Enhancement by pain and stress of analgesia produced by epidural sufentanil in the rat.

abstract：:Positive pressure ventilation can affect hemodynamic stability by neuroreflex-mediated activity. Inhalational anesthesia is known to attenuate the arterial baroreflex function; however, little information is known about the effect of volatile anesthetics on the lung inflation reflex. The influence of isoflurane on sta...

journal_title：Anesthesiology

authors： Cheng EY,Kay J,Hoka S,Bosnjak ZJ,Coon RL,Kampine JP

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:The use of nicotinic agonists for analgesia is limited by their unacceptable side effects. Sazetidine-A is a new partial agonist nicotinic ligand that has very high selectivity for beta2-containing nicotinic acetylcholine receptors. It potently and selectively desensitizes alpha4beta2 nicotinic acetylcholine...

journal_title：Anesthesiology

authors： Cucchiaro G,Xiao Y,Gonzalez-Sulser A,Kellar KJ

更新日期：2008-09-01 00:00:00

abstract：:Complications after major surgery are a leading cause of morbidity and mortality. The etiology of postoperative complications is complex, but poor cardiorespiratory reserve appears to be a key factor. There is increasing interest in the use of central and mixed venous oxygen saturation to guide therapeutic interventio...

journal_title：Anesthesiology

authors： Shepherd SJ,Pearse RM

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Investigators in the authors' laboratory previously established the critical participation of the cerulospinal noradrenergic pathway in muscular rigidity elicited by fentanyl. The identification of colocalization of glutamate with tyrosine hydroxylase in most locus ceruleus neurons suggests a role for cerulo...

journal_title：Anesthesiology

authors： Fu MJ,Tsen LY,Lee TY,Lui PW,Chan SH

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Global cerebral ischemia is associated with delayed neuronal death. Given the role of caspases in apoptosis, caspase inhibitors may provide neuronal protection after cardiac arrest. To this end, the authors generated a transgenic rat line expressing baculovirus p35, a broad-spectrum caspase inhibitor, in cen...

journal_title：Anesthesiology

authors： Vogel P,Putten Hv,Popp E,Krumnikl JJ,Teschendorf P,Galmbacher R,Kisielow M,Wiessner C,Schmitz A,Tomaselli KJ,Schmitz B,Martin E,Böttiger BW

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Patients undergoing cardiac surgery employing cardiopulmonary bypass frequently require transfusion of homologous blood products and, therefore, are exposed to the risk of transfusions. Autologous platelet-rich plasma administration may reduce homologous transfusion and attendant risks. METHODS:In a blinded...

journal_title：Anesthesiology

authors： Ereth MH,Oliver WC Jr,Beynen FM,Mullany CJ,Orszulak TA,Santrach PJ,Ilstrup DM,Weaver AL,Williamson KR

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:The Shannon entropy is a standard measure for the order state of sequences. It quantifies the degree of skew of the distribution of values. Increasing hypnotic drug concentrations increase electroencephalographic amplitude. The probability density function of the amplitude values broadens and flattens, there...

journal_title：Anesthesiology

authors： Bruhn J,Lehmann LE,Röpcke H,Bouillon TW,Hoeft A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The surface membrane Ca(2+)-adenosine triphosphatase and Na(+)-Ca(2+) exchanger transport Ca(2+) out of the ventricular myocyte, competing for cytosolic Ca(2+) with the Ca(2+)-adenosine triphosphatase located in the sarcoplasmic reticulum. In this study the authors examined the effects of halothane, isoflura...

journal_title：Anesthesiology

authors： Hannon JD,Cody MJ

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:About one in four patients suffers from postoperative nausea and vomiting. Fortunately, risk scores have been developed to better manage this outcome in hospitalized patients, but there is currently no risk score for postdischarge nausea and vomiting (PDNV) in ambulatory surgical patients. METHODS:We conduc...

journal_title：Anesthesiology

authors： Apfel CC,Philip BK,Cakmakkaya OS,Shilling A,Shi YY,Leslie JB,Allard M,Turan A,Windle P,Odom-Forren J,Hooper VD,Radke OC,Ruiz J,Kovac A

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Although halothane reduces digitalis toxicity, other anesthetics, notably cyclopropane, increase toxicity. This study determined the effects of isoflurane on digitalis toxicity in isolated cardiac tissue and compared these effects with those of halothane. METHODS:Standard microelectrode techniques were used...

journal_title：Anesthesiology

authors： Gallagher JD

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:A class Ib antiarrhythmic drug, mexiletine, augments relaxations produced by adenosine triphosphate (ATP) sensitive K+ channel openers in isolated rat aortas, suggesting that it produces changes in the vasodilation mediated by ATP-sensitive K+ channels. Nitric oxide can induce its vasodilator effect via K+ c...

journal_title：Anesthesiology

authors： Kinoshita H,Ishikawa T,Hatano Y

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the effects of two imidazoline-derived intravenous anesthetics, etomidate and midazolam, on vascular adenosine triphosphate-sensitive potassium (KATP) channel activity. METHODS:In isolated rat aorta, isometric tension was recorded to examine the anesthetic effects on...

journal_title：Anesthesiology

authors： Nakamura A,Kawahito S,Kawano T,Nazari H,Takahashi A,Kitahata H,Nakaya Y,Oshita S

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The dorsal horn of the spinal cord is a pivotal point for transmission of neuronal pain. During spinal and epidural anesthesia, the neurons of the dorsal horn are exposed to local anesthetics. Unfortunately, little is known about the action of local anesthetics on the major ionic conductances in dorsal horn ...

journal_title：Anesthesiology

authors： Olschewski A,Hempelmann G,Vogel W,Safronov BV

更新日期：1998-01-01 00:00:00

abstract：:The antinociceptive interaction on the tail flick (TF) and hot plate (HP) tests between opioid analgesics and medetomidine after intravenous (iv) or intrathecal administration were examined by isobolographic analysis. Male Sprague-Dawley rats received fixed ratios of medetomidine to morphine, fentanyl, and meperidine ...

journal_title：Anesthesiology

authors： Ossipov MH,Harris S,Lloyd P,Messineo E,Lin BS,Bagley J

更新日期：1990-12-01 00:00:00

abstract：:It is a common practice for anesthesia to substitute for one another, especially for short breaks during long surgical procedures. The assets and liabilities of this practice of relief have not been examined previously. In the course of gathering 1,089 reports of preventable errors and failures associated with anesthe...

journal_title：Anesthesiology

authors： Cooper JB,Long CD,Newbower RS,Philip JH

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to halothane or heat stress. METHODS:Because oxidative species may play a criti...

journal_title：Anesthesiology

authors： Michelucci A,Paolini C,Canato M,Wei-Lapierre L,Pietrangelo L,De Marco A,Reggiani C,Dirksen RT,Protasi F

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether progressive levels of hypothermia (37, 34, 31, or 28 degrees C) during cardiopulmonary bypass (CPB) in pigs reduce the physiologic and metabolic consequences of global cerebral ischemia. METHODS:Sagittal sinus and cortical microdialysis catheters were inserted ...

journal_title：Anesthesiology

authors： Conroy BP,Lin CY,Jenkins LW,DeWitt DS,Zornow MH,Uchida T,Johnston WE

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:The health-related effects of the operating room environment are unclear. The authors compared mortality risks of anesthesiologists to those of internal medicine physicians between 1979 and 1995. METHODS:The Physician Master File database, a listing of all US physicians, was used to identify anesthesiologis...

journal_title：Anesthesiology

authors： Alexander BH,Checkoway H,Nagahama SI,Domino KB

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:In pediatric patients, obstruction of the upper airway is a common problem during general anesthesia. Chin lift is a commonly used technique to improve upper airway patency. However, little is known about the mechanism underlying this technique. METHODS:The authors studied the effect of the chin lift maneuv...

journal_title：Anesthesiology

authors： Reber A,Wetzel SG,Schnabel K,Bongartz G,Frei FJ

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Intraoperative remifentanil infusions have been associated with postoperative opioid-induced hyperalgesia and tolerance. Using a previously identified subpopulation of spinal neurons that displays an augmentation in N-methyl-D-aspartate (NMDA) receptor current after chronic morphine, investigations were unde...

journal_title：Anesthesiology

authors： Zhao M,Joo DT

更新日期：2008-08-01 00:00:00

abstract：:This study reports effects of halothane on tumor cells in vitro. Cells from the human colon cancer cell line HT-29 were exposed to various concentrations of halothane for 8-72 h. The effect of this exposure on this colon cancer cell line, with and without coincubation with the biologic response modifier gamma-interfer...

journal_title：Anesthesiology

authors： Rudnick S,Stevenson GW,Hall SC,Espinoza-Delgado I,Stevenson HC,Longo DL

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The rate of administration of an intravenous anesthetic induction agent is an important variable determining the total dose required to reach a given endpoint, such as loss of consciousness (LOC). The influence of infusion rate on the dose-response relationship has not been described rigorously. In this stud...

journal_title：Anesthesiology

authors： Gentry WB,Krejcie TC,Henthorn TK,Shanks CA,Howard KA,Gupta DK,Avram MJ

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate a new, physiologically inspired method for the analysis of the electroencephalogram during propofol-remifentanil anesthesia. Based on fixed-order autoregressive moving-average modeling, this method was hypothesized to be capable of dissociating the effects that hypno...

journal_title：Anesthesiology

authors： Liley DT,Sinclair NC,Lipping T,Heyse B,Vereecke HE,Struys MM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:There is an increasing interest in the use of dexmedetomidine for anesthesia and sedation. Here, we used the mouse organotypic hippocampal slice culture to investigate whether dexmedetomidine exhibits postconditioning properties against oxygen and glucose deprivation (OGD). The role of the focal adhesion and...

journal_title：Anesthesiology

authors： Dahmani S,Rouelle D,Gressens P,Mantz J

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Although automated closed-loop control systems may improve quality of care, their safety must be proved under extreme control conditions. This study describes a simulation methodology to test automated controllers and its application in a comparison of two published controllers for Bispectral Index (BIS)-gui...

journal_title：Anesthesiology

authors： Struys MM,De Smet T,Greenwald S,Absalom AR,Bingé S,Mortier EP

更新日期：2004-03-01 00:00:00

abstract：:Intrathecally administered alpha 2-adrenergic agonists produce analgesia in humans but may also produce hypotension and bradycardia. To further characterize hemodynamic depression produced by intrathecally administered alpha 2-adrenergic agonists, clonidine (100-1,500 micrograms) was injected into the cervical, thorac...

journal_title：Anesthesiology

authors： Eisenach JC,Tong CY

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Serious complications related to regional anesthesia have previously been described primarily in case reports and retrospective surveys. The authors prospectively evaluated a multicenter series of regional anesthetics, using preplanned criteria to measure the incidence and characteristics of associated serio...

journal_title：Anesthesiology

authors： Auroy Y,Narchi P,Messiah A,Litt L,Rouvier B,Samii K

更新日期：1997-09-01 00:00:00

abstract：:To determine whether neuronal firing is affected by anesthetics, the behavior of neurons in the mesencephalic reticular formation in response to repetitive somatosensory stimulation at 2/sec was studied during wakefulness and during nitrous oxide, halothane, and thiopental anesthesia in the cat. With clinical doses of...

journal_title：Anesthesiology

authors： Shimoji K,Matsuki M,Shimizu H,Maruyama Y,Aida S

更新日期：1977-10-01 00:00:00

abstract：:To assess the effect of a glucose infusion on brain extracellular fluid (ECF) during systemic hypoxia, changes in glucose and lactate concentrations in cerebral ECF during and after moderate hypoxic hypoxia were measured in adult, conscious, unrestrained rats, with a microdialysis probe in the posterior hippocampus. T...

journal_title：Anesthesiology

authors： Harada M,Okuda C,Sawa T,Murakami T

更新日期：1992-10-01 00:00:00

abstract：INTRODUCTION:Directional connectivity from anterior to posterior brain regions (or "feedback" connectivity) has been shown to be inhibited by propofol and sevoflurane. In this study the authors tested the hypothesis that ketamine would also inhibit cortical feedback connectivity in frontoparietal networks. METHODS:Sur...

journal_title：Anesthesiology

authors： Lee U,Ku S,Noh G,Baek S,Choi B,Mashour GA

更新日期：2013-06-01 00:00:00