The effect of clonidine on cerebral blood flow velocity, carbon dioxide cerebral vasoreactivity, and response to increased arterial pressure in human volunteers.

abstract：BACKGROUND:The medical, social, and economic effects of the teaching mission on delivery of care at an academic medical center (AMC) are not fully understood. When a free-standing private practice ambulatory clinic with no teaching mission was merged into an AMC, a natural experiment was created. The authors compared p...

journal_title：Anesthesiology

authors： Williams KA,Chambers CG,Dada M,Hough D,Aron R,Ulatowski JA

更新日期：2012-04-01 00:00:00

abstract：:The cerebral metabolic effects of a massive dose of thiopental (177 mg/kg) were investigated in seven dogs. The systemic circulation was supported with an extracorporeal circuit. At an infusion rate of 2 mg/kg/min, cerebral oxygen consumption (CMR(O(2))) decreased progressively until cerebral electrical silence was pr...

journal_title：Anesthesiology

authors： Michenfelder JD

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Diffusion of nitrous oxide into the cuff of the endotracheal tube results in an increase in cuff pressure. Excessive endotracheal tube cuff pressure may impair tracheal mucosal perfusion and cause tracheal damage and sore throat. Filling the cuff of the endotracheal tube with saline instead of air prevents t...

journal_title：Anesthesiology

authors： Combes X,Schauvliege F,Peyrouset O,Motamed C,Kirov K,Dhonneur G,Duvaldestin P

更新日期：2001-11-01 00:00:00

abstract：:Although suppression of thermoregulatory mechanisms by anesthetics is generally assumed, the extent to which thermoregulation is active during general anesthesia is not known. The only thermoregulatory responses available to anesthetized, hypothermic patients are vasoconstriction and non-shivering thermogenesis. To te...

journal_title：Anesthesiology

authors： Sessler DI,Olofsson CI,Rubinstein EH,Beebe JJ

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Impaired excitatory and inhibitory balance in the spinal dorsal horn has a crucial role in the pathophysiology of chronic pain. The authors addressed the therapeutic impact of increasing spinal glycine applied exogenously or via blockade of glycine transporter 1 using its selective inhibitors sarcosine and N...

journal_title：Anesthesiology

authors： Tanabe M,Takasu K,Yamaguchi S,Kodama D,Ono H

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Conflicting results have been reported concerning the effect of platelet transfusion on several outcomes. The aim of this study was to assess the independent effect of a single early intraoperative platelet transfusion on bleeding and adverse outcomes in cardiac surgery patients. METHODS:For this observatio...

journal_title：Anesthesiology

authors： van Hout FM,Hogervorst EK,Rosseel PM,van der Bom JG,Bentala M,van Dorp EL,van Geloven N,Brand A,van der Meer NJ,van de Watering LM

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Good postoperative recovery is increasingly recognized as an important outcome after surgery. The authors created a new Post-operative Quality Recovery Scale (PQRS) that tracks multiple domains of recovery from immediate to long-term time periods in patients of varying ages, languages, and cultures. METHODS...

journal_title：Anesthesiology

authors： Royse CF,Newman S,Chung F,Stygall J,McKay RE,Boldt J,Servin FS,Hurtado I,Hannallah R,Yu B,Wilkinson DJ

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The long-lasting high-affinity opioid buprenorphine has complex pharmacology, including ceiling effects with respect to analgesia and respiratory depression. Plasma concentrations of the major buprenorphine metabolites norbuprenorphine, buprenorphine-3-glucuronide, and norbuprenorphine-3-glucuronide approxim...

journal_title：Anesthesiology

authors： Brown SM,Holtzman M,Kim T,Kharasch ED

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The rate of administration of an intravenous anesthetic induction agent is an important variable determining the total dose required to reach a given endpoint, such as loss of consciousness (LOC). The influence of infusion rate on the dose-response relationship has not been described rigorously. In this stud...

journal_title：Anesthesiology

authors： Gentry WB,Krejcie TC,Henthorn TK,Shanks CA,Howard KA,Gupta DK,Avram MJ

更新日期：1994-08-01 00:00:00

abstract：:Characteristics of nocturnal sleep were investigated in six patients after anesthesia and cholecystectomy and in another six after anesthesia and gastroplasty. All night polysomnographic recordings were obtained while each patient slept in a private surgical ward room through two nights before and five or six nights a...

journal_title：Anesthesiology

authors： Knill RL,Moote CA,Skinner MI,Rose EA

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Chronic pain is associated with depression. In rodents, pain is often assessed by sensory hypersensitivity, which does not sufficiently measure affective responses. Low-dose ketamine has been used to treat both pain and depression, but it is not clear whether ketamine can relieve depression associated with c...

journal_title：Anesthesiology

authors： Wang J,Goffer Y,Xu D,Tukey DS,Shamir DB,Eberle SE,Zou AH,Blanck TJ,Ziff EB

更新日期：2011-10-01 00:00:00

abstract：:The pattern of breathing and lung mechanics were evaluated during the first 7 h of life in full-term healthy newborns delivered by cesarean section with bupivacaine epidural anesthesia, without (group 1) or with the addition of 100 micrograms of fentanyl (group 2). Respiration and oxyhemoglobin saturation (SpO2) were ...

journal_title：Anesthesiology

authors： Benlabed M,Dreizzen E,Ecoffey C,Escourrou P,Migdal M,Gaultier C

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (NO), a selective vasodilator, improves oxygenation in many patients with adult respiratory distress syndrome (ARDS). Vasoconstrictors may also improve oxygenation, possibly by enhancing hypoxic pulmonary vasoconstriction. This study compared the effects of phenylephrine, NO, and their c...

journal_title：Anesthesiology

authors： Doering EB,Hanson CW 3rd,Reily DJ,Marshall C,Marshall BE

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:The authors report on the appearance of misleading square wave "phantom" capnograph tracings for approximately 3 min after disconnection from the Siemens Servo 900c ventilator. A series of experiments are described to examine the mechanism of this phenomenon. METHODS:Patients were ventilated using the Sieme...

journal_title：Anesthesiology

authors： Ginosar Y,Baranov D

更新日期：1997-03-01 00:00:00

abstract：:Clinical studies have reported that body core temperature decreases during prolonged surgery and anesthesia. Although this finding has been attributed primarily to increased heat loss resulting from exposure of body cavities and infusion of cold solutions, it is generally recognized that anesthesia interferes with the...

journal_title：Anesthesiology

authors： Passias TC,Mekjavić IB,Eiken O

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Despite the fact that obesity is a known risk factor for cardiovascular disease, many studies have failed to demonstrate that obesity is independently associated with an increased risk of cardiovascular morbidity and mortality in nondiabetic patients undergoing coronary artery bypass graft surgery. The autho...

journal_title：Anesthesiology

authors： Pan W,Hindler K,Lee VV,Vaughn WK,Collard CD

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics depress left ventricular contractile function by altering voltage-dependent slow calcium (Ca2+) channel activity in the sarcolemmal membrane. This investigation examined the left ventricular systolic and diastolic mechanical effects of the dihydropyridine Ca2+ channel antagonist nifedipi...

journal_title：Anesthesiology

authors： Pagel PS,Hettrick DA,Warltier DC

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:The combining of epidural anesthesia with general anesthesia impairs central and peripheral thermoregulatory control and therefore is often accompanied by unintended intraoperative hypothermia. However, little is known about the cardiovascular response to hypothermia during combined epidural and general anes...

journal_title：Anesthesiology

authors： Yoshida M,Shibata K,Itoh H,Yamamoto K

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Oxidation of propofol to 4-hydroxypropofol represents a significant pathway in the metabolism of this anesthetic agent in humans. The aim of this study was to identify the principal cytochrome P-450 (CYP) isoforms mediating this biotransformation. METHODS:Propofol hydroxylation activities and enzyme kinetic...

journal_title：Anesthesiology

authors： Court MH,Duan SX,Hesse LM,Venkatakrishnan K,Greenblatt DJ

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) attenuates the conversion of plasminogen to plasmin. Polymorphisms of the PAI-1 gene are associated with varying PAI-1 levels and risk of prothrombotic events in nonsurgical patients. The purpose of this study, a secondary analysis of a clinical trial, was to investi...

journal_title：Anesthesiology

authors： Iribarren JL,Jimenez JJ,Hernández D,Brouard M,Riverol D,Lorente L,de La Llana R,Nassar I,Perez R,Martinez R,Mora ML

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Several beneficial effects of local anesthetics (LAs) were shown to be due to inhibition of G protein-coupled receptor signaling. Differences in exposure time might explain discrepancies in concentrations of LAs required to achieve these protective effects in vivo and in vitro (approximately 100-fold higher)...

journal_title：Anesthesiology

authors： Hollmann MW,Herroeder S,Kurz KS,Hoenemann CW,Struemper D,Hahnenkamp K,Durieux ME

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and often leads to multiorgan dysfunction and systemic inflammation. Volatile anesthetics have potent antiinflammatory effects. We aimed to determine whether the representative volatile anesthetic isoflurane protects against acut...

journal_title：Anesthesiology

authors： Kim M,Park SW,Kim M,D'Agati VD,Lee HT

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:During laparoscopic surgery utilizing carbon dioxide as the insufflating agent, nitrous oxide will diffuse into the peritoneal cavity if it is used as part of the anesthetic. Bowel perforation and the subsequent release of volatile bowel gas could create a explosion hazard. METHODS:Two related studies were ...

journal_title：Anesthesiology

authors： Neuman GG,Sidebotham G,Negoianu E,Bernstein J,Kopman AF,Hicks RG,West ST,Haring L

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Preoperative anemia is frequent in patients undergoing orthopedic surgery. The purpose of this study was to assess the preoperative increase of hemoglobin in iron deficiency anemia patients treated with intravenous iron. METHODS:After obtaining written informed consent, 20 patients with iron deficiency anem...

journal_title：Anesthesiology

authors： Theusinger OM,Leyvraz PF,Schanz U,Seifert B,Spahn DR

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Active sodium transport is the primary mechanism that drives alveolar fluid clearance. In the current study, the effects of exposure to halothane and isoflurane on alveolar fluid clearance in rats were evaluated. METHODS:Rats were exposed to either halothane (0.4% for 6 h or 2% for 2 h) or isoflurane (0.6% ...

journal_title：Anesthesiology

authors： Rezaiguia-Delclaux S,Jayr C,Luo DF,Saïdi NE,Meignan M,Duvaldestin P

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (NO), an endothelium-derived relaxing factor, is a selective pulmonary vasodilator. The authors investigated whether inhaled NO decreases pulmonary vascular resistance (PVR) while preserving hypoxic pulmonary vasoconstriction and whether it maintains or improves oxygenation in patients d...

journal_title：Anesthesiology

authors： Rich GF,Lowson SM,Johns RA,Daugherty MO,Uncles DR

更新日期：1994-01-01 00:00:00

abstract：:The effect of enflurane (2% and 4% inspired) on left ventricular (LV) function were examined in chronically instrumented dogs, both intact and after isolation of their hearts and lungs from the systemic circulation. Enflurane in the intact dogs increased heart rate (32 +/- 5% with 2% and 41 +/- 4% with 4%) and elicite...

journal_title：Anesthesiology

authors： Zimpfer M,Gilly H,Krösl P,Schlag G,Steinbereithner K

更新日期：1983-02-01 00:00:00

abstract：:In a recent editorial, Kapur described perioperative nausea and vomiting as "the big 'little problem' following ambulatory surgery."257 Although the actual morbidity associated with nausea is relatively low in health outpatients, it should not be considered an unavoidable part of the perioperative experience. The avai...

journal_title：Anesthesiology

authors： Watcha MF,White PF

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Intravenous infusion of lidocaine decreases postoperative pain and speeds the return of bowel function. The authors therefore tested the hypothesis that perioperative lidocaine infusion facilitates acute rehabilitation protocol in patients undergoing laparoscopic colectomy. METHODS:Forty patients scheduled ...

journal_title：Anesthesiology

authors： Kaba A,Laurent SR,Detroz BJ,Sessler DI,Durieux ME,Lamy ML,Joris JL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Whether coronary steal is induced by inhaled anesthetic agents remains controversial in part because multiple factors determine collateral blood flow. METHODS:We used an established model to determine how halothane, isoflurane, and desflurane affect the hemodynamic determinants of coronary collateral blood ...

journal_title：Anesthesiology

authors： Mignella R,Buffington CW

更新日期：1995-10-01 00:00:00