Ventilatory effects of dexmedetomidine, atipamezole, and isoflurane in dogs.

abstract：BACKGROUND:The long-term use of opioids for analgesia carries significant risk for tolerance, addiction, and diversion. These adverse effects are largely mediated by μ-opioid receptors in the central nervous system. Based on the authors' previous observation that morphine and δ-opioid receptor agonists synergize in spi...

journal_title：Anesthesiology

authors： Bruce DJ,Peterson CD,Kitto KF,Akgün E,Lazzaroni S,Portoghese PS,Fairbanks CA,Wilcox GL

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:With percutaneous recordings of muscle nerve sympathetic activity (MSA), it is possible to study interactions between the autonomic nervous system and anesthetics. This study describes the effects of propofol infusion both before and during microlaryngoscopy. METHODS:Nine patients participated. MSA was reco...

journal_title：Anesthesiology

authors： Sellgren J,Ejnell H,Elam M,Pontén J,Wallin BG

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Forced-air warming is sometimes unable to maintain perioperative normothermia. Therefore, the authors compared heat transfer, regional heat distribution, and core rewarming of forced-air warming with a novel circulating-water garment. METHODS:Nine volunteers were each evaluated on two randomly ordered study...

journal_title：Anesthesiology

authors： Taguchi A,Ratnaraj J,Kabon B,Sharma N,Lenhardt R,Sessler DI,Kurz A

更新日期：2004-05-01 00:00:00

abstract：:Distribution and elimination of lidocaine and mepivacaine were studies in 114 subjects after obstetric epidural anesthesia, Epinephrine significantly lowered the concentrations of lidocaine in the mothers' circulations by about 33 per cent, and the concentrations of mepivacaine by about 22 per cent. It also significan...

journal_title：Anesthesiology

authors： Brown WU,Bell GC,Lurie AO,Weiss B,Scanlon JW,Alper MH

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:Aprotinin has been reported to reduce blood loss and transfusion requirements in patients having major orthopedic operations. Data on whether epsilon amino-caproic acid (EACA) is effective in this population are sparse. METHODS:Sixty-nine adults with malignancy scheduled for either pelvic, extremity or spin...

journal_title：Anesthesiology

authors： Amar D,Grant FM,Zhang H,Boland PJ,Leung DH,Healey JA

更新日期：2003-02-01 00:00:00

abstract：:The authors determined the effects of intravenous infusion and epidural administration of lidocaine on the control of ventilation in two groups of eight healthy unpremedicated subjects. In the intravenous group, an injection of 1.5 mg/kg lidocaine was followed by an infusion at a rate of 60 micrograms X kg-1 X min-1 f...

journal_title：Anesthesiology

authors： Labaille T,Clergue F,Samii K,Ecoffey C,Berdeaux A

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:General anesthetics may modify airway responsiveness. The authors investigated the effect of thiopental, propofol, and etomidate on airway smooth muscle. METHODS:Contraction experiments were done in human airway rings that were either normal or passively sensitized with asthmatic serum. The effect of propof...

journal_title：Anesthesiology

authors： Ouedraogo N,Roux E,Forestier F,Rossetti M,Savineau JP,Marthan R

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Previous studies integrated opioid benefit and harm into one single function-the utility function-to determine the drug toxicity (respiratory depression) in light of its wanted effect (analgesia). This study further refined the concept of the utility function using the respiratory and analgesic effects of th...

journal_title：Anesthesiology

authors： Roozekrans M,van der Schrier R,Aarts L,Sarton E,van Velzen M,Niesters M,Dahan A,Olofsen E

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Optimal risk adjustment is a requisite precondition for monitoring quality of care and interpreting public reports of hospital outcomes. Current risk-adjustment measures have been criticized for including baseline variables that are difficult to obtain and inadequately adjusting for high-risk patients. The a...

journal_title：Anesthesiology

authors： Dalton JE,Kurz A,Turan A,Mascha EJ,Sessler DI,Saager L

更新日期：2011-06-01 00:00:00

abstract：:Critically ill patients must often breathe spontaneously through an endotracheal tube that acts as a fixed inspiratory and expiratory tubular airway resistor. Although this practice is common, its effect on the pattern of breathing is not known. The mean breathing patterns of seven normal, healthy male subjects and ei...

journal_title：Anesthesiology

authors： Weissman C,Askanazi J,Rosenbaum SH,Damask MC,Hyman AI,Kinney JM

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:The analgesic efficacy and side effect profile of intravenous parecoxib, a novel cyclooxygenase type-2 (COX-2) inhibitor, was assessed in a double-blinded, placebo-controlled study involving patients undergoing major gynecologic surgical procedures. METHODS:After Institutional Review Board approval, 60 cons...

journal_title：Anesthesiology

authors： Tang J,Li S,White PF,Chen X,Wender RH,Quon R,Sloninsky A,Naruse R,Kariger R,Webb T,Norel E

更新日期：2002-06-01 00:00:00

abstract：:Robert D. Dripps, M.D. (1911 to 1973), helped found academic anesthesiology. Newly reviewed teaching slides from the University of Pennsylvania (Philadelphia, Pennsylvania) contain six anesthesia records from 1965 to 1967 that involved Dripps. They illustrate the clinical philosophy he taught-to consider administratio...

journal_title：Anesthesiology

authors： Johnstone RE,Fleisher LA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Sevoflurane is a volatile general anesthetic that differs in chemical nature from the gaseous anesthetic nitrous oxide. In a controlled laboratory setting, the authors characterized the subjective, psychomotor, and analgesic effects of sevoflurane and nitrous oxide at two equal minimum alveolar subanesthetic...

journal_title：Anesthesiology

authors： Galinkin JL,Janiszewski D,Young CJ,Klafta JM,Klock PA,Coalson DW,Apfelbaum JL,Zacny JP

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Ca2+-permeable non-N-methyl-D-aspartate receptors are found in the spinal dorsal horn and represent a presumptive target for glutamatergic transmission in nociceptive processing. This study characterized the analgesic profile associated with the blockade of these spinal receptors by intrathecally delivered a...

journal_title：Anesthesiology

authors： Sorkin LS,Yaksh TL,Doom CM

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Lamotrigine is a sodium channel blocker that inhibits the neuronal release of glutamate. Systemic administration of lamotrigine induces analgesia in short- and long-term models of hyperalgesia in rats. Considering the key role of N-methyl-D-aspartate receptors in the sensitization of dorsal horn neurons that...

journal_title：Anesthesiology

authors： Klamt JG

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Chloroprocaine has been associated with severe back pain after epidural anesthesia. Factors proposed to contribute to this problem are: 1) the preservative disodium ethylenediaminetetraacetic acid (EDTA), 2) large volumes of chloroprocaine, 3) low pH of chloroprocaine, and 4) local infiltration with chloropr...

journal_title：Anesthesiology

authors： Stevens RA,Urmey WF,Urquhart BL,Kao TC

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Rapid assessment of hepatic function early after reperfusion of the liver graft is of great importance, because it may allow for prompt detection of incipient hepatic graft failure. The current study was undertaken to determine whether the continuous recording of neuromuscular transmission could be used as a...

journal_title：Anesthesiology

authors： Pittet JF,Morel DR,Mentha G,Schopfer C,Belenger J,Benakis A,Tassonyi E

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Potentiation by general anesthetics of gamma-aminobutyric acid (GABA)-mediated inhibitory transmission in the central nervous system is attributed to GABA(A) receptor-mediated postsynaptic effects. However, the role of presynaptic mechanisms in general anesthetic action is not well characterized, and evidenc...

journal_title：Anesthesiology

authors： Murugaiah KD,Hemmings HC Jr

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics such as isoflurane are widely used in clinical and research contexts. Concerns have been raised that the effects of these drugs on the central nervous system may result in long-term impairment after surgery or general anesthesia. Hence, this study aimed to detect how different isoflurane...

journal_title：Anesthesiology

authors： Valentim AM,Di Giminiani P,Ribeiro PO,Rodrigues P,Olsson IA,Antunes LM

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Isoflurane anesthesia produces cardiovascular and respiratory depression, although the specific mechanisms are not fully understood. Cranial visceral afferents, which innervate the heart and lungs, synapse centrally onto neurons within the medial portion of the nucleus tractus solitarius (NTS). Isoflurane mo...

journal_title：Anesthesiology

authors： Peters JH,McDougall SJ,Mendelowitz D,Koop DR,Andresen MC

更新日期：2008-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the analgesic contribution of intravenously administered lidocaine and to correlate it with blood levels of the drug. In a double-blind manner, 14 healthy male volunteers received saline solution or lidocaine, 0.2 per cent, at three increasingly greater rates of infusion on tw...

journal_title：Anesthesiology

authors： Rowlingson JC,DiFazio CA,Foster J,Carron H

更新日期：1980-01-01 00:00:00

abstract：:To assess depth of anesthesia for intravenous anesthetics using clinical stimuli and observed responses, it is necessary to achieve constant serum concentrations of drug that result in constant biophase or central nervous system concentrations. The goal of this investigation was to use a computer-controlled infusion p...

journal_title：Anesthesiology

authors： Bührer M,Maitre PO,Hung OR,Ebling WF,Shafer SL,Stanski DR

更新日期：1992-08-01 00:00:00

abstract：:The treatment of venous air embolism by aspiration from central venous catheters is well established. However, some anesthesiologists prefer to use a pulmonary artery catheter to monitor patients undergoing a neurosurgical procedure in the sitting position. While offering certain advantages, pulmonary artery catheters...

journal_title：Anesthesiology

authors： Bowdle TA,Artru AA

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:Opioids are powerful analgesics, but are also common drugs of abuse. Few studies have examined how neuropathic pain alters the pharmacology of opioids in modulating limbic pathways that underlie abuse liability. METHODS:Rats with or without spinal nerve ligation (SNL) were implanted with electrodes into t...

journal_title：Anesthesiology

authors： Ewan EE,Martin TJ

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Ketamine is an anesthetic drug. Subanesthetic doses of ketamine have been shown to reduce interleukin-6 concentrations after surgery and to reduce mortality and the production of tumor necrosis factor alpha and interleukin 6 in septic animals. Similarly, adenosine was shown to reduce tumor necrosis factor al...

journal_title：Anesthesiology

authors： Mazar J,Rogachev B,Shaked G,Ziv NY,Czeiger D,Chaimovitz C,Zlotnik M,Mukmenev I,Byk G,Douvdevani A

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:To eliminate the influence of hydrostatic pressure, proper transducer positions for central venous pressure and pulmonary artery wedge pressure are at the uppermost blood levels of right atrium (RA) and left atrium (LA). This study was performed to investigate accurate reference levels of central venous pres...

journal_title：Anesthesiology

authors： Seo JH,Jung CW,Bahk JH

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:In pediatric patients, the Bispectral Index (BIS), derived from the electroencephalogram, and the composite A-Line autoregressive index (cAAI), derived from auditory evoked potentials and the electroencephalogram, have been used as measurements of depth of hypnosis during anesthesia. The performance and reli...

journal_title：Anesthesiology

authors： Blussé van Oud-Alblas HJ,Peters JW,de Leeuw TG,Tibboel D,Klein J,Weber F

更新日期：2008-05-01 00:00:00

abstract：:The time course of changes in brain electrical activity during halothane anesthesia was examined in 12 malignant hyperthermia-susceptible (MHS) and 14 normal (nMHS) swine. Power densities in selected frequency bands were calculated from the electroen-cephalogram (EEG). EEG and systemic variables were determined over a...

journal_title：Anesthesiology

authors： Kochs E,Hoffman WE,Roewer N,Schulte am Esch J

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Cerebrospinal fluid (CSF) outflow to intra- and extracranial subarachnoid spaces caused by arterial inflow to the brain predominantly compensates systolic increases in cerebral blood volume. Phase-contrast magnetic resonance imaging is a new tool for noninvasive assessment of CSF displacement by measuring CS...

journal_title：Anesthesiology

authors： Kolbitsch C,Schocke M,Lorenz IH,Kremser C,Zschiegner F,Pfeiffer KP,Felber S,Aichner F,Hörmann C,Benzer A

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) attenuates the conversion of plasminogen to plasmin. Polymorphisms of the PAI-1 gene are associated with varying PAI-1 levels and risk of prothrombotic events in nonsurgical patients. The purpose of this study, a secondary analysis of a clinical trial, was to investi...

journal_title：Anesthesiology

authors： Iribarren JL,Jimenez JJ,Hernández D,Brouard M,Riverol D,Lorente L,de La Llana R,Nassar I,Perez R,Martinez R,Mora ML

更新日期：2008-04-01 00:00:00