Positive experimental demonstration of the negative brain "protective" effects of anesthetics following cardiac arrest.

abstract：BACKGROUND:Halothane anesthesia causes spindles in the electroencephalogram (EEG), but the cellular and molecular mechanisms generating these spindles remain incompletely understood. The current study tested the hypothesis that halothane-induced EEG spindles are regulated, in part, by pontine cholinergic mechanisms. M...

journal_title：Anesthesiology

authors： Keifer JC,Baghdoyan HA,Lydic R

更新日期：1996-04-01 00:00:00

abstract：:Chronic muscle disuse decreases the sensitivity of skeletal muscle to nondepolarizing relaxants, such as metocurine (MTC). In this study, the authors determined whether chronic conditioning would produce the opposite effect and increase the sensitivity of skeletal muscle to MTC. Five dogs were exercised by daily runni...

journal_title：Anesthesiology

authors： Gronert GA,White DA,Shafer SL,Matteo RS

更新日期：1989-06-01 00:00:00

abstract：:To examine the effects of cardiac surgery and cardiopulmonary bypass (CPB) on the lung, functional residual capacity (FRC) and lung-thorax compliance were measured at four stages during open heart surgery in 15 children. The patients were anesthetized with fentanyl/droperidol and N2O/O2, paralyzed, and ventilated with...

journal_title：Anesthesiology

authors： Jonmarker C,Larsson A,Werner O

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Adaptive support ventilation can speed weaning after coronary artery surgery compared with protocolized weaning using other modes. There are no data to support this mode of weaning after cardiac valvular surgery. Furthermore, control group weaning times have been long, suggesting that the results may reflect...

journal_title：Anesthesiology

authors： Zhu F,Gomersall CD,Ng SK,Underwood MJ,Lee A

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Cerebral injury is among the most common and disabling complications of open heart surgery. Attempts to provide neuroprotection have yielded conflicting results. We assessed the potential of propofol-induced burst suppression during open heart surgery to provide cerebral protection as determined by postopera...

journal_title：Anesthesiology

authors： Roach GW,Newman MF,Murkin JM,Martzke J,Ruskin A,Li J,Guo A,Wisniewski A,Mangano DT

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Halothane has been previously shown in vitro to decrease both the inward calcium current in isolated cells and the density of calcium antagonist binding sites in cardiac sarcolemmal membranes prepared from several species, including humans, presumably contributing to the negative inotropic effects seen with ...

journal_title：Anesthesiology

authors： Lee DL,Zhang J,Blanck TJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Inflammation is a key element in the pathophysiology of cerebral ischemia. This study investigated the role of N-Myc downstream-regulated gene-2 in nuclear transcription factor κB-mediated inflammation in ischemia models. METHODS:Mice (n = 6 to 12) with or without nuclear transcription factor κB inhibitor p...

journal_title：Anesthesiology

authors： Deng YL,Ma YL,Zhang ZL,Zhang LX,Guo H,Qin P,Hou YS,Gao ZJ,Hou WG

更新日期：2018-03-01 00:00:00

abstract：:Five healthy, nonpregnant volunteers were studied before and after induction of lumbar epidural anesthesia to determine the cause of central hypothermia during epidural anesthesia. Cutaneous heat loss was measured from 10 area-weighted sites using thermal flux transducers. Oxygen consumption was measured and converted...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Glosten B,McGuire J

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:A high proportion of patients having cardiac bypass surgery receive erythrocyte transfusions. Decisions about when to transfuse patients having surgery for coronary artery disease may impact on erythrocyte utilization and patient morbidity and mortality. There are no published data about the factors that inf...

journal_title：Anesthesiology

authors： Shehata N,Wilson K,Mazer CD,Tomlinson G,Streiner D,Hebert P,Naglie G

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Morphine is widely used in patients undergoing surgical operations and is also reported to mediate cardioprotection of preconditioning. The current study determined effects of morphine at therapeutic to pharmacologic concentrations on cardiac action potential, L-type Ca2+ current (ICa.L), delayed rectifier K...

journal_title：Anesthesiology

authors： Xiao GS,Zhou JJ,Wang GY,Cao CM,Li GR,Wong TM

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Ca2+-permeable non-N-methyl-D-aspartate receptors are found in the spinal dorsal horn and represent a presumptive target for glutamatergic transmission in nociceptive processing. This study characterized the analgesic profile associated with the blockade of these spinal receptors by intrathecally delivered a...

journal_title：Anesthesiology

authors： Sorkin LS,Yaksh TL,Doom CM

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:The pharmacokinetics and pharmacodynamics of succinylcholine were studied simultaneously in anesthetized patients to understand why the drug has a rapid onset and short duration of action. A quantitative model describing the concentration-effect relation of succinylcholine was proposed. The correlation betwe...

journal_title：Anesthesiology

authors： Roy JJ,Donati F,Boismenu D,Varin F

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Although the use of an anesthesiology "airway" rotation to train the nonanesthesiologist is commonly employed, little data exist on the utility, clinical exposure, and outcomes of these programs. METHODS:A prospectively collected observational dataset of airway procedures completed by trainees in a 4-week, ...

journal_title：Anesthesiology

authors： Grissom TE,Sappenfield J,Galvagno SM Jr,Cherry SV,Chang YC,Hu PF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Recent studies have questioned the importance of the gravitational model of pulmonary perfusion. Because low levels of positive end-expiratory pressure (PEEP) are commonly used during anesthesia, the authors studied the distribution of pulmonary blood flow with low levels of PEEP using a high spatial resolut...

journal_title：Anesthesiology

authors： Kallas HJ,Domino KB,Glenny RW,Anderson EA,Hlastala MP

更新日期：1998-05-01 00:00:00

abstract：:Systolic pressure variation (SPV) is defined as the difference between the maximum and minimum values of systolic blood pressure following a single positive pressure breath. An increase in the SPV is known to occur clinically during hypovolemia. This study aims to quantify SPV during graded hemorrhage in ventilated do...

journal_title：Anesthesiology

authors： Perel A,Pizov R,Cotev S

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Isoflurane anesthesia produces cardiovascular and respiratory depression, although the specific mechanisms are not fully understood. Cranial visceral afferents, which innervate the heart and lungs, synapse centrally onto neurons within the medial portion of the nucleus tractus solitarius (NTS). Isoflurane mo...

journal_title：Anesthesiology

authors： Peters JH,McDougall SJ,Mendelowitz D,Koop DR,Andresen MC

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:This study was conducted to compare the performance accuracy of the independent variables Bispectral Index (BIS), A-Line ARX index (AAI), and predicted propofol effect-site concentration (CePROP) to measure the dependent variables of loss of responses to different stimulation defined as loss of response to v...

journal_title：Anesthesiology

authors： Struys MM,Vereecke H,Moerman A,Jensen EW,Verhaeghen D,De Neve N,Dumortier FJ,Mortier EP

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Although opioids remain the standard therapy for the treatment of postoperative pain, the prevalence of opioid misuse is rising. The extent to which opioid abuse or dependence affects readmission rates and healthcare utilization is not fully understood. It was hypothesized that surgical patients with a histo...

journal_title：Anesthesiology

authors： Gupta A,Nizamuddin J,Elmofty D,Nizamuddin SL,Tung A,Minhaj M,Mueller A,Apfelbaum J,Shahul S

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Anesthetic preconditioning (APC) is a clinically important phenomenon in which volatile anesthetics (VAs) protect tissues such as heart against ischemic injury. The mechanism of APC is thought to involve K channels encoded by the Slo gene family, and the authors showed previously that slo-2 is required for A...

journal_title：Anesthesiology

authors： Wojtovich AP,Smith CO,Urciuoli WR,Wang YT,Xia XM,Brookes PS,Nehrke K

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:A decrease in radial artery blood pressure relative to central arterial blood pressure is commonly associated with the rewarming phase of cardiopulmonary bypass. Decreased hand vascular resistance has been suggested as a possible mechanism. Although decreased blood viscosity due to hemodilution may contribut...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Moayeri A,Katz JA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:The authors conducted a randomized controlled trial to determine whether parental presence during induction of anesthesia (PPIA) is associated with parental physiologic and behavioral manifestations of stress. METHODS:Children and their parents (N = 80) were randomly assigned to one of three groups: (1) PPI...

journal_title：Anesthesiology

authors： Kain ZN,Caldwell-Andrews AA,Mayes LC,Wang SM,Krivutza DM,LoDolce ME

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Epidural morphine yields postoperative pain relief and hemodynamic stability. However, the effects of epidural morphine on sympathetic tone are unclear. This study was designed to elucidate the effects of epidural morphine on cardiac (CSNA) and renal (RSNA) sympathetic nerve activity by direct measurement in...

journal_title：Anesthesiology

authors： Mori T,Nishikawa K,Terai T,Yukioka H,Asada A

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:We have previously shown that intralipid (lipid emulsion) protects the heart against ischemia/reperfusion injury and bupivacaine-induced cardiotoxicity. However, the precise underlying mechanisms are not fully understood. Here we explored the hypothesis that free fatty acid receptor-1 or G-protein-coupled re...

journal_title：Anesthesiology

authors： Umar S,Li J,Hannabass K,Vaillancourt M,Cunningham CM,Moazeni S,Mahajan A,Eghbali M

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Frailty is associated with adverse postoperative outcomes, but it remains unclear which measure of frailty is best. This study compared two approaches: the Modified Frailty Index, which is a deficit accumulation model (number of accumulated deficits), and the Hopkins Frailty Score, which is a phenotype model...

journal_title：Anesthesiology

authors： Sonny A,Kurz A,Skolaris LA,Boehm L,Reynolds A,Cummings KC 3rd,Makarova N,Yang D,Sessler DI

更新日期：2020-01-01 00:00:00

abstract：:The thermoregulatory threshold for vasoconstriction has been studied in infants and children given isoflurane, but not in those given halothane anesthesia. More importantly, the effect of vasoconstriction on central temperature in pediatric patients remains unknown. Also unknown is the effect of caudal analgesia on va...

journal_title：Anesthesiology

authors： Bissonnette B,Sessler DI

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Perioperative thoracic epidural analgesia reduces stress response and pain scores and may improve outcome after cardiac surgery. This prospective, randomized trial was designed to compare the effectiveness of patient-controlled thoracic epidural analgesia with patient-controlled analgesia with intravenous mo...

journal_title：Anesthesiology

authors： Hansdottir V,Philip J,Olsen MF,Eduard C,Houltz E,Ricksten SE

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:In the partial CO(2) rebreathing method, monitored changes in CO(2) elimination and end-tidal CO(2) in response to a brief rebreathing period are used to estimate cardiac output. However, dynamic changes in CO(2) production during ischemia and reperfusion may affect the accuracy of these estimates. This stud...

journal_title：Anesthesiology

authors： Kotake Y,Moriyama K,Innami Y,Shimizu H,Ueda T,Morisaki H,Takeda J

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Halogenated anesthetics potentiate the positive inotropic effects of alpha- and beta-adrenoceptor stimulations. Although diabetes mellitus induces significant myocardial abnormalities, the interaction of halogenated anesthetics and adrenoceptor stimulation in diabetic myocardium remains unknown. METHODS:Lef...

journal_title：Anesthesiology

authors： Amour J,David JS,Vivien B,Coriat P,Riou B

更新日期：2004-11-01 00:00:00

abstract：:To investigate the hemodynamic correlates of perioperative regional wall motion abnormalities (RWMA), we measured wall motion continuously via transesophageal echocardiography (TEE), and related RWMA to continuously measured hemodynamic indices of myocardial oxygen supply and demand (heart rate [HR] and systemic and p...

journal_title：Anesthesiology

authors： Leung JM,O'Kelly BF,Mangano DT

更新日期：1990-11-01 00:00:00

abstract：:We recorded the frequency with which anesthesia personnel came in contact with patient body fluids in order to provide an empirical basis for the recommendation of relevant precautions. Anesthesia personnel completed a questionnaire when performing a range of standardized procedures. The rate of contact with blood was...

journal_title：Anesthesiology

authors： Kristensen MS,Sloth E,Jensen TK

更新日期：1990-10-01 00:00:00