Effects of Different Crystalloid Solutions on Hemodynamics, Peripheral Perfusion, and the Microcirculation in Experimental Abdominal Sepsis.


BACKGROUND:Crystalloid solutions are used to restore intravascular volume in septic patients, but each solution has limitations. The authors compared the effects of three crystalloid solutions on hemodynamics, organ function, microcirculation, and survival in a sepsis model. METHODS:Peritonitis was induced by injection of autologous feces in 21 anesthetized, mechanically ventilated adult sheep. After baseline measurements, animals were randomized to lactated Ringer's (LR), normal saline (NS), or PlasmaLyte as resuscitation fluid. The sublingual microcirculation was assessed using sidestream dark field videomicroscopy and muscle tissue oxygen saturation with near-infrared spectroscopy. RESULTS:NS administration was associated with hyperchloremic acidosis. NS-treated animals had lower cardiac index and left ventricular stroke work index than LR-treated animals from 8 h and lower mean arterial pressure than LR-treated animals from 12 h. NS-treated animals had a lower proportion of perfused vessels than LR-treated animals after 12 h (median, 82 [71 to 83] vs. 85 [82 to 89], P = 0.04) and greater heterogeneity of proportion of perfused vessels than PlasmaLyte or LR groups at 18 h. Muscle tissue oxygen saturation was lower at 16 h in the NS group than in the other groups. The survival time of NS-treated animals was shorter than that of the LR group (17 [14 to 20] vs. 26 [23 to 29] h, P < 0.01) but similar to that of the PlasmaLyte group (20 [12 to 28] h, P = 0.74). CONCLUSIONS:In this abdominal sepsis model, resuscitation with NS was associated with hyperchloremic acidosis, greater hemodynamic instability, a more altered microcirculation, and more severe organ dysfunction than with balanced fluids. Survival time was shorter than in the LR group.






Orbegozo D,Su F,Santacruz C,He X,Hosokawa K,Creteur J,De Backer D,Vincent JL




Has Abstract


2016-10-01 00:00:00














  • Isoform-selective effects of isoflurane on voltage-gated Na+ channels.

    abstract:BACKGROUND:Voltage-gated Na channels modulate membrane excitability in excitable tissues. Inhibition of Na channels has been implicated in the effects of volatile anesthetics on both nervous and peripheral excitable tissues. The authors investigated isoform-selective effects of isoflurane on the major Na channel isofor...


    pub_type: 杂志文章


    authors: OuYang W,Hemmings HC Jr

    更新日期:2007-07-01 00:00:00

  • Effects of halothane and isoflurane on cytosolic calcium ion concentrations and contraction in the vascular smooth muscle of the rat aorta.

    abstract:BACKGROUND:Halothane and isoflurane have been reported to suppress the contraction of vascular smooth muscle, although the exact mechanism has not been explained fully. This study examined the effect of halothane and isoflurane on cytosolic calcium ion (Ca2+) concentrations ([Ca2+]cyt), which was measured simultaneousl...


    pub_type: 杂志文章


    authors: Tsuchida H,Namba H,Yamakage M,Fujita S,Notsuki E,Namiki A

    更新日期:1993-03-01 00:00:00

  • Effect of intrathecal non-NMDA EAA receptor antagonist LY293558 in rats: a new class of drugs for spinal anesthesia.

    abstract:BACKGROUND:Excitatory amino acid receptors are important for both sensory and motor function in the spinal cord. We studied the effects of intrathecal LY293558, a competitive non-N-methyl-D-aspartate excitatory amino acid receptor antagonist, on motor and sensory function in rats to determine whether drugs blocking the...


    pub_type: 杂志文章


    authors: Von Bergen NH,Subieta A,Brennan TJ

    更新日期:2002-07-01 00:00:00

  • Concentration-effect relation of succinylcholine chloride during propofol anesthesia.

    abstract:BACKGROUND:The pharmacokinetics and pharmacodynamics of succinylcholine were studied simultaneously in anesthetized patients to understand why the drug has a rapid onset and short duration of action. A quantitative model describing the concentration-effect relation of succinylcholine was proposed. The correlation betwe...


    pub_type: 杂志文章


    authors: Roy JJ,Donati F,Boismenu D,Varin F

    更新日期:2002-11-01 00:00:00

  • Retrograde light-guided laryngoscopy for tracheal intubation: clinical practice and comparison with conventional direct laryngoscopy.

    abstract:BACKGROUND:Tracheal intubation with conventional laryngoscopy requires many trials until beginners are sufficiently skilled in intubating patients safely. To facilitate intubation, the authors used retrograde light-guided laryngoscopy (RLGL) and compared its feasibility with conventional direct laryngoscopy (DL). METH...


    pub_type: 杂志文章,随机对照试验


    authors: Yang T,Hou J,Li J,Zhang X,Zhu X,Ni W,Mao Y,Deng X

    更新日期:2013-05-01 00:00:00

  • Effects of subanesthetic concentrations of isoflurane and their interactions with epinephrine on acquisition and retention of the rabbit nictitating membrane response.

    abstract:BACKGROUND:Evidence concerning the concentrations of volatile anesthetics that prevent learning and recall is limited. Epinephrine is believed to enable learning during anesthesia. We investigated the effects of isoflurane and its interaction with epinephrine on learning and subsequent retention of the rabbit's classic...


    pub_type: 杂志文章


    authors: el-Zahaby HM,Ghoneim MM,Johnson GM,Gormezano I

    更新日期:1994-07-01 00:00:00

  • Administration of nitrous oxide to pediatric patients provides analgesia for venous cannulation.

    abstract::To determine whether administration of nitrous oxide, 50% and 70%, could provide analgesia and anxiolysis during venous cannulation in pediatric patients, 165 ASA Physical Status 1 patients scheduled for elective surgery were studied. Children, 3 weeks to 18 yr of age, were randomly assigned either to receive nitrous ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Henderson JM,Spence DG,Komocar LM,Bonn GE,Stenstrom RJ

    更新日期:1990-02-01 00:00:00

  • Alfentanil pharmacokinetics and metabolism in humans.

    abstract::The metabolism of alfentanil was studied in three healthy subjects after a 1-h infusion of 2.5 mg alfentanil-3H. One of the subjects was a poor hydroxylator of debrisoquine. Pharmacokinetic parameters were similar in the three subjects and were in the same range as those reported for volunteers. The majority of the ad...


    pub_type: 杂志文章


    authors: Meuldermans W,Van Peer A,Hendrickx J,Woestenborghs R,Lauwers W,Heykants J,Vanden Bussche G,Van Craeyvelt H,Van der Aa P

    更新日期:1988-10-01 00:00:00

  • Sevoflurane Enhances Proliferation, Metastatic Potential of Cervical Cancer Cells via the Histone Deacetylase 6 Modulation In Vitro.

    abstract:BACKGROUND:Sevoflurane is commonly used for cervical cancer surgery, but its effect on cervical cancer cell biology remains unclear. This mechanistic study explores how sevoflurane affects the proliferation and metastatic potential of immortalized cervical cancer cell lines. METHODS:Cultured cervical cancer Caski and ...


    pub_type: 杂志文章


    authors: Zhang W,Sheng B,Chen S,Zhao H,Wu L,Sun Y,Cui J,Zhu X,Ma D

    更新日期:2020-06-01 00:00:00

  • Ulnar neuropathy. Incidence, outcome, and risk factors in sedated or anesthetized patients.

    abstract:BACKGROUND:Ulnar neuropathy is well-recognized as a potential complication of procedures performed on anesthetized patients. However, reported outcomes and risk factors for this problem are based on small series and anecdotes. METHODS:We retrospectively reviewed the perioperative courses of 1,129,692 consecutive patie...


    pub_type: 杂志文章


    authors: Warner MA,Warner ME,Martin JT

    更新日期:1994-12-01 00:00:00

  • Intrathecal adenosine: interactions with spinal clonidine and neostigmine in rat models of acute nociception and postoperative hypersensitivity.

    abstract:BACKGROUND:Spinal adenosine receptor agonists exert antinociception in animal models of acute and chronic pain, but adenosine itself has not been examined. The authors tested the antinociceptive and antihypersensitivity interactions of intrathecal adenosine and its interactions with intrathecal clonidine and neostigmin...


    pub_type: 杂志文章


    authors: Chiari AI,Eisenach JC

    更新日期:1999-05-01 00:00:00

  • Effect of nitrous oxide on the oxyhemoglobin dissociation curve and PO2 measurements.

    abstract::Blood from 20 ASA physical status I patients collected before and after induction of anesthesia was used in vitro to reexamine the effects of nitrous oxide on the oxyhemoglobin dissociation curve and the response of the oxygen electrode. The preinduction P50 values with and without 70% N2O were 28.4 +/- 0.1 mmHg and 2...


    pub_type: 杂志文章


    authors: Kambam JR,Holaday DA

    更新日期:1987-02-01 00:00:00

  • Pulmonary shunting during alveolar hypoventilation in the dog.

    abstract::Pulmonary shunting (Qs/Qt) was measured in 16 anesthetized and paralyzed healthy beagle puppies during a control period when the end-expired CO2 concentration was 5 per cent and during alveolar hypoventilation, when the PaCO2 increased to 100 plus or minus 13 torr (mean plus or minus SE) and the ;Ha vecame 7.04 plus o...


    pub_type: 杂志文章


    authors: Stone JG,Sullivan SF

    更新日期:1975-04-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis.

    abstract:BACKGROUND:Rocuronium, like other steroidal nondepolarizing muscle relaxants, may in part be eliminated by the liver. To determine the influence of liver disease on its neuromuscular blocking effect, we studied the pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis. METHODS:Eighteen patient...


    pub_type: 杂志文章


    authors: Khalil M,D'Honneur G,Duvaldestin P,Slavov V,De Hys C,Gomeni R

    更新日期:1994-06-01 00:00:00

  • Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment.

    abstract:BACKGROUND:: Recent population studies have suggested that children with multiple exposures to anesthesia and surgery at an early age are at an increased risk of cognitive impairment. The authors therefore have established an animal model with single versus multiple exposures of anesthetic(s) in young versus adult mice...


    pub_type: 杂志文章


    authors: Shen X,Dong Y,Xu Z,Wang H,Miao C,Soriano SG,Sun D,Baxter MG,Zhang Y,Xie Z

    更新日期:2013-03-01 00:00:00

  • Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics.

    abstract:BACKGROUND:Several beneficial effects of local anesthetics (LAs) were shown to be due to inhibition of G protein-coupled receptor signaling. Differences in exposure time might explain discrepancies in concentrations of LAs required to achieve these protective effects in vivo and in vitro (approximately 100-fold higher)...


    pub_type: 杂志文章


    authors: Hollmann MW,Herroeder S,Kurz KS,Hoenemann CW,Struemper D,Hahnenkamp K,Durieux ME

    更新日期:2004-04-01 00:00:00

  • Quantitative Research Methods in Medical Education.

    abstract::There has been a dramatic growth of scholarly articles in medical education in recent years. Evaluating medical education research requires specific orientation to issues related to format and content. Our goal is to review the quantitative aspects of research in medical education so that clinicians may understand the...


    pub_type: 杂志文章,评审


    authors: Ratelle JT,Sawatsky AP,Beckman TJ

    更新日期:2019-07-01 00:00:00

  • Effect of needle puncture on morphine and lidocaine flux through the spinal meninges of the monkey in vitro. Implications for combined spinal-epidural anesthesia.

    abstract:BACKGROUND:Combined spinal-epidural anesthesia is a technique growing in popularity. However, there have been no attempts to investigate the risk of epidural drug reaching the subarachnoid space in high concentration by passing through the meningeal hole left by the spinal needle. This study begins to address this ques...


    pub_type: 杂志文章


    authors: Bernards CM,Kopacz DJ,Michel MZ

    更新日期:1994-04-01 00:00:00

  • Serious complications related to regional anesthesia: results of a prospective survey in France.

    abstract:BACKGROUND:Serious complications related to regional anesthesia have previously been described primarily in case reports and retrospective surveys. The authors prospectively evaluated a multicenter series of regional anesthetics, using preplanned criteria to measure the incidence and characteristics of associated serio...


    pub_type: 杂志文章


    authors: Auroy Y,Narchi P,Messiah A,Litt L,Rouvier B,Samii K

    更新日期:1997-09-01 00:00:00

  • Infection during chronic epidural catheterization: diagnosis and treatment.

    abstract::A potentially serious complication of long-term epidural catheterization in cancer patients is infection. The early signs of infection were studied in 350 patients in whom long-term epidural catheters were inserted. Three areas of the catheter track were found to be involved; exit site and superficial catheter track i...


    pub_type: 杂志文章


    authors: Du Pen SL,Peterson DG,Williams A,Bogosian AJ

    更新日期:1990-11-01 00:00:00

  • Effects of blood glucose changes and physostigmine on anesthetic requirements of halothane in rats.

    abstract:BACKGROUND:Although hyper- and hypoglycemia induce neurophysiologic changes, there have been no reports on the effects of blood glucose changes on anesthetic requirements. This study examined the effects of hyper- and hypoglycemia on the minimum alveolar concentration (MAC) of halothane in rats. In addition, based on a...


    pub_type: 杂志文章


    authors: Ishizawa Y,Ohta S,Shimonaka H,Dohi S

    更新日期:1997-08-01 00:00:00

  • Stereoselectivity of bupivacaine in local anesthetic-sensitive ion channels of peripheral nerve.

    abstract:BACKGROUND:The local anesthetic bupivacaine exists in two stereoisomeric forms, R(+)- and S(-)-bupivacaine. Because of its lower cardiac and central nervous system toxicity, attempts were made recently to introduce S(-)-bupivacaine into clinical anesthesia. We investigated stereoselective actions of R(+)-and S(-)-bupiv...


    pub_type: 杂志文章


    authors: Nau C,Vogel W,Hempelmann G,Bräu ME

    更新日期:1999-09-01 00:00:00

  • Pulsus alternans during general anesthesia with halothane: effects of permissive hypercapnia.

    abstract:BACKGROUND:Pulsus alternans is a classic type of abnormal pulse. It can be defined as a regular alternation of pulse amplitude in which runs of weak and strong beats follow each other alternatively without any change in cycle length. It may be a sign of severe decompensated congestive heart failure. The authors infrequ...


    pub_type: 杂志文章


    authors: Saghaei M,Mortazavian M

    更新日期:2000-07-01 00:00:00

  • Association of ethnicity with the minimum alveolar concentration of sevoflurane.

    abstract:BACKGROUND:Selective breeding produces animal strains with varying anesthetic sensitivity. It thus seems unlikely that various human ethnicities have identical anesthetic requirements. Therefore, the authors tested the hypothesis that the minimum alveolar concentration of sevoflurane differs significantly as a function...


    pub_type: 杂志文章,随机对照试验


    authors: Ezri T,Sessler D,Weisenberg M,Muzikant G,Protianov M,Mascha E,Evron S

    更新日期:2007-07-01 00:00:00

  • Thoracic epidural analgesia augments ileal mucosal capillary perfusion and improves survival in severe acute pancreatitis in rats.

    abstract:BACKGROUND:Acute pancreatitis has been linked to intestinal barrier dysfunction and systemic inflammatory response with high mortality. Thoracic epidural analgesia improves intestinal perfusion. The authors hypothesized that thoracic epidural analgesia influences microcirculation injury, inflammatory response, and outc...


    pub_type: 杂志文章


    authors: Freise H,Lauer S,Anthonsen S,Hlouschek V,Minin E,Fischer LG,Lerch MM,Van Aken HK,Sielenkämper AW

    更新日期:2006-08-01 00:00:00

  • Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology.

    abstract:BACKGROUND:CW002 is a neuromuscular blocking drug that is inactivated by endogenous L-cysteine. This study determined the exogenous L-cysteine dose-response relationship for CW002 reversal along with acute cardiovascular effects and organ toxicity in dogs. METHODS:Six dogs were each studied four times during isofluran...


    pub_type: 杂志文章


    authors: Sunaga H,Malhotra JK,Yoon E,Savarese JJ,Heerdt PM

    更新日期:2010-04-01 00:00:00

  • The pharmacodynamics and pharmacokinetics of vecuronium in patients anesthetized with isoflurane with normal renal function or with renal failure.

    abstract::The duration of action and the pharmacokinetics of vecuronium were compared in patients with and without renal function. Twenty patients were studied: 12 with renal failure who were to receive kidney transplants from cadaveric donors, and eight with normal renal function. After oral premedication with diazepam, 10 mg,...


    pub_type: 杂志文章


    authors: Lynam DP,Cronnelly R,Castagnoli KP,Canfell PC,Caldwell J,Arden J,Miller RD

    更新日期:1988-08-01 00:00:00

  • Isoflurane causes endothelium-dependent inhibition of contractile responses of canine coronary arteries.

    abstract::The authors sought to determine if isoflurane would attenuate effects of three different types of vasoconstrictors on isolated segments of canine epicardial coronary arteries removed from healthy dogs. As the endothelium has a major role in regulating epicardial coronary artery tone, and as it modulates the effect of ...


    pub_type: 杂志文章


    authors: Blaise G,Sill JC,Nugent M,Van Dyke RA,Vanhoutte PM

    更新日期:1987-10-01 00:00:00

  • Development and feasibility of a scale to assess postoperative recovery: the post-operative quality recovery scale.

    abstract:BACKGROUND:Good postoperative recovery is increasingly recognized as an important outcome after surgery. The authors created a new Post-operative Quality Recovery Scale (PQRS) that tracks multiple domains of recovery from immediate to long-term time periods in patients of varying ages, languages, and cultures. METHODS...


    pub_type: 杂志文章


    authors: Royse CF,Newman S,Chung F,Stygall J,McKay RE,Boldt J,Servin FS,Hurtado I,Hannallah R,Yu B,Wilkinson DJ

    更新日期:2010-10-01 00:00:00

  • Single-dose Antibiotic Prophylaxis in Regional Anesthesia: A Retrospective Registry Analysis.

    abstract:BACKGROUND:Catheter-related infection is a serious complication of continuous regional anesthesia. The authors tested the hypothesis that single-dose antibiotic prophylaxis is associated with a lower incidence of catheter-related infections. METHODS:Our analysis was based on cases in the 25-center German Network for R...


    pub_type: 杂志文章


    authors: Bomberg H,Krotten D,Kubulus C,Wagenpfeil S,Kessler P,Steinfeldt T,Standl T,Gottschalk A,Stork J,Meissner W,Birnbaum J,Koch T,Sessler DI,Volk T,Raddatz A

    更新日期:2016-09-01 00:00:00