Ionic basis of the differential effects of intravenous anesthetics on erythromycin-induced prolongation of ventricular repolarization in the guinea pig heart.

abstract：BACKGROUND:Several investigations into brain activation caused by pain have suggested that the multiple painful stimulations used in typical block designs may cause attenuation over time of the signal within activated areas. The effect this may have on pain investigations using multiple tasks has not been investigated....

journal_title：Anesthesiology

authors： Ibinson JW,Small RH,Algaze A,Roberts CJ,Clark DL,Schmalbrock P

更新日期：2004-10-01 00:00:00

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Traumatic brain injury induces cellular proliferation in the hippocampus, which generates new neurons and glial cells during recovery. This process is regulated by N-methyl-D-aspartate-type glutamate receptors, which are inhibite...

journal_title：Anesthesiology

authors： Peters AJ,Villasana LE,Schnell E

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers improve cognitive function. The authors therefore tested the primary hypothesis that preoperative use of angiotensin inhibitors is associated with less delirium in critical care patients. Post hoc, the association between postoperativ...

journal_title：Anesthesiology

authors： Farag E,Liang C,Mascha EJ,Argalious MY,Ezell J,Maheshwari K,Esa WAS,Troianos CA,Sessler DI

更新日期：2020-07-01 00:00:00

abstract：:To determine if continuous positive airway pressure (CPAP) or expiratory positive airway pressure (EPAP) is superior for achieving or maintaining effective lung volume in spontaneously breathing critically ill patients in acute respiratory failure, the authors measured functional residual capacity (FRC), airway and es...

journal_title：Anesthesiology

authors： Schlobohm RM,Falltrick RT,Quan SF,Katz JA

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Offset analgesia, in which a disproportionally large amount of analgesia becomes apparent upon a slight decrease in noxious heat stimulation, has not been described previously in patients with chronic pain. METHODS:Offset analgesia responses in 10 patients with neuropathic pain (in both legs) were compared ...

journal_title：Anesthesiology

authors： Niesters M,Hoitsma E,Sarton E,Aarts L,Dahan A

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:General anesthetics modify airway responsiveness by several mechanisms, including direct effects on airway smooth muscle and reductions in neural reflex activity. Halothane has been shown to reduce responsiveness through both of these mechanisms. The airway effects of barbiturates are controversial, and the ...

journal_title：Anesthesiology

authors： Mehr EH,Lindeman KS

更新日期：1993-08-01 00:00:00

abstract：:The authors undertook a prospective study of 30 patients undergoing halothane anesthesia for coronary-artery revascularization to ascertain which clinically monitored hemodynamic variables--or combination of variables--associated with myocardial oxygen supply and demand best predict myocardial ischemia. Simultaneous r...

journal_title：Anesthesiology

authors： Lieberman RW,Orkin FK,Jobes DR,Schwartz AJ

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:Ventilator-associated pneumonia (VAP) requires early diagnosis and adequate antibiotic therapy. The aim of this prospective postmortem study was to assess the accuracy of direct examination and quantification of intracellular organisms (ICO) for the diagnosis of VAP. METHODS:Total and differential cell coun...

journal_title：Anesthesiology

authors： Papazian L,Autillo-Touati A,Thomas P,Bregeon F,Garbe L,Saux P,Seite R,Gouin F

更新日期：1997-08-01 00:00:00

abstract：:There has been a dramatic growth of scholarly articles in medical education in recent years. Evaluating medical education research requires specific orientation to issues related to format and content. Our goal is to review the quantitative aspects of research in medical education so that clinicians may understand the...

journal_title：Anesthesiology

authors： Ratelle JT,Sawatsky AP,Beckman TJ

更新日期：2019-07-01 00:00:00

abstract：:Chloroprocaine, 0.5 per cent, with physiologic saline solution, has a specific gravity of 1.007 and a osmolarity of 283 mOsm/l, which increase to a specific gravity of 1.025 and an osmolarity of 542 mOsm/l when chloroprocaine is prepared in dextrose, 5 per cent. Chloroprocaine, 2.7 per cent, shows similar increases in...

journal_title：Anesthesiology

authors： Park YR,Eastwood DW

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:The spinal delivery of the cholinesterase inhibitor neostigmine yields analgesia in rats and augments the analgesic effects of alpha 2 agonists in sheep. To assess its activity in humans, preclinical toxicology studies to define its safety were required in two species. METHODS:Rats with chronic intrathecal ...

journal_title：Anesthesiology

authors： Yaksh TL,Grafe MR,Malkmus S,Rathbun ML,Eisenach JC

更新日期：1995-02-01 00:00:00

abstract：:There is controversy about whether N2O increases cerebral blood flow and cortical oxygen consumption (CMRO2) in rats. Cortical and subcortical blood flow and CMRO2 were measured in awake, unrestrained rats while awake and during 70% N2O administration using radioactive microspheres. In the awake state, cortical and su...

journal_title：Anesthesiology

authors： Baughman VL,Hoffman WE,Miletich DJ,Albrecht RF

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:The myocardial negative inotropic effects of desflurane are less pronounced than those of other halogenated anesthetics, partly because of intramyocardial catecholamine store release. However, the effects of desflurane on aging myocardium are unknown, whereas aging is known to be associated with an attenuati...

journal_title：Anesthesiology

authors： Rozenberg S,Besse S,Amour J,Vivien B,Tavernier B,Riou B

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The mechanisms that underlie the supraspinal central nervous system effects of systemic lidocaine are poorly understood and not solely explained by Na(+) channel blockade. Among other potential targets is the hyperpolarization-activated cation current, I(h), which is blocked by lidocaine in peripheral neuron...

journal_title：Anesthesiology

authors： Putrenko I,Schwarz SK

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The permutation entropy, the approximate entropy, and the index of consciousness are some of the most recently studied electroencephalogram-derived indexes. In this work, a thorough comparison of these indexes was performed using propofol anesthesia in a rabbit model. METHODS:Six rabbits were anesthetized w...

journal_title：Anesthesiology

authors： Silva A,Campos S,Monteiro J,Venâncio C,Costa B,Guedes de Pinho P,Antunes L

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block. METHODS:Twenty-seven male surgical patients aged 18-...

journal_title：Anesthesiology

authors： Sorgenfrei IF,Norrild K,Larsen PB,Stensballe J,Ostergaard D,Prins ME,Viby-Mogensen J

更新日期：2006-04-01 00:00:00

abstract：:We performed a prospective randomized controlled trial to assess the efficacy of a chlorhexidine dressing in reducing the microbial flora at the insertion site of epidural catheters. These catheters were used for acute pain management and were dressed either by a standardized method or with a CHX/urethane sponge compo...

journal_title：Anesthesiology

authors： Shapiro JM,Bond EL,Garman JK

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Initial anesthetic-induced hypothermia results largely from core-to-peripheral redistribution of heat. Nifedipine administration may minimize hypothermia by inducing vasodilation well before induction of anesthesia. Although vasodilation would redistribute heat to peripheral tissues, thermoregulatory respons...

journal_title：Anesthesiology

authors： Vassilieff N,Rosencher N,Sessler DI,Conseiller C,Lienhart A

更新日期：1994-01-01 00:00:00

abstract：:The effect of liposome encapsulation on the analgesia produced by intrathecally administered alfentanil was examined in the rat. In rats prepared with chronic intrathecal catheters, alfentanil in doses of 1-50 micrograms was administered intrathecally in either saline or in multilamellar liposomes (dipalmitoylphosphat...

journal_title：Anesthesiology

authors： Bernards CM,Luger TJ,Malmberg AB,Hill HF,Yaksh TL

更新日期：1992-09-01 00:00:00

abstract：:This study examined whether pain or stress can enhance the analgesic effects of spinally administered opiates. The experiments determined the effects of mechanically produced pain and of the stress of being restrained on the analgesic effects of 0.63 microgram of epidural sufentanil in rats using a tail-withdrawal pro...

journal_title：Anesthesiology

authors： Van den Hoogen RH,Bervoets K,Colpaert FC

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Percutaneous cricothyroidotomy is a lifesaving procedure for airway obstruction in trauma victims who need airway establishment and cannot be intubated or in whom intubation has failed. METHODS:The purpose of this study was to examine whether there is a training effect using Seldinger technique emergency cr...

journal_title：Anesthesiology

authors： Schaumann N,Lorenz V,Schellongowski P,Staudinger T,Locker GJ,Burgmann H,Pikula B,Hofbauer R,Schuster E,Frass M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Propofol is short-acting intravenous general anesthetics that reduces cardiovascular hemodynamics. The effects of propofol on intrinsic myocardial contractility, however, remain debatable. The aim of the current study was to test the hypothesis that inhibitory effects of propofol on left ventricular (LV) con...

journal_title：Anesthesiology

authors： Kuzumoto N,Kitagawa Y,Uemura K,Ueyama T,Yoshida K,Furuya H,Takaki M

更新日期：2004-10-01 00:00:00

abstract：:Eighty-six patients undergoing coronary artery bypass graft (n = 63) or intracardiac (n = 23) surgery were randomly assigned with respect to the target value for PaCO2 during cardiopulmonary bypass. In 44 patients the target PaCO2 was 40 mmHg, measured at the standard electrode temperature of 37 degrees C, while in 42...

journal_title：Anesthesiology

authors： Bashein G,Townes BD,Nessly ML,Bledsoe SW,Hornbein TF,Davis KB,Goldstein DE,Coppel DB

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:CW002 is a neuromuscular blocking drug that is inactivated by endogenous L-cysteine. This study determined the exogenous L-cysteine dose-response relationship for CW002 reversal along with acute cardiovascular effects and organ toxicity in dogs. METHODS:Six dogs were each studied four times during isofluran...

journal_title：Anesthesiology

authors： Sunaga H,Malhotra JK,Yoon E,Savarese JJ,Heerdt PM

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Kinins (e.g., bradykinin) acting through the constitutively expressed B2 and the injury-induced B1 receptors are involved in pain and hyperalgesia, as previously shown by use of receptor-selective antagonists and single-receptor knockout models. Because the overall contribution of kinins to painful processes...

journal_title：Anesthesiology

authors： Cayla C,Labuz D,Machelska H,Bader M,Schäfer M,Stein C

更新日期：2012-02-01 00:00:00

abstract：:Oral transmucosal fentanyl citrate (OTFC) is a novel, noninvasive dosage form of fentanyl used to provide children and adults with sedation, anxiolysis, and analgesia. In order to determine the bioavailability and absorption of fentanyl from OTFC, 12 volunteers were given intravenous fentanyl citrate or OTFC 15 microg...

journal_title：Anesthesiology

authors： Streisand JB,Varvel JR,Stanski DR,Le Maire L,Ashburn MA,Hague BI,Tarver SD,Stanley TH

更新日期：1991-08-01 00:00:00

abstract：:The safety and efficacy of epidural morphine injected into the caudal space for control of postoperative pain following open cardiac surgery in children was studied. Thirty-two children between the ages of 2-12 yr for whom early postoperative tracheal extubation was anticipated were randomly assigned to control and st...

journal_title：Anesthesiology

authors： Rosen KR,Rosen DA

更新日期：1989-03-01 00:00:00

abstract：:The mechanisms of persistent differential blocks that accompany subarachnoid and epidural anesthesia are clarified here with the aid of two principles derived from in vitro study of individual myelinated axons: 1) conduction can leap two consecutive blocked nodes but not three, and 2) a fiber length with more than thr...

journal_title：Anesthesiology

authors： Fink BR

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Electrical stimulation of acupuncture point P6 reduces the incidence of postoperative nausea or vomiting (PONV) in adult patients. However, acupressure, laser stimulation of P6, and acupuncture during anesthesia have not been effective for reducing PONV in the pediatric population. The authors studied the ef...

journal_title：Anesthesiology

authors： Rusy LM,Hoffman GM,Weisman SJ

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Previous studies integrated opioid benefit and harm into one single function-the utility function-to determine the drug toxicity (respiratory depression) in light of its wanted effect (analgesia). This study further refined the concept of the utility function using the respiratory and analgesic effects of th...

journal_title：Anesthesiology

authors： Roozekrans M,van der Schrier R,Aarts L,Sarton E,van Velzen M,Niesters M,Dahan A,Olofsen E

更新日期：2018-05-01 00:00:00