Abstract:
:The influence of isoflurane on membrane currents, action potentials, and contraction was investigated in single cells isolated from guinea-pig ventricle. Isoflurane (1.65-4.45%) reduced the action potential duration at 20% and 90% repolarization times. When step depolarizations were applied under voltage-clamp conditions, there was a depression by isoflurane both of the second inward (calcium) current and of the contraction (measured by an optical method). Isoflurane also depressed "tail" currents, which were recorded on repolarization following a voltage-clamp step to 0 mV and which are thought to be activated by cytosolic calcium. Additional actions of isoflurane were investigated using a paired-pulse protocol. The observations were consistent with a reduction by isoflurane of calcium release. This action together with the reduction of calcium influx during the second inward current would contribute to the negative inotropic effect of isoflurane.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Terrar DA,Victory JGdoi
10.1097/00000542-198811000-00017subject
Has Abstractpub_date
1988-11-01 00:00:00pages
742-9issue
5eissn
0003-3022issn
1528-1175journal_volume
69pub_type
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