Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort.

abstract：BACKGROUND:The authors' purpose of this study was to elucidate the mechanisms of direct effects of halothane on the contractile proteins and Ca2+ release from the sarcoplasmic reticulum Ca2+ stores using isolated skinned strips (sarcolemma permealized with saponin) from rabbit pulmonary arteries. METHODS:The sarcoplas...

journal_title：Anesthesiology

authors： Su JY,Tang LJ

更新日期：1998-04-01 00:00:00

abstract：:To determine the percentage of anesthetic metabolized and to assess the role of metabolism in the total elimination of inhaled anesthetics, the authors administered isoflurane, enflurane, halothane, and methoxyflurane simultaneously, for 2 h, to nine healthy patients. Total anesthetic uptake during the 2 h of washin a...

journal_title：Anesthesiology

authors： Carpenter RL,Eger EI 2nd,Johnson BH,Unadkat JD,Sheiner LB

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:The most sensitive diagnostic criterion of myasthenia gravis is a decrement in the muscular response to repetitive stimulation. The authors hypothesized that myasthenia gravis patients who show a train-of-four ratio (T4/T1) < 0.9 in the preanesthetic period will have increased sensitivity to nondepolarizing ...

journal_title：Anesthesiology

authors： Mann R,Blobner M,Jelen-Esselborn S,Busley R,Werner C

更新日期：2000-08-01 00:00:00

abstract：:The neonatal neurobehavioral effects of bupivacaine, mepivacaine, and 2-chloroprocaine used in random sequence for pudendal block anesthesia were studied. The neurobehavioral status of 54 infants was studied 4 and 24 hours after delivery. Except for a significant difference in the responses to pinprick, there was no s...

journal_title：Anesthesiology

authors： Merkow AJ,McGuinness GA,Erenberg A,Kennedy RL

更新日期：1980-04-01 00:00:00

abstract：:Sevoflurane was submitted to phase-1 studies in man following extensive testing in animal species during maintenance, was administered with oxygen to produce one hour of anesthesia in six healthy adult male volunteers. Respiratory and cardiovascular functions, the electroencephalogram, arterial blood gases, blood sevo...

journal_title：Anesthesiology

authors： Holaday DA,Smith FR

更新日期：1981-02-01 00:00:00

abstract：:Rats were given standardized injections of 3H-L-proline into the trigeminal ganglion and 14C-lidocaine hydrochloride at the infraorbital foramen. The 3H-L-proline was always injected 2.5 h before removal of the nerve. Lidocaine, 1, 2, and 4%, produced a concentration-related inhibition of entry of 3H-labeled rapid axo...

journal_title：Anesthesiology

authors： Fink BR,Kish SJ

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:One-lung ventilation (OLV) results in alveolar proinflammatory effects, whereas their extent may depend on administration of anesthetic drugs. The current study evaluates the effects of different volatile anesthetics compared with an intravenous anesthetic and the relationship between pulmonary and systemic ...

journal_title：Anesthesiology

authors： Schilling T,Kozian A,Senturk M,Huth C,Reinhold A,Hedenstierna G,Hachenberg T

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Pain behavior in response to skin incision is developmentally regulated, but little is known about the underlying neuronal mechanisms. The authors hypothesize that the spatial activation and intensity of dorsal horn neuron responses to skin incision differ in immature and adult spinal cord. METHODS:Single w...

journal_title：Anesthesiology

authors： Ririe DG,Bremner LR,Fitzgerald M

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:High-frequency oscillatory ventilation (HFOV) at higher frequencies minimizes the tidal volume. However, whether increased frequencies during HFOV can reduce ventilator-induced lung injury remains unknown. METHODS:After the induction of acute respiratory distress syndrome in the model by repeated lavages, 2...

journal_title：Anesthesiology

authors： Liu S,Yi Y,Wang M,Chen Q,Huang Y,Liu L,Xie J,Zhou D,Qiu H

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Although noninvasive blood pressure (NIBP) monitoring during anesthesia is a standard of care, reference ranges for blood pressure in anesthetized children are not available. We developed sex- and age-specific reference ranges for NIBP in children during anesthesia and surgery. METHODS:In this retrospective...

journal_title：Anesthesiology

authors： de Graaff JC,Pasma W,van Buuren S,Duijghuisen JJ,Nafiu OO,Kheterpal S,van Klei WA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Uptake of a second gas of a delivered gas mixture decreases the amount of carrier gas and potent inhaled anesthetic leaving the circle system through the pop-off valve. The authors hypothesized that the vaporizer settings required to maintain constant end-expired sevoflurane concentration (Etsevo) during min...

journal_title：Anesthesiology

authors： Hendrickx JF,Coddens J,Callebaut F,Artico H,Deloof T,Demeyer I,De Wolf AM

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Caveolae are a nexus for protective signaling. Trafficking of caveolin to mitochondria is essential for adaptation to cellular stress though the trafficking mechanisms remain unknown. The authors hypothesized that G protein-coupled receptor/inhibitory G protein (Gi) activation leads to caveolin trafficking t...

journal_title：Anesthesiology

authors： Wang J,Schilling JM,Niesman IR,Headrick JP,Finley JC,Kwan E,Patel PM,Head BP,Roth DM,Yue Y,Patel HH

更新日期：2014-09-01 00:00:00

abstract：:The authors used pharmacokinetic and pharmacodynamic modeling to explain the time course of neuromuscular blockade following single or multiple doses of three nondepolarizing muscle relaxants. Published and unpublished pharmacokinetic and pharmacodynamic data for 13 normal subjects were used to simulate the duration o...

journal_title：Anesthesiology

authors： Fisher DM,Rosen JI

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Increasing age appears to be associated with a slower onset of neuromuscular blockade, but such an effect has not been studied with the same doses of the same drugs across pediatric and adult age groups. METHODS:The authors measured the evoked compound action potential of the adductor pollicis muscle in res...

journal_title：Anesthesiology

authors： Koscielniak-Nielsen ZJ,Bevan JC,Popovic V,Baxter MR,Donati F,Bevan DR

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Halothane has been previously shown in vitro to decrease both the inward calcium current in isolated cells and the density of calcium antagonist binding sites in cardiac sarcolemmal membranes prepared from several species, including humans, presumably contributing to the negative inotropic effects seen with ...

journal_title：Anesthesiology

authors： Lee DL,Zhang J,Blanck TJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We...

journal_title：Anesthesiology

authors： Makaryus R,Lee H,Robinson J,Enikolopov G,Benveniste H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Isoflurane induces cell apoptosis by an unknown mechanism. The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on the endoplasmic reticulum (ER) membrane, causing excessive calcium release, triggering apoptosis. METHODS:The authors determined isoflurane-induced cy...

journal_title：Anesthesiology

authors： Wei H,Liang G,Yang H,Wang Q,Hawkins B,Madesh M,Wang S,Eckenhoff RG

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The authors investigated the impact of acute normovolemic hemodilution (ANH) on intrarenal oxygenation and its functional short-term consequences in pigs. METHODS:Renal microvascular oxygenation (µPO2) was measured in cortex, outer and inner medulla via three implanted optical fibers by oxygen-dependent que...

journal_title：Anesthesiology

authors： Konrad FM,Mik EG,Bodmer SI,Ates NB,Willems HF,Klingel K,de Geus HR,Stolker RJ,Johannes T

更新日期：2013-08-01 00:00:00

abstract：:Malpractice claims filed against anesthesiologists for care involving obstetric (OB) anesthesia (n = 190) were taken from the American Society of Anesthesiologists' Closed Claims Database and compared to claims not involving OB cases (n = 1351). The most common complications in the OB claims were (percentage of all OB...

journal_title：Anesthesiology

authors： Chadwick HS,Posner K,Caplan RA,Ward RJ,Cheney FW

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Active sodium transport is the primary mechanism that drives alveolar fluid clearance. In the current study, the effects of exposure to halothane and isoflurane on alveolar fluid clearance in rats were evaluated. METHODS:Rats were exposed to either halothane (0.4% for 6 h or 2% for 2 h) or isoflurane (0.6% ...

journal_title：Anesthesiology

authors： Rezaiguia-Delclaux S,Jayr C,Luo DF,Saïdi NE,Meignan M,Duvaldestin P

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Percutaneous cannulation of the internal jugular vein in infants is technically more difficult and carries a higher risk of carotid artery puncture than in older children and adults. In this prospective study, the authors tested their hypothesis that using an ultrasound scanner would increase the success of ...

journal_title：Anesthesiology

authors： Verghese ST,McGill WA,Patel RI,Sell JE,Midgley FM,Ruttimann UE

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Recent evidence suggests that anesthetic action within the spinal cord is important in suppressing somatic responses to painful stimuli. Whether the brain influences this response is not clear. This study was designed to test the hypothesis that the brain affects anesthetic requirements. METHODS:Six goats w...

journal_title：Anesthesiology

authors： Borges M,Antognini JF

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:The direct action of sevoflurane on systemic resistance arteries is not fully understood. METHODS:Isometric force was recorded in isolated rat small mesenteric arteries. RESULTS:Sevoflurane (2-5%) enhanced contractile response to norepinephrine only in the presence of endothelium, but inhibited it in its a...

journal_title：Anesthesiology

authors： Izumi K,Akata T,Takahashi S

更新日期：2000-05-01 00:00:00

abstract：:To determine whether neuronal firing is affected by anesthetics, the behavior of neurons in the mesencephalic reticular formation in response to repetitive somatosensory stimulation at 2/sec was studied during wakefulness and during nitrous oxide, halothane, and thiopental anesthesia in the cat. With clinical doses of...

journal_title：Anesthesiology

authors： Shimoji K,Matsuki M,Shimizu H,Maruyama Y,Aida S

更新日期：1977-10-01 00:00:00

abstract：:Although Ernest Shackleton's Endurance Antarctic expedition of 1914 to 1916 is a famous epic of survival, the medical achievements of the two expedition doctors have received little formal examination. Marooned on Elephant Island after the expedition ship sank, Drs. Macklin and McIlroy administered a chloroform anesth...

journal_title：Anesthesiology

authors： Firth PG

更新日期：2016-07-01 00:00:00

abstract：:The authors had previously observed a deleterious cerebrovascular effect of prolonged hypothermia in primates and cats. In this study they examined the systemic as well as cerebral hemodynamic and metabolic effects of 24 hours of hypothermia in the dog. With decreases in temperature to 29 C, cardiac output (Q) and who...

journal_title：Anesthesiology

authors： Steen PA,Milde JH,Michenfelder JD

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND:Ketamine was previously suggested to relax vascular smooth muscle by reducing the intracellular Ca2+ concentration ([Ca2+]i). However, no direct evidence is available to indicate that ketamine reduces the [Ca2+]i in vascular smooth muscle of systemic resistance arteries. METHODS:Endothelium-intact or -denud...

journal_title：Anesthesiology

authors： Akata T,Izumi K,Nakashima M

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:The anticonvulsant gabapentin, proven effective for neuropathic pain in two large, placebo-controlled clinical trials, is widely used for treatment of chronic pain. Preclinical studies have demonstrated analgesic and antiallodynic effects in models involving neuronal sensitization and nerve injury, without a...

journal_title：Anesthesiology

authors： Dirks J,Petersen KL,Rowbotham MC,Dahl JB

更新日期：2002-07-01 00:00:00

abstract：:Pain perception to minor physical stimuli has been hypothesized to be related to subsequent pain ratings after surgery. The objective of this systematic review was to evaluate the correlation between preoperative pain sensitivity and postoperative pain intensity. After a literature search of MEDLINE, EMBASE, and meeti...

journal_title：Anesthesiology

authors： Abrishami A,Chan J,Chung F,Wong J

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Protamine causes multiple adverse reactions. Heparinase I, a specific enzyme that inactivates heparin, is a possible alternative to protamine. In this study, the authors examined the efficacy of heparinase I to reverse heparin-induced anticoagulation in vitro and compared heparinase I to protamine as an anta...

journal_title：Anesthesiology

authors： Michelsen LG,Kikura M,Levy JH,Lee MK,Lee KC,Zimmermann JJ,Szlam F

更新日期：1996-08-01 00:00:00