Alterations in brain electrical activity may indicate the onset of malignant hyperthermia in swine.

abstract：BACKGROUND:Some patients develop recrudescence after a malignant hyperthermia (MH) reaction, but it is not clear which patients are at risk. The authors analyzed clinical variables associated with recrudescence after a clinical MH episode. METHODS:Data were obtained from Adverse Metabolic Reaction to Anesthesia report...

journal_title：Anesthesiology

authors： Burkman JM,Posner KL,Domino KB

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:We previously described the use of the nematode Caenorabditis elegans as a genetic model for studying the mechanism of action of volatile anesthetics. All previous strains of C. elegans with altered responses to anesthetics have been identified by screening the response to halothane. The current study was de...

journal_title：Anesthesiology

authors： Morgan PG,Sedensky MM

更新日期：1994-10-01 00:00:00

abstract：:Ropivacaine is an amide local anesthetic structurally related to, but appearing less cardiotoxic, than bupivacaine. The authors' investigation was designed in a randomized, double-blind fashion to compare the clinical effectiveness of ropivacaine and bupivacaine in patients undergoing lower-extremity surgery. Forty-fi...

journal_title：Anesthesiology

authors： Brown DL,Carpenter RL,Thompson GE

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene (677C>T, 1298A>C) cause elevated plasma homocysteine concentrations and have been linked to fatal outcomes after nitrous oxide anesthesia. This study tested the hypothesis that patients with common MTHFR 677C>T or 1298A>C mutations develop hig...

journal_title：Anesthesiology

authors： Nagele P,Zeugswetter B,Wiener C,Burger H,Hüpfl M,Mittlböck M,Födinger M

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Diphenhydramine is used as an antipruritic and antiemetic in patients receiving opioids. Whether it might exacerbate opioid-induced ventilatory depression has not been determined. METHODS:The ventilatory response to carbon dioxide during hyperoxia and the ventilatory response to hypoxia during hypercapnia (...

journal_title：Anesthesiology

authors： Babenco HD,Blouin RT,Conard PF,Gross JB

更新日期：1998-09-01 00:00:00

abstract：:Patients with mitral valve disease can develop pulmonary artery hypertension that persists after mitral valve replacement. In 1987, nitric oxide (NO) was reported to be an important factor accounting for the biologic activity of endothelium-derived relaxing factor. Inhaled NO was subsequently reported to be a selectiv...

journal_title：Anesthesiology

authors： Girard C,Lehot JJ,Pannetier JC,Filley S,Ffrench P,Estanove S

更新日期：1992-11-01 00:00:00

abstract：:This study examined whether pain or stress can enhance the analgesic effects of spinally administered opiates. The experiments determined the effects of mechanically produced pain and of the stress of being restrained on the analgesic effects of 0.63 microgram of epidural sufentanil in rats using a tail-withdrawal pro...

journal_title：Anesthesiology

authors： Van den Hoogen RH,Bervoets K,Colpaert FC

更新日期：1988-07-01 00:00:00

abstract：:No significant change in pseudocholinesterase levels was observed in random specimens of whole blood stored for as long as 30 days. Levels in plasma anticoagulated with heparin or ethylenediaminetetraacetic acid declined only slightly. Therefore, massive transfusions do not contraindicate succinylcholine administratio...

journal_title：Anesthesiology

authors： Lanks KW,Sklar GS

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND:Ca is the dominant second messenger in primary sensory neurons. In addition, disrupted Ca signaling is a prominent feature in pain models involving peripheral nerve injury. Standard cytoplasmic Ca recording techniques use high K or field stimulation and dissociated neurons. To compare findings in intact dors...

journal_title：Anesthesiology

authors： Gemes G,Rigaud M,Koopmeiners AS,Poroli MJ,Zoga V,Hogan QH

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:We aimed to assess the clinical effectiveness of intravenous exenatide compared to insulin in perioperative blood glucose control in coronary artery bypass grafting surgery patients. METHODS:Patients more than 18 yr old admitted for elective coronary artery bypass grafting were included in a phase II/III no...

journal_title：Anesthesiology

authors： Besch G,Perrotti A,Mauny F,Puyraveau M,Baltres M,Flicoteaux G,Salomon du Mont L,Barrucand B,Samain E,Chocron S,Pili-Floury S

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that desflurane and isoflurane produce similar hemodynamic actions. This investigation examined the cardiovascular effects of desflurane and isoflurane in the presence or absence of dexmedetomidine, a highly selective alpha 2-adrenergic agonist that may be clinically useful as a p...

journal_title：Anesthesiology

authors： Kersten J,Pagel PS,Tessmer JP,Roerig DL,Schmeling WT,Warltier DC

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The observation that peripheral trauma causes enhanced spinal neuronal excitability has provided the scientific rationale for the concept of "pre-emptive analgesia." The premise has been that only noxious stimuli cause sensitization in sensory pathways, but this premise has not been tested in the conscious s...

journal_title：Anesthesiology

authors： Herrero JF,Headley PM

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate a new, physiologically inspired method for the analysis of the electroencephalogram during propofol-remifentanil anesthesia. Based on fixed-order autoregressive moving-average modeling, this method was hypothesized to be capable of dissociating the effects that hypno...

journal_title：Anesthesiology

authors： Liley DT,Sinclair NC,Lipping T,Heyse B,Vereecke HE,Struys MM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Intensive care unit (ICU) patients often need blood transfusion, but no reliable predictors of transfusion requirements are available at ICU admission. The authors hypothesized that ICU patients with functional iron deficiency may be at higher risk for developing anemia, requiring blood transfusion. Their ob...

journal_title：Anesthesiology

authors： Fernandez R,Tubau I,Masip J,Muñoz L,Roig I,Artigas A

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:The mechanisms of action of general anesthetics are not completely understood. Many general anesthetics are reported to potentiate gamma-aminobutyric acid (GABAA) and glycine receptors in the central nervous system (CNS) and to inhibit the muscle-type nicotinic acetylcholine receptor (nAChR). The effects of ...

journal_title：Anesthesiology

authors： Flood P,Ramirez-Latorre J,Role L

更新日期：1997-04-01 00:00:00

abstract：:The cerebral metabolic effects of a massive dose of thiopental (177 mg/kg) were investigated in seven dogs. The systemic circulation was supported with an extracorporeal circuit. At an infusion rate of 2 mg/kg/min, cerebral oxygen consumption (CMR(O(2))) decreased progressively until cerebral electrical silence was pr...

journal_title：Anesthesiology

authors： Michenfelder JD

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The authors sought to understand neural correlates of anesthetic-induced unconsciousness. Cortical gamma oscillations have been associated with neural processes supporting conscious perception, but the effect of general anesthesia on these oscillations is controversial. In this study, the authors examined th...

journal_title：Anesthesiology

authors： Imas OA,Ropella KM,Ward BD,Wood JD,Hudetz AG

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Offset analgesia, in which a disproportionally large amount of analgesia becomes apparent upon a slight decrease in noxious heat stimulation, has not been described previously in patients with chronic pain. METHODS:Offset analgesia responses in 10 patients with neuropathic pain (in both legs) were compared ...

journal_title：Anesthesiology

authors： Niesters M,Hoitsma E,Sarton E,Aarts L,Dahan A

更新日期：2011-11-01 00:00:00

abstract：:To determine whether disuse atrophy of skeletal muscle results in resistance to pancuronium, the dose response to pancuronium was determined simultaneously in both gastrocnemius muscles of six dogs that had one hind limb immobilized in a plaster cast for one month. Muscle responses were evoked during pentobarbital-nit...

journal_title：Anesthesiology

authors： Gronert GA

更新日期：1981-11-01 00:00:00

abstract：:The safety and efficacy of epidural morphine injected into the caudal space for control of postoperative pain following open cardiac surgery in children was studied. Thirty-two children between the ages of 2-12 yr for whom early postoperative tracheal extubation was anticipated were randomly assigned to control and st...

journal_title：Anesthesiology

authors： Rosen KR,Rosen DA

更新日期：1989-03-01 00:00:00

abstract：:The effects of halothane on the beating response of rat heart cells in tissue culture were studied using an optical-electronic monitoring device. A dose-response curve was obtained over a concentration range to as much as 5 vol per cent halothane. The clinical dosage of 1 vol per cent halothane decreased the inotropic...

journal_title：Anesthesiology

authors： Stong LJ,Hartzell CR,McCarl RL

更新日期：1975-02-01 00:00:00

abstract：:The goal of this randomized study of high-risk surgical patients was to determine whether intraoperative thoracic epidural anesthesia in combination with light general anesthesia alters postoperative morbidity when compared to a standard technique of "balanced" general anesthesia. A total of 173 patients scheduled for...

journal_title：Anesthesiology

authors： Baron JF,Bertrand M,Barré E,Godet G,Mundler O,Coriat P,Viars P

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Pulsus alternans is a classic type of abnormal pulse. It can be defined as a regular alternation of pulse amplitude in which runs of weak and strong beats follow each other alternatively without any change in cycle length. It may be a sign of severe decompensated congestive heart failure. The authors infrequ...

journal_title：Anesthesiology

authors： Saghaei M,Mortazavian M

更新日期：2000-07-01 00:00:00

abstract：:The effects of subparalytic doses of succinylcholine and d-tubocurarine on epinephrine-induced cardiac arrhythmias during halothane anesthesia were evaluated in dogs. Succinylcholine markedly increased (P is less than .05) the arrhythmogenicity of epinephrine and d-tubocurarine slightly decreased (P is less than .05) ...

journal_title：Anesthesiology

authors： Tucker WK,Munson ES

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Mechanical ventilation is delivered to sedated patients during anesthesia, but also to nonsedated patients (ventilator weaning, noninvasive ventilation). In these circumstances, patient-ventilator asynchrony may occur, provoking discomfort and unduly increasing work of breathing. In certain cases, it is asso...

journal_title：Anesthesiology

authors： Raux M,Ray P,Prella M,Duguet A,Demoule A,Similowski T

更新日期：2007-11-01 00:00:00

abstract：:Substance abuse is a major socioeconomic problem. However, the ready availability of potent narcotic and sedative drugs probably constitutes a unique risk for anesthesiologists. Until recently, few anesthesia departments were prepared to recognize or safely manage afflicted colleagues. Because we felt it important to ...

journal_title：Anesthesiology

authors： Lecky JH,Aukburg SJ,Conahan TJ 3rd,Geer RT,Ominsky AJ,Gross J,Muravchick S,Wollman H

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Tracheal intubation frequently results in reversible bronchoconstriction. Propofol has been reported to minimize this response in healthy patients and in asthma patients, but may be unsuitable for hemodynamically unstable patients for whom etomidate may be preferable. The current study examined respiratory r...

journal_title：Anesthesiology

authors： Eames WO,Rooke GA,Wu RS,Bishop MJ

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:The concept of the axillary "sheath" has been a central tenet of brachial plexus regional anesthesia for many years. Recent investigations have cast doubt on its nature and existence. This study further examines the issue. METHODS:Computerized axial tomographic dye studies were performed using continuous ca...

journal_title：Anesthesiology

authors： Cornish PB,Leaper C

更新日期：2006-09-01 00:00:00

abstract：:Anesthesia and surgery are a risk for all, the healthy as well as the sick. While the prevention of adverse outcomes in healthy patients is paramount, enhancement of safety for critically ill patients is also essential, since they are more likely to suffer a SNO after a critical incident. Dangers originate from a vari...

journal_title：Anesthesiology

authors： Gaba DM,Maxwell M,DeAnda A

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Perioperative ischemic optic neuropathy (ION) causes visual loss in spinal fusion. Previous case-control studies are limited by study size and lack of a random sample. The purpose of this study was to study trends in ION incidence in spinal fusion and risk factors in a large nationwide administrative hospita...

journal_title：Anesthesiology

authors： Rubin DS,Parakati I,Lee LA,Moss HE,Joslin CE,Roth S

更新日期：2016-09-01 00:00:00