Mechanism of myocardial protection by isoflurane. Role of adenosine triphosphate-regulated potassium (KATP) channels.

abstract：BACKGROUND:A relatively small number of inhibitory interneurons can control the excitability and synchronization of large numbers of pyramidal cells in hippocampus and other cortical regions. Thus, anesthetic modulation of interneurons could play an important role for the maintenance of anesthesia. The aim of this stud...

journal_title：Anesthesiology

authors： Nishikawa K,MacIver MB

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:It is not always possible to predict when tracheal intubation will be difficult or impossible. The authors wanted to determine whether indirect laryngoscopy could identify patients in whom intubation was difficult. METHODS:Indirect laryngoscopy was done in 2,504 patients. The Wilson risk sum score and the m...

journal_title：Anesthesiology

authors： Yamamoto K,Tsubokawa T,Shibata K,Ohmura S,Nitta S,Kobayashi T

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Although respiratory depression is the most well-known and dangerous side effect of opioids, no pharmacokinetic-pharmacodynamic model exists for its quantitative analysis. The development of such a model was the aim of this study. METHODS:After institutional approval approval and informed consent were obtai...

journal_title：Anesthesiology

authors： Bouillon T,Schmidt C,Garstka G,Heimbach D,Stafforst D,Schwilden H,Hoeft A

更新日期：1999-07-01 00:00:00

abstract：:EEG amplitude dominance in awake man is posterior. During EEG monitoring in patients, the authors observed the abrupt appearance of anterior amplitude dominance during induction of anesthesia with halothane, enflurane, or thiopental. This EEG change is coincident with loss of eyelid reflex and loss of ability to respo...

journal_title：Anesthesiology

authors： Tinker JH,Sharbrough FW,Michenfelder JD

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Pain following thoracotomy can persist for years with an undetermined impact on quality of life. Factors hypothesized to modulate this painful experience include analgesic regimen, gender, and type of incision. METHODS:A total of 157 generally healthy patients of both genders scheduled for segmentectomy, lo...

journal_title：Anesthesiology

authors： Ochroch EA,Gottschalk A,Augostides J,Carson KA,Kent L,Malayaman N,Kaiser LR,Aukburg SJ

更新日期：2002-11-01 00:00:00

abstract：:We sought to determine the percent delivery by metered-dose inhaler (MDI) of a preparation of salbutamol (albuterol) to the distal end of either pediatric-size tracheal tubes or a narrow-gauge catheter. A bench model consisting of a swivel actuator; 3.0-6.0-mm ID tracheal tubes all 16 cm in length or a 19-G (standard ...

journal_title：Anesthesiology

authors： Taylor RH,Lerman J

更新日期：1991-02-01 00:00:00

abstract：:The authors evaluated the systemic and cerebral hemodynamic and metabolic effects of 1 h of hypotension to a mean arterial pressure of either 50 mmHg or 40 mmHg induced by intravenous adenosine or ATP in dogs maintained on 70% nitrous oxide and 0.1% halothane. Following the hypotensive period, brain biopsy specimens w...

journal_title：Anesthesiology

authors： Newberg LA,Milde JH,Michenfelder JD

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Airway pressure-release ventilation provides ventilation comparable to controlled mechanical ventilation (CMV), but with lower peak airway pressures and less dead-space ventilation. To obtain these advantages for patients administered general anesthesia, the authors (1) designed a mode similar to airway pres...

journal_title：Anesthesiology

authors： Bratzke E,Downs JB,Smith RA

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Perioperative ischemic optic neuropathy (ION) causes visual loss in spinal fusion. Previous case-control studies are limited by study size and lack of a random sample. The purpose of this study was to study trends in ION incidence in spinal fusion and risk factors in a large nationwide administrative hospita...

journal_title：Anesthesiology

authors： Rubin DS,Parakati I,Lee LA,Moss HE,Joslin CE,Roth S

更新日期：2016-09-01 00:00:00

abstract：:Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver, or brain. Genomic, proteomic, and metabolomic approaches highlight common injury mechanisms leading to acute organ failure. This underlines the need to focus on therapeutic strategies affecting multiple injury pathways. Th...

journal_title：Anesthesiology

authors： Monsel A,Zhu YG,Gennai S,Hao Q,Liu J,Lee JW

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:A decrease in radial artery blood pressure relative to central arterial blood pressure is commonly associated with the rewarming phase of cardiopulmonary bypass. Decreased hand vascular resistance has been suggested as a possible mechanism. Although decreased blood viscosity due to hemodilution may contribut...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Moayeri A,Katz JA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:It has been suggested that blood transfusion has an adverse effect on long-term health, mainly through immune modulation and tumor promotion. To further assess this concern, the authors have performed a prospective observational study with the hypothesis that after taking perioperative risk factors relevant ...

journal_title：Anesthesiology

authors： Weightman WM,Gibbs NM,Sheminant MR,Newman MA,Grey DE

更新日期：2009-08-01 00:00:00

abstract：:Cardiac output and myocardial blood flow decrease dramatically in a dose-dependent pattern in the young lamb during isoflurane anesthesia. This raises important questions about the ability of the young lamb to increase myocardial performance if oxygen delivery were compromised by a decrease in oxygen content during an...

journal_title：Anesthesiology

authors： Brett CM,Teitel DF,Heymann MA,Rudolph AM

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:It is well established that neuronal nicotinic acetylcholine receptors (nAChRs) are sensitive to inhalational anesthetics. The authors previously reported that halothane potently blocked alpha4beta2-type nAChRs of rat cortical neurons. However, the effect of isoflurane, which is widely used clinically, on nA...

journal_title：Anesthesiology

authors： Yamashita M,Mori T,Nagata K,Yeh JZ,Narahashi T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Inhalation anesthetics may interfere with the synthesis or action of endothelium-derived vasoactive factors. We investigated the effects of desflurane, enflurane, halothane, isoflurane, and sevoflurane on the release of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the isolated endoth...

journal_title：Anesthesiology

authors： Lischke V,Busse R,Hecker M

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Clinical concentrations of volatile anesthetics significantly influence contractile response to the sympathetic neurotransmitter norepinephrine although its precise mechanisms remain unclarified. In this study, we investigated its possible alterations in diabetes, as well as its underlying mechanisms. METHO...

journal_title：Anesthesiology

authors： Yoshino J,Akata T,Shirozu K,Izumi K,Hoka S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Few data support an association between blood pressure variability and clinical outcomes during cardiac surgery. We tested the hypothesis that intraoperative systolic blood pressure variability outside a targeted blood pressure range predicts 30-day mortality in patients undergoing cardiac surgery. METHODS:...

journal_title：Anesthesiology

authors： Aronson S,Stafford-Smith M,Phillips-Bute B,Shaw A,Gaca J,Newman M,Cardiothoracic Anesthesiology Research Endeavors.

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Preoperative anemia is frequent in patients undergoing orthopedic surgery. The purpose of this study was to assess the preoperative increase of hemoglobin in iron deficiency anemia patients treated with intravenous iron. METHODS:After obtaining written informed consent, 20 patients with iron deficiency anem...

journal_title：Anesthesiology

authors： Theusinger OM,Leyvraz PF,Schanz U,Seifert B,Spahn DR

更新日期：2007-12-01 00:00:00

abstract：:The authors determined the effects of intravenous infusion and epidural administration of lidocaine on the control of ventilation in two groups of eight healthy unpremedicated subjects. In the intravenous group, an injection of 1.5 mg/kg lidocaine was followed by an infusion at a rate of 60 micrograms X kg-1 X min-1 f...

journal_title：Anesthesiology

authors： Labaille T,Clergue F,Samii K,Ecoffey C,Berdeaux A

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:The observation that peripheral trauma causes enhanced spinal neuronal excitability has provided the scientific rationale for the concept of "pre-emptive analgesia." The premise has been that only noxious stimuli cause sensitization in sensory pathways, but this premise has not been tested in the conscious s...

journal_title：Anesthesiology

authors： Herrero JF,Headley PM

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:In cardiac myocytes, lidocaine reduces but mexiletine increases adenosine triphosphate (ATP)-sensitive K+ currents, suggesting that these class Ib antiarrhythmic drugs may differentially modify the activity of ATP-sensitive K+ channels. The effects of lidocaine and mexiletine on arterial relaxations induced ...

journal_title：Anesthesiology

authors： Kinoshita H,Ishikawa T,Hatano Y

更新日期：1999-04-01 00:00:00

abstract：:In the absence of data on the anatomic localization of the cuff of the laryngeal mask airway (LMA) in children, radiologic images were obtained from 50 infants and children (aged 1 month to 15 yr) undergoing diagnostic radiologic procedures during halothane and N2O:O2 anesthesia. In 46 patients, the cuff of the LMA wa...

journal_title：Anesthesiology

authors： Goudsouzian NG,Denman W,Cleveland R,Shorten G

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:The current study was designed to test the hypothesis that the fibromyalgia survey criteria would be directly associated with increased opioid consumption after hysterectomy even when accounting for other factors previously described as being predictive for acute postoperative pain. METHODS:Two hundred eigh...

journal_title：Anesthesiology

authors： Janda AM,As-Sanie S,Rajala B,Tsodikov A,Moser SE,Clauw DJ,Brummett CM

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Despite improvements in neonatal heart surgery, neurologic complications continue to occur from low-flow cardiopulmonary bypass (LF-CPB) and deep hypothermic circulatory arrest (DHCA). Desflurane confers neuroprotection against ischemia at normothermia and for DHCA. This study compared neurologic outcome of ...

journal_title：Anesthesiology

authors： Loepke AW,Priestley MA,Schultz SE,McCann J,Golden J,Kurth CD

更新日期：2002-12-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the induction of convulsions by local anesthetics were investigated in mice and rats. Intraventricular administration of 0.8-1.6 mg GABA protected rats against convulsions induced by procaine, lidocaine, cocaine, and tetracaine in a dose-related manner. Intraperitoneal ...

journal_title：Anesthesiology

authors： Ikeda M,Dohi T,Tsujimoto A

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND:The authors' purpose in this study was to compare prospectively four different anesthetic induction and maintenance techniques using nitrous oxide with halothane and/or propofol for vomiting and recovery after outpatient tonsillectomy and adenoidectomy procedures in children. METHODS:Eighty unpremedicated c...

journal_title：Anesthesiology

authors： Ved SA,Walden TL,Montana J,Lea DE,Tefft MC,Kataria BK,Pudimat MA,Nicodemus HF,Milmoe GJ

更新日期：1996-07-01 00:00:00

abstract：:The mechanisms of persistent differential blocks that accompany subarachnoid and epidural anesthesia are clarified here with the aid of two principles derived from in vitro study of individual myelinated axons: 1) conduction can leap two consecutive blocked nodes but not three, and 2) a fiber length with more than thr...

journal_title：Anesthesiology

authors： Fink BR

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Alpha-2B adrenoceptor is the vasoconstrictive subtype in the mouse. Human alpha2B-AR deletion (D) allele has been associated with loss of short-term agonist-promoted receptor desensitization, which may lead to increased vasoconstriction on alpha2 activation. The goal of this study was to test the hypothesis ...

journal_title：Anesthesiology

authors： Talke P,Stapelfeldt C,Lobo E,Brown R,Scheinin M,Snapir A

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:In patients with acute respiratory distress syndrome (ARDS), the ventilatory approach is based on tidal volume (VT) of 10-15 ml/kg and positive end-expiratory pressure (PEEP). To avoid further pulmonary injury, decreasing VT and allowing PaCO2 to increase (permissive hypercapnia) has been suggested. Effects ...

journal_title：Anesthesiology

authors： Ranieri VM,Mascia L,Fiore T,Bruno F,Brienza A,Giuliani R

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:An in vitro model of epidural catheter contamination was used to determine if disconnected catheters can be safely reconnected. METHODS:Epidural catheters were filled with brain-heart infusion (BHI) broth or preservative-free saline containing 5 micrograms/ml fentanyl. Escherichia coli, Pseudomonas aerugino...

journal_title：Anesthesiology

authors： Langevin PB,Gravenstein N,Langevin SO,Gulig PA

更新日期：1996-10-01 00:00:00