Ketamine Alters Hippocampal Cell Proliferation and Improves Learning in Mice after Traumatic Brain Injury.


WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Traumatic brain injury induces cellular proliferation in the hippocampus, which generates new neurons and glial cells during recovery. This process is regulated by N-methyl-D-aspartate-type glutamate receptors, which are inhibited by ketamine. The authors hypothesized that ketamine treatment after traumatic brain injury would reduce hippocampal cell proliferation, leading to worse behavioral outcomes in mice. METHODS:Traumatic brain injury was induced in mice using a controlled cortical impact injury, after which mice (N = 118) received either ketamine or vehicle systemically for 1 week. The authors utilized immunohistochemical assays to evaluate neuronal, astroglial, and microglial cell proliferation and survival 3 days, 2 weeks, and 6 weeks postintervention. The Morris water maze reversal task was used to assess cognitive recovery. RESULTS:Ketamine dramatically increased microglial proliferation in the granule cell layer of the hippocampus 3 days after injury (injury + vehicle, 2,800 ± 2,700 cells/mm, n = 4; injury + ketamine, 11,200 ± 6,600 cells/mm, n = 6; P = 0.012). Ketamine treatment also prevented the production of astrocytes 2 weeks after injury (sham + vehicle, 2,400 ± 3,200 cells/mm, n = 13; injury + vehicle, 10,500 ± 11,300 cells/mm, n = 12; P = 0.013 vs. sham + vehicle; sham + ketamine, 3,500 ± 4,900 cells/mm, n = 14; injury + ketamine, 4,800 ± 3,000 cells/mm, n = 13; P = 0.955 vs. sham + ketamine). Independent of injury, ketamine temporarily reduced neurogenesis (vehicle-exposed, 105,100 ± 66,700, cells/mm, n = 25; ketamine-exposed, 74,300 ± 29,200 cells/mm, n = 27; P = 0.031). Ketamine administration improved performance in the Morris water maze reversal test after injury, but had no effect on performance in sham-treated mice. CONCLUSIONS:Ketamine alters hippocampal cell proliferation after traumatic brain injury. Surprisingly, these changes were associated with improvement in a neurogenesis-related behavioral recall task, suggesting a possible benefit from ketamine administration after traumatic brain injury in mice. Future studies are needed to determine generalizability and mechanism.






Peters AJ,Villasana LE,Schnell E




Has Abstract


2018-08-01 00:00:00












  • Both local anesthetics and salbutamol pretreatment affect reflex bronchoconstriction in volunteers with asthma undergoing awake fiberoptic intubation.

    abstract:BACKGROUND:Awake tracheal intubation may evoke reflex bronchoconstriction in asthmatics. Whether this effect is altered by the choice of the local anesthetic used or by pretreatment with a beta2-adrenoceptor agonist is unknown. Therefore, we assessed the effect of awake fiberoptic intubation after lidocaine or dyclonin...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Groeben H,Schlicht M,Stieglitz S,Pavlakovic G,Peters J

    更新日期:2002-12-01 00:00:00

  • Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice.

    abstract:BACKGROUND:The mechanisms of ventilator-induced lung injury, an iatrogenic inflammatory condition induced by mechanical ventilation, are not completely understood. Toll-like receptor 4 (TLR4) signaling via the adaptor protein myeloid differentiation factor 88 (MyD88) is proinflammatory and plays a critical role in host...


    pub_type: 杂志文章


    authors: Li H,Su X,Yan X,Wasserloos K,Chao W,Kaynar AM,Liu ZQ,Leikauf GD,Pitt BR,Zhang LM

    更新日期:2010-09-01 00:00:00

  • Effect of increased intracranial pressure on regional hypoxic pulmonary vasoconstriction.

    abstract::The effects of increased intracranial pressure (ICP) and increased cardiac output (QT) on the pulmonary vascular response to regional alveolar hypoxia were compared in pentobarbital-anesthetized, closed-chested dogs. A bronchial divider was inserted, the right lung (RL) was continuously ventilated with 100% O2, and th...


    pub_type: 杂志文章


    authors: Domino KB,Hlastala MP,Cheney FW

    更新日期:1990-03-01 00:00:00

  • New ultrathin-walled endotracheal tube with a novel laryngeal seal design. Long-term evaluation in sheep.

    abstract:BACKGROUND:A new endotracheal tube (ETT) was fabricated and tested in sheep. It had no tracheal cuff; airway seal was achieved at the level of the glottis through a no-pressure seal made of "gills"; the laryngeal portion was oval-shaped; and the wall thickness was reduced to 0.2 mm. METHODS:Sheep were tracheally intub...


    pub_type: 杂志文章


    authors: Reali-Forster C,Kolobow T,Giacomini M,Hayashi T,Horiba K,Ferrans VJ

    更新日期:1996-01-01 00:00:00

  • Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.

    abstract:BACKGROUND:Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the authors explored whether postoperative nadir platelet counts are associated with acute kidney injury...


    pub_type: 杂志文章


    authors: Kertai MD,Zhou S,Karhausen JA,Cooter M,Jooste E,Li YJ,White WD,Aronson S,Podgoreanu MV,Gaca J,Welsby IJ,Levy JH,Stafford-Smith M,Mathew JP,Fontes ML

    更新日期:2016-02-01 00:00:00

  • Sepsis is associated with a preferential diaphragmatic atrophy: a critically ill patient study using tridimensional computed tomography.

    abstract:BACKGROUND:Diaphragm and psoas are affected during sepsis in animal models. Whether diaphragm or limb muscle is preferentially affected during sepsis in the critically ill remains unclear. METHODS:Retrospective secondary analysis study including 40 patients, comparing control (n = 17) and critically ill patients, with...


    pub_type: 杂志文章


    authors: Jung B,Nougaret S,Conseil M,Coisel Y,Futier E,Chanques G,Molinari N,Lacampagne A,Matecki S,Jaber S

    更新日期:2014-05-01 00:00:00

  • A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats.

    abstract:BACKGROUND:Chronic pain is associated with depression. In rodents, pain is often assessed by sensory hypersensitivity, which does not sufficiently measure affective responses. Low-dose ketamine has been used to treat both pain and depression, but it is not clear whether ketamine can relieve depression associated with c...


    pub_type: 杂志文章


    authors: Wang J,Goffer Y,Xu D,Tukey DS,Shamir DB,Eberle SE,Zou AH,Blanck TJ,Ziff EB

    更新日期:2011-10-01 00:00:00

  • Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics.

    abstract:BACKGROUND:Several beneficial effects of local anesthetics (LAs) were shown to be due to inhibition of G protein-coupled receptor signaling. Differences in exposure time might explain discrepancies in concentrations of LAs required to achieve these protective effects in vivo and in vitro (approximately 100-fold higher)...


    pub_type: 杂志文章


    authors: Hollmann MW,Herroeder S,Kurz KS,Hoenemann CW,Struemper D,Hahnenkamp K,Durieux ME

    更新日期:2004-04-01 00:00:00

  • Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement.

    abstract:BACKGROUND:Rapid development of acute opioid tolerance is well established in animals and is more likely to occur with large doses of short-acting drugs. The authors therefore tested the hypothesis that intraoperative remifentanil administration results in acute opioid tolerance that is manifested by increased postoper...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Guignard B,Bossard AE,Coste C,Sessler DI,Lebrault C,Alfonsi P,Fletcher D,Chauvin M

    更新日期:2000-08-01 00:00:00

  • Distinct roles for sarcolemmal and mitochondrial adenosine triphosphate-sensitive potassium channels in isoflurane-induced protection against oxidative stress.

    abstract:BACKGROUND:Cardiac preconditioning, including that induced by halogenated anesthetics, is an innate protective mechanism against ischemia-reperfusion injury. The adenosine triphosphate-sensitive potassium (K(ATP)) channels are considered essential in preconditioning mechanism. However, it is unclear whether K(ATP) chan...


    pub_type: 杂志文章


    authors: Marinovic J,Bosnjak ZJ,Stadnicka A

    更新日期:2006-07-01 00:00:00

  • In vivo fluorescence-mediated tomography imaging demonstrates atorvastatin-mediated reduction of lesion macrophages in ApoE-/- mice.

    abstract:BACKGROUND:Macrophage recruitment into atherosclerotic plaques drives lesion progression, destabilization, and rupture. Chronic statin treatment reduces macrophage plaque content. Information on dynamics of macrophage recruitment would help assessing plaque vulnerability and guiding therapy. Techniques to image macroph...


    pub_type: 杂志文章


    authors: Larmann J,Frenzel T,Schmitz M,Hahnenkamp A,Demmer P,Immenschuh S,Tietge UJ,Bremer C,Theilmeier G

    更新日期:2013-07-01 00:00:00

  • Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes.

    abstract:BACKGROUND:Combining a hypnotic and an analgesic to produce sedation, analgesia, and surgical immobility required for clinical anesthesia is more common than administration of a volatile anesthetic alone. The aim of this study was to apply response surface methods to characterize the interactions between remifentanil a...


    pub_type: 杂志文章,随机对照试验


    authors: Manyam SC,Gupta DK,Johnson KB,White JL,Pace NL,Westenskow DR,Egan TD

    更新日期:2006-08-01 00:00:00

  • Isoflurane and an alpha 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord.

    abstract::Analgesia is an important component of general anesthesia. alpha 2-adrenoceptor agonists such as clonidine and dexmedetomidine are effective analgesics at the spinal level, and furthermore, they reduce the volatile anesthetic requirement. In order to probe a possible spinal-level contribution to general anesthetic-ind...


    pub_type: 杂志文章


    authors: Savola MK,Woodley SJ,Maze M,Kendig JJ

    更新日期:1991-09-01 00:00:00

  • Reporting of ethical approval and informed consent in clinical research published in leading anesthesia journals.

    abstract:BACKGROUND:Ethical conduct in human research in anesthesia includes approval by an institutional review board (IRB) or ethics committee and informed consent. Evidence of these is sometimes lacking in journal publications. METHODS:The authors reviewed all publications involving human subjects in six leading anesthesia ...


    pub_type: 杂志文章


    authors: Myles PS,Tan N

    更新日期:2003-11-01 00:00:00

  • Extubation Failure in Brain-injured Patients: Risk Factors and Development of a Prediction Score in a Preliminary Prospective Cohort Study.

    abstract:BACKGROUND:The decision to extubate brain-injured patients with residual impaired consciousness holds a high degree of uncertainty of success. The authors developed a pragmatic clinical score predictive of extubation failure in brain-injured patients. METHODS:One hundred and forty brain-injured patients were prospecti...


    pub_type: 杂志文章


    authors: Godet T,Chabanne R,Marin J,Kauffmann S,Futier E,Pereira B,Constantin JM

    更新日期:2017-01-01 00:00:00

  • The effects of diazepam on cerebral blood flow and oxygen consumption in rats and its synergistic interaction with nitrous oxide.

    abstract::The effects of diazepam on cerebral blood flow (CBF) and cerebral oxygen uptake (CMRO2) was studied using a 133xenon modification of the Kety-Schmidt (1948) technique in paralyzed, artifically ventilated rats with and without simultaneous administration of 70 per cent nitrous oxide. Diazepam was given iv in doses that...


    pub_type: 杂志文章


    authors: Carlsson C,Hgerdal M,Kaasik AE,Siesjö BK

    更新日期:1976-09-01 00:00:00

  • The minimum alveolar concentration of isoflurane in patients undergoing bilateral tubal ligation in the postpartum period.

    abstract:BACKGROUND:The minimum alveolar concentration (MAC) of volatile anesthetics is decreased during pregnancy, but MAC in the early postpartum period has not been reported. The aim of this study was to determine the MAC of isoflurane and to evaluate the relation between MAC and serum progesterone and beta-endorphin in pati...


    pub_type: 杂志文章


    authors: Zhou HH,Norman P,DeLima LG,Mehta M,Bass D

    更新日期:1995-06-01 00:00:00

  • Isoform-selective effects of isoflurane on voltage-gated Na+ channels.

    abstract:BACKGROUND:Voltage-gated Na channels modulate membrane excitability in excitable tissues. Inhibition of Na channels has been implicated in the effects of volatile anesthetics on both nervous and peripheral excitable tissues. The authors investigated isoform-selective effects of isoflurane on the major Na channel isofor...


    pub_type: 杂志文章


    authors: OuYang W,Hemmings HC Jr

    更新日期:2007-07-01 00:00:00

  • The neurologic and adaptive capacity score is not a reliable method of newborn evaluation.

    abstract:BACKGROUND:The Neurologic and Adaptive Capacity Score (NACS) is a multi-item scale that was published in 1982 to measure the effects of intrapartum drugs on the neonate. Although this scoring system has been widely used in obstetric anesthesia research, studies confirming its reliability have not been published. The pu...


    pub_type: 临床试验,杂志文章


    authors: Halpern SH,Littleford JA,Brockhurst NJ,Youngs PJ,Malik N,Owen HC

    更新日期:2001-06-01 00:00:00

  • The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons.

    abstract:BACKGROUND:Aqueous suspensions of the local anesthetic n-butyl-p-aminobenzoate (BAB), epidurally applied in terminal cancer patients, resulted in a sensory blockade, lasting up to several months. To investigate the mechanism of action on the cellular level, the effect of 100 microM BAB on Na+ action potentials and on N...


    pub_type: 杂志文章


    authors: Van den Berg RJ,Van Soest PF,Wang Z,Grouls RJ,Korsten HH

    更新日期:1995-06-01 00:00:00

  • Morphologic changes in mouse spermatozoa after exposure to inhalational anesthetics during early spermatogenesis.

    abstract::The authors studied anesthetic mutagenesis following exposure in vivo by use of an adaptation of the mouse spermatozoa morphology assay of Wyrobek and Bruce. The epididymal spermatozoa of (C57B1/C3H)F1 mice were examined for morphologic abnormalities following exposure to near-0.1 MAC and greater concentrations of gen...


    pub_type: 杂志文章


    authors: Land PC,Owen EL,Linde HW

    更新日期:1981-01-01 00:00:00

  • Discharge Readiness after Tricompartment Knee Arthroplasty: Adductor Canal versus Femoral Continuous Nerve Blocks-A Dual-center, Randomized Trial.

    abstract:BACKGROUND:The authors conducted a randomized, controlled, parallel-arm, superiority study to test the hypothesis that a continuous adductor canal block decreases the time to attain four discharge criteria compared with a continuous femoral nerve block after tricompartment knee arthroplasty. METHODS:Subjects undergoin...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Machi AT,Sztain JF,Kormylo NJ,Madison SJ,Abramson WB,Monahan AM,Khatibi B,Ball ST,Gonzales FB,Sessler DI,Mascha EJ,You J,Nakanote KA,Ilfeld BM

    更新日期:2015-08-01 00:00:00

  • Potassium channel-mediated hyperpolarization of mesenteric vascular smooth muscle by isoflurane.

    abstract:BACKGROUND:A primary source of calcium (Ca2+) necessary for excitation contraction in vascular smooth muscle (VSM) is influx via voltage-dependent Ca2+ channels. Thus, force generation in VSM is coupled closely to resting transmembrane potential, which itself is primarily a function of potassium conductance. Previously...


    pub_type: 杂志文章


    authors: Kokita N,Stekiel TA,Yamazaki M,Bosnjak ZJ,Kampine JP,Stekiel WJ

    更新日期:1999-03-01 00:00:00

  • Halothane and isoflurane differentially affect the regulation of dopamine and gamma-aminobutyric acid release mediated by presynaptic acetylcholine receptors in the rat striatum.

    abstract:BACKGROUND:General anesthetics are thought to produce their hypnotic effects mainly by acting at ligand-gated ionic channels in the central nervous system (CNS). Although it is well established that volatile anesthetics significantly modify the activity of the acetylcholine nicotinic receptors of the neuromuscular junc...


    pub_type: 杂志文章


    authors: Salord F,Keita H,Lecharny JB,Henzel D,Desmonts JM,Mantz J

    更新日期:1997-03-01 00:00:00

  • The neonatal neurobehavioral effects of bupivacaine, mepivacaine, and 2-chloroprocaine used for pudendal block.

    abstract::The neonatal neurobehavioral effects of bupivacaine, mepivacaine, and 2-chloroprocaine used in random sequence for pudendal block anesthesia were studied. The neurobehavioral status of 54 infants was studied 4 and 24 hours after delivery. Except for a significant difference in the responses to pinprick, there was no s...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Merkow AJ,McGuinness GA,Erenberg A,Kennedy RL

    更新日期:1980-04-01 00:00:00

  • Acute surgical anemia influences the cardioprotective effects of beta-blockade: a single-center, propensity-matched cohort study.

    abstract:BACKGROUND:Despite decreasing cardiac events, perioperative beta-blockade also increases perioperative stroke and mortality. Major bleeding and/or hypotension are independently associated with these outcomes. To investigate the hypothesis that beta-blockade limits the cardiac reserve to compensate for acute surgical an...


    pub_type: 杂志文章


    authors: Beattie WS,Wijeysundera DN,Karkouti K,McCluskey S,Tait G,Mitsakakis N,Hare GM

    更新日期:2010-01-01 00:00:00

  • Lack of nephrotoxicity by 6% hydroxyethyl starch 130/0.4 during hip arthroplasty: a randomized controlled trial.

    abstract:BACKGROUND:Hydroxyethyl starch (HES) is commonly used as plasma expander during surgery but may be nephrotoxic as seen in studies in patients with sepsis. The authors hypothesized that the possible nephrotoxicity of 6% HES 130/0.4 could be revealed by measurements of urinary excretion of neutrophil gelatinase-associate...


    pub_type: 杂志文章,随机对照试验


    authors: Kancir AS,Pleckaitiene L,Hansen TB,Ekeløf NP,Pedersen EB

    更新日期:2014-11-01 00:00:00

  • Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia.

    abstract:BACKGROUND:Cisatracurium, one of the ten isomers in atracurium, is a nondepolarizing muscle relaxant with an intermediate duration of action. It is more potent and less likely to release histamine than atracurium. As one of the isomers composing atracurium, it presumably undergoes Hofmann elimination. This study was co...


    pub_type: 临床试验,杂志文章


    authors: Lien CA,Schmith VD,Belmont MR,Abalos A,Kisor DF,Savarese JJ

    更新日期:1996-02-01 00:00:00

  • Propofol: its role in changing the practice of anesthesia.

    abstract::Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia. By Audrey Shafer, Van A. Doze, Steven L. Shafer, and Paul F. White. Anesthesiology 1988; 69:348-56. Reprinted with permission.The pharmacokinetic and pharmacodynamic properties of propofol (Diprivan) were studied in 50 elective surg...


    pub_type: 古典文章,评论,杂志文章


    authors: White PF

    更新日期:2008-12-01 00:00:00

  • Effects of isoflurane on cerebral autoregulation in dogs.

    abstract::The effect of decreased cerebral perfusion pressure (CPP) on regional cerebral blood flow (CBF) with radiolabeled microspheres in dogs receiving either 1.4% or 2.8% isoflurane following anesthesia induction with thiopental (12 mg/kg, iv bolus) was studied. Mean arterial blood pressure (MABP), cerebrospinal fluid press...


    pub_type: 杂志文章


    authors: McPherson RW,Traystman RJ

    更新日期:1988-10-01 00:00:00