Abstract:
:The dosage and blood concentration of lidocaine required to produce central nervous and cardiovascular system toxicity in both nonasphyxiated and asphyxiated fetuses were determined in ten pregnant baboons with fetuses of average gestation of 158 days (term, 185 days). Lidocaine was infused into the fetal jugular vein until cardiac arrest occurred, following which fetal brain, heart, lungs liver and kidneys were obtained. Mean dosage and blood concentration of lidocaine associated with seizures were 9.4 mg/kg and 15.2 micrograms/ml, respectively, in the nonasphyxiated fetuses, and 3.9 mg/kg and 5.6 micrograms/ml, respectively, in the asphyxiated ones. The dosage and blood concentration of the drug required to produce cardiac arrest were significantly higher in the nonasphyxiated group (35 mg/kg and 269 micrograms/ml, respectively) compared to the sphyxiated group (9 mg/kg and 40 micrograms/ml, respectively). Tissue-plasma ratios of lidocaine were significantly higher (P less than 0.05) in the brain, heart, and liver of the asphyxiated fetuses as compared with the nonasphyxiated ones. The relative proportion of the injected dose found in the organs was also higher (P less than 0.05) in the asphyxiated group. These results indicate that the increased sensitivity of the asphyxiated fetus to lidocaine may be related in part to a greater uptake of local anesthetics by the fetal organs.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Morishima HO,Covino BGdoi
10.1097/00000542-198103000-00002subject
Has Abstractpub_date
1981-03-01 00:00:00pages
182-6issue
3eissn
0003-3022issn
1528-1175journal_volume
54pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract::Ropivacaine is an amide local anesthetic structurally related to, but appearing less cardiotoxic, than bupivacaine. The authors' investigation was designed in a randomized, double-blind fashion to compare the clinical effectiveness of ropivacaine and bupivacaine in patients undergoing lower-extremity surgery. Forty-fi...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199004000-00010
更新日期:1990-04-01 00:00:00
abstract::Sevoflurane was submitted to phase-1 studies in man following extensive testing in animal species during maintenance, was administered with oxygen to produce one hour of anesthesia in six healthy adult male volunteers. Respiratory and cardiovascular functions, the electroencephalogram, arterial blood gases, blood sevo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198102000-00002
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:The effects of anesthetics on ischemia-induced ventricular arrhythmias remain poorly studied. This study investigated the effects of propofol and sevoflurane on the survival rate and morbidity as a result of ventricular arrhythmias, and defined a possible mechanism for the arrhythmogenic properties of anesth...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318190b537
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:General anesthetics are thought to produce their hypnotic effects mainly by acting at ligand-gated ionic channels in the central nervous system (CNS). Although it is well established that volatile anesthetics significantly modify the activity of the acetylcholine nicotinic receptors of the neuromuscular junc...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199703000-00016
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:The pharmacology of oxycodone is poorly understood despite its growing clinical use. The discrepancy between its good clinical effectiveness after systemic administration and the loss of potency after spinal administration led the authors to study the pharmacodynamic effects of oxycodone and its metabolites ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200610000-00027
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:The authors explored the database of the first International Study of Postoperative Cognitive Dysfunction study to specify the domains of cognitive function that were most vulnerable and to determine the pattern of deterioration in patients with preoperative cognitive impairment. METHODS:One thousand two hu...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/00000542-200703000-00006
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Recent advances have indicated a complex interplay between the autonomic nervous system and the innate immune system. Targeting neural networks for the treatment of sepsis is being developed as a therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities of the autonomic ner...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3182426ebd
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:The mechanisms of amino-amide local anesthetic agent-induced vasoconstriction remain unclear. The current study was designed to examine the roles of the protein kinase C (PKC), Rho kinase, and p44/42 mitogen-activated protein kinase (p44/42 MAPK) signaling pathways in calcium (Ca2+)-sensitization mechanisms ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200509000-00018
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Ten-eleven translocation methylcytosine dioxygenase converts 5-methylcytosine in DNA to 5-hydroxymethylcytosine, which plays an important role in gene transcription. Although 5-hydroxymethylcytosine is enriched in mammalian neurons, its regulatory function in nociceptive information processing is unknown. M...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001632
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Acute kidney injury is a common complication after cardiac surgery, leading to increased morbidity and mortality. One suggested cause for acute kidney injury is extracorporeal circulation-induced ischemia-reperfusion injury. In animal studies, cyclosporine has been shown to reduce ischemia-reperfusion injury...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000002104
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Conflicting results have been reported concerning the effect of platelet transfusion on several outcomes. The aim of this study was to assess the independent effect of a single early intraoperative platelet transfusion on bleeding and adverse outcomes in cardiac surgery patients. METHODS:For this observatio...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001518
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:This study aimed to characterize the electroencephalogram in children who emerged with emergence delirium (ED) compared with children without ED using methods that involved the assessment of cortical functional connectivity. METHODS:Children aged 5 to 15 yr had multichannel electroencephalographic recording...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000376
更新日期:2014-10-01 00:00:00
abstract::The authors hypothesized that relaxation of airway smooth muscle by halothane lessens the dependence of airway resistance on lung volume, and that halothane alters the relationship between pulmonary resistance and lung volume by changing both the airway and tissue components of pulmonary resistance. The relationship a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199202000-00012
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Macrophage recruitment into atherosclerotic plaques drives lesion progression, destabilization, and rupture. Chronic statin treatment reduces macrophage plaque content. Information on dynamics of macrophage recruitment would help assessing plaque vulnerability and guiding therapy. Techniques to image macroph...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318291c18b
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The anticonvulsant gabapentin has proven effective for neuropathic pain in three large placebo-controlled clinical trials. Experimental and clinical studies have demonstrated antihyperalgesic effects in models involving central neuronal sensitization. It has been suggested that central neuronal sensitization...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200209000-00007
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Repetitive C-fiber stimulation induces a state of facilitated processing of sensory information in the dorsal horn, while chronic nerve compression gives rise to a hyperalgesic state, characterized by spontaneous neuronal activity generated by voltage-sensitive sodium channels, as well as spinal facilitation...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::Isoflurane has protective properties during experimental global brain ischemia or hypoxia. However, this has not been evaluated in the more common case of focal ischemia, e.g., as caused by middle cerebral artery occlusion (MCAO). The authors therefore compared the effects of isoflurane, thiopental, and N2O/fentanyl a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198704000-00002
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:The local anesthetic bupivacaine exists in two stereoisomeric forms, R(+)- and S(-)-bupivacaine. Because of its lower cardiac and central nervous system toxicity, attempts were made recently to introduce S(-)-bupivacaine into clinical anesthesia. We investigated stereoselective actions of R(+)-and S(-)-bupiv...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199909000-00031
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptoti...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318294934d
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Cortical networks generate diverse patterns of rhythmic activity. Theta oscillations (4-12 Hz) are commonly observed during spatial learning and working memory tasks. The authors ask how etomidate, acting predominantly via gamma-aminobutyric acid type A (GABAA) receptors containing beta2 or beta3 subunits, a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200502000-00017
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) attenuates the conversion of plasminogen to plasmin. Polymorphisms of the PAI-1 gene are associated with varying PAI-1 levels and risk of prothrombotic events in nonsurgical patients. The purpose of this study, a secondary analysis of a clinical trial, was to investi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318167aecc
更新日期:2008-04-01 00:00:00
abstract::I653 is a new volatile anesthetic structurally similar to enflurane and isoflurane. Since enflurane can induce convulsions, whereas isoflurane progressively depresses cortical electrical activity, the authors believed it important to assess the effect of I653 on the EEG (in both the "time" and "frequency" domain). The...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198809000-00002
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:Despite pharmacological treatment, 70-80% of patients report moderate to severe pain after surgery. Because nicotine has been reported to have analgesic properties in animal and human volunteer studies, the authors assessed the analgesic efficacy of a single 3 mg dose of nicotine nasal spray administered bef...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200412000-00023
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:A relatively small number of inhibitory interneurons can control the excitability and synchronization of large numbers of pyramidal cells in hippocampus and other cortical regions. Thus, anesthetic modulation of interneurons could play an important role for the maintenance of anesthesia. The aim of this stud...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200102000-00025
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Voltage-gated Na channels modulate membrane excitability in excitable tissues. Inhibition of Na channels has been implicated in the effects of volatile anesthetics on both nervous and peripheral excitable tissues. The authors investigated isoform-selective effects of isoflurane on the major Na channel isofor...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/01.anes.0000268390.28362.4a
更新日期:2007-07-01 00:00:00
abstract::Rats were given standardized injections of 3H-L-proline into the trigeminal ganglion and 14C-lidocaine hydrochloride at the infraorbital foramen. The 3H-L-proline was always injected 2.5 h before removal of the nerve. Lidocaine, 1, 2, and 4%, produced a concentration-related inhibition of entry of 3H-labeled rapid axo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197602000-00009
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Pulsus alternans is a classic type of abnormal pulse. It can be defined as a regular alternation of pulse amplitude in which runs of weak and strong beats follow each other alternatively without any change in cycle length. It may be a sign of severe decompensated congestive heart failure. The authors infrequ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200007000-00017
更新日期:2000-07-01 00:00:00
abstract::The tape recorded EEGs of 127 patients anesthetized with large doses of opioids were retrospectively analyzed for evidence of opioid-induced seizures, and in particular, correlated with movements that occurred during induction and could be clinically interpreted as seizures. Bilateral EEG leads in patients receiving f...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198912000-00008
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to halothane or heat stress. METHODS:Because oxidative species may play a criti...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000748
更新日期:2015-09-01 00:00:00
abstract::Neurophysiologic and local cerebral metabolic mapping techniques indicate that seizures associated with lidocaine toxicity originate in subcortical brain structures. Normally local cerebral blood flow (l-CBF) is quantitatively coupled to local cerebral metabolic rate for glucose (l-CMRg). In the present study the resp...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198606000-00016
更新日期:1986-06-01 00:00:00