Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice.

abstract：BACKGROUND:The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. METHODS:Pigs (n = 27, 9 per group) were anesthetized and me...

journal_title：Anesthesiology

authors： Kimberger O,Arnberger M,Brandt S,Plock J,Sigurdsson GH,Kurz A,Hiltebrand L

更新日期：2009-03-01 00:00:00

abstract：:Vastus lateralis muscle was excised from normal pigs and from pigs susceptible to malignant hyperthermia. Anesthesia consisted of diazepam, N2O:O2, and a lidocaine field block. In the susceptible (MHS) pigs, respiratory control in mitochondria of excised muscle was normal, while electron transport was accelerated. Glu...

journal_title：Anesthesiology

authors： Britt BA,Endrenyi L,Cadman DL,Fan HM,Fung HY

更新日期：1975-03-01 00:00:00

abstract：:The effect of chronic renal failure (RF) on the pharmacokinetics of morphine was studied in nine patients with end-stage RF, aged 58 +/- 8 yr (SD), and in seven control patients, aged 58 +/- 15 yr, undergoing peripheral surgery under general anesthesia. All patients received 0.2 mg X kg-1 as an intravenous bolus injec...

journal_title：Anesthesiology

authors： Chauvin M,Sandouk P,Scherrmann JM,Farinotti R,Strumza P,Duvaldestin P

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:The authors used the American Society of Anesthesiologists Closed Claims Project database to determine changes in the proportion of claims for death or permanent brain damage over a 26-yr period and to identify factors associated with the observed changes. METHODS:The Closed Claims Project is a structured e...

journal_title：Anesthesiology

authors： Cheney FW,Posner KL,Lee LA,Caplan RA,Domino KB

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Recent advances have indicated a complex interplay between the autonomic nervous system and the innate immune system. Targeting neural networks for the treatment of sepsis is being developed as a therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities of the autonomic ner...

journal_title：Anesthesiology

authors： Song JG,Li HH,Cao YF,Lv X,Zhang P,Li YS,Zheng YJ,Li Q,Yin PH,Song SL,Wang HY,Wang XR

更新日期：2012-02-01 00:00:00

abstract：:The effects of continuous positive airway pressure (CPAP) on cardiovascular dynamics and pulmonary shunt (QS/QT) were investigated in 12 dogs before and during sodium nitroprusside infusion that decreased mean arterial blood pressure 40-50 per cent. Before nitroprusside infusion, 5 cm H2O CPAP significantly, P less th...

journal_title：Anesthesiology

authors： Hodges MR,Stanley TH,Johansen RK

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Diphenhydramine is used as an antipruritic and antiemetic in patients receiving opioids. Whether it might exacerbate opioid-induced ventilatory depression has not been determined. METHODS:The ventilatory response to carbon dioxide during hyperoxia and the ventilatory response to hypoxia during hypercapnia (...

journal_title：Anesthesiology

authors： Babenco HD,Blouin RT,Conard PF,Gross JB

更新日期：1998-09-01 00:00:00

abstract：:The effects of halothane (0.45 and 0.9 mM, equivalent to 0.7 and 1.5%, respectively), isoflurane (0.54 and 1.23 mM, equivalent to 0.9 and 2.0%, respectively) and enflurane (0.65 and 1.48 mM, equivalent to 1.2 and 2.5%, respectively) on macroscopic L- and T-type Ca2+ channel currents were compared in single canine card...

journal_title：Anesthesiology

authors： Eskinder H,Rusch NJ,Supan FD,Kampine JP,Bosnjak ZJ

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Isoflurane-anesthetized rats have better outcome from global cerebral ischemia than rats anesthetized with fentanyl and nitrous oxide. The authors wanted to determine whether circulating catecholamine concentrations depend on the anesthetic agent and whether sympathetic ganglionic blockade affects anesthetic...

journal_title：Anesthesiology

authors： Mackensen GB,Nellgård B,Miura Y,Chu CT,Dexter F,Pearlstein RD,Warner DS

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Identifying functionally relevant anesthetic-binding sites in pentameric ligand-gated ion channels (pLGICs) is an important step toward understanding the molecular mechanisms underlying anesthetic action. The anesthetic propofol is known to inhibit cation-conducting pLGICs, including a prokaryotic pLGIC from...

journal_title：Anesthesiology

authors： Kinde MN,Bu W,Chen Q,Xu Y,Eckenhoff RG,Tang P

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Breastfeeding is an important public health concern. High cumulative doses of epidural fentanyl administered for labor analgesia have been reported to be associated with early termination of breastfeeding. We tested the hypothesis that breastfeeding success is adversely influenced by the cumulative epidural ...

journal_title：Anesthesiology

authors： Lee AI,McCarthy RJ,Toledo P,Jones MJ,White N,Wong CA

更新日期：2017-10-01 00:00:00

abstract：:Systolic pressure variation (SPV) is defined as the difference between the maximum and minimum values of systolic blood pressure following a single positive pressure breath. An increase in the SPV is known to occur clinically during hypovolemia. This study aims to quantify SPV during graded hemorrhage in ventilated do...

journal_title：Anesthesiology

authors： Perel A,Pizov R,Cotev S

更新日期：1987-10-01 00:00:00

abstract：:Central and peripheral pulmonary mucociliary clearance was assessed by tantalum bronchography and serial chest roentgenograms in dogs. Thiopental, 25 mg/kg, did not change clearance from awake values. Halothane 1.2 MAC, for six hours, delayed both central and peripheral clearance by at least three hours. After halotha...

journal_title：Anesthesiology

authors： Forbes AR,Gamsu G

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Administrators at hospitals with a fixed annual budget may want to focus surgical services on priority areas to ensure its community receives the best health services possible. However, many hospitals lack the detailed managerial accounting data needed to ensure that such a change does not increase operating...

journal_title：Anesthesiology

authors： Dexter F,Blake JT,Penning DH,Sloan B,Chung P,Lubarsky DA

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Nonsteroidal antiinflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest that these drugs act, in part, by blocking prostaglandin production in the spinal cord. The authors tested intrathecal ketorolac in patients with chronic or postoperative pain. METHODS:After...

journal_title：Anesthesiology

authors： Eisenach JC,Curry R,Rauck R,Pan P,Yaksh TL

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Age is a known risk factor for postoperative complications, but the genetic factors that account for variability in age at presentation for surgery have not been characterized. Because thrombosis is a critical process in the development of coronary syndromes, the authors hypothesized that patients bearing th...

journal_title：Anesthesiology

authors： Donahue BS,Byrne DW,Gailani D,George AL Jr

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Although the use of an anesthesiology "airway" rotation to train the nonanesthesiologist is commonly employed, little data exist on the utility, clinical exposure, and outcomes of these programs. METHODS:A prospectively collected observational dataset of airway procedures completed by trainees in a 4-week, ...

journal_title：Anesthesiology

authors： Grissom TE,Sappenfield J,Galvagno SM Jr,Cherry SV,Chang YC,Hu PF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Previous studies integrated opioid benefit and harm into one single function-the utility function-to determine the drug toxicity (respiratory depression) in light of its wanted effect (analgesia). This study further refined the concept of the utility function using the respiratory and analgesic effects of th...

journal_title：Anesthesiology

authors： Roozekrans M,van der Schrier R,Aarts L,Sarton E,van Velzen M,Niesters M,Dahan A,Olofsen E

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:In an effort to measure and improve the quality of perioperative care, the Surgical Care Improvement Project (SCIP) was introduced in 2003. The SCIP guidelines are evidence-based process measures designed to reduce preventable morbidity, but it remains to be determined whether SCIP-measure compliance is asso...

journal_title：Anesthesiology

authors： Scott AV,Stonemetz JL,Wasey JO,Johnson DJ,Rivers RJ,Koch CG,Frank SM

更新日期：2015-07-01 00:00:00

abstract：:Total lung capacity, vital capacity, residual volume, and functional residual capacity were determined by body plethysmography and the single-breath oxygen (SBO2) test was performed at 0, 5, and 11 cm H20 continuous positive airway pressure in healthy, awake, seated, spontaneously breathing subjects. Mean values for t...

journal_title：Anesthesiology

authors： Abboud N,Rehder K,Rodarte JR,Hyatt RE

更新日期：1975-02-01 00:00:00

abstract：:The formation of acute edema in the tracheobronchial mucosa following local instillation of hydrochloric acid or gastric juice was studied in rats. Protein extravasation using the Evans blue technique was measured and used to indicate edema formation. A pH dependent Evans blue extravasation was observed whereby pH 2 p...

journal_title：Anesthesiology

authors： Martling CR,Lundberg JM

更新日期：1988-03-01 00:00:00

abstract：INTRODUCTION:Opioids are powerful analgesics, but are also common drugs of abuse. Few studies have examined how neuropathic pain alters the pharmacology of opioids in modulating limbic pathways that underlie abuse liability. METHODS:Rats with or without spinal nerve ligation (SNL) were implanted with electrodes into t...

journal_title：Anesthesiology

authors： Ewan EE,Martin TJ

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Lidocaine inhalation attenuates histamine-induced bronchospasm while evoking airway anesthesia. Because this occurs at plasma concentrations much lower than those required for intravenous lidocaine to attenuate bronchial reactivity, this effect is likely related to topical airway anesthesia and presumably in...

journal_title：Anesthesiology

authors： Groeben H,Grosswendt T,Silvanus MT,Pavlakovic G,Peters J

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:General anesthetics are thought to produce their hypnotic effects mainly by acting at ligand-gated ionic channels in the central nervous system (CNS). Although it is well established that volatile anesthetics significantly modify the activity of the acetylcholine nicotinic receptors of the neuromuscular junc...

journal_title：Anesthesiology

authors： Salord F,Keita H,Lecharny JB,Henzel D,Desmonts JM,Mantz J

更新日期：1997-03-01 00:00:00

abstract：:Nonsteroidal antiinflammatory drugs (NSAIDs) are commonly combined with intravenous morphine patient-controlled analgesia to relieve postoperative pain. NSAIDs have a documented 30-50% sparing effect on morphine consumption. However, most of the studies have not demonstrated a decrease in morphine adverse effects. A m...

journal_title：Anesthesiology

authors： Marret E,Kurdi O,Zufferey P,Bonnet F

更新日期：2005-06-01 00:00:00

abstract：:This study was performed to determine the potency of succinylcholine using the single-dose technique, and to test the ability of the cumulative dose technique for generating dose-response data. Thirty-eight adult patients received single doses (n = 18), cumulative doses (n = 10), or cumulative doses of succinylcholine...

journal_title：Anesthesiology

authors： Smith CE,Donati F,Bevan DR

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:This study investigated the ability of the modified continual reassessment method (MCRM) to determine the maximum tolerated dose of the opioid antagonist nalmefene, which does not reverse analgesia in an acceptable number of postoperative patients receiving epidural fentanyl in 0.075% bupivacaine. METHODS:I...

journal_title：Anesthesiology

authors： Dougherty TB,Porche VH,Thall PF

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Protein kinase C (PKC) is a family of serine/threonine kinases that contains more than 10 isozymes. Evidence suggests that PKC may play important roles in pain modulation, but the isozyme-specific effects of PKC on different aspects of pain modulation are not fully understood. We hypothesize that different P...

journal_title：Anesthesiology

authors： Zhao C,Leitges M,Gereau RW 4th

更新日期：2011-12-01 00:00:00

abstract：:Complications after major surgery are a leading cause of morbidity and mortality. The etiology of postoperative complications is complex, but poor cardiorespiratory reserve appears to be a key factor. There is increasing interest in the use of central and mixed venous oxygen saturation to guide therapeutic interventio...

journal_title：Anesthesiology

authors： Shepherd SJ,Pearse RM

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The hanging drop technique is used for identifying the cervical epidural space, using its negative pressure. However, it is doubtful whether the epidural space intrinsically exhibits a negative pressure. We designed this study to test the hypothesis that the cervical epidural pressure (CEP) is significantly ...

journal_title：Anesthesiology

authors： Moon JY,Lee PB,Nahm FS,Kim YC,Choi JB

更新日期：2010-09-01 00:00:00