems of medical malpractice and malpractice insurance coverage are primarily in the hands of state legislatures. Legislation enacted has been primarily palliative, to assure continued availability of professional liability insurance. Unfortunately, no limit can be placed on the costs of such c...

journal_title：Anesthesiology

authors： Dornette WH

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:In cardiac patients, pulmonary capillary wedge pressure (PCWP) is estimated using color M-mode Doppler study of left ventricular filling and Doppler tissue imaging. The goal of this study was to assess whether echocardiography accurately estimates PCWP in critically ill patients. METHODS:Sixty ventilated pa...

journal_title：Anesthesiology

authors： Bouhemad B,Nicolas-Robin A,Benois A,Lemaire S,Goarin JP,Rouby JJ

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Administrators at hospitals with a fixed annual budget may want to focus surgical services on priority areas to ensure its community receives the best health services possible. However, many hospitals lack the detailed managerial accounting data needed to ensure that such a change does not increase operating...

journal_title：Anesthesiology

authors： Dexter F,Blake JT,Penning DH,Sloan B,Chung P,Lubarsky DA

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:About one in four patients suffers from postoperative nausea and vomiting. Fortunately, risk scores have been developed to better manage this outcome in hospitalized patients, but there is currently no risk score for postdischarge nausea and vomiting (PDNV) in ambulatory surgical patients. METHODS:We conduc...

journal_title：Anesthesiology

authors： Apfel CC,Philip BK,Cakmakkaya OS,Shilling A,Shi YY,Leslie JB,Allard M,Turan A,Windle P,Odom-Forren J,Hooper VD,Radke OC,Ruiz J,Kovac A

更新日期：2012-09-01 00:00:00

abstract：:No significant change in pseudocholinesterase levels was observed in random specimens of whole blood stored for as long as 30 days. Levels in plasma anticoagulated with heparin or ethylenediaminetetraacetic acid declined only slightly. Therefore, massive transfusions do not contraindicate succinylcholine administratio...

journal_title：Anesthesiology

authors： Lanks KW,Sklar GS

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND:The myocardial negative inotropic effects of desflurane are less pronounced than those of other halogenated anesthetics, partly because of intramyocardial catecholamine store release. However, the effects of desflurane on aging myocardium are unknown, whereas aging is known to be associated with an attenuati...

journal_title：Anesthesiology

authors： Rozenberg S,Besse S,Amour J,Vivien B,Tavernier B,Riou B

更新日期：2006-11-01 00:00:00

abstract：:To determine the effects of cardiopulmonary bypass (CPB) and hypothermia on the neuromuscular blockade produced by pancuronium, this relaxant was infused intravenously into 10 anesthetized patients to produce and maintain 90% depression of the twitch tension of the adductor pollicis muscle following supramaximal ulnar...

journal_title：Anesthesiology

authors： d'Hollander AA,Duvaldestin P,Henzel D,Nevelsteen M,Bomblet JP

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and often leads to multiorgan dysfunction and systemic inflammation. Volatile anesthetics have potent antiinflammatory effects. We aimed to determine whether the representative volatile anesthetic isoflurane protects against acut...

journal_title：Anesthesiology

authors： Kim M,Park SW,Kim M,D'Agati VD,Lee HT

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The mechanisms that underlie the supraspinal central nervous system effects of systemic lidocaine are poorly understood and not solely explained by Na(+) channel blockade. Among other potential targets is the hyperpolarization-activated cation current, I(h), which is blocked by lidocaine in peripheral neuron...

journal_title：Anesthesiology

authors： Putrenko I,Schwarz SK

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Labor pain derives primarily from stimulation of afferents innervating the uterine cervix and lower uterine segment. The authors have previously shown that the excitability of these afferents is regulated by sex hormones and test in this study whether pregnancy also alters their excitability. METHODS:After ...

journal_title：Anesthesiology

authors： Liu B,Tong C,Eisenach JC

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Moxonidine, a novel imidazoline-alpha2-adrenergic receptor-selective analgesic, was recently identified as antinociceptive but has yet to be evaluated in neuropathic pain models. alpha2-adrenergic receptor-selective analgesics, and high-efficacy opioids, effectively inhibit neuropathic pain behaviors in rode...

journal_title：Anesthesiology

authors： Fairbanks CA,Nguyen HO,Grocholski BM,Wilcox GL

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The use of nicotinic agonists for analgesia is limited by their unacceptable side effects. Sazetidine-A is a new partial agonist nicotinic ligand that has very high selectivity for beta2-containing nicotinic acetylcholine receptors. It potently and selectively desensitizes alpha4beta2 nicotinic acetylcholine...

journal_title：Anesthesiology

authors： Cucchiaro G,Xiao Y,Gonzalez-Sulser A,Kellar KJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The pharmacokinetics of epidurally administered drugs has been the subject of many studies, yet drug concentration in the epidural space has never been measured. This study was undertaken to characterize the epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidurally administered opioids on the ...

journal_title：Anesthesiology

authors： Bernards CM,Shen DD,Sterling ES,Adkins JE,Risler L,Phillips B,Ummenhofer W

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Neurocognitive dysfunction is a common complication of cardiac surgery using cardiopulmonary bypass (CPB). Elucidating injury mechanisms and developing neuroprotective strategies have been hampered by the lack of a suitable long-term recovery model of CPB. The purpose of this study was to investigate neurolo...

journal_title：Anesthesiology

authors： Mackensen GB,Sato Y,Nellgård B,Pineda J,Newman MF,Warner DS,Grocott HP

更新日期：2001-12-01 00:00:00

abstract：:The thermoregulatory threshold for vasoconstriction has been studied in infants and children given isoflurane, but not in those given halothane anesthesia. More importantly, the effect of vasoconstriction on central temperature in pediatric patients remains unknown. Also unknown is the effect of caudal analgesia on va...

journal_title：Anesthesiology

authors： Bissonnette B,Sessler DI

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Intravenously administered anesthetics directly inhibit airway smooth muscle contraction. Because many anesthetic agents affect membrane ion channel function and sustained contraction of airway smooth muscle requires the influx of Ca2+ through voltage-dependent Ca2+ channels, it was hypothesized that intrave...

journal_title：Anesthesiology

authors： Yamakage M,Hirshman CA,Croxton TL

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Propofol is an intravenous anesthetic agent that may impair host defense system. The aim of this study was to evaluate the effects of propofol on macrophage functions and its possible mechanism. METHODS:Mouse macrophage-like Raw 264.7 cells were exposed to propofol, at 3, 30 (a clinically relevant concentra...

journal_title：Anesthesiology

authors： Chen RM,Wu CH,Chang HC,Wu GJ,Lin YL,Sheu JR,Chen TL

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Massive release of central excitatory neurotransmitters is an important initial step in ischemic neuronal injury, and modification of this process may provide neuroprotection. We studied the protective effects of the voltage-dependent sodium channel antagonist riluzole and the N-methyl-d-aspartate receptor a...

journal_title：Anesthesiology

authors： Lips J,de Haan P,Bodewits P,Vanicky I,Dzoljic M,Jacobs MJ,Kalkman CJ

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:A relatively small number of inhibitory interneurons can control the excitability and synchronization of large numbers of pyramidal cells in hippocampus and other cortical regions. Thus, anesthetic modulation of interneurons could play an important role for the maintenance of anesthesia. The aim of this stud...

journal_title：Anesthesiology

authors： Nishikawa K,MacIver MB

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that volatile anesthetics cause not only vasodilation but also vasoconstriction, depending on the experimental conditions. However, the mechanism of the constrictive effect of volatile anesthetics has not been clarified. The aim of this study was to evaluate the vasoconstrictor effects...

journal_title：Anesthesiology

authors： Kakuyama M,Hatano Y,Nakamura K,Toda H,Terasako K,Nishiwada M,Mori K

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Nitrous oxide causes an acute increase in plasma homocysteine that is more pronounced in patients with the methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C gene variant. In this randomized controlled trial, the authors sought to determine whether patients carrying the MTHFR C677T or A1298C variant...

journal_title：Anesthesiology

authors： Nagele P,Brown F,Francis A,Scott MG,Gage BF,Miller JP,VINO Study Team.

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Recent evidences have documented that several pharmacologic actions of alpha2-adrenoceptor agonists are mediated via activation of not only alpha2-adrenoceptors, but also by imidazoline receptors, which are nonadrenergic receptors in the central nervous system. However, the effect of imidazoline receptors on...

journal_title：Anesthesiology

authors： Kagawa K,Mammoto T,Hayashi Y,Kamibayashi T,Mashimo T,Yoshiya I

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:The combining of epidural anesthesia with general anesthesia impairs central and peripheral thermoregulatory control and therefore is often accompanied by unintended intraoperative hypothermia. However, little is known about the cardiovascular response to hypothermia during combined epidural and general anes...

journal_title：Anesthesiology

authors： Yoshida M,Shibata K,Itoh H,Yamamoto K

更新日期：2001-04-01 00:00:00