Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model.

abstract：BACKGROUND:Nitric oxide (NO) formed from L-arginine is exhaled by mammals and regulates pulmonary vascular tone. Little is known about how its formation is stimulated. METHODS:The concentration of NO in exhaled air was monitored by chemiluminescence in pentobarbital-anesthetized rabbits receiving mechanical ventilatio...

journal_title：Anesthesiology

authors： Persson MG,Lönnqvist PA,Gustafsson LE

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Effects of volatile anesthetic agents on N-methyl-D-aspartate (NMDA) receptor-mediated excitatory synaptic transmission have not been well characterized. The authors compared effects produced by halothane and isoflurane on electrophysiologic properties of NMDA and non-NMDA receptor-mediated synaptic response...

journal_title：Anesthesiology

authors： Nishikawa K,MacIver MB

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Occasionally, emergency perioperative pacing is necessary. Transcutaneous cardiac pacing is noninvasive, safe, and readily available. Its feasibility and hemodynamic effects during thoracic surgery and one-lung ventilation have not been established. METHODS:Twenty anesthetized patients (aged 25-70 yr) witho...

journal_title：Anesthesiology

authors： Amar D,Gross JN,Burt M,Schwinger ME,Rusch VW,Reinsel RA

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptoti...

journal_title：Anesthesiology

authors： Sabir H,Bishop S,Cohen N,Maes E,Liu X,Dingley J,Thoresen M

更新日期：2013-08-01 00:00:00

abstract：:Cardiac arrest causes a rapid loss of cerebral adenosine triphosphate [corrected] (ATP) and a decrease in cerebral intracellular pH (pHi). Depending on the efficacy of cardiopulmonary resuscitation (CPR), cerebral blood flow levels (CBF) ranging from near zero to near normal have been reported experimentally. Using 31...

journal_title：Anesthesiology

authors： Eleff SM,Schleien CL,Koehler RC,Shaffner DH,Tsitlik J,Halperin HR,Rogers MC,Traystman RJ

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Intrathecal sufentanil (ITS) is frequently used to provide analgesia during labor. Decreases in blood pressure and sensory changes in this circumstance suggest that ITS may have a local anesthetic effect and thus cause a sympathectomy. To determine whether ITS given to laboring women causes a sympathectomy, ...

journal_title：Anesthesiology

authors： Riley ET,Walker D,Hamilton CL,Cohen SE

更新日期：1997-10-01 00:00:00

abstract：INTRODUCTION:Spinal alpha2-adrenoceptor stimulation produces analgesia in neuropathic pain states, and this effect in animals is blocked by the inhibitors of brain-derived neurotrophic factor (BDNF) function. In rats, alpha2-adrenoceptor stimulation normally inhibits acetylcholine release, but it excites release after ...

journal_title：Anesthesiology

authors： Hayashida K,Eisenach JC

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The mechanisms of ventilator-induced lung injury, an iatrogenic inflammatory condition induced by mechanical ventilation, are not completely understood. Toll-like receptor 4 (TLR4) signaling via the adaptor protein myeloid differentiation factor 88 (MyD88) is proinflammatory and plays a critical role in host...

journal_title：Anesthesiology

authors： Li H,Su X,Yan X,Wasserloos K,Chao W,Kaynar AM,Liu ZQ,Leikauf GD,Pitt BR,Zhang LM

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The mechanisms that underlie the supraspinal central nervous system effects of systemic lidocaine are poorly understood and not solely explained by Na(+) channel blockade. Among other potential targets is the hyperpolarization-activated cation current, I(h), which is blocked by lidocaine in peripheral neuron...

journal_title：Anesthesiology

authors： Putrenko I,Schwarz SK

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:In cardiac myocytes, lidocaine reduces but mexiletine increases adenosine triphosphate (ATP)-sensitive K+ currents, suggesting that these class Ib antiarrhythmic drugs may differentially modify the activity of ATP-sensitive K+ channels. The effects of lidocaine and mexiletine on arterial relaxations induced ...

journal_title：Anesthesiology

authors： Kinoshita H,Ishikawa T,Hatano Y

更新日期：1999-04-01 00:00:00

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:Acute respiratory distress syndrome is defined according to clinical criteria, but lack of precise characterization may contribute to negative trials and impede personalized care. Polymorphisms of aquaporin-5, a key mediator of inflammation, may impact outcome. WHAT THIS ARTICLE T...

journal_title：Anesthesiology

authors： Rahmel T,Rump K,Peters J,Adamzik M

更新日期：2019-03-01 00:00:00

abstract：:Arterial and peripheral venous plasma levels of bupivacaine were determined in 30 patients following epidural anesthesia using 150 and 225 mg, as well as following intercostal nerve block with 400 mg. Arterial levels were consistently higher than levels in simultaneously sampled venous blood, and the highest levels oc...

journal_title：Anesthesiology

authors： Moore DC,Mather LE,Bridenbaugh PO,Bridenbaugh LD,Balfour RI,Lysons DF,Horton WG

更新日期：1976-07-01 00:00:00

abstract：:Opioid receptors have been targeted for the treatment of pain and related disorders for thousands of years and remain the most widely used analgesics in the clinic. Mu (μ), kappa (κ), and delta (δ) opioid receptors represent the originally classified receptor subtypes, with opioid receptor like-1 (ORL1) being the leas...

journal_title：Anesthesiology

authors： Al-Hasani R,Bruchas MR

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The role of endothelial nitric oxide synthase (eNOS) in isoflurane postconditioning (IsoPC)-elicited cardioprotection is poorly understood. The authors addressed this issue using eNOS mice. METHODS:In vivo or Langendorff-perfused mouse hearts underwent 30 min of ischemia followed by 2 h of reperfusion in th...

journal_title：Anesthesiology

authors： Ge ZD,Pravdic D,Bienengraeber M,Pratt PF Jr,Auchampach JA,Gross GJ,Kersten JR,Warltier DC

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Vascular endothelium plays an important role in the regulation of vascular tone. Volatile anesthetics have been shown to attenuate endothelium-mediated relaxation in conductance arteries, such as aorta. However, significant differences in volatile anesthetic pharmacology between these large vessels and the s...

journal_title：Anesthesiology

authors： Akata T,Nakashima M,Kodama K,Boyle WA 3rd,Takahashi S

更新日期：1995-01-01 00:00:00

abstract：:The pharmacokinetics and protein binding of propofol were studied in ten patients with cirrhosis and in ten control patients undergoing elective surgery. All patients received 2.5 mg.kg-1 propofol as an intravenous bolus injection for the induction of anesthesia. Whole blood propofol concentrations were measured at in...

journal_title：Anesthesiology

authors： Servin F,Desmonts JM,Haberer JP,Cockshott ID,Plummer GF,Farinotti R

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Intravenous infusion of lidocaine decreases postoperative pain and speeds the return of bowel function. The authors therefore tested the hypothesis that perioperative lidocaine infusion facilitates acute rehabilitation protocol in patients undergoing laparoscopic colectomy. METHODS:Forty patients scheduled ...

journal_title：Anesthesiology

authors： Kaba A,Laurent SR,Detroz BJ,Sessler DI,Durieux ME,Lamy ML,Joris JL

更新日期：2007-01-01 00:00:00

abstract：:Magnesium plays a fundamental role in many cellular functions, and thus there is increasing interest in its role in clinical medicine. Although numerous experimental studies indicate positive effects of magnesium in a variety of disease states, large clinical trials often give conflicting results. However, there is cl...

journal_title：Anesthesiology

authors： Herroeder S,Schönherr ME,De Hert SG,Hollmann MW

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Conflicting opinions are present in the literature regarding the origin of the negative inotropic effect of propofol on the myocardium. This study aims to resolve these discrepancies by investigating the inotropic effects of propofol the L-type calcium channels and the sodium-calcium exchanger (NCX). METHOD...

journal_title：Anesthesiology

authors： de Ruijter W,Stienen GJ,van Klarenbosch J,de Lange JJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Anesthesia during the synaptogenic period induces dendritic spine formation, which may affect neurodevelopment. The authors, therefore, evaluated whether changes in synaptic transmission after dendritic spine formation induced by sevoflurane were associated with long-term behavioral changes. The effects of s...

journal_title：Anesthesiology

authors： Chung W,Ryu MJ,Heo JY,Lee S,Yoon S,Park H,Park S,Kim Y,Kim YH,Yoon SH,Shin YS,Lee WH,Ju X,Kweon GR,Ko Y

更新日期：2017-02-01 00:00:00

abstract：:To investigate the hemodynamic correlates of perioperative regional wall motion abnormalities (RWMA), we measured wall motion continuously via transesophageal echocardiography (TEE), and related RWMA to continuously measured hemodynamic indices of myocardial oxygen supply and demand (heart rate [HR] and systemic and p...

journal_title：Anesthesiology

authors： Leung JM,O'Kelly BF,Mangano DT

更新日期：1990-11-01 00:00:00

abstract：:Four volunteers judged eight levels of thermal stimuli induced by a Hardy dolorimeter, varying in intensity from extremely painful to a low level seldom even perceived. Half of the 406 stimuli were applied during acupuncture and half either before insertion or after removal of the needles. The experimental design mini...

journal_title：Anesthesiology

authors： Day RL,Kitahata LM,Kao FF,Motoyama EK,Hardy JD

更新日期：1975-11-01 00:00:00

abstract：:Neurophysiologic studies indicate that local anesthetic-induced seizures are generated in subcortical brain structures. The authors utilized a quantitative autoradiographic technique to measure cerebral metabolism during lidocaine-induced seizure activity in rats anesthetized with nitrous oxide. Local cerebral metabol...

journal_title：Anesthesiology

authors： Ingvar M,Shapiro HM

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Perioperative thoracic epidural analgesia reduces stress response and pain scores and may improve outcome after cardiac surgery. This prospective, randomized trial was designed to compare the effectiveness of patient-controlled thoracic epidural analgesia with patient-controlled analgesia with intravenous mo...

journal_title：Anesthesiology

authors： Hansdottir V,Philip J,Olsen MF,Eduard C,Houltz E,Ricksten SE

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Pulmonary function is impaired during pneumoperitoneum mainly as a result of atelectasis formation. We studied the effects of 10 cm H2O of positive end-expiratory pressure (PEEP) and PEEP followed by a recruitment maneuver (PEEP+RM) on end-expiratory lung volume (EELV), oxygenation and respiratory mechanics ...

journal_title：Anesthesiology

authors： Futier E,Constantin JM,Pelosi P,Chanques G,Kwiatkoskwi F,Jaber S,Bazin JE

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The severity of spontaneous myocardial hypercarbic acidosis during cardiac arrest previously has been predictive of the likelihood of restoring spontaneous circulation. The present study investigated whether hypercarbia itself impairs cardiac resuscitation. Since coronary perfusion pressure is the overriding...

journal_title：Anesthesiology

authors： Maldonado FA,Weil MH,Tang W,Bisera J,Gazmuri RJ,Johnson B,D'Alessio A

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Whether anesthetic agents administered during gamete intrafallopian transfer (GIFT) affect reproductive outcome is controversial. This multicenter pilot trial and survey had two purposes: to evaluate the effect of propofol, nitrous oxide, midazolam, and isoflurane on pregnancy outcome after GIFT, and to dete...

journal_title：Anesthesiology

authors： Beilin Y,Bodian CA,Mukherjee T,Andres LA,Vincent RD Jr,Hock DL,Sparks AE,Munson AK,Minnich ME,Steinkampf MP,Christman GM,McKay RS,Eisenkraft JB

更新日期：1999-01-01 00:00:00

abstract：:Blood from 20 ASA physical status I patients collected before and after induction of anesthesia was used in vitro to reexamine the effects of nitrous oxide on the oxyhemoglobin dissociation curve and the response of the oxygen electrode. The preinduction P50 values with and without 70% N2O were 28.4 +/- 0.1 mmHg and 2...

journal_title：Anesthesiology

authors： Kambam JR,Holaday DA

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Only limited data exist comparing differences in sensory function and responses to neural blockade in infant and adult rats. Therefore, the authors sought (1) to compare baseline thermal, proprioceptive, and postural responses in infant, adolescent, and adult rats; and (2) to compare the effects of sciatic n...

journal_title：Anesthesiology

authors： Hu D,Hu R,Berde CB

更新日期：1997-04-01 00:00:00

abstract：:The authors evaluated the systemic and cerebral hemodynamic and metabolic effects of 1 h of hypotension to a mean arterial pressure of either 50 mmHg or 40 mmHg induced by intravenous adenosine or ATP in dogs maintained on 70% nitrous oxide and 0.1% halothane. Following the hypotensive period, brain biopsy specimens w...

journal_title：Anesthesiology

authors： Newberg LA,Milde JH,Michenfelder JD

更新日期：1985-04-01 00:00:00