Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury.

abstract：:The authors studied anesthetic mutagenesis following exposure in vivo by use of an adaptation of the mouse spermatozoa morphology assay of Wyrobek and Bruce. The epididymal spermatozoa of (C57B1/C3H)F1 mice were examined for morphologic abnormalities following exposure to near-0.1 MAC and greater concentrations of gen...

journal_title：Anesthesiology

authors： Land PC,Owen EL,Linde HW

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Studies on receptor knockout mice have so far shown that of the three alpha2-adrenoceptor subtypes, the alpha(2A) adrenoceptor has a major role in mediating the powerful central analgesia induced by synthetic alpha2-adrenoceptor agonists. However, because a knockout of the gene for the alpha(2A) adrenoceptor...

journal_title：Anesthesiology

authors： Mansikka H,Lähdesmäki J,Scheinin M,Pertovaara A

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Results from previous studies on the effect of nitrous oxide (N2O) on the cerebral circulation are conflicting. Early reports claim N2O to have no effect whereas recent findings demonstrate a cerebral cortical vasodilatation during N2O inhalation, but the regional cerebral blood flow (CBF) in the subcortical...

journal_title：Anesthesiology

authors： Reinstrup P,Ryding E,Algotsson L,Berntman L,Uski T

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Ventilator-associated pneumonia is a clear risk factor for acute lung injury which has been poorly described in trauma patients. This prospective study was undertaken to estimate the incidence of such ventilator-associated pneumonia leading to acute lung injury, the risk factors, and the associated morbidity...

journal_title：Anesthesiology

authors： Stéphan F,Mabrouk N,Decailliot F,Delclaux C,Legrand P

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:The placement of the superficial cervical plexus block has been the subject of controversy. Although the investing cervical fascia has been considered as an impenetrable barrier, clinically, the placement of the block deep or superficial to the fascia provides the same effective anesthesia. The underlying me...

journal_title：Anesthesiology

authors： Nash L,Nicholson HD,Zhang M

更新日期：2005-11-01 00:00:00

abstract：:To determine whether disuse atrophy of skeletal muscle results in resistance to pancuronium, the dose response to pancuronium was determined simultaneously in both gastrocnemius muscles of six dogs that had one hind limb immobilized in a plaster cast for one month. Muscle responses were evoked during pentobarbital-nit...

journal_title：Anesthesiology

authors： Gronert GA

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:Xenon is a general anesthetic with neuroprotective properties. Xenon inhibition at the glycine-binding site of the N-Methyl-D-aspartate (NMDA) receptor mediates xenon neuroprotection against ischemic injury in vitro. Here we identify specific amino acids important for xenon binding to the NMDA receptor, with...

journal_title：Anesthesiology

authors： Armstrong SP,Banks PJ,McKitrick TJ,Geldart CH,Edge CJ,Babla R,Simillis C,Franks NP,Dickinson R

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Anesthetic drugs administered to immature animals may cause neurohistopathologic changes and alterations in behavior. The authors studied association between anesthetic exposure before age 4 yr and the development of reading, written language, and math learning disabilities (LD). METHODS:This was a populati...

journal_title：Anesthesiology

authors： Wilder RT,Flick RP,Sprung J,Katusic SK,Barbaresi WJ,Mickelson C,Gleich SJ,Schroeder DR,Weaver AL,Warner DO

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and neutrophils. This study investigated the effects of neutrophil elastase on organ injury after unilateral lung acid instillation by administrating a specific neutrophil elastase inhibitor, ONO...

journal_title：Anesthesiology

authors： Kaneko K,Kudoh I,Hattori S,Yamada H,Ohara M,Wiener-Kronish J,Okumura F

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Postoperative nausea and vomiting (PONV) is still common, especially among female patients. Our hypothesis is that coinduction with clonidine reduces the incidence of PONV in adult patients undergoing breast cancer surgery. METHODS:Sixty-eight women premedicated with midazolam were randomly allocated to coi...

journal_title：Anesthesiology

authors： Oddby-Muhrbeck E,Eksborg S,Bergendahl HT,Muhrbeck O,Lönnqvist PA

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Suboptimal tissue perfusion and oxygenation during surgery may be responsible for postoperative nausea and vomiting in some patients. This trial tested the hypothesis that muscular tissue oxygen saturation-guided intraoperative care reduces postoperative nausea and vomiting. METHODS:This multicenter, pragma...

journal_title：Anesthesiology

authors： Li G,Tian DD,Wang X,Feng X,Zhang W,Bao J,Wang DX,Ai YQ,Liu Y,Zhang M,Xu M,Mu DL,Zhao X,Dai F,Yang JJ,Che X,Yanez D,Guo X,Meng L,iMODIPONV Research Group.

更新日期：2020-08-01 00:00:00

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Craniotomy for brain tumor displays significant morbidity and mortality, and no score is available to discriminate high-risk patients. Our objective was to validate a prediction score for postoperative neurosurgical complications...

journal_title：Anesthesiology

authors： Cinotti R,Bruder N,Srairi M,Paugam-Burtz C,Beloeil H,Pottecher J,Geeraerts T,Atthar V,Guéguen A,Triglia T,Josserand J,Vigouroux D,Viquesnel S,Lakhal K,Galliez M,Blanloeil Y,Le Thuaut A,Feuillet F,Rozec B,Asehnoune K

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Since the effects of antiemetic doses of droperidol on the QT interval have not been previously studied, the authors designed a randomized, double-blind, placebo-controlled study to evaluate the intraoperative and postoperative effects of small-dose droperidol (0.625 and 1.25 mg intravenous) on the QT interv...

journal_title：Anesthesiology

authors： White PF,Song D,Abrao J,Klein KW,Navarette B

更新日期：2005-06-01 00:00:00

abstract：:Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia. The authors investigated this possibility in cats by determining whether or not pentylenetetrazol- (Metrazol) or lidocaine-seizure thresholds decreased after repeated enflurane exposure. The lido...

journal_title：Anesthesiology

authors： Heavner JE,Amory DW

更新日期：1981-05-01 00:00:00

abstract：:Previous investigators have identified an aortic-to-radial artery pressure gradient thought to develop during rewarming and discontinuation of cardiopulmonary bypass. The authors measured mean aortic and radial artery pressures before, during, and after cardiopulmonary bypass in 30 patients, to determine when the pres...

journal_title：Anesthesiology

authors： Rich GF,Lubanski RE Jr,McLoughlin TM

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Melanocortin peptides improve hemodynamic parameters and prevent death during severe hemorrhagic shock. In the present research we determined influences of a synthetic melanocortin 1/4 receptor agonist on the molecular changes that occur in rat liver during hemorrhage. METHODS:Controlled-volume hemorrhage w...

journal_title：Anesthesiology

authors： Lonati C,Sordi A,Giuliani D,Spaccapelo L,Leonardi P,Carlin A,Ottani A,Galantucci M,Grieco P,Catania A,Guarini S

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical pain. The relation...

journal_title：Anesthesiology

authors： Peters CM,Hayashida K,Suto T,Houle TT,Aschenbrenner CA,Martin TJ,Eisenach JC

更新日期：2015-04-01 00:00:00

abstract：:EEG amplitude dominance in awake man is posterior. During EEG monitoring in patients, the authors observed the abrupt appearance of anterior amplitude dominance during induction of anesthesia with halothane, enflurane, or thiopental. This EEG change is coincident with loss of eyelid reflex and loss of ability to respo...

journal_title：Anesthesiology

authors： Tinker JH,Sharbrough FW,Michenfelder JD

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Although transesophageal echocardiography allows continuous intraoperative cardiac monitoring, the technique has been limited by the lack of a method for realtime, quantitative assessment of cardiac chamber size and systolic function. Automated border detection (ABD), based on an analysis of integrated backs...

journal_title：Anesthesiology

authors： Perrino AC Jr,Luther MA,O'Connor TZ,Cohen IS

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Dysrhythmias and death occur in patients with acquired long QT syndrome (LQTS). Little information exists regarding interactions between anesthetics and drugs that prolong ventricular repolarization. Therefore the effects of three commonly used intravenous anesthetics on ventricular repolarization were inves...

journal_title：Anesthesiology

authors： Morey TE,Martynyuk AE,Napolitano CA,Raatikainen MJ,Guyton TS,Dennis DM

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Macrophage recruitment into atherosclerotic plaques drives lesion progression, destabilization, and rupture. Chronic statin treatment reduces macrophage plaque content. Information on dynamics of macrophage recruitment would help assessing plaque vulnerability and guiding therapy. Techniques to image macroph...

journal_title：Anesthesiology

authors： Larmann J,Frenzel T,Schmitz M,Hahnenkamp A,Demmer P,Immenschuh S,Tietge UJ,Bremer C,Theilmeier G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Recent studies have questioned the importance of the gravitational model of pulmonary perfusion. Because low levels of positive end-expiratory pressure (PEEP) are commonly used during anesthesia, the authors studied the distribution of pulmonary blood flow with low levels of PEEP using a high spatial resolut...

journal_title：Anesthesiology

authors： Kallas HJ,Domino KB,Glenny RW,Anderson EA,Hlastala MP

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Several beneficial effects of local anesthetics (LAs) were shown to be due to inhibition of G protein-coupled receptor signaling. Differences in exposure time might explain discrepancies in concentrations of LAs required to achieve these protective effects in vivo and in vitro (approximately 100-fold higher)...

journal_title：Anesthesiology

authors： Hollmann MW,Herroeder S,Kurz KS,Hoenemann CW,Struemper D,Hahnenkamp K,Durieux ME

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Inhalational anesthetics inhibit the nitric oxide-guanylyl cyclase signaling pathway, but the site of this inhibition is not yet clear. This study was designed to test the hypothesis that receptor activation or downstream signaling events leading to nitric oxide synthase activation are important sites for th...

journal_title：Anesthesiology

authors： Zuo Z,Tichotsky A,Johns RA

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Although respiratory depression is the most well-known and dangerous side effect of opioids, no pharmacokinetic-pharmacodynamic model exists for its quantitative analysis. The development of such a model was the aim of this study. METHODS:After institutional approval approval and informed consent were obtai...

journal_title：Anesthesiology

authors： Bouillon T,Schmidt C,Garstka G,Heimbach D,Stafforst D,Schwilden H,Hoeft A

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. METHODS:Pigs (n = 27, 9 per group) were anesthetized and me...

journal_title：Anesthesiology

authors： Kimberger O,Arnberger M,Brandt S,Plock J,Sigurdsson GH,Kurz A,Hiltebrand L

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger inflammation are unclear. The authors hypothesize that extracellular histones, a newly identified inflammatory mediator, play important roles in the pathogenesis of ARDS....

journal_title：Anesthesiology

authors： Zhang Y,Wen Z,Guan L,Jiang P,Gu T,Zhao J,Lv X,Wen T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The analgesic activity of morphine-6-glucuronide (M-6-G) is well recognized for its contribution to the effects of morphine and its possible use as an opioid analgesic with a wider therapeutic range than morphine. The present study attempted to quantify the relative contribution of M-6-G to analgesia observe...

journal_title：Anesthesiology

authors： Lötsch J,Kobal G,Stockmann A,Brune K,Geisslinger G

更新日期：1997-12-01 00:00:00

abstract：:The effects of halothane on the beating response of rat heart cells in tissue culture were studied using an optical-electronic monitoring device. A dose-response curve was obtained over a concentration range to as much as 5 vol per cent halothane. The clinical dosage of 1 vol per cent halothane decreased the inotropic...

journal_title：Anesthesiology

authors： Stong LJ,Hartzell CR,McCarl RL

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:The aim of this study was to characterize cervical cord, root, and bony spine claims in the American Society of Anesthesiologists Closed Claims database to formulate hypotheses regarding mechanisms of injury. METHODS:All general anesthesia claims (1970-2007) in the Closed Claims database were searched to id...

journal_title：Anesthesiology

authors： Hindman BJ,Palecek JP,Posner KL,Traynelis VC,Lee LA,Sawin PD,Tredway TL,Todd MM,Domino KB

更新日期：2011-04-01 00:00:00