Dishabituation of mesencephalic reticular neurons by anesthetics.

abstract：BACKGROUND:The authors sought to determine whether subjects with pathophysiological conditions that are characterized by increased concentrations of aldosterone have increased susceptibility to the side effects of neonatal anesthesia with sevoflurane. METHODS:Postnatal day 4-20 (P4-P20) rats were exposed to sevofluran...

journal_title：Anesthesiology

authors： Cao W,Pavlinec C,Gravenstein N,Seubert CN,Martynyuk AE

更新日期：2012-10-01 00:00:00

abstract：:Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia. The authors investigated this possibility in cats by determining whether or not pentylenetetrazol- (Metrazol) or lidocaine-seizure thresholds decreased after repeated enflurane exposure. The lido...

journal_title：Anesthesiology

authors： Heavner JE,Amory DW

更新日期：1981-05-01 00:00:00

abstract：:Dexmedetomidine (DMED) is a highly selective centrally acting alpha 2-adrenergic agonist thought to provide significant sedation without appreciable ventilatory effects. This double-blind, placebo-controlled experiment evaluated four dose levels of DMED (0.25, 0.5, 1.0, and 2.0 micrograms/kg intravenously over 2 min) ...

journal_title：Anesthesiology

authors： Belleville JP,Ward DS,Bloor BC,Maze M

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Acute pancreatitis has been linked to intestinal barrier dysfunction and systemic inflammatory response with high mortality. Thoracic epidural analgesia improves intestinal perfusion. The authors hypothesized that thoracic epidural analgesia influences microcirculation injury, inflammatory response, and outc...

journal_title：Anesthesiology

authors： Freise H,Lauer S,Anthonsen S,Hlouschek V,Minin E,Fischer LG,Lerch MM,Van Aken HK,Sielenkämper AW

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear. The authors examined the effects of furosemide and mannitol, alone and in combination, on brain water content in brain-injured rats. METHODS:Anesthetized rats were subjected t...

journal_title：Anesthesiology

authors： Todd MM,Cutkomp J,Brian JE

更新日期：2006-12-01 00:00:00

abstract：INTRODUCTION:Directional connectivity from anterior to posterior brain regions (or "feedback" connectivity) has been shown to be inhibited by propofol and sevoflurane. In this study the authors tested the hypothesis that ketamine would also inhibit cortical feedback connectivity in frontoparietal networks. METHODS:Sur...

journal_title：Anesthesiology

authors： Lee U,Ku S,Noh G,Baek S,Choi B,Mashour GA

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Pulmonary function is impaired during pneumoperitoneum mainly as a result of atelectasis formation. We studied the effects of 10 cm H2O of positive end-expiratory pressure (PEEP) and PEEP followed by a recruitment maneuver (PEEP+RM) on end-expiratory lung volume (EELV), oxygenation and respiratory mechanics ...

journal_title：Anesthesiology

authors： Futier E,Constantin JM,Pelosi P,Chanques G,Kwiatkoskwi F,Jaber S,Bazin JE

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the authors explored whether postoperative nadir platelet counts are associated with acute kidney injury...

journal_title：Anesthesiology

authors： Kertai MD,Zhou S,Karhausen JA,Cooter M,Jooste E,Li YJ,White WD,Aronson S,Podgoreanu MV,Gaca J,Welsby IJ,Levy JH,Stafford-Smith M,Mathew JP,Fontes ML

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Up to 84% of women who undergo operative vaginal delivery receive neuraxial analgesia. However, little is known about the association between neuraxial analgesia and neonatal morbidity in women who undergo operative vaginal delivery. The authors hypothesized that neuraxial analgesia is associated with a redu...

journal_title：Anesthesiology

authors： Butwick AJ,Wong CA,Lee HC,Blumenfeld YJ,Guo N

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The design of an endotracheal tube has been shown to influence the passage of the tube through the glottis during fiberoptic intubation. Difficulty in passing the endotracheal tube can occur if the aryepiglottic folds obstruct the passage of the bevel. The relevant aspects of endotracheal tube design include...

journal_title：Anesthesiology

authors： Greer JR,Smith SP,Strang T

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical pain. The relation...

journal_title：Anesthesiology

authors： Peters CM,Hayashida K,Suto T,Houle TT,Aschenbrenner CA,Martin TJ,Eisenach JC

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Patients who are homozygous for the atypical mutation, compound heterozygous for atypical and silent mutations, or homozygous for silent mutations (SS) respond to mivacurium with extensively prolonged neuromuscular block. Although important, exact phenotyping of these patients is difficult. This article pres...

journal_title：Anesthesiology

authors： Gätke MR,Ostergaard D,Bundgaard JR,Varin F,Viby-Mogensen J

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Although considerable evidence indicates neuronal Ca channels play significant roles in pain perception, their possible importance in hypersensitization after acute inflammation has not been investigated. METHODS:Using carrageenan for inducing hypersensitization, the authors investigated the analgesic effec...

journal_title：Anesthesiology

authors： Yokoyama K,Kurihara T,Makita K,Tanabe T

更新日期：2003-12-01 00:00:00

abstract：:The effects of local infiltration anesthesia, brachial plexus blockade, isoflurane, or halothane anesthesia on blood flow through the brachial artery and through a newly created forearm arteriovenous fistula (AVF) were compared in 36 patients with endstage renal failure. Brachial artery blood flow was measured at two ...

journal_title：Anesthesiology

authors： Mouquet C,Bitker MO,Bailliart O,Rottembourg J,Clergue F,Montejo LS,Martineaud JP,Viars P

更新日期：1989-06-01 00:00:00

abstract：:The effects of halothane on uptake and phosphorylation of uridine, and on cellular ATP content were studied in Tetrahymena pyriformis, a ciliate protozoan. Exposure to halothane inhibited the accumulation of 14C-uridine into the following acid-soluble intracellular pools: UTP, UDP, UMP, and an unidentified compound. H...

journal_title：Anesthesiology

authors： Conklin KA,Lau SS

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:In pediatric patients, the Bispectral Index (BIS), derived from the electroencephalogram, and the composite A-Line autoregressive index (cAAI), derived from auditory evoked potentials and the electroencephalogram, have been used as measurements of depth of hypnosis during anesthesia. The performance and reli...

journal_title：Anesthesiology

authors： Blussé van Oud-Alblas HJ,Peters JW,de Leeuw TG,Tibboel D,Klein J,Weber F

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptoti...

journal_title：Anesthesiology

authors： Sabir H,Bishop S,Cohen N,Maes E,Liu X,Dingley J,Thoresen M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics depress left ventricular contractile function by altering voltage-dependent slow calcium (Ca2+) channel activity in the sarcolemmal membrane. This investigation examined the left ventricular systolic and diastolic mechanical effects of the dihydropyridine Ca2+ channel antagonist nifedipi...

journal_title：Anesthesiology

authors： Pagel PS,Hettrick DA,Warltier DC

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:To eliminate the influence of hydrostatic pressure, proper transducer positions for central venous pressure and pulmonary artery wedge pressure are at the uppermost blood levels of right atrium (RA) and left atrium (LA). This study was performed to investigate accurate reference levels of central venous pres...

journal_title：Anesthesiology

authors： Seo JH,Jung CW,Bahk JH

更新日期：2007-08-01 00:00:00

abstract：:The authors have previously attributed the mechanism for the 50-67% decrease in the required dose of thiopental for induction of anesthesia in aged human patients to a decrease in the initial distribution volume for thiopental. Using a larger group of patients and volunteers studied in the laboratory, the authors have...

journal_title：Anesthesiology

authors： Stanski DR,Maitre PO

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Previous studies demonstrated that both edrophonium and neostigmine affect mivacurium's pharmacokinetics, thereby potentially affecting its recovery profile. However, those studies were not clinically relevant because mivacurium was still infused after the antagonists were given. In the present study, the au...

journal_title：Anesthesiology

authors： Szenohradszky J,Fogarty D,Kirkegaard-Nielsen H,Brown R,Sharma ML,Fisher DM

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:A decrease in radial artery blood pressure relative to central arterial blood pressure is commonly associated with the rewarming phase of cardiopulmonary bypass. Decreased hand vascular resistance has been suggested as a possible mechanism. Although decreased blood viscosity due to hemodilution may contribut...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Moayeri A,Katz JA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Alveolar overdistension and repetitive derecruitment-recruitment contribute to ventilator-induced lung injury (VILI). The authors investigated (1) whether inflammatory cell activation due to VILI was assessable by positron emission tomography and (2) whether cell activation due to dynamic overdistension alon...

journal_title：Anesthesiology

authors： Musch G,Venegas JG,Bellani G,Winkler T,Schroeder T,Petersen B,Harris RS,Melo MF

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Recent evidence indicates that vascular adenosine triphosphate-sensitive potassium (K(ATP)) channels in vascular smooth muscle cells are critical in the regulation of vascular tonus under both physiologic and pathophysiologic conditions. Studies of the interaction of volatile anesthetics with vascular K(ATP)...

journal_title：Anesthesiology

authors： Tanaka K,Kawano T,Nakamura A,Nazari H,Kawahito S,Oshita S,Takahashi A,Nakaya Y

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Postoperative visual loss after prone spine surgery is increasingly reported in association with ischemic optic neuropathy, but its etiology is unknown. METHODS:To describe the clinical characteristics of these patients, the authors analyzed a retrospectively collected series of 93 spine surgery cases volun...

journal_title：Anesthesiology

authors： Lee LA,Roth S,Posner KL,Cheney FW,Caplan RA,Newman NJ,Domino KB

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Aqueous suspensions of the local anesthetic n-butyl-p-aminobenzoate (BAB), epidurally applied in terminal cancer patients, resulted in a sensory blockade, lasting up to several months. To investigate the mechanism of action on the cellular level, the effect of 100 microM BAB on Na+ action potentials and on N...

journal_title：Anesthesiology

authors： Van den Berg RJ,Van Soest PF,Wang Z,Grouls RJ,Korsten HH

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:The memory-blocking properties of general anesthetics are of high clinical relevance and scientific interest. The inhalational anesthetic xenon antagonizes N-methyl-D-aspartate (NMDA) receptors. It is unknown if xenon affects long-term potentiation (LTP), a cellular correlate for memory formation. In hippoca...

journal_title：Anesthesiology

authors： Kratzer S,Mattusch C,Kochs E,Eder M,Haseneder R,Rammes G

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:The dose-response relation for spinal ropivacaine is undetermined, and there are few data available for obstetric patients. METHODS:In a prospective, randomized, double-blind investigation, the authors studied 72 patients undergoing elective cesarean delivery. An epidural catheter was placed at the L2-L3 ve...

journal_title：Anesthesiology

authors： Khaw KS,Ngan Kee WD,Wong EL,Liu JY,Chung R

更新日期：2001-12-01 00:00:00

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception. Ketamine infusions can produce significant relief of neuropathic pain, but the treatment is resource i...

journal_title：Anesthesiology

authors： Bosma RL,Cheng JC,Rogachov A,Kim JA,Hemington KS,Osborne NR,Venkat Raghavan L,Bhatia A,Davis KD

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Postoperative nausea and vomiting (PONV) is still common, especially among female patients. Our hypothesis is that coinduction with clonidine reduces the incidence of PONV in adult patients undergoing breast cancer surgery. METHODS:Sixty-eight women premedicated with midazolam were randomly allocated to coi...

journal_title：Anesthesiology

authors： Oddby-Muhrbeck E,Eksborg S,Bergendahl HT,Muhrbeck O,Lönnqvist PA

更新日期：2002-05-01 00:00:00