Sodium channel in human malignant hyperthermia.

abstract：BACKGROUND:In this open, randomized study, the pharmacokinetics, clinical efficacy, and safety of a 48-h continuous interscalene infusion of 2 mg/ml ropivacaine for postoperative pain relief were investigated in patients undergoing open major shoulder surgery. METHODS:An initial interscalene block with 30 ml ropivacai...

journal_title：Anesthesiology

authors： Ekatodramis G,Borgeat A,Huledal G,Jeppsson L,Westman L,Sjövall J

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Medical errors exact an inordinate toll on healthcare costs. One of the most publicized and analyzed type of medical error is wrong-site surgery. Yet, despite the burgeoning number of procedures performed, no literature exists on wrong-site pain management injections. The purpose of this study was to estimat...

journal_title：Anesthesiology

authors： Cohen SP,Hayek SM,Datta S,Bajwa ZH,Larkin TM,Griffith S,Hobelmann G,Christo PJ,White R

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Surgery causes changes in hemostasis, leading to a hypercoagulable state. This postoperative increase in hemostatic function is attenuated in patients receiving regional anesthesia compared with those receiving general anesthesia. Regional anesthesia also decreases the neuroendocrine response to surgery comp...

journal_title：Anesthesiology

authors： Rosenfeld BA,Faraday N,Campbell D,Dise K,Bell W,Goldschmidt P

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:It is increasingly important to evaluate patients' recovery after ambulatory surgery. The authors developed the Functional Recovery Index (FRI) to assess postdischarge functional recovery for ambulatory surgical patients. METHODS:The scale development involved four phases: item generation, item selection, r...

journal_title：Anesthesiology

authors： Wong J,Tong D,De Silva Y,Abrishami A,Chung F

更新日期：2009-03-01 00:00:00

abstract：:Anesthesiologist-reviewers examined 1,175 anesthetic-related closed malpractice claims from 17 professional liability insurance companies. The claims were filed between 1974 and 1988. The reviewers were asked to determine if the negative outcome was preventable by proper use of additional monitoring devices available ...

journal_title：Anesthesiology

authors： Tinker JH,Dull DL,Caplan RA,Ward RJ,Cheney FW

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:To interpret correctly the results from studies performed during surgery and anesthesia it is necessary to dissect the separate effect of the anesthetic technique itself. The purpose of this study was to investigate the metabolic effects of epidural blockade (T7-S1) with bupivacaine 0.25% after 12 h fasting ...

journal_title：Anesthesiology

authors： Schricker T,Klubien K,Wykes L,Carli F

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:To assess changing patterns of injury and liability associated with central venous or pulmonary artery catheters, the authors analyzed closed malpractice claims for central catheter injuries in the American Society of Anesthesiologists Closed Claims database. METHODS:All claims for which a central catheter ...

journal_title：Anesthesiology

authors： Domino KB,Bowdle TA,Posner KL,Spitellie PH,Lee LA,Cheney FW

更新日期：2004-06-01 00:00:00

abstract：:The cerebral and systemic hemodynamic and metabolic effects of hypotension induced with desflurane were examined in 11 dogs. During a steady-state baseline period under 1 MAC desflurane (7.2%), the following were measured or derived: arterial, pulmonary artery, and pulmonary artery occlusion pressures; arterial, mixed...

journal_title：Anesthesiology

authors： Milde LN,Milde JH

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Little is known about the influence of liver transplantation on the pharmacokinetics of most anesthetic drugs. The authors determined the pharmacokinetics of rocuronium during liver transplantation and examined whether variability in pharmacokinetics could explain variability in recovery of neuromuscular fun...

journal_title：Anesthesiology

authors： Fisher DM,Ramsay MA,Hein HA,Marcel RJ,Sharma M,Ramsay KJ,Miller RD

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:During laparoscopic surgery utilizing carbon dioxide as the insufflating agent, nitrous oxide will diffuse into the peritoneal cavity if it is used as part of the anesthetic. Bowel perforation and the subsequent release of volatile bowel gas could create a explosion hazard. METHODS:Two related studies were ...

journal_title：Anesthesiology

authors： Neuman GG,Sidebotham G,Negoianu E,Bernstein J,Kopman AF,Hicks RG,West ST,Haring L

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Etomidate is a sedative hypnotic that is often used in critically ill patients because it provides superior hemodynamic stability. However, it also binds with high affinity to 11beta-hydroxylase, potently suppressing the synthesis of steroids by the adrenal gland that are necessary for survival. The authors ...

journal_title：Anesthesiology

authors： Cotten JF,Forman SA,Laha JK,Cuny GD,Husain SS,Miller KW,Nguyen HH,Kelly EW,Stewart D,Liu A,Raines DE

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Endothelium-derived hyperpolarizing factor is thought to be a cytochrome P450-derived arachidonic acid metabolite that hyperpolarizes vascular smooth muscle cells by opening Ca(2+)-activated K+ channels (K+Ca channels). In the rabbit carotid artery both volatile and intravenous anesthetics inhibit the acetyl...

journal_title：Anesthesiology

authors： Kessler P,Lischke V,Hecker M

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to the electrical activity of the diaphragm. This study aimed to compare the ventilatory and gas exchange effects between NAVA and pressure support ventilation (PSV) during the w...

journal_title：Anesthesiology

authors： Coisel Y,Chanques G,Jung B,Constantin JM,Capdevila X,Matecki S,Grasso S,Jaber S

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Intrathecal sufentanil (ITS) is frequently used to provide analgesia during labor. Decreases in blood pressure and sensory changes in this circumstance suggest that ITS may have a local anesthetic effect and thus cause a sympathectomy. To determine whether ITS given to laboring women causes a sympathectomy, ...

journal_title：Anesthesiology

authors： Riley ET,Walker D,Hamilton CL,Cohen SE

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the mos...

journal_title：Anesthesiology

authors： Pham T,Serpa Neto A,Pelosi P,Laffey JG,De Haro C,Lorente JA,Bellani G,Fan E,Brochard LJ,Pesenti A,Schultz MJ,Artigas A,LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group.

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Patient blood management combines the use of several transfusion alternatives. Integrated use of erythropoietin, cell saver, and/or postoperative drain reinfusion devices on allogeneic erythrocyte use was evaluated using a restrictive transfusion threshold. METHODS:In a factorial design, adult elective hip-...

journal_title：Anesthesiology

authors： So-Osman C,Nelissen RG,Koopman-van Gemert AW,Kluyver E,Pöll RG,Onstenk R,Van Hilten JA,Jansen-Werkhoven TM,van den Hout WB,Brand R,Brand A

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:No externally validated risk score for postoperative pulmonary complications (PPCs) is currently available. The authors tested the generalizability of the Assess Respiratory Risk in Surgical Patients in Catalonia risk score for PPCs in a large European cohort (Prospective Evaluation of a RIsk Score for posto...

journal_title：Anesthesiology

authors： Mazo V,Sabaté S,Canet J,Gallart L,de Abreu MG,Belda J,Langeron O,Hoeft A,Pelosi P

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Clinical concentrations of volatile anesthetics significantly influence contractile response to the sympathetic neurotransmitter norepinephrine although its precise mechanisms remain unclarified. In this study, we investigated its possible alterations in diabetes, as well as its underlying mechanisms. METHO...

journal_title：Anesthesiology

authors： Yoshino J,Akata T,Shirozu K,Izumi K,Hoka S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:In airway smooth muscle (ASM), volatile anesthetics deplete sarcoplasmic reticulum (SR) Ca(2+) stores by increasing Ca(2+) "leak." Accordingly, SR replenishment becomes dependent on Ca(2+) influx. Depletion of SR Ca(2+) stores triggers Ca(2+) influx via specific plasma membrane channels, store-operated Ca(2+...

journal_title：Anesthesiology

authors： Pabelick CM,Ay B,Prakash YS,Sieck GC

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Hypoalbuminemia may increase the risk of acute kidney injury (AKI). The authors investigated whether the immediate preoperative administration of 20% albumin solution affects the incidence of AKI after off-pump coronary artery bypass surgery. METHODS:In this prospective, single-center, randomized, parallel-...

journal_title：Anesthesiology

authors： Lee EH,Kim WJ,Kim JY,Chin JH,Choi DK,Sim JY,Choo SJ,Chung CH,Lee JW,Choi IC

更新日期：2016-05-01 00:00:00

abstract：:Cognitive performance in postsurgical patients may be impaired by disturbances of normal circadian rhythm analogous to those produced by rapid transmeridian travel ("jet lag"). We therefore tested the hypothesis that isoflurane anesthesia alone produces a phase-delay in the human circadian temperature rhythm. We monit...

journal_title：Anesthesiology

authors： Sessler DI,Lee KA,McGuire J

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Chronic neck pain after whiplash injury is caused by cervical zygapophysial joints in 50% of patients. Diagnostic blocks of nerves supplying the joints are performed using fluoroscopy. The authors' hypothesis was that the third occipital nerve can be visualized and blocked with use of an ultrasound-guided te...

journal_title：Anesthesiology

authors： Eichenberger U,Greher M,Kapral S,Marhofer P,Wiest R,Remonda L,Bogduk N,Curatolo M

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Densities in dependent lung regions worsen oxygenation in patients with acute respiratory distress syndrome. Identification of these densities requires examination using computed tomography (CT). In this study, the authors evaluated the use of transesophageal echocardiography (TEE) to estimate densities in t...

journal_title：Anesthesiology

authors： Tsubo T,Sakai I,Suzuki A,Okawa H,Ishihara H,Matsuki A

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Pain following thoracotomy can persist for years with an undetermined impact on quality of life. Factors hypothesized to modulate this painful experience include analgesic regimen, gender, and type of incision. METHODS:A total of 157 generally healthy patients of both genders scheduled for segmentectomy, lo...

journal_title：Anesthesiology

authors： Ochroch EA,Gottschalk A,Augostides J,Carson KA,Kent L,Malayaman N,Kaiser LR,Aukburg SJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and often leads to multiorgan dysfunction and systemic inflammation. Volatile anesthetics have potent antiinflammatory effects. We aimed to determine whether the representative volatile anesthetic isoflurane protects against acut...

journal_title：Anesthesiology

authors： Kim M,Park SW,Kim M,D'Agati VD,Lee HT

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the brain areas in which hypnosis modulates cerebral responses to a noxious stimulus. METHODS:The protocol used a factorial ...

journal_title：Anesthesiology

authors： Faymonville ME,Laureys S,Degueldre C,DelFiore G,Luxen A,Franck G,Lamy M,Maquet P

更新日期：2000-05-01 00:00:00

abstract：:In MH, skeletal muscle acutely and unexpectedly increases its oxygen consumption and lactate production, resulting in greater heat production, respiratory and metabolic acidosis, muscle ridigity, sympathetic stimulation, and increased cellular permeability. The best-accepted theory is that MH is due to an inability to...

journal_title：Anesthesiology

authors： Gronert GA

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:Traditional strategies for myofascial pain relief provide transient, incomplete, variable, or unpredictable outcomes. Botulinum toxin is itself an analgesic but can also cause sustained muscular relaxation, thereby possibly affording even greater relief than traditional therapies. METHODS:The study goal was...

journal_title：Anesthesiology

authors： Ferrante FM,Bearn L,Rothrock R,King L

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Recent studies have revealed that N2O exerts its antinociceptive effect by inducing opioid peptide release in the brain stem, thereby activating the descending noradrenergic inhibitory neurons, which modulate pain processing in the spinal cord. However, the precise neuronal pathways that mediate these events...

journal_title：Anesthesiology

authors： Ohashi Y,Guo T,Orii R,Maze M,Fujinaga M

更新日期：2003-10-01 00:00:00

abstract：:The anesthetic effects and interactions of midazolam and fentanyl were determined in terms of their reduction of enflurane MAC in dogs, and the effects of their specific antagonists were also investigated. Control enflurane MAC was determined by the tail clamp method in 18 mongrel dogs. Each animal then received an iv...

journal_title：Anesthesiology

authors： Schwieger IM,Hall RI,Szlam F,Hug CC Jr

更新日期：1989-04-01 00:00:00