Role of K+ channels in augmented relaxations to sodium nitroprusside induced by mexiletine in rat aortas.

abstract：:Interposition of activated carbon between a nitrogen analyzer needle valve and gas mixtures containing halothane, methoxyflurane, enflurane, or isoflurane eliminated the interfering effects of these agents, but added sampling delays. Placement of a carbon-filled Swinney adaptor in the sampling line between the needle ...

journal_title：Anesthesiology

authors： Gilmour IJ,Holland R,Craig DB

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:It is well established that neuronal nicotinic acetylcholine receptors (nAChRs) are sensitive to inhalational anesthetics. The authors previously reported that halothane potently blocked alpha4beta2-type nAChRs of rat cortical neurons. However, the effect of isoflurane, which is widely used clinically, on nA...

journal_title：Anesthesiology

authors： Yamashita M,Mori T,Nagata K,Yeh JZ,Narahashi T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Melanocortin peptides improve hemodynamic parameters and prevent death during severe hemorrhagic shock. In the present research we determined influences of a synthetic melanocortin 1/4 receptor agonist on the molecular changes that occur in rat liver during hemorrhage. METHODS:Controlled-volume hemorrhage w...

journal_title：Anesthesiology

authors： Lonati C,Sordi A,Giuliani D,Spaccapelo L,Leonardi P,Carlin A,Ottani A,Galantucci M,Grieco P,Catania A,Guarini S

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Age is a known risk factor for postoperative complications, but the genetic factors that account for variability in age at presentation for surgery have not been characterized. Because thrombosis is a critical process in the development of coronary syndromes, the authors hypothesized that patients bearing th...

journal_title：Anesthesiology

authors： Donahue BS,Byrne DW,Gailani D,George AL Jr

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Animal studies have provided considerable evidence to support a role of histamine in the central nervous system in thermoregulation, and premedication with a histamine H2 receptor antagonist before general anesthesia is used to reduce the risk of acid aspiration. The authors investigated whether premedicatio...

journal_title：Anesthesiology

authors： Hirose M,Hara Y,Matsusaki M

更新日期：1995-12-01 00:00:00

abstract：:The effects of halothane, tetrodotoxin (TTX), veratridine (VTD), and alterations of extracellular calcium ion concentration [Ca++]0) on regional differences of canine Purkinje fiber action potential duration (APD50 and APD90) were investigated in vitro at a paced rate of 75 beats per min. Under control conditions (n =...

journal_title：Anesthesiology

authors： Turner LA,Marijic J,Kampine JP,Bosnjak ZJ

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Recent interest in shortening the fasting interval after ingestion of milk products demonstrated large volumes of breast milk in the stomach 2 h after breastfeeding. Although aspiration is a rare event, if it were to occur with human breast milk, it is important to understand the extent of the lung injury th...

journal_title：Anesthesiology

authors： O'Hare B,Lerman J,Endo J,Cutz E

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:The authors evaluated optimal adrenergic support using norepinephrine, dopamine, and dobutamine in a clinically relevant model of septic shock. METHODS:Twenty-eight mature, female, anesthetized sheep (weight, 30.5 +/- 3.6 kg) underwent cecal ligation and perforation and were randomized into four groups of s...

journal_title：Anesthesiology

authors： Sun Q,Tu Z,Lobo S,Dimopoulos G,Nagy N,Rogiers P,De Backer D,Vincent JL

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Systemic magnesium has been used to minimize postoperative pain with conflicting results by clinical studies. It remains unknown whether the administration of perioperative systemic magnesium can minimize postoperative pain. The objective of the current investigation was to evaluate the effect of systemic ma...

journal_title：Anesthesiology

authors： De Oliveira GS Jr,Castro-Alves LJ,Khan JH,McCarthy RJ

更新日期：2013-07-01 00:00:00

abstract：INTRODUCTION:Spinal alpha2-adrenoceptor stimulation produces analgesia in neuropathic pain states, and this effect in animals is blocked by the inhibitors of brain-derived neurotrophic factor (BDNF) function. In rats, alpha2-adrenoceptor stimulation normally inhibits acetylcholine release, but it excites release after ...

journal_title：Anesthesiology

authors： Hayashida K,Eisenach JC

更新日期：2010-08-01 00:00:00

abstract：:To examine the effects of cardiac surgery and cardiopulmonary bypass (CPB) on the lung, functional residual capacity (FRC) and lung-thorax compliance were measured at four stages during open heart surgery in 15 children. The patients were anesthetized with fentanyl/droperidol and N2O/O2, paralyzed, and ventilated with...

journal_title：Anesthesiology

authors： Jonmarker C,Larsson A,Werner O

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Initial postoperative core temperature is a physician and hospital performance measure. However, the extent to which core temperature changes during emergence from anesthesia and transport from the operating room to the postanesthesia care unit (PACU) remains unknown. Similarly, the accuracy of many noninvas...

journal_title：Anesthesiology

authors： Langham GE,Maheshwari A,Contrera K,You J,Mascha E,Sessler DI

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Oral clonidine may influence plasma glucose and lipid homeostasis by modulating endocrinologic responses to surgical stress. The effect of oral clonidine premedication on plasma glucose and lipid homeostasis associated with exogenous glucose infusion were investigated in children undergoing minor surgery. M...

journal_title：Anesthesiology

authors： Nishina K,Mikawa K,Maekawa N,Shiga M,Obara H

更新日期：1998-04-01 00:00:00

abstract：:The effect of decreased cerebral perfusion pressure (CPP) on regional cerebral blood flow (CBF) with radiolabeled microspheres in dogs receiving either 1.4% or 2.8% isoflurane following anesthesia induction with thiopental (12 mg/kg, iv bolus) was studied. Mean arterial blood pressure (MABP), cerebrospinal fluid press...

journal_title：Anesthesiology

authors： McPherson RW,Traystman RJ

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:Breast surgery is associated with a high incidence of postoperative nausea and vomiting. Propofol and prophylactic administration of ondansetron are associated with a lower incidence of postoperative nausea and vomiting. To date no comparison of these two drugs has been reported. A randomized study was done ...

journal_title：Anesthesiology

authors： Gan TJ,Ginsberg B,Grant AP,Glass PS

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Days alive and out of hospital is a potentially useful patient-centered quality measure for perioperative care in adult surgical patients. However, there has been very limited prior validation of this endpoint with respect to its ability to capture differences in patient-level risk factor profiles and longer...

journal_title：Anesthesiology

authors： Jerath A,Austin PC,Wijeysundera DN

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:An animal experimental model of acute lung injury after intratracheal instillation of acidified milk products has been recently demonstrated. Exogenous administration of surfactant has proved to be successful treatment for acute lung injury induced by many causes including acid aspiration. The authors conduc...

journal_title：Anesthesiology

authors： Nishina K,Mikawa K,Takao Y,Maekawa N,Obara H

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Studies have shown that permissive hypotension for uncontrolled hemorrhagic shock can result in good resuscitation outcome. The ideal target mean arterial pressure (MAP) and the tolerance time for permissive hypotension have not been determined. METHODS:To elucidate the ideal target MAP and tolerance time f...

journal_title：Anesthesiology

authors： Li T,Zhu Y,Hu Y,Li L,Diao Y,Tang J,Liu L

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Active sodium transport is the primary mechanism that drives alveolar fluid clearance. In the current study, the effects of exposure to halothane and isoflurane on alveolar fluid clearance in rats were evaluated. METHODS:Rats were exposed to either halothane (0.4% for 6 h or 2% for 2 h) or isoflurane (0.6% ...

journal_title：Anesthesiology

authors： Rezaiguia-Delclaux S,Jayr C,Luo DF,Saïdi NE,Meignan M,Duvaldestin P

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:N-methyl-D-aspartate (NDMA) antagonists have minimal effects on acute nociception but block facilitated states of processing. In contrast, the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonists decrease acute noxious responses. Morphine (a mu-opioid agonist) can also decrease acute n...

journal_title：Anesthesiology

authors： Nishiyama T,Yaksh TL,Weber E

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical pain. The relation...

journal_title：Anesthesiology

authors： Peters CM,Hayashida K,Suto T,Houle TT,Aschenbrenner CA,Martin TJ,Eisenach JC

更新日期：2015-04-01 00:00:00

abstract：:The neonatal heart is especially vulnerable to cardiac depression caused by halothane. The cause of this sensitivity is uncertain. Isolated, perfused, isovolumic, contracting neonatal rabbit hearts were studied using 31P NMR to determine whether changes in concentrations of high energy phosphates (HEP) or intracellula...

journal_title：Anesthesiology

authors： McAuliffe JJ,Hickey PR

更新日期：1987-08-01 00:00:00

abstract：:The purpose of this study was to evaluate the analgesic contribution of intravenously administered lidocaine and to correlate it with blood levels of the drug. In a double-blind manner, 14 healthy male volunteers received saline solution or lidocaine, 0.2 per cent, at three increasingly greater rates of infusion on tw...

journal_title：Anesthesiology

authors： Rowlingson JC,DiFazio CA,Foster J,Carron H

更新日期：1980-01-01 00:00:00

abstract：:Blood from 20 ASA physical status I patients collected before and after induction of anesthesia was used in vitro to reexamine the effects of nitrous oxide on the oxyhemoglobin dissociation curve and the response of the oxygen electrode. The preinduction P50 values with and without 70% N2O were 28.4 +/- 0.1 mmHg and 2...

journal_title：Anesthesiology

authors： Kambam JR,Holaday DA

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:The permutation entropy, the approximate entropy, and the index of consciousness are some of the most recently studied electroencephalogram-derived indexes. In this work, a thorough comparison of these indexes was performed using propofol anesthesia in a rabbit model. METHODS:Six rabbits were anesthetized w...

journal_title：Anesthesiology

authors： Silva A,Campos S,Monteiro J,Venâncio C,Costa B,Guedes de Pinho P,Antunes L

更新日期：2011-08-01 00:00:00

abstract：:Continuous lumbar epidural anesthesia was instituted in 49 healthy parturients who were randomly assigned to three treatment groups: 14 patients received chloroprocaine, 3 per cent; 19 received bupivacaine, 0.5 per cent, and 16 received a mixture containing chloroprocaine, 1.5 per cent, and bupivacaine, 0.375 per cent...

journal_title：Anesthesiology

authors： Cohen SE,Thurlow A

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:Airway pressure-release ventilation provides ventilation comparable to controlled mechanical ventilation (CMV), but with lower peak airway pressures and less dead-space ventilation. To obtain these advantages for patients administered general anesthesia, the authors (1) designed a mode similar to airway pres...

journal_title：Anesthesiology

authors： Bratzke E,Downs JB,Smith RA

更新日期：1998-08-01 00:00:00

abstract：:The dosage and blood concentration of lidocaine required to produce central nervous and cardiovascular system toxicity in both nonasphyxiated and asphyxiated fetuses were determined in ten pregnant baboons with fetuses of average gestation of 158 days (term, 185 days). Lidocaine was infused into the fetal jugular vein...

journal_title：Anesthesiology

authors： Morishima HO,Covino BG

更新日期：1981-03-01 00:00:00

abstract：:Dexmedetomidine (DMED) is a novel alpha 2 adrenergic agonist that has been shown to have potent analgesic and anesthetic sparing effects. This study was designed to investigate the effects of DMED, both alone and combined with isoflurane, on resting ventilation, the hypercapnic response, and the hypoxic response in do...

journal_title：Anesthesiology

authors： Nguyen D,Abdul-Rasool I,Ward D,Hsieh J,Kobayashi D,Hadlock S,Singer F,Bloor B

更新日期：1992-04-01 00:00:00

abstract：:The metabolism of alfentanil was studied in three healthy subjects after a 1-h infusion of 2.5 mg alfentanil-3H. One of the subjects was a poor hydroxylator of debrisoquine. Pharmacokinetic parameters were similar in the three subjects and were in the same range as those reported for volunteers. The majority of the ad...

journal_title：Anesthesiology

authors： Meuldermans W,Van Peer A,Hendrickx J,Woestenborghs R,Lauwers W,Heykants J,Vanden Bussche G,Van Craeyvelt H,Van der Aa P

更新日期：1988-10-01 00:00:00