Abstract:
:In late 1846, following his successful public demonstrations of surgical anesthesia, Boston dentist William T. G. Morton selected Letheon as the commercial name for the ether-based "preparation" he had used to produce insensibility to pain. We have not identified a first-hand account of the coinage of Letheon. Although the name ultimately derives from the Greek Lēthē, the adjective Lethean, much in use in the mid-19th century, may have influenced Morton and those he called on to assist in finding a commercial name. By one unverified account, the name Letheon might have been coined independently by both Augustus Addison Gould, M.D., and Henry Jacob Bigelow, M.D.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Haridas RP,Gionfriddo M,Bause GSdoi
10.1097/ALN.0000000000002969subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1210-1222issue
6eissn
0003-3022issn
1528-1175journal_volume
131pub_type
历史文章,杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and neutrophils. This study investigated the effects of neutrophil elastase on organ injury after unilateral lung acid instillation by administrating a specific neutrophil elastase inhibitor, ONO...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199709000-00025
更新日期:1997-09-01 00:00:00
abstract::Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver, or brain. Genomic, proteomic, and metabolomic approaches highlight common injury mechanisms leading to acute organ failure. This underlines the need to focus on therapeutic strategies affecting multiple injury pathways. Th...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/ALN.0000000000000446
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:The value of exercise electrocardiography in the prediction of perioperative cardiac risk has yet to be defined. This study was performed to determine the predictive value of exercise electrocardiography as compared with clinical parameters and resting electrocardiography. METHODS:A total of 204 patients at...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200101000-00011
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Factor VII is the most affected clotting factor during the early phase of warfarin therapy. An international normalized ratio (INR) of more than 1.4 is considered unsafe for epidural catheter placement or removal, according to the American Society of Regional Anesthesia and Pain Medicine. The authors tested ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181ca6cfc
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The memory-blocking properties of general anesthetics are of high clinical relevance and scientific interest. The inhalational anesthetic xenon antagonizes N-methyl-D-aspartate (NMDA) receptors. It is unknown if xenon affects long-term potentiation (LTP), a cellular correlate for memory formation. In hippoca...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3182475d66
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Ca2+-permeable non-N-methyl-D-aspartate receptors are found in the spinal dorsal horn and represent a presumptive target for glutamatergic transmission in nociceptive processing. This study characterized the analgesic profile associated with the blockade of these spinal receptors by intrathecally delivered a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200110000-00028
更新日期:2001-10-01 00:00:00
abstract::The revised model of coagulation has implications for therapy of both hemorrhagic and thrombotic disorders. Of particular interest to anesthesiologists is the management of clotting abnormalities before, during, and after surgery. Most hereditary and acquired coagulation factor deficiencies can be managed by specific ...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/00000542-200403000-00036
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Anesthetics administered to immature brains may cause histopathological changes and long-term behavioral abnormalities. The association between perinatal exposure to anesthetics during Cesarean delivery (CD) and development of learning disabilities (LD) was determined in a population-based birth cohort. MET...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181adf481
更新日期:2009-08-01 00:00:00
abstract::Analgesia is an important component of general anesthesia. alpha 2-adrenoceptor agonists such as clonidine and dexmedetomidine are effective analgesics at the spinal level, and furthermore, they reduce the volatile anesthetic requirement. In order to probe a possible spinal-level contribution to general anesthetic-ind...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199109000-00017
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Although respiratory depression is the most well-known and dangerous side effect of opioids, no pharmacokinetic-pharmacodynamic model exists for its quantitative analysis. The development of such a model was the aim of this study. METHODS:After institutional approval approval and informed consent were obtai...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199907000-00023
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Anesthetic potency is assessed by determination of the anesthetic concentration that prevents gross, purposeful movement in response to noxious stimulation. It is unclear whether anesthetics cause a progressive decrease in the number and force of limb movements evoked by noxious stimulation, or a step decrea...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199910000-00027
更新日期:1999-10-01 00:00:00
abstract::The effect of physostigmine on the loss of consciousness and respiratory depression induced in rabbits by flunitrazepam, 1 mg/kg, was studied to demonstrate whether the restoration of consciousness and respiration rate results from an increase in central cholinergic activity or from an interference by physostigmine wi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198602000-00020
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:In patients with acute respiratory distress syndrome (ARDS), the ventilatory approach is based on tidal volume (VT) of 10-15 ml/kg and positive end-expiratory pressure (PEEP). To avoid further pulmonary injury, decreasing VT and allowing PaCO2 to increase (permissive hypercapnia) has been suggested. Effects ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199510000-00010
更新日期:1995-10-01 00:00:00
abstract::Isoflurane has a lesser ability than halothane to induce contracture in malignant hyperthermia (MH) muscle in vitro. This does not necessarily imply that isoflurane is not as potent an MH trigger as halothane in vivo. A hypothesis was tested that in vitro treatment with Bay K 8644, an activator of both the dihydropyri...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199204000-00010
更新日期:1992-04-01 00:00:00
abstract::Recent reports have described resistance to pancuronium-induced neuromuscular blockade in patients chronically receiving anticonvulsants. This study examines the pharmacokinetics and pharmacodynamics of metocurine (MTC) in 12 patients undergoing craniotomy--six on chronic phenytoin therapy and six comparable controls....
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198509000-00009
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Days alive and out of hospital is a potentially useful patient-centered quality measure for perioperative care in adult surgical patients. However, there has been very limited prior validation of this endpoint with respect to its ability to capture differences in patient-level risk factor profiles and longer...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002701
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Patient-controlled analgesia (PCA) with intravenous morphine and patient-controlled epidural analgesia (PCEA), using an opioid either alone or in combination with a local anesthetic, are two major advances in the management of pain after major surgery. However, these techniques have been evaluated poorly in ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200002000-00025
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Recent studies have questioned the importance of the gravitational model of pulmonary perfusion. Because low levels of positive end-expiratory pressure (PEEP) are commonly used during anesthesia, the authors studied the distribution of pulmonary blood flow with low levels of PEEP using a high spatial resolut...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199805000-00021
更新日期:1998-05-01 00:00:00
abstract::Intrathecally administered alpha 2-adrenergic agonists produce analgesia in humans but may also produce hypotension and bradycardia. To further characterize hemodynamic depression produced by intrathecally administered alpha 2-adrenergic agonists, clonidine (100-1,500 micrograms) was injected into the cervical, thorac...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199104000-00021
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:It has been known that skeletal muscles show atrophic changes after prolonged sedation or general anesthesia. Whether these effects are due to anesthesia itself or disuse during anesthesia has not been fully clarified. Autophagy dysregulation has been implicated in muscle-wasting conditions. This study teste...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000561
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The Pediatric Perioperative Cardiac Arrest (POCA) Registry was formed in 1994 in an attempt to determine the clinical factors and outcomes associated with cardiac arrest in anesthetized children. METHODS:Institutions that provide anesthesia for children are voluntarily enrolled in the POCA Registry. A repre...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200007000-00007
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Sympathetic nerve activity was recorded in the leg during high thoracic epidural anesthesia with a segmental sensory blockade of the upper thoracic dermatomes to test the hypothesis that the sympathetic blockade accompanying thoracic epidural anesthesia includes caudal parts of the sympathetic nervous system...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-199911000-00021
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Multicapillary column ion-mobility spectrometry (MCC-IMS) may identify volatile components in exhaled gas. The authors therefore used MCC-IMS to evaluate exhaled gas in a rat model of sepsis, inflammation, and hemorrhagic shock. METHODS:Male Sprague-Dawley rats were anesthetized and ventilated via tracheost...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000420
更新日期:2015-01-01 00:00:00
abstract::The authors evaluated the systemic and cerebral hemodynamic and metabolic effects of 1 h of hypotension to a mean arterial pressure of either 50 mmHg or 40 mmHg induced by intravenous adenosine or ATP in dogs maintained on 70% nitrous oxide and 0.1% halothane. Following the hypotensive period, brain biopsy specimens w...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198504000-00010
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:Load-dependent impairment of left ventricular (LV) function was observed after leg elevation in a subgroup of coronary surgery patients. The present study investigated underlying mechanisms by comparing hemodynamic effects of an increase in LV systolic pressures with leg elevation to effects of a similar inc...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199908000-00011
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Etomidate is a sedative hypnotic that is often used in critically ill patients because it provides superior hemodynamic stability. However, it also binds with high affinity to 11beta-hydroxylase, potently suppressing the synthesis of steroids by the adrenal gland that are necessary for survival. The authors ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181cf40ed
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the brain areas in which hypnosis modulates cerebral responses to a noxious stimulus. METHODS:The protocol used a factorial ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-200005000-00013
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Chloroprocaine has been associated with severe back pain after epidural anesthesia. Factors proposed to contribute to this problem are: 1) the preservative disodium ethylenediaminetetraacetic acid (EDTA), 2) large volumes of chloroprocaine, 3) low pH of chloroprocaine, and 4) local infiltration with chloropr...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199303000-00013
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Volatile anesthetics depress left ventricular contractile function by altering voltage-dependent slow calcium (Ca2+) channel activity in the sarcolemmal membrane. This investigation examined the left ventricular systolic and diastolic mechanical effects of the dihydropyridine Ca2+ channel antagonist nifedipi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199407000-00026
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:An in vitro model of epidural catheter contamination was used to determine if disconnected catheters can be safely reconnected. METHODS:Epidural catheters were filled with brain-heart infusion (BHI) broth or preservative-free saline containing 5 micrograms/ml fentanyl. Escherichia coli, Pseudomonas aerugino...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199610000-00025
更新日期:1996-10-01 00:00:00