Opioid facilitation of rewarding electrical brain stimulation is suppressed in rats with neuropathic pain.

abstract：BACKGROUND:Conventional cardiopulmonary resuscitation (CPR) includes 80-100/min precordial compressions with intermittent positive pressure ventilation (IPPV) after every fifth compression. To prevent gastric insufflation, chest compressions are held during IPPV if the patient is not intubated. Elimination of IPPV woul...

journal_title：Anesthesiology

authors： Hevesi ZG,Thrush DN,Downs JB,Smith RA

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Opioids are used by patients who have conditions ranging from the acute pain of surgery and chronic cancer pain to substance abuse. Despite their widespread use and considerable experimental data about them, little is known about how opioids may alter in vivo immunity in humans. This study was designed to ev...

journal_title：Anesthesiology

authors： Yeager MP,Colacchio TA,Yu CT,Hildebrandt L,Howell AL,Weiss J,Guyre PM

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Global cerebral ischemia is associated with delayed neuronal death. Given the role of caspases in apoptosis, caspase inhibitors may provide neuronal protection after cardiac arrest. To this end, the authors generated a transgenic rat line expressing baculovirus p35, a broad-spectrum caspase inhibitor, in cen...

journal_title：Anesthesiology

authors： Vogel P,Putten Hv,Popp E,Krumnikl JJ,Teschendorf P,Galmbacher R,Kisielow M,Wiessner C,Schmitz A,Tomaselli KJ,Schmitz B,Martin E,Böttiger BW

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Glutamate has been implicated in the pathophysiology of neuronal injury associated with cerebral hypoxia-ischemia. A model using chronic in utero microdialysis was developed to sample the extracellular space of the fetal brain. Using this model, we tested the hypothesis that glutamate efflux from the parasag...

journal_title：Anesthesiology

authors： Penning DH,Chestnut DH,Dexter F,Hrdy J,Poduska D,Atkins B

更新日期：1995-02-01 00:00:00

abstract：:Volatile anesthetics inhibit phagocytic cell function, yet little is known about their effects on target tissues or on the target tissue response to stimulated phagocytes. Experiments were performed to determine how exposure to halothane and isoflurane changes rat pulmonary artery endothelial cell (RPAEC) viability in...

journal_title：Anesthesiology

authors： Shayevitz JR,Varani J,Ward PA,Knight PR

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:The distribution and elimination of 0.9% saline given by intravenous infusion has not been compared between the conscious state and during inhalational anesthesia. METHODS:Six adult sheep received an intravenous infusion of 25 ml/kg of 0.9% saline over 20 min in the conscious state and also during isofluran...

journal_title：Anesthesiology

authors： Brauer KI,Svensén C,Hahn RG,Traber LD,Prough DS

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Emergence delirium has been investigated in several clinical trials. However, no reliable and valid rating scale exists to measure this phenomenon in children. Therefore, the authors developed and evaluated the Pediatric Anesthesia Emergence Delirium (PAED) scale to measure emergence delirium in children. M...

journal_title：Anesthesiology

authors： Sikich N,Lerman J

更新日期：2004-05-01 00:00:00

abstract：:Methylnaltrexone Reverses Chronic Opioid-induced Constipation: A Randomized, Controlled Trial. By Yuan CS, Foss JF, O'Connor M, Osinski J, Karrison T, Moss J, Roizen MF. JAMA 2000; 130:142-8. Reprinted with permission. CONTEXT:Constipation is the most common chronic adverse effect of opioid pain medications in patien...

journal_title：Anesthesiology

authors： Moss J

更新日期：2019-01-01 00:00:00

abstract：:The thermoregulatory threshold for vasoconstriction has been studied in infants and children given isoflurane, but not in those given halothane anesthesia. More importantly, the effect of vasoconstriction on central temperature in pediatric patients remains unknown. Also unknown is the effect of caudal analgesia on va...

journal_title：Anesthesiology

authors： Bissonnette B,Sessler DI

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:We aimed to assess the clinical effectiveness of intravenous exenatide compared to insulin in perioperative blood glucose control in coronary artery bypass grafting surgery patients. METHODS:Patients more than 18 yr old admitted for elective coronary artery bypass grafting were included in a phase II/III no...

journal_title：Anesthesiology

authors： Besch G,Perrotti A,Mauny F,Puyraveau M,Baltres M,Flicoteaux G,Salomon du Mont L,Barrucand B,Samain E,Chocron S,Pili-Floury S

更新日期：2017-11-01 00:00:00

abstract：UNLABELLED:BACKGROUND. Injection of local anesthetic into cerebrospinal fluid (CSF) produces anesthesia of unpredictable extent and duration. Although many factors have been identified that affect the extent of spinal anesthesia, correlations are relatively poor and the extent of spread remains unpredictable. This stud...

journal_title：Anesthesiology

authors： Carpenter RL,Hogan QH,Liu SS,Crane B,Moore J

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Malignant hyperthermia is associated with mutations within the gene encoding the skeletal muscle ryanodine receptor, the calcium channel that releases Ca from sarcoplasmic reticulum stores triggering muscle contraction, and other metabolic activities. More than 200 variants have been identified in the ryanod...

journal_title：Anesthesiology

authors： Sato K,Pollock N,Stowell KM

更新日期：2010-06-01 00:00:00

abstract：:The hepatic effects of repeated anesthesia of phenobarbital-induced Fischer 344 rats with 1% halothane/14% oxygen were investigated, after anesthetics were administered at either 1-day or 5-day intervals. Urinary excretion of fluoride, a product of reductive halothane metabolism, was increased in the 24-h period follo...

journal_title：Anesthesiology

authors： Plummer JL,Hall PD,Jenner MA,Cousins MJ

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:In pediatric patients, obstruction of the upper airway is a common problem during general anesthesia. Chin lift is a commonly used technique to improve upper airway patency. However, little is known about the mechanism underlying this technique. METHODS:The authors studied the effect of the chin lift maneuv...

journal_title：Anesthesiology

authors： Reber A,Wetzel SG,Schnabel K,Bongartz G,Frei FJ

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the relationship of four postanesthesia care unit (PACU) cardiovascular events to long-term outcomes (unplanned critical care admission or mortality) and to evaluate the contribution of anesthetic management compared with other perioperative factors in predicting th...

journal_title：Anesthesiology

authors： Rose DK,Cohen MM,DeBoer DP

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Awareness during anesthesia is foremost assessed with postoperative interviews, which may underestimate its incidence. On-line monitors such as the Bispectral Index and patient response to verbal command are not necessarily commonly used. This study investigated response to command during deep sedation (Bisp...

journal_title：Anesthesiology

authors： Kerssens C,Klein J,Bonke B

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Crystalloid solutions are used to restore intravascular volume in septic patients, but each solution has limitations. The authors compared the effects of three crystalloid solutions on hemodynamics, organ function, microcirculation, and survival in a sepsis model. METHODS:Peritonitis was induced by injectio...

journal_title：Anesthesiology

authors： Orbegozo D,Su F,Santacruz C,He X,Hosokawa K,Creteur J,De Backer D,Vincent JL

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Administrators at hospitals with a fixed annual budget may want to focus surgical services on priority areas to ensure its community receives the best health services possible. However, many hospitals lack the detailed managerial accounting data needed to ensure that such a change does not increase operating...

journal_title：Anesthesiology

authors： Dexter F,Blake JT,Penning DH,Sloan B,Chung P,Lubarsky DA

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that volatile anesthetics cause not only vasodilation but also vasoconstriction, depending on the experimental conditions. However, the mechanism of the constrictive effect of volatile anesthetics has not been clarified. The aim of this study was to evaluate the vasoconstrictor effects...

journal_title：Anesthesiology

authors： Kakuyama M,Hatano Y,Nakamura K,Toda H,Terasako K,Nishiwada M,Mori K

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Percutaneous cricothyroidotomy is a lifesaving procedure for airway obstruction in trauma victims who need airway establishment and cannot be intubated or in whom intubation has failed. METHODS:The purpose of this study was to examine whether there is a training effect using Seldinger technique emergency cr...

journal_title：Anesthesiology

authors： Schaumann N,Lorenz V,Schellongowski P,Staudinger T,Locker GJ,Burgmann H,Pikula B,Hofbauer R,Schuster E,Frass M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, the authors evaluated safety and efficacy of NeoSTX alone and combined with 0.2% bupivacaine (Bup) wit...

journal_title：Anesthesiology

authors： Lobo K,Donado C,Cornelissen L,Kim J,Ortiz R,Peake RW,Kellogg M,Alexander ME,Zurakowski D,Kurgansky KE,Peyton J,Bilge A,Boretsky K,McCann ME,Berde CB,Cravero J

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Adaptive support ventilation can speed weaning after coronary artery surgery compared with protocolized weaning using other modes. There are no data to support this mode of weaning after cardiac valvular surgery. Furthermore, control group weaning times have been long, suggesting that the results may reflect...

journal_title：Anesthesiology

authors： Zhu F,Gomersall CD,Ng SK,Underwood MJ,Lee A

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The long-term use of opioids for analgesia carries significant risk for tolerance, addiction, and diversion. These adverse effects are largely mediated by μ-opioid receptors in the central nervous system. Based on the authors' previous observation that morphine and δ-opioid receptor agonists synergize in spi...

journal_title：Anesthesiology

authors： Bruce DJ,Peterson CD,Kitto KF,Akgün E,Lazzaroni S,Portoghese PS,Fairbanks CA,Wilcox GL

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Isoflurane induces cell apoptosis by an unknown mechanism. The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on the endoplasmic reticulum (ER) membrane, causing excessive calcium release, triggering apoptosis. METHODS:The authors determined isoflurane-induced cy...

journal_title：Anesthesiology

authors： Wei H,Liang G,Yang H,Wang Q,Hawkins B,Madesh M,Wang S,Eckenhoff RG

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Blood conservation techniques are being increasingly used because of the increased cost and lack of availability of allogeneic blood. Cell salvage offers great blood savings opportunities but is thought to be contraindicated in a number of areas (e.g., blood contaminated with bacteria). Several outcome studi...

journal_title：Anesthesiology

authors： Waters JH,Tuohy MJ,Hobson DF,Procop G

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The pharmacokinetics of epidurally administered drugs has been the subject of many studies, yet drug concentration in the epidural space has never been measured. This study was undertaken to characterize the epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidurally administered opioids on the ...

journal_title：Anesthesiology

authors： Bernards CM,Shen DD,Sterling ES,Adkins JE,Risler L,Phillips B,Ummenhofer W

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Nonimmobilizers are agents that lack anesthetic properties, although their chemical structure is very similar to known anesthetics. The primary action site of both agents, whether at the membrane or target protein level, is still a matter of debate. However, increasing evidence points to the distinct modific...

journal_title：Anesthesiology

authors： Koubi L,Tarek M,Bandyopadhyay S,Klein ML,Scharf D

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Hyperkalemic cardiac arrest after the administration of succinylcholine (SCh) to critically ill intensive care patients has been attributed to changes in the acetylcholine receptors (AChRs) at the muscle membrane. The current study attempts to characterize the contributory roles of chronic administration of ...

journal_title：Anesthesiology

authors： Yanez P,Martyn JA

更新日期：1996-02-01 00:00:00

abstract：:Patients with mitral valve disease can develop pulmonary artery hypertension that persists after mitral valve replacement. In 1987, nitric oxide (NO) was reported to be an important factor accounting for the biologic activity of endothelium-derived relaxing factor. Inhaled NO was subsequently reported to be a selectiv...

journal_title：Anesthesiology

authors： Girard C,Lehot JJ,Pannetier JC,Filley S,Ffrench P,Estanove S

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics (VAs) have been found to induce a delayed protective response called preconditioning to subsequent hypoxic/ischemic injury. VA preconditioning has been primarily studied in canine and rodent heart. A more genetically tractable model of VA preconditioning would be extremely useful. Here, ...

journal_title：Anesthesiology

authors： Jia B,Crowder CM

更新日期：2008-03-01 00:00:00