Hypothermic modulation of cerebral ischemic injury during cardiopulmonary bypass in pigs.

abstract：BACKGROUND:Halothane and isoflurane have been shown to differentially effect mechanisms of contraction in working myocardial fibers. The aim of this study was to compare effects of halothane and isoflurane on contractile force (CF) and Ca2+ transients in canine cardiac Purkinje fiber preparations. METHODS:Fiber prepar...

journal_title：Anesthesiology

authors： Stowe DF,Sprung J,Turner LA,Kampine JP,Bosnjak ZJ

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Indirect evidence supports a role of spinal cholinergic neurons in tonically reducing response to noxious mechanical stimulation and in effecting analgesia from alpha2-adrenergic agonists. This study directly assessed the role of cholinergic neurons in regulating the level of mechanical allodynia and in part...

journal_title：Anesthesiology

authors： Paqueron X,Li X,Bantel C,Tobin JR,Voytko ML,Eisenach JC

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:The dose-response relation for spinal ropivacaine is undetermined, and there are few data available for obstetric patients. METHODS:In a prospective, randomized, double-blind investigation, the authors studied 72 patients undergoing elective cesarean delivery. An epidural catheter was placed at the L2-L3 ve...

journal_title：Anesthesiology

authors： Khaw KS,Ngan Kee WD,Wong EL,Liu JY,Chung R

更新日期：2001-12-01 00:00:00

abstract：:Systolic pressure variation (SPV) is defined as the difference between the maximum and minimum values of systolic blood pressure following a single positive pressure breath. An increase in the SPV is known to occur clinically during hypovolemia. This study aims to quantify SPV during graded hemorrhage in ventilated do...

journal_title：Anesthesiology

authors： Perel A,Pizov R,Cotev S

更新日期：1987-10-01 00:00:00

abstract：:The authors determined the thiopental dose needed for satisfactory induction in ten neonates, 0-14 days of age, and 20 infants, 1-6 months of age. A single iv bolus of thiopental was given. Thirty seconds after injection the anesthesia mask was applied and the response was observed during the following 30 s while the ...

journal_title：Anesthesiology

authors： Westrin P,Jonmarker C,Werner O

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Hydroxyethyl starch (HES) is commonly used as plasma expander during surgery but may be nephrotoxic as seen in studies in patients with sepsis. The authors hypothesized that the possible nephrotoxicity of 6% HES 130/0.4 could be revealed by measurements of urinary excretion of neutrophil gelatinase-associate...

journal_title：Anesthesiology

authors： Kancir AS,Pleckaitiene L,Hansen TB,Ekeløf NP,Pedersen EB

更新日期：2014-11-01 00:00:00

abstract：:Chronic muscle disuse decreases the sensitivity of skeletal muscle to nondepolarizing relaxants, such as metocurine (MTC). In this study, the authors determined whether chronic conditioning would produce the opposite effect and increase the sensitivity of skeletal muscle to MTC. Five dogs were exercised by daily runni...

journal_title：Anesthesiology

authors： Gronert GA,White DA,Shafer SL,Matteo RS

更新日期：1989-06-01 00:00:00

abstract：:In a recent editorial, Kapur described perioperative nausea and vomiting as "the big 'little problem' following ambulatory surgery."257 Although the actual morbidity associated with nausea is relatively low in health outpatients, it should not be considered an unavoidable part of the perioperative experience. The avai...

journal_title：Anesthesiology

authors： Watcha MF,White PF

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Intraoperative remifentanil infusions have been associated with postoperative opioid-induced hyperalgesia and tolerance. Using a previously identified subpopulation of spinal neurons that displays an augmentation in N-methyl-D-aspartate (NMDA) receptor current after chronic morphine, investigations were unde...

journal_title：Anesthesiology

authors： Zhao M,Joo DT

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Renal and hepatic toxicity of the fluorinated ether volatile anesthetics is caused by biotransformation to toxic metabolites. Metabolism also contributes significantly to the elimination pharmacokinetics of some volatile agents. Although innumerable studies have explored anesthetic metabolism in animals, the...

journal_title：Anesthesiology

authors： Kharasch ED,Thummel KE

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Spinal nitric oxide (NO) is important for the analgesic actions of morphine and cholinergic agents. Its role in the analgesic effect of delta-opioid receptor agonists is not known. In the present study, the authors determined the role of spinal endogenous NO in the antinociceptive effect of intrathecal [D-Pe...

journal_title：Anesthesiology

authors： Chen SR,Pan HL

更新日期：2003-01-01 00:00:00

abstract：:The effects of halothane on the beating response of rat heart cells in tissue culture were studied using an optical-electronic monitoring device. A dose-response curve was obtained over a concentration range to as much as 5 vol per cent halothane. The clinical dosage of 1 vol per cent halothane decreased the inotropic...

journal_title：Anesthesiology

authors： Stong LJ,Hartzell CR,McCarl RL

更新日期：1975-02-01 00:00:00

abstract：:Thiopental-14C (30 mg and 10 muCi/kg) was injected intravenously into rats 36-48 hours following bilateral nephrectomy and one minute after pretreatment with sulfadimethoxine (30 mg/kg, iv). Control groups of normal and sham-operated animals were used. The distributions of radioactivity in plasma, brain, and heart 1, ...

journal_title：Anesthesiology

authors： Ghoneim MM,Pandya HB,Kelley SE,Fischer LJ,Corry RJ

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Clonidine produces analgesia after spinal injection by activating alpha2-adrenergic receptors. Recently, clonidine has been demonstrated to increase spinal release of norepinephrine (NE) in vivo, in contrast to that anticipated by classic presynaptic autoinhibition. The purpose of the current study was to de...

journal_title：Anesthesiology

authors： Li X,Zhao Z,Pan HL,Eisenach JC,Paqueron X

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:A focal cortical cryogenic brain injury has been reported to reduce the brain pentobarbital concentrations needed to prevent movement in response to pain in rats. This occurred despite any apparent behavioral changes in the awake animals. To determine whether this was true with other anesthetics, the authors...

journal_title：Anesthesiology

authors： Todd MM,Weeks JB,Warner DS

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Xenon has been shown to be neuroprotective in several models of in vitro and in vivo neuronal injury. However, its putative neuroprotective properties have not been evaluated in focal cerebral ischemia. The purpose of this study was to determine if xenon offers neuroprotection in a mouse model of middle cere...

journal_title：Anesthesiology

authors： Homi HM,Yokoo N,Ma D,Warner DS,Franks NP,Maze M,Grocott HP

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Because oral erythromycin administration has been associated with reduced elimination of alfentanil, suspicion has been raised about related opioids with similar metabolic pathways. A controlled crossover study of sufentanil pharmacokinetics was undertaken to resolve this issue. METHODS:Six subjects had mea...

journal_title：Anesthesiology

authors： Bartkowski RR,Goldberg ME,Huffnagle S,Epstein RH

更新日期：1993-02-01 00:00:00

abstract：:Using magnetic resonance spectroscopy, the authors tested whether cerebral concentrations of inhaled anesthetics do not increase proportionately at inspired concentrations exceeding 3% 1) because anesthetics bind to and saturate specific sites in the brain or 2) because anesthetic-induced depression of ventilation lim...

journal_title：Anesthesiology

authors： Lockhart SH,Cohen Y,Yasuda N,Kim F,Litt L,Eger EI 2nd,Chang LH,James T

更新日期：1990-09-01 00:00:00

abstract：:Neurophysiologic studies indicate that local anesthetic-induced seizures are generated in subcortical brain structures. The authors utilized a quantitative autoradiographic technique to measure cerebral metabolism during lidocaine-induced seizure activity in rats anesthetized with nitrous oxide. Local cerebral metabol...

journal_title：Anesthesiology

authors： Ingvar M,Shapiro HM

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Frailty is associated with adverse postoperative outcomes, but it remains unclear which measure of frailty is best. This study compared two approaches: the Modified Frailty Index, which is a deficit accumulation model (number of accumulated deficits), and the Hopkins Frailty Score, which is a phenotype model...

journal_title：Anesthesiology

authors： Sonny A,Kurz A,Skolaris LA,Boehm L,Reynolds A,Cummings KC 3rd,Makarova N,Yang D,Sessler DI

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Physiologic data that is automatically collected during anesthesia is widely used for medical record keeping and clinical research. These data contain artifacts, which are not relevant in clinical care, but may influence research results. The aim of this study was to explore the effect of different methods o...

journal_title：Anesthesiology

authors： Pasma W,Peelen LM,van Buuren S,van Klei WA,de Graaff JC

更新日期：2020-04-01 00:00:00

abstract：:Two groups of women, ASA physical status 1, undergoing surgery for primary breast cancer, were studied to assess the effect of alcohol intake on alfentanil pharmacodynamics. Patients in group 1 (n = 6) had an average daily consumption of 20-40 g alcohol. Patients in group 2 (n = 8) were life-long abstainers or drank o...

journal_title：Anesthesiology

authors： Lemmens HJ,Bovill JG,Hennis PJ,Gladines MP,Burm AG

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Breastfeeding is an important public health concern. High cumulative doses of epidural fentanyl administered for labor analgesia have been reported to be associated with early termination of breastfeeding. We tested the hypothesis that breastfeeding success is adversely influenced by the cumulative epidural ...

journal_title：Anesthesiology

authors： Lee AI,McCarthy RJ,Toledo P,Jones MJ,White N,Wong CA

更新日期：2017-10-01 00:00:00

abstract：:Oral transmucosal fentanyl citrate (OTFC) is a novel, noninvasive dosage form of fentanyl used to provide children and adults with sedation, anxiolysis, and analgesia. In order to determine the bioavailability and absorption of fentanyl from OTFC, 12 volunteers were given intravenous fentanyl citrate or OTFC 15 microg...

journal_title：Anesthesiology

authors： Streisand JB,Varvel JR,Stanski DR,Le Maire L,Ashburn MA,Hague BI,Tarver SD,Stanley TH

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Recent evidence suggests that anesthetic action within the spinal cord is important in suppressing somatic responses to painful stimuli. Whether the brain influences this response is not clear. This study was designed to test the hypothesis that the brain affects anesthetic requirements. METHODS:Six goats w...

journal_title：Anesthesiology

authors： Borges M,Antognini JF

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:In 2001, the Centers for Medicare and Medicaid Services issued a rule allowing U.S. states to "opt out" of the regulations requiring physician supervision of nurse anesthetists in an effort to increase access to anesthesia care. Whether "opt out" has successfully achieved this goal remains unknown. METHODS:...

journal_title：Anesthesiology

authors： Sun EC,Dexter F,Miller TR,Baker LC

更新日期：2017-03-01 00:00:00

abstract：:The pharmacokinetics and protein binding of propofol were studied in ten patients with cirrhosis and in ten control patients undergoing elective surgery. All patients received 2.5 mg.kg-1 propofol as an intravenous bolus injection for the induction of anesthesia. Whole blood propofol concentrations were measured at in...

journal_title：Anesthesiology

authors： Servin F,Desmonts JM,Haberer JP,Cockshott ID,Plummer GF,Farinotti R

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Rapid assessment of hepatic function early after reperfusion of the liver graft is of great importance, because it may allow for prompt detection of incipient hepatic graft failure. The current study was undertaken to determine whether the continuous recording of neuromuscular transmission could be used as a...

journal_title：Anesthesiology

authors： Pittet JF,Morel DR,Mentha G,Schopfer C,Belenger J,Benakis A,Tassonyi E

更新日期：1994-07-01 00:00:00

abstract：:Sevoflurane, 1.4 per cent (MAC), was administered to groups of Fischer 344 rats for 10 hours, 4 hours, or 1 hour; additional rats received 0.5 per cent methoxyflurane for 3 hours or 1 hour. Urinary inorganic fluoride excretion of sevoflurane in vivo was a third to a fourth that of methoxyflurane. However, using hepati...

journal_title：Anesthesiology

authors： Cook TL,Beppu WJ,Hitt BA,Kosek JC,Mazze RI

更新日期：1975-07-01 00:00:00

abstract：:Characteristics of nocturnal sleep were investigated in six patients after anesthesia and cholecystectomy and in another six after anesthesia and gastroplasty. All night polysomnographic recordings were obtained while each patient slept in a private surgical ward room through two nights before and five or six nights a...

journal_title：Anesthesiology

authors： Knill RL,Moote CA,Skinner MI,Rose EA

更新日期：1990-07-01 00:00:00