Abstract:
:The hepatic effects of repeated anesthesia of phenobarbital-induced Fischer 344 rats with 1% halothane/14% oxygen were investigated, after anesthetics were administered at either 1-day or 5-day intervals. Urinary excretion of fluoride, a product of reductive halothane metabolism, was increased in the 24-h period following anesthesia, but was the same after the first, second, and third anesthetics. Rats killed 24 h after a single anesthetic all had centrilobular hepatocellular necrosis. All animals killed 24 h after the second or third anesthetic also had centrilobular necrosis, but, in most animals, this was no more extensive than that following a single anesthetic, regardless of whether the interval between anesthetics was one or five days.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Plummer JL,Hall PD,Jenner MA,Cousins MJdoi
10.1097/00000542-198709000-00013subject
Has Abstractpub_date
1987-09-01 00:00:00pages
355-60issue
3eissn
0003-3022issn
1528-1175journal_volume
67pub_type
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