Abstract:
BACKGROUND:Lamotrigine inhibits glutamate release through the preferential blockade of voltage-dependent Na+ channels. In contrast, morphine reduces release of excitatory amino acids through the activation of opioid receptors and also inhibits tetrodotoxin-resistant Na+ channels on peripheral afferent neurons. The current study was designed to investigate the antinociceptive effects of locally administered morphine and lamotrigine. The interaction between morphine and lamotrigine at the periphery was also examined. METHODS:Morphine, lamotrigine, or a combination of morphine and lamotrigine was administered locally to female Wistar rats, and the antinociceptive effect was determined in the formalin test. Isobolographic analyses were used to define the nature of the functional interactions between morphine and lamotrigine. RESULTS:Peripheral administration of either morphine or lamotrigine produced a dose-related antinociceptive effect. Isobolographic analyses revealed that peripheral morphine and lamotrigine interacted synergistically in the formalin test. CONCLUSIONS:The study shows a functional interaction between lamotrigine and morphine at the peripheral level.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Argüelles CF,Torres-López JE,Granados-Soto Vdoi
10.1097/00000542-200204000-00020subject
Has Abstractpub_date
2002-04-01 00:00:00pages
921-5issue
4eissn
0003-3022issn
1528-1175pii
00000542-200204000-00020journal_volume
96pub_type
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