Differential effects of etomidate and midazolam on vascular adenosine triphosphate-sensitive potassium channels: isometric tension and patch clamp studies.

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Hypotension is a risk factor for adverse perioperative outcomes. Machine-learning methods allow large amounts of data for development of robust predictive analytics. The authors hypothesized that machine-learning methods can prov...

journal_title：Anesthesiology

authors： Kendale S,Kulkarni P,Rosenberg AD,Wang J

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Rapid elimination of nitrous oxide from the lungs at the end of inhalational anesthesia dilutes alveolar oxygen, producing "diffusion hypoxia." A similar dilutional effect on accompanying volatile anesthetic agent has not been evaluated and may impact the speed of emergence. METHODS:Twenty patients undergoi...

journal_title：Anesthesiology

authors： Peyton PJ,Chao I,Weinberg L,Robinson GJ,Thompson BR

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Only limited data exist comparing differences in sensory function and responses to neural blockade in infant and adult rats. Therefore, the authors sought (1) to compare baseline thermal, proprioceptive, and postural responses in infant, adolescent, and adult rats; and (2) to compare the effects of sciatic n...

journal_title：Anesthesiology

authors： Hu D,Hu R,Berde CB

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:A combination of opioid and nonopioid analgesic drugs may improve the quality of postoperative analgesia as well as reduce opioid requirements and their associated side effects. Studies have shown synergism between gabapentin and morphine in animal and human experiments and in the treatment of incisional pai...

journal_title：Anesthesiology

authors： Turan A,Karamanlioğlu B,Memiş D,Hamamcioglu MK,Tükenmez B,Pamukçu Z,Kurt I

更新日期：2004-04-01 00:00:00

abstract：:Patients with mitral valve disease can develop pulmonary artery hypertension that persists after mitral valve replacement. In 1987, nitric oxide (NO) was reported to be an important factor accounting for the biologic activity of endothelium-derived relaxing factor. Inhaled NO was subsequently reported to be a selectiv...

journal_title：Anesthesiology

authors： Girard C,Lehot JJ,Pannetier JC,Filley S,Ffrench P,Estanove S

更新日期：1992-11-01 00:00:00

abstract：:The use of isoflurane in patients with coronary artery disease remains controversial because of the possibility of "coronary steal". In this study, the effects of isoflurane and halothane on global and regional myocardial blood flow and metabolism were compared, and the relationship between steal-induced myocardial is...

journal_title：Anesthesiology

authors： Pulley DD,Kirvassilis GV,Kelermenos N,Kater K,Barzilai B,Genton RE,Efstathiou C,Lappas DG

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Hypotension induced by sodium nitroprusside can minimize intraoperative blood loss. The release of endogenous catecholamines can influence adrenoceptors of platelets and thus might change the ability of platelets to aggregate. METHODS:Forty patients undergoing nasal septum, tympanoplastic, or sphenoid sinus...

journal_title：Anesthesiology

authors： Dietrich GV,Heesen M,Boldt J,Hempelmann G

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Differentiating drug-related changes and state-related changes on the electroencephalogram during anesthetic-induced unconsciousness has remained a challenge. To distinguish these, we designed a rigorous experimental protocol with two drugs known to have distinct molecular mechanisms of action. We hypothesiz...

journal_title：Anesthesiology

authors： Scheinin A,Kallionpää RE,Li D,Kallioinen M,Kaisti K,Långsjö J,Maksimow A,Vahlberg T,Valli K,Mashour GA,Revonsuo A,Scheinin H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the authors explored whether postoperative nadir platelet counts are associated with acute kidney injury...

journal_title：Anesthesiology

authors： Kertai MD,Zhou S,Karhausen JA,Cooter M,Jooste E,Li YJ,White WD,Aronson S,Podgoreanu MV,Gaca J,Welsby IJ,Levy JH,Stafford-Smith M,Mathew JP,Fontes ML

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Sevoflurane administered to neonatal rats induces neurobehavioral abnormalities and epigenetic reprogramming of their germ cells; the latter can pass adverse effects of sevoflurane to future offspring. As germ cells are susceptible to reprogramming by environmental factors across the lifespan, the authors hy...

journal_title：Anesthesiology

authors： Ju LS,Yang JJ,Xu N,Li J,Morey TE,Gravenstein N,Seubert CN,Setlow B,Martynyuk AE

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Electroconvulsion therapy is likely to serve as an effective preconditioning stimulus for inducing tolerance to ischemic brain injury. The current study examines whether electrical stimuli on the spinal cord is also capable of inducing tolerance to ischemic spinal cord injury by transient aortic occlusion. ...

journal_title：Anesthesiology

authors： Kakinohana M,Harada H,Mishima Y,Kano T,Sugahara K

更新日期：2005-07-01 00:00:00

abstract：:Postoperative adrenocortical function was compared in 23 out-patients receiving either thiopental, 4 mg/kg, for induction and a thiopental infusion, 0.26 mg . kg-1 . min-1, in combination with nitrous oxide 70% for maintenance of anesthesia (control); etomidate, 0.4 mg/kg, for induction followed by an etomidate infusi...

journal_title：Anesthesiology

authors： Wagner RL,White PF

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Reversal of residual neuromuscular blockade by acetylcholinesterase inhibitors (e.g., neostigmine) improves respiratory function. However, neostigmine may also impair muscle strength. We hypothesized that neostigmine administered after recovery of the train-of-four (TOF) ratio impairs upper airway integrity ...

journal_title：Anesthesiology

authors： Herbstreit F,Zigrahn D,Ochterbeck C,Peters J,Eikermann M

更新日期：2010-12-01 00:00:00

abstract：:The effects of anesthetic drugs on lipid order were evaluated by the fluorescence polarization of the probe molecule, 1,6-diphenyl-1,3,5-hexatriene (DPH) incorporated into vesicles of dimyristoylphosphatidylcholine (DMPC) and DMPC with 10 mol% ganglioside (GD1a). Anesthetics (enflurane, chloroform, diethylether, pento...

journal_title：Anesthesiology

authors： Harris RA,Groh GI

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:N-methyl-D-aspartate (NDMA) antagonists have minimal effects on acute nociception but block facilitated states of processing. In contrast, the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonists decrease acute noxious responses. Morphine (a mu-opioid agonist) can also decrease acute n...

journal_title：Anesthesiology

authors： Nishiyama T,Yaksh TL,Weber E

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether either regional anesthesia (RA) or general anesthesia (GA) provided the best analgesia with the fewest adverse effects up to 2 weeks after ambulatory hand surgery. METHODS:Patients undergoing ambulatory hand surgery were randomly assigned to RA (axillary br...

journal_title：Anesthesiology

authors： McCartney CJ,Brull R,Chan VW,Katz J,Abbas S,Graham B,Nova H,Rawson R,Anastakis DJ,von Schroeder H

更新日期：2004-08-01 00:00:00

abstract：:The serum and urinary concentrations of fluorinated metabolites of isoflurane after inhalation of three different concentrations of isoflurane were studied in 18 ASA physical status 1 or 2 patients, scheduled for orthopedic or otolaryngeal surgery. Isoflurane was administered for 60 min during fentanyl-nitrous oxide-o...

journal_title：Anesthesiology

authors： Davidkova T,Kikuchi H,Fujii K,Mukaida K,Sato N,Kawachi S,Morio M

更新日期：1988-08-01 00:00:00

abstract：:The effects of morphine, halothane, and their various combinations on the purposeful movement (PM) response and the heart rate (HR) increase caused by noxious stimulation were studied in 250 rat experiments. Doses that block the PM and HR responses for the single agent and for combinations were determined with a probi...

journal_title：Anesthesiology

authors： Kissin I,Kerr CR,Smith LR

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:The authors recently established that the analgesic actions of the inhalation anesthetic nitrous oxide were mediated by noradrenergic bulbospinal neurons and spinal alpha2B adrenoceptors. They now determined whether noradrenergic brainstem nuclei and descending spinal pathways are responsible for the antinoc...

journal_title：Anesthesiology

authors： Kingery WS,Agashe GS,Guo TZ,Sawamura S,Davies MF,Clark JD,Kobilka BK,Maze M

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the mos...

journal_title：Anesthesiology

authors： Pham T,Serpa Neto A,Pelosi P,Laffey JG,De Haro C,Lorente JA,Bellani G,Fan E,Brochard LJ,Pesenti A,Schultz MJ,Artigas A,LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group.

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Our objective was to elucidate the direct effects of fentanyl and morphine on cardiac excitation-contraction coupling using individual, field-stimulated rat ventricular myocytes. METHODS:Freshly isolated myocytes were loaded with fura-2 and field stimulated (0.3 Hz) at 28 degrees C. Amplitude and timing of ...

journal_title：Anesthesiology

authors： Kanaya N,Zakhary DR,Murray PA,Damron DS

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Morbidly obese patients, during anesthesia and paralysis, experience more severe impairment of respiratory mechanics and gas exchange than normal subjects. The authors hypothesized that positive end-expiratory pressure (PEEP) induces different responses in normal subjects (n = 9; body mass index < 25 kg/m2) ...

journal_title：Anesthesiology

authors： Pelosi P,Ravagnan I,Giurati G,Panigada M,Bottino N,Tredici S,Eccher G,Gattinoni L

更新日期：1999-11-01 00:00:00

abstract：:Carotid endarterectomy requires temporary surgical occlusion of the involved carotid artery. During occlusion, the minimally acceptable (critical) internal carotid artery stump pressure is reported to be 50 torr, whereas for regional cerebral blood flow (rCBF), a critical range is reported to be 18-24 ml/100 g/min. Du...

journal_title：Anesthesiology

authors： McKay RD,Sundt TM,Michenfelder JD,Gronert GA,Messick JM,Sharbrough FW,Piepgras DG

更新日期：1976-10-01 00:00:00

abstract：BACKGROUND:Propofol (2,6-diisopropylphenol) is one of the most frequently used anesthetic agents. One of the main side effects of propofol is to reduce blood pressure, which is thought to occur by inhibiting the release of catecholamines from sympathetic neurons. Here, the authors hypothesized that propofol-induced hyp...

journal_title：Anesthesiology

authors： Han L,Fuqua S,Li Q,Zhu L,Hao X,Li A,Gupta S,Sandhu R,Lonart G,Sugita S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from limitations in assessing this complex subjective experience. However, human brain neuroimaging techniques enable the assessment of functional and neur...

journal_title：Anesthesiology

authors： Harris RE,Napadow V,Huggins JP,Pauer L,Kim J,Hampson J,Sundgren PC,Foerster B,Petrou M,Schmidt-Wilcke T,Clauw DJ

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The effects of anesthetics on ischemia-induced ventricular arrhythmias remain poorly studied. This study investigated the effects of propofol and sevoflurane on the survival rate and morbidity as a result of ventricular arrhythmias, and defined a possible mechanism for the arrhythmogenic properties of anesth...

journal_title：Anesthesiology

authors： Hirata N,Kanaya N,Kamada N,Kimura S,Namiki A

更新日期：2009-01-01 00:00:00

abstract：:The authors evaluated the systemic and cerebral hemodynamic and metabolic effects of 1 h of hypotension to a mean arterial pressure of either 50 mmHg or 40 mmHg induced by intravenous adenosine or ATP in dogs maintained on 70% nitrous oxide and 0.1% halothane. Following the hypotensive period, brain biopsy specimens w...

journal_title：Anesthesiology

authors： Newberg LA,Milde JH,Michenfelder JD

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and neutrophils. This study investigated the effects of neutrophil elastase on organ injury after unilateral lung acid instillation by administrating a specific neutrophil elastase inhibitor, ONO...

journal_title：Anesthesiology

authors： Kaneko K,Kudoh I,Hattori S,Yamada H,Ohara M,Wiener-Kronish J,Okumura F

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Epidural morphine yields postoperative pain relief and hemodynamic stability. However, the effects of epidural morphine on sympathetic tone are unclear. This study was designed to elucidate the effects of epidural morphine on cardiac (CSNA) and renal (RSNA) sympathetic nerve activity by direct measurement in...

journal_title：Anesthesiology

authors： Mori T,Nishikawa K,Terai T,Yukioka H,Asada A

更新日期：1998-06-01 00:00:00

abstract：:To determine whether disuse atrophy of skeletal muscle results in resistance to pancuronium, the dose response to pancuronium was determined simultaneously in both gastrocnemius muscles of six dogs that had one hind limb immobilized in a plaster cast for one month. Muscle responses were evoked during pentobarbital-nit...

journal_title：Anesthesiology

authors： Gronert GA

更新日期：1981-11-01 00:00:00