Abstract:
BACKGROUND:In cardiac myocytes, lidocaine reduces but mexiletine increases adenosine triphosphate (ATP)-sensitive K+ currents, suggesting that these class Ib antiarrhythmic drugs may differentially modify the activity of ATP-sensitive K+ channels. The effects of lidocaine and mexiletine on arterial relaxations induced by K+ channel openers have not been studied. Therefore, the current study was designed to evaluate whether lidocaine and mexiletine may produce changes in relaxations to the ATP-sensitive K+ channel openers cromakalim and pinacidil in isolated rat thoracic aortas. METHODS:Rings of rat thoracic aortas without endothelia were suspended for isometric force recording. Concentration-response curves were obtained in a cumulative fashion. During submaximal contractions to phenylephrine (3 x 10(-7) M), relaxations to cromakalim (10(-7) to 3 x 10(-5) M), pinacidil (10(-7) to 3 x 10(-5) M), or diltiazem (10(-7) to 3 x 10(-4) M) were obtained. Lidocaine (10(-5) to 3 x 10(-4) M), mexiletine (10(-5) to 10(-4) M) or glibenclamide (5 x 10(-6) M) was applied 15 min before addition of phenylephrine. RESULTS:During contractions to phenylephrine, cromakalim and pinacidil induced concentration-dependent relaxations. A selective ATP-sensitive K+ channel antagonist, glibenclamide (5 x 10(-6) M), abolished these relaxations, whereas it did not alter relaxations to a voltage-dependent Ca2+ channel inhibitor, diltiazem (10(-7) to 3 x 10(-4) M). Lidocaine (more than 10(-5) M) significantly reduced relaxations to cromakalim or pinacidil in a concentration-dependent fashion, whereas lidocaine (3 x 10(-4) M) did not affect relaxations to diltiazem. In contrast, mexiletine (more than 10(-5) M) significantly augmented relaxations to cromakalim or pinacidil. Glibenclamide (5 x 10(-6) M) abolished relaxations to cromakalim or pinacidil in arteries treated with mexiletine (10(-4) M). CONCLUSIONS:These results suggest that lidocaine impairs but mexiletine augments vasodilation mediated by ATP-sensitive K+ channels in smooth muscle cells.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Kinoshita H,Ishikawa T,Hatano Ydoi
10.1097/00000542-199904000-00032subject
Has Abstractpub_date
1999-04-01 00:00:00pages
1165-70issue
4eissn
0003-3022issn
1528-1175journal_volume
90pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract::Medical records of 38 patients undergoing anesthesia and surgery for removal of an insulinoma were reviewed to determine 1) the safety of avoiding intraoperative glucose, 2) the appropriate frequency of plasma glucose analysis, and 3) the accuracy of using rebound hyperglycemia as an indication of tumor removal. Plasm...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198311000-00001
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from limitations in assessing this complex subjective experience. However, human brain neuroimaging techniques enable the assessment of functional and neur...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000017
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the effects of two imidazoline-derived intravenous anesthetics, etomidate and midazolam, on vascular adenosine triphosphate-sensitive potassium (KATP) channel activity. METHODS:In isolated rat aorta, isometric tension was recorded to examine the anesthetic effects on...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200703000-00016
更新日期:2007-03-01 00:00:00
abstract::Premedication with diazepam, hydroxyzine or secobarbital significantly increased ketamine-induced sleep time (137 +/- 3.5 min, 135 +/- 9.2 min, 128 +/- 4.7 min) over that of unpremedicated controls (98.5 +/- 4.4 min) in man. The corresponding mean plasma half-lives (t1/2) of ketamine were longer in patients premedicat...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197509000-00007
更新日期:1975-09-01 00:00:00
abstract::Postoperative itching is an important problem in the postoperative care unit. Pruritus after surgery may be drug induced (including intrathecal opioids) or secondary to a preexisting systemic disease. Mechanisms of itching are complex and not completely understood. The purpose of this review is to highlight new discov...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/00000542-200507000-00025
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:The abundance of a specific sodium channel subunit (SkM2) appeared to be altered in vitro in cell cultures from persons susceptible to malignant hyperthermia. This study sought to determine whether these findings are artifacts of cell culture or whether they may be relevant to malignant hyperthermia. METHOD...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199705000-00004
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Dysrhythmias and death occur in patients with acquired long QT syndrome (LQTS). Little information exists regarding interactions between anesthetics and drugs that prolong ventricular repolarization. Therefore the effects of three commonly used intravenous anesthetics on ventricular repolarization were inves...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199711000-00022
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:A high proportion of patients having cardiac bypass surgery receive erythrocyte transfusions. Decisions about when to transfuse patients having surgery for coronary artery disease may impact on erythrocyte utilization and patient morbidity and mortality. There are no published data about the factors that inf...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200607000-00008
更新日期:2006-07-01 00:00:00
abstract::The cerebral and systemic hemodynamic and metabolic effects of hypotension induced with desflurane were examined in 11 dogs. During a steady-state baseline period under 1 MAC desflurane (7.2%), the following were measured or derived: arterial, pulmonary artery, and pulmonary artery occlusion pressures; arterial, mixed...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199103000-00021
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Anesthetics inhibit airway smooth muscle contraction in part by a direct effect on the smooth muscle cell. This study tested the hypothesis that the anesthetics halothane and hexanol, which both relax airway smooth muscle in vitro, inhibit acetylcholine-promoted nucleotide exchange at the alpha subunit of th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200407000-00019
更新日期:2004-07-01 00:00:00
abstract::The purpose of this study was to evaluate the analgesic contribution of intravenously administered lidocaine and to correlate it with blood levels of the drug. In a double-blind manner, 14 healthy male volunteers received saline solution or lidocaine, 0.2 per cent, at three increasingly greater rates of infusion on tw...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198001000-00005
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:mu-Opioids administered spinally produce a potent, dose-dependent analgesic response in preclinical and clinical investigations. Side-effect profile of these compounds may be altered as a function of pharmacokinetics. The effects of intrathecal and intraperitoneal remifentanil, an esterase-metabolized mu opi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199601000-00012
更新日期:1996-01-01 00:00:00
abstract::The dosage and blood concentration of lidocaine required to produce central nervous and cardiovascular system toxicity in both nonasphyxiated and asphyxiated fetuses were determined in ten pregnant baboons with fetuses of average gestation of 158 days (term, 185 days). Lidocaine was infused into the fetal jugular vein...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198103000-00002
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND:The impact of intraoperative ventilation on postoperative pulmonary complications is not defined. The authors aimed at determining the effectiveness of protective mechanical ventilation during open abdominal surgery on a modified Clinical Pulmonary Infection Score as primary outcome and postoperative pulmona...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0b013e31829102de
更新日期:2013-06-01 00:00:00
abstract::This study examined the interaction between thiopental and epinephrine in inducing ventricular arrhythmias in dogs. The arrhythmogenic threshold of epinephrine was determined during anesthesia with either halothane alone, thiopental alone, etomidate plus different doses of thiopental, or halothane plus different doses...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198912000-00017
更新日期:1989-12-01 00:00:00
abstract::A potentially serious complication of long-term epidural catheterization in cancer patients is infection. The early signs of infection were studied in 350 patients in whom long-term epidural catheters were inserted. Three areas of the catheter track were found to be involved; exit site and superficial catheter track i...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199011000-00018
更新日期:1990-11-01 00:00:00
abstract::Changes in hepatic plasma flow (HPF) during sodium nitroprusside (SNP) induced hypotension were studied in 14 patients undergoing intracranial aneurysm surgery under neurolept anesthesia. Patients were monitored with the use of a radial artery catheter and a thermistor-tipped Swan-Ganz catheter. Hypotension was induce...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198509000-00008
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Impaired excitatory and inhibitory balance in the spinal dorsal horn has a crucial role in the pathophysiology of chronic pain. The authors addressed the therapeutic impact of increasing spinal glycine applied exogenously or via blockade of glycine transporter 1 using its selective inhibitors sarcosine and N...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31816c9044
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:The authors evaluated optimal adrenergic support using norepinephrine, dopamine, and dobutamine in a clinically relevant model of septic shock. METHODS:Twenty-eight mature, female, anesthetized sheep (weight, 30.5 +/- 3.6 kg) underwent cecal ligation and perforation and were randomized into four groups of s...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200304000-00015
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Surgical resection remains the best option for long-term survival in many solid tumors. Surgery can, however, lead to tumor cell release into the circulation. Data have suggested differential effects of anesthetic agents on cancer cell growth. This retrospective analysis investigated the association of anest...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000936
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine. However, the role of tonic spinal cholinergic activity and its interaction with alpha2-adrenergic systems in normal and neuropathic conditions and to different sensory methods has not...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200307000-00030
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Pulse oximeters have been reported to fail to record data in 1.12-2.50% of cases in which anesthesia records were handwritten. There is reason to believe that these may be underestimates. Computerized anesthesia records may provide insight into the true incidence of pulse oximetry data failures and factors t...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199604000-00013
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:The authors' objective was to assess the role of protein kinase C (PKC) and nitric oxide synthase (NOS) in mediating the effects of propofol on diabetic cardiomyocyte contractility, intracellular free Ca2+ concentration ([Ca2+]i), and myofilament Ca2+ sensitivity. METHODS:Freshly isolated ventricular myocyt...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200605000-00014
更新日期:2006-05-01 00:00:00
abstract::In order to determine whether or not irritation of the nasal passage with commonly used volatile anesthetics can elicit airway reflexes, we investigated respiratory, laryngeal, and tracheal responses to nasal insufflation of three volatile anesthetics (enflurane, isoflurane, and halothane) in 13 patients anesthetized ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199109000-00010
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Spinal adenosine receptor agonists exert antinociception in animal models of acute and chronic pain, but adenosine itself has not been examined. The authors tested the antinociceptive and antihypersensitivity interactions of intrathecal adenosine and its interactions with intrathecal clonidine and neostigmin...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199905000-00026
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Percutaneous cannulation of the internal jugular vein in infants is technically more difficult and carries a higher risk of carotid artery puncture than in older children and adults. In this prospective study, the authors tested their hypothesis that using an ultrasound scanner would increase the success of ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199907000-00013
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Oral gabapentin is approved as an anticonvulsant medication and to treat postherpetic neuralgia. Its nonopioid properties and presumed spinal site of analgesic action made the study on intrathecal gabapentin attractive to establish the minimum effective dose for a later, pivotal trial. METHODS:The authors e...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ALN.0b013e3182a10fbf
更新日期:2013-09-01 00:00:00
abstract::This study examined the efficacy of patient-controlled epidural analgesia (PCEA) during labor and compared the suitability of three different PCEA solutions. After establishing effective epidural analgesia with 12 ml of 0.25% bupivacaine, 72 parturients in active labor were randomly assigned to one of four groups: phy...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199001000-00009
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The combining of epidural anesthesia with general anesthesia impairs central and peripheral thermoregulatory control and therefore is often accompanied by unintended intraoperative hypothermia. However, little is known about the cardiovascular response to hypothermia during combined epidural and general anes...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200104000-00023
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Compared to other perioperative complications, failure to rescue (i.e., death after suffering a complication) is highest after perioperative myocardial infarction (a myocardial infarction that occurs intraoperatively or within 30 days after surgery). The purpose of this study was to identify patient and surg...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000003330
更新日期:2020-07-01 00:00:00